This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to seco... See more...

Aliases for JAM2 Gene

Aliases for JAM2 Gene

  • Junctional Adhesion Molecule 2 2 3 4 5
  • VE-JAM 2 3 4
  • JAM-B 2 3 4
  • Vascular Endothelial Junction-Associated Molecule 3 4
  • Junctional Adhesion Molecule B 3 4
  • C21orf43 3 4
  • CD322 2 3
  • VEJAM 3 4
  • JAM-2 3 4
  • JAMB 2 3
  • JAM-IT/VE-JAM 3
  • CD322 Antigen 4
  • PRO245 3
  • IBGC8 3
  • JAM2 5

External Ids for JAM2 Gene

Previous HGNC Symbols for JAM2 Gene

  • C21orf43

Previous GeneCards Identifiers for JAM2 Gene

  • GC21P023590
  • GC21P023673
  • GC21P025933
  • GC21P027011
  • GC21P012414

Summaries for JAM2 Gene

Entrez Gene Summary for JAM2 Gene

  • This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for JAM2 Gene

JAM2 (Junctional Adhesion Molecule 2) is a Protein Coding gene. Diseases associated with JAM2 include Basal Ganglia Calcification, Idiopathic, 8, Autosomal Recessive and Basal Ganglia Calcification, Idiopathic, 1. Among its related pathways are Insulin receptor recycling and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is JAM3.

UniProtKB/Swiss-Prot Summary for JAM2 Gene

  • Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes (PubMed:11590146, PubMed:11823489, PubMed:24357068). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow (PubMed:24357068). At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium (PubMed:12239159). Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1 (PubMed:12070135). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity). May also play a role in angiogenesis (By similarity).

Gene Wiki entry for JAM2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for JAM2 Gene

Genomics for JAM2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for JAM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J025606 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.1 50 2.8 BCLAF1 SP1 ZNF654 ZNF207 NCOR1 MYC ZNF600 SIX5 SSRP1 ZNF580 MRPL39 JAM2 GABPA lnc-JAM2-1
GH21J025561 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.3 -44.6 -44649 4.2 BCLAF1 SP1 ZNF207 POLR2A BCL11A TARDBP TRIM22 CTCF IRF4 EBF1 EU375836 HSALNG0132380 MIR155HG JAM2 MRPL39 ENSG00000229962 MIR155 lnc-MRPL39-15 lnc-MRPL39-2
GH21J025638 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 255.7 +32.3 32329 3 BCLAF1 ZNF600 ZNF223 ZIC2 ZBTB10 ZNF341 ZNF513 KLF9 SP2 SMC3 JAM2 MRPL39 GABPA ATP5PF lnc-GABPA-10 piR-61101-438 lnc-JAM2-1
GH21J025717 Enhancer 0.8 Ensembl ENCODE 10.3 +110.2 110151 1.4 NFIC ZNF316 NFE2 PRDM6 MAFG ZBTB33 ATF4 MAFF DPF2 CEBPB HSALNG0132386 MRPL39 JAM2 piR-57460-422 ATP5PF GABPA lnc-JAM2-1
GH21J025670 Enhancer 0.5 Ensembl ENCODE 11.6 +63.1 63144 1 JUND MAFF MRPL39 JAM2 piR-60146-101 ENSG00000287109 GABPA lnc-JAM2-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around JAM2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for JAM2

Genomic Locations for JAM2 Gene

Latest Assembly
chr21:25,607,550-25,717,562
(GRCh38/hg38)
Size:
110,013 bases
Orientation:
Plus strand

Previous Assembly
chr21:27,011,570-27,089,874
(GRCh37/hg19 by Entrez Gene)
Size:
78,305 bases
Orientation:
Plus strand

chr21:27,011,584-27,089,874
(GRCh37/hg19 by Ensembl)
Size:
78,291 bases
Orientation:
Plus strand

Genomic View for JAM2 Gene

Genes around JAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JAM2 Gene

Proteins for JAM2 Gene

  • Protein details for JAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57087-JAM2_HUMAN
    Recommended name:
    Junctional adhesion molecule B
    Protein Accession:
    P57087
    Secondary Accessions:
    • B2R6T9
    • B4DGT9
    • Q6UXG6
    • Q6YNC1

    Protein attributes for JAM2 Gene

    Size:
    298 amino acids
    Molecular mass:
    33207 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for JAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JAM2 Gene

Post-translational modifications for JAM2 Gene

  • Glycosylation at Asn98, Asn187, and Asn236
  • Modification sites at PhosphoSitePlus

