Aliases for JAK1 Gene
External Ids for JAK1 Gene
Previous HGNC Symbols for JAK1 Gene
Previous GeneCards Identifiers for JAK1 Gene
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
GeneCards Summary for JAK1 Gene
JAK1 (Janus Kinase 1) is a Protein Coding gene. Diseases associated with JAK1 include Leukemia, Acute, X-Linked and Polycythemia Vera. Among its related pathways are RET signaling and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TYK2.
UniProtKB/Swiss-Prot Summary for JAK1 Gene
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952).