Aliases for JAG2 Gene
External Ids for JAG2 Gene
- HGNC: 6189
- Entrez Gene: 3714
- Ensembl: ENSG00000184916
- OMIM: 602570
- UniProtKB: Q9Y219
Previous GeneCards Identifiers for JAG2 Gene
- GC14M102987
- GC14M099599
- GC14M103579
- GC14M104679
- GC14M105607
- GC14M085799
Summaries for JAG2 Gene
-
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for JAG2 Gene
JAG2 (Jagged 2) is a Protein Coding gene. Diseases associated with JAG2 include Ossifying Fibroma and Shipyard Eye. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and Notch signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include calcium ion binding and Notch binding. An important paralog of this gene is JAG1.
UniProtKB/Swiss-Prot for JAG2 Gene
-
Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).
Additional gene information for JAG2 Gene
- Monarch Initiative
- Search for JAG2 at DataMed
- Search for JAG2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JAG2 Gene
Genomics for JAG2 Gene
GeneHancer (GH) Regulatory Elements for JAG2 Gene
Promoters and enhancers for JAG2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around JAG2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the JAG2 gene promoter:
-
- Hand1
- E47
- NF-1
- HEN1
- USF-1
- USF-1:USF-2
- USF1
- USF2
- MyoD
- AhR
Regulatory Element Products
Genomic Locations for JAG2 Gene
Genomic Locations for JAG2 Gene
- chr14:105,140,981-105,168,824
- (GRCh38/hg38)
- Size:
- 27,844 bases
- Orientation:
- Minus strand
- chr14:105,607,318-105,635,161
- (GRCh37/hg19)
- Size:
- 27,844 bases
- Orientation:
- Minus strand
Genomic View for JAG2 Gene
Genes around JAG2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.33 by Entrez Gene
- 14q32.33 by HGNC
- 14q32.33 by Ensembl
JAG2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for JAG2 Gene
Proteins for JAG2 Gene
-
Protein details for JAG2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y219-JAG2_HUMAN
- Recommended name:
- Protein jagged-2
- Protein Accession:
- Q9Y219
- Q9UE17
- Q9UE99
- Q9UNK8
- Q9Y6P9
- Q9Y6Q0
Protein attributes for JAG2 Gene
- Size:
- 1238 amino acids
- Molecular mass:
- 133367 Da
- Quaternary structure:
- No Data Available
Protein Expression for JAG2 Gene
Post-translational modifications for JAG2 Gene
Other Protein References for JAG2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for JAG2 (Jagged 2)
-
Custom Antibody ServicesOriGene Antibodies for JAG2
- Novus Biologicals Antibodies for JAG2
-
Abcam antibodies for JAG2
- Invitrogen Antibodies for JAG2
- antibodies-online: Search results for 116 available JAG2 Antibodies ranked by validation data
- Compare Top JAG2 Antibodies
-
Recommended
- 25 FACS Antibodies (anti-mouse)
- 15 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 1 EIA Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 51 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 FACS Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 11 WB Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 1 EIA Antibody (anti-rat)
- 1 IHC Antibody (anti-rat)
- GeneTex Jag2 Antibody for JAG2
-
Custom Antibody ServicesProSci Antibodies for JAG2
-
Santa Cruz Biotechnology (SCBT) Antibodies for JAG2
Protein Products
- R&D Systems Proteins and Enzymes for JAG2 (Jagged 2)
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for JAG2
- Origene Custom Protein Services for JAG2
- Novus Biologicals proteins for JAG2
- GeneTex Proteins for JAG2
-
ProSci Proteins for JAG2
-
Abcam proteins for JAG2
Assay Products
No data available for DME Specific Peptides for JAG2 Gene
Domains & Families for JAG2 Gene
Gene Families for JAG2 Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for JAG2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for JAG2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for JAG2 Gene
Function for JAG2 Gene
Molecular function for JAG2 Gene
- UniProtKB/Swiss-Prot Function:
- Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).