Assay products for research

  • Boster Bio ELISA Kits for JAM2

No data available for DME Specific Peptides for JAM2 Gene

Domains & Families for JAM2 Gene

Gene Families for JAM2 Gene

Protein Domains for JAM2 Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
  • Immunoglobulin V-set

Suggested Antigen Peptide Sequences for JAM2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50148, highly similar to Junctional adhesion molecule B (B4DGT9_HUMAN)
  • Vascular endothelial junction-associated molecule (JAM2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P57087

UniProtKB/Swiss-Prot:

JAM2_HUMAN :
  • The Ig-like V-type domain is necessary and sufficient to mediate interaction with JAM3 and integrin alpha-4/beta-1.
  • Belongs to the immunoglobulin superfamily.
Domain:
  • The Ig-like V-type domain is necessary and sufficient to mediate interaction with JAM3 and integrin alpha-4/beta-1.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with JAM2: view

Function for JAM2 Gene

Molecular function for JAM2 Gene

UniProtKB/Swiss-Prot Function:
Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes (PubMed:11590146, PubMed:11823489, PubMed:24357068). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow (PubMed:24357068). At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium (PubMed:12239159). Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1 (PubMed:12070135). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity). May also play a role in angiogenesis (By similarity).

Phenotypes From GWAS Catalog for JAM2 Gene

Gene Ontology (GO) - Molecular Function for JAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IDA 12070135
GO:0005515 protein binding IPI 11590146
genes like me logo Genes that share ontologies with JAM2: view
genes like me logo Genes that share phenotypes with JAM2: view

Human Phenotype Ontology for JAM2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for JAM2 Gene

MGI Knock Outs for JAM2:
  • Jam2 Jam2<tm1Okud>
  • Jam2 Jam2<tm1.1(cre)Jrs>
  • Jam2 Jam2<tm1.2Rha>
  • Jam2 Jam2<tm1.1(KOMP)Mbp>

Animal Models for research

  • Taconic Biosciences Mouse Models for JAM2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JAM2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for JAM2 Gene

Localization for JAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JAM2 Gene

Cell membrane. Single-pass type I membrane protein. Cell junction. Cell junction, tight junction. Note=Localized at tight junctions of both epithelial and endothelial cells (By similarity). Specifically localized within the somatodendritic compartment of neurons and excluded from the axon (By similarity). {ECO:0000250 UniProtKB:Q9JI59}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JAM2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for JAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 10779521
GO:0005923 bicellular tight junction IEA --
GO:0009986 cell surface IDA 19740376
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with JAM2: view

Pathways & Interactions for JAM2 Gene

genes like me logo Genes that share pathways with JAM2: view

Pathways by source for JAM2 Gene

Gene Ontology (GO) - Biological Process for JAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development ISS --
GO:0007520 myoblast fusion ISS --
GO:0030198 extracellular matrix organization TAS --
GO:0031642 negative regulation of myelination ISS --
GO:0035633 maintenance of permeability of blood-brain barrier NAS 30280653
genes like me logo Genes that share ontologies with JAM2: view

No data available for SIGNOR curated interactions for JAM2 Gene

Drugs & Compounds for JAM2 Gene

No Compound Related Data Available

Transcripts for JAM2 Gene

mRNA/cDNA for JAM2 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JAM2

Alternative Splicing Database (ASD) splice patterns (SP) for JAM2 Gene

No ASD Table

Relevant External Links for JAM2 Gene

GeneLoc Exon Structure for
JAM2

Expression for JAM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for JAM2 Gene

Protein differential expression in normal tissues from HIPED for JAM2 Gene

This gene is overexpressed in Placenta (15.2), Testis (9.5), Spinal cord (9.2), Frontal cortex (7.3), and Gallbladder (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for JAM2 Gene



Protein tissue co-expression partners for JAM2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for JAM2

SOURCE GeneReport for Unigene cluster for JAM2 Gene:

Hs.517227

mRNA Expression by UniProt/SwissProt for JAM2 Gene:

P57087-JAM2_HUMAN
Tissue specificity: Highly expressed in heart, placenta, lung, foreskin and lymph node (PubMed:10779521, PubMed:10945976). Prominently expressed on high endothelial venules and also present on the endothelia of other vessels (at protein level) (PubMed:10779521, PubMed:10945976). Also expressed in the brain in the caudate nuclei (PubMed:31851307).

