Aliases for JAML Gene
External Ids for JAML Gene
Previous HGNC Symbols for JAML Gene
GeneCards Summary for JAML Gene
JAML (Junction Adhesion Molecule Like) is a Protein Coding gene. Diseases associated with JAML include Febrile Seizures, Familial, 5. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is SCN4B.
UniProtKB/Swiss-Prot Summary for JAML Gene
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.