- GENATLAS Biochemistry:
- NOTCH1 ligand,homolog to rat jagged 2 and Drosophila serrate,Dres30,mouse homolog,expressed in high levels in embryonic limb buds,first branchial arch,developing cochlea and the organ of Corti,central and peripheral nervous system,retina,tooth buds,thymus,submandilas gland,stomach
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005112 | Notch binding | IPI | 9315665 |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16713569 |
| GO:0008083 | growth factor activity | IDA | 10383933 |
Phenotypes for JAG2 Gene
- MGI mutant phenotypes for JAG2:
-
inferred from 5 alleles
- respiratory system phenotype
- limbs/digits/tail phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- no phenotypic analysis
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- craniofacial phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- hearing/vestibular/ear phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for JAG2:
-
- Increased shRNA abundance (Z-score > 2)
- Increased number of mitotic cells
- Increased G1 DNA content
- Effect on mitosis
- Dynamic nuclei (hole, folded or small irregular)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- no effect
- Decreased cell number
- Increased vaccinia virus (VACV) infection
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased gamma-H2AX phosphorylation
- Decreased IL-8 secretion
Animal Models for JAG2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for JAG2
-
CRISPR Products
-
OriGene CRISPR knockouts for JAG2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for JAG2
- genomics-online: gRNA clones - Search results for 55 available JAG2 gene related products
- Overview of 55 available JAG2 gene related products
- Applied Biological Materials CRISPR for JAG2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for JAG2
- GenScript: Design CRISPR guide RNA sequences for JAG2
miRNA for JAG2 Gene
- miRTarBase miRNAs that target JAG2
-
- hsa-mir-335-5p (MIRT016805)
- hsa-mir-124-3p (MIRT022161)
- hsa-mir-484 (MIRT042161)
- hsa-mir-92a-3p (MIRT049515)
- hsa-mir-624-3p (MIRT053421)
- hsa-mir-6809-3p (MIRT647278)
- hsa-mir-6832-3p (MIRT647279)
- hsa-mir-6833-3p (MIRT647280)
- hsa-mir-4768-5p (MIRT647281)
- hsa-mir-493-5p (MIRT647282)
- hsa-let-7g-3p (MIRT647283)
- hsa-let-7a-2-3p (MIRT647284)
- hsa-let-7c-3p (MIRT647285)
- hsa-mir-4753-3p (MIRT647286)
- hsa-mir-1286 (MIRT647287)
- hsa-mir-130b-5p (MIRT647288)
- hsa-mir-761 (MIRT647289)
- hsa-mir-3619-5p (MIRT647290)
- hsa-mir-214-3p (MIRT647291)
- hsa-mir-8083 (MIRT647292)
- hsa-mir-6165 (MIRT647293)
- hsa-mir-410-3p (MIRT731729)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for JAG2
- Browse OriGene Inhibitory RNA Products For JAG2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JAG2
- genomics-online: shRNA clones - Search results for 55 available JAG2 gene related products
- Overview of 55 available JAG2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for JAG2
- VectorBuilder custom plasmid, inducible vectors for JAG2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for JAG2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for JAG2
- Applied Biological Materials Clones for JAG2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for JAG2 (Jagged 2)
Cell Line Products
-
Horizon Cell Lines for JAG2
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for JAG2 Gene
Localization for JAG2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for JAG2 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | ISS | 10910909 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for JAG2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by NOTCH1 | ||
| 2 | NOTCH2 Activation and Transmission of Signal to the Nucleus | ||
| 3 | Notch signaling pathway (KEGG) | ||
| 4 | HIV Life Cycle |
.45
|
|
| 5 | Gastric cancer |
.62
|
|
Pathways by source for JAG2 Gene
5 BioSystems pathways for JAG2 Gene
19 Reactome pathways for JAG2 Gene
5 KEGG pathways for JAG2 Gene
1 GeneGo (Thomson Reuters) pathway for JAG2 Gene
2 R&D Systems pathways for JAG2 Gene
1 Cell Signaling Technology pathway for JAG2 Gene
Interacting Proteins for JAG2 Gene
Selected Interacting proteins:
ENSP00000328169
Q9Y219-JAG2_HUMAN
for JAG2 Gene via
STRING
UniProtKB
IID
GPS-Prot Interaction Network for JAG2
SIGNOR curated interactions for JAG2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | IEA | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0003016 | respiratory system process | IEA | -- |
| GO:0007154 | cell communication | IEA | -- |
| GO:0007219 | Notch signaling pathway | TAS | -- |
Transcripts for JAG2 Gene
mRNA/cDNA for JAG2 Gene
- (2) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (9) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000331782 5835 bps (uc001yqg.4)
- ENST00000347004 5720 bps (uc001yqh.5)
- ENST00000546616 2275 bps (uc059fyt.1)
- ENST00000553244 866 bps (uc059fyu.1)
- ENST00000553051 768 bps (uc059fyv.1)
CRISPR Products
-