Evidence on tissue expression from TISSUES for JAM2 Gene

  • Nervous system(4.8)
  • Heart(4.5)
  • Lung(4.4)
  • Bone marrow(4.2)
  • Muscle(2.1)
  • Eye(2)
genes like me logo Genes that share expression patterns with JAM2: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for JAM2 Gene

Orthologs for JAM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for JAM2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia JAM2 29 30
  • 99.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia JAM2 29 30
  • 90.75 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia JAM2 29 30
  • 90.63 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Jam2 29
  • 83.93 (n)
Mouse
(Mus musculus)
Mammalia Jam2 29 16 30
  • 83.45 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia JAM2 30
  • 71 (a)
OneToOne
Chicken
(Gallus gallus)
Aves JAM2 29 30
  • 66.37 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia JAM2 30
  • 51 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia jam2 29
  • 61.51 (n)
Zebrafish
(Danio rerio)
Actinopterygii jam2a 30
  • 31 (a)
OneToMany
jam2b 30
  • 30 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 22 (a)
OneToMany
Species where no ortholog for JAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for JAM2 Gene

ENSEMBL:
Gene Tree for JAM2 (if available)
TreeFam:
Gene Tree for JAM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for JAM2: view image
Alliance of Genome Resources:
Additional Orthologs for JAM2

Paralogs for JAM2 Gene

(2) SIMAP similar genes for JAM2 Gene using alignment to 3 proteins:

  • JAM2_HUMAN
  • A8MQ45_HUMAN
  • H0YEX9_HUMAN
genes like me logo Genes that share paralogs with JAM2: view

Variants for JAM2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for JAM2 Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
rs1230941179 Pathogenic: Basal ganglia calcification, idiopathic, 8, autosomal recessive 25,698,786(+) G/C
NM_021219.4(JAM2):c.504G>C (p.Trp168Cys)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs1383641309 Pathogenic: Basal ganglia calcification, idiopathic, 8, autosomal recessive 25,693,837(+) G/A
NM_021219.4(JAM2):c.323G>A (p.Arg108His)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs1600978441 Pathogenic: Basal ganglia calcification, idiopathic, 8, autosomal recessive 25,639,822(+) A/G
NM_021219.4(JAM2):c.1A>G (p.Met1Val)
INITIATIOR_CODON_VARIANT,MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs1601038626 Pathogenic: Basal ganglia calcification, idiopathic, 8, autosomal recessive 25,689,871(+) AT/A
NM_021219.4(JAM2):c.143del (p.Ile47_Leu48insTer)
NONSENSE,NON_CODING_TRANSCRIPT_VARIANT,INTRON
rs1601038704 Pathogenic: Basal ganglia calcification, idiopathic, 8, autosomal recessive 25,689,908(+) CCAGA/C
NM_021219.4(JAM2):c.177_180del (p.Ser59_Arg60insTer)
FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for JAM2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for JAM2 Gene

Variant ID Type Subtype PubMed ID
esv2664665 CNV deletion 23128226
esv3646714 CNV loss 21293372
nsv1064561 CNV loss 25217958
nsv1114274 CNV deletion 24896259

Variation tolerance for JAM2 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JAM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JAM2
Leiden Open Variation Database (LOVD)
JAM2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JAM2 Gene

Disorders for JAM2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for JAM2 Gene - From: OMI, CVR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search JAM2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

JAM2_HUMAN
  • Basal ganglia calcification, idiopathic, 8, autosomal recessive (IBGC8) [MIM:618824]: A form of basal ganglia calcification, a genetically heterogeneous condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas. {ECO:0000269 PubMed:31851307, ECO:0000269 PubMed:32142645}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for JAM2

genes like me logo Genes that share disorders with JAM2: view

No data available for Genatlas for JAM2 Gene

Publications for JAM2 Gene

  1. Biallelic loss-of-function mutations in JAM2 cause primary familial brain calcification. (PMID: 31851307) Cen Z … Luo W (Brain : a journal of neurology 2020) 3 4 72
  2. Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells. (PMID: 10779521) Palmeri D … Rosen SD (The Journal of biological chemistry 2000) 2 3 4
  3. A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactions. (PMID: 10945976) Cunningham SA … Brock TA (The Journal of biological chemistry 2000) 2 3 4
  4. Bi-allelic JAM2 Variants Lead to Early-Onset Recessive Primary Familial Brain Calcification. (PMID: 32142645) Schottlaender LV … Houlden H (American journal of human genetics 2020) 3 4
  5. Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells. (PMID: 24357068) Arcangeli ML … Aurrand-Lions M (Stem cells (Dayton, Ohio) 2014) 3 4

Products for JAM2 Gene

Sources for JAM2 Gene