OriGene CRISPR knockouts for JAG2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for JAG2
- genomics-online: gRNA clones - Search results for 55 available JAG2 gene related products
- Overview of 55 available JAG2 gene related products
- Applied Biological Materials CRISPR for JAG2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for JAG2
- GenScript: Design CRISPR guide RNA sequences for JAG2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for JAG2
- Browse OriGene Inhibitory RNA Products For JAG2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JAG2
- genomics-online: shRNA clones - Search results for 55 available JAG2 gene related products
- Overview of 55 available JAG2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for JAG2
- VectorBuilder custom plasmid, inducible vectors for JAG2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for JAG2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for JAG2
- Applied Biological Materials Clones for JAG2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for JAG2 (Jagged 2)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - |
| ExUns: | 20b | ^ | 21 | ^ | 22 | ^ | 23 |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: | |||||||
| SP7: | |||||||
| SP8: |
Expression for JAG2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
- Fetal Matrix Cells Hair Follicle
- Basal Cells Trachea
- Inner Enamel Epithelial Cells Dental Enamel
- Fetal Medulla Cells Hair Shaft
- Brain (Nervous System)
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
- Fetal Matrix Cells Hair Follicle
- Fetal Medulla Cells Hair Shaft
- Basal Keratinocytes Embryonic Epidermis
-
Tooth (Integumentary System)
- Primary Enamel Knot Cells Enamel Knot
- Inner Enamel Epithelial Cells Dental Enamel
- Stellate Reticulum Cells Dental Core
- Outer Enamel Epithelial Cells Dental Enamel
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Primitive Streak (Early Embryonic Tissues)
- Notochord Cells Notochord
-
Cartilage (Muscoskeletal System)
- Notochord Cells Notochord
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Umbilical Cord (Extraembryonic Tissues)
This gene is overexpressed in Platelet (48.8) and Heart (20.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for JAG2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of JAG2 Gene:
JAG2SOURCE GeneReport for Unigene cluster for JAG2 Gene:
Hs.433445mRNA Expression by UniProt/SwissProt for JAG2 Gene:
Q9Y219-JAG2_HUMAN
Tissue specificity:
Expressed in heart, placenta and skeletal muscle and to a lesser extent in pancreas. Very low expression in brain, lung, liver and kidney.
Evidence on tissue expression from TISSUES for JAG2 Gene
- Nervous system(4.5)
- Heart(4.4)
- Bone marrow(4.3)
- Skin(2.2)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for JAG2
- genomics-online: primer clones - Search results for 55 available JAG2 gene related products
- Overview of 55 available JAG2 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for JAG2 Gene
Orthologs for JAG2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | JAG2 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Jag2 33 |
|
||
| cow (Bos Taurus) |
Mammalia | JAG2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Jag2 16 34 33 |
|
||
| dog (Canis familiaris) |
Mammalia | JAG2 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | JAG2 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | JAG2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | JAG2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | JAG2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | jag2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | jag2b 34 33 |
|
OneToMany | |
| JAG2 (1 of 3) 34 |
|
OneToMany | |||
| CABZ01041002.1 34 |
|
OneToMany | |||
| jag2 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Dl 35 |
|
|
|
| SP1070 35 |
|
|
|||
| Ser 34 35 |
|
OneToMany | |||
| C901 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | W02C12.1 35 |
|
|
|
| apx-1 35 |
|
|
|||
| R05G6.9 35 |
|
|
|||
| Y69H2.11 35 |
|
|
|||
| clec-78 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for JAG2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for JAG2 Gene
- ENSEMBL:
- Gene Tree for JAG2 (if available)
- TreeFam:
- Gene Tree for JAG2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for JAG2: view image
Paralogs for JAG2 Gene
Variants for JAG2 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs587632836 | benign, not specified | 105,168,370(-) | CAGCAGCAGCAGCAGC/CAGCAGCAGCAGC/CAGCAGCAGCAGCAGCAGC | coding_sequence_variant, inframe_deletion, inframe_insertion, non_coding_transcript_variant | |
| rs1000061038 | -- | 105,159,078(-) | C/A | intron_variant | |
| rs1000088191 | -- | 105,166,744(-) | G/A | intron_variant | |
| rs1000329828 | -- | 105,160,076(-) | A/C | intron_variant | |
| rs1000367024 | -- | 105,168,546(-) | C/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant |
Residual Variation Intolerance Score:
8.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.13;
75.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for JAG2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JAG2 Gene
Disorders for JAG2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ossifying fibroma |
|
|
| shipyard eye |
|
|
| popliteal pterygium syndrome |
|
|
Search JAG2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for JAG2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for JAG2 Gene
Publications for JAG2 Gene
- Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene. (PMID: 10662552) Deng Y … Li L (Genomics 2000) 2 3 4 22 58
- Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. (PMID: 9315665) Luo B … Sklar J (Molecular and cellular biology 1997) 2 3 4 22 58
- Detection of Notch signaling molecules in cemento-ossifying fibroma of the jaws. (PMID: 20040020) Zhang TH … Zheng GS (Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2010) 3 22 58
- Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. (PMID: 20133585) Yustein JT … Dang CV (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 22 58
- MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. (PMID: 20572854) Jagomägi T … Metspalu A (European journal of oral sciences 2010) 3 44 58
Products for JAG2 Gene
- R&D Systems Antibodies for JAG2 (Jagged 2)
- R&D Systems Proteins and Enzymes for JAG2 (Jagged 2)
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for JAG2 (Jagged 2)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for JAG2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for JAG2
- Origene Custom Protein Services for JAG2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for JAG2
- Browse OriGene Inhibitory RNA Products For JAG2
- OriGene qPCR primer pairs for JAG2
- OriGene CRISPR knockouts for JAG2
- OriGene ORF clones in human for JAG2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For JAG2
- GenScript: Next-day shipping of latest version cDNA ORF clones for JAG2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for JAG2
- GenScript Custom Assay Services for JAG2
- GenScript Custom overexpressing Cell Line Services for JAG2
- GenScript: Design CRISPR guide RNA sequences for JAG2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for JAG2
- Sino Biological Human cDNA Clone for JAG2
- Browse Sino Biological Recombinant Proteins
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- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for JAG2
- Novus Biologicals proteins for JAG2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Abcam antibodies for JAG2
- Abcam proteins for JAG2
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- Cyagen custom Knockout/knockin (KOKI) mouse models for JAG2
- VectorBuilder custom plasmid, inducible vectors for JAG2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for JAG2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 116 available JAG2 Antibodies ranked by validation data
- Compare Top JAG2 Antibodies
- Recommended
- 25 FACS Antibodies (anti-mouse)
- 15 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 1 EIA Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 51 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 FACS Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 11 WB Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 1 EIA Antibody (anti-rat)
- 1 IHC Antibody (anti-rat)
- antibodies-online: Search results for 10 available JAG2 Elisa Kits ranked by validation data
- Compare Top JAG2 Elisa Kits
- antibodies-online: Search results for 15 available JAG2 Proteins ranked by validation data
- Compare Top JAG2 Proteins
- GeneTex Jag2 Antibody for JAG2
- GeneTex Proteins for JAG2
- Santa Cruz Biotechnology (SCBT) Antibodies for JAG2
- Search Santa Cruz Biotechnology (SCBT) for JAG2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for JAG2
- Custom Antibody ServicesProSci Antibodies for JAG2
- ProSci Proteins for JAG2
- Horizon Cell Lines for JAG2
- genomics-online: cdna clones - Search results for 55 available JAG2 gene related products
- Overview of 55 available JAG2 gene related products
- orf clones - Search results for 55 available JAG2 gene related products
- Overview of 55 available JAG2 gene related products
- genomics-online: gRNA clones - Search results for 55 available JAG2 gene related products
- Overview of 55 available JAG2 gene related products
- genomics-online: primer clones - Search results for 55 available JAG2 gene related products
- Overview of 55 available JAG2 gene related products
- genomics-online: shRNA clones - Search results for 55 available JAG2 gene related products
- Overview of 55 available JAG2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for JAG2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for JAG2
- GeneCopoeia miRNA 3'UTR Target clone products for JAG2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JAG2
Sources for JAG2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt