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The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different ... See more...
Aliases for JAG2 Gene
Aliases for JAG2 Gene
External Ids for JAG2 Gene
- HGNC: 6189
- NCBI Entrez Gene: 3714
- Ensembl: ENSG00000184916
- OMIM®: 602570
- UniProtKB/Swiss-Prot: Q9Y219
Previous GeneCards Identifiers for JAG2 Gene
- GC14M102987
- GC14M099599
- GC14M103579
- GC14M104679
- GC14M105607
- GC14M085799
Summaries for JAG2 Gene
-
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for JAG2 Gene
JAG2 (Jagged Canonical Notch Ligand 2) is a Protein Coding gene. Diseases associated with JAG2 include Ossifying Fibroma and Tongue Carcinoma. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include calcium ion binding and Notch binding. An important paralog of this gene is JAG1.
UniProtKB/Swiss-Prot Summary for JAG2 Gene
-
Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).
Additional gene information for JAG2 Gene
- HGNC (6189)
- NCBI Entrez Gene (3714)
- Ensembl (ENSG00000184916)
- OMIM® (602570)
- UniProtKB/Swiss-Prot (Q9Y219)
- Open Targets Platform(ENSG00000184916)
- Monarch Initiative
- Search for JAG2 at DataMed
- Search for JAG2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for JAG2 Gene
Genomics for JAG2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for JAG2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around JAG2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for JAG2
- Top Transcription factor binding sites by QIAGEN in the JAG2 gene promoter:
-
- AhR
- E47
- Hand1
- HEN1
- MyoD
- NF-1
- USF-1
- USF-1:USF-2
- USF1
- USF2
Genomic Locations for JAG2 Gene
Latest Assembly
- chr14:105,140,981-105,168,824
- (GRCh38/hg38)
- Size:
- 27,844 bases
- Orientation:
- Minus strand
Previous Assembly
- chr14:105,607,332-105,635,113
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 27,782 bases
- Orientation:
- Minus strand
- chr14:105,607,318-105,635,161
- (GRCh37/hg19 by Ensembl)
- Size:
- 27,844 bases
- Orientation:
- Minus strand
Genomic View for JAG2 Gene
Genes around JAG2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.33 by HGNC
- 14q32.33 by Entrez Gene
- 14q32.33 by Ensembl
JAG2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for JAG2 Gene
Proteins for JAG2 Gene
-
Protein details for JAG2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y219-JAG2_HUMAN
- Recommended name:
- Protein jagged-2
- Protein Accession:
- Q9Y219
- Q9UE17
- Q9UE99
- Q9UNK8
- Q9Y6P9
- Q9Y6Q0
Protein attributes for JAG2 Gene
- Size:
- 1238 amino acids
- Molecular mass:
- 133367 Da
- Quaternary structure:
- No Data Available
Protein Expression for JAG2 Gene
Post-translational modifications for JAG2 Gene
Other Protein References for JAG2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences JAG2 / Jagged-2 Antibody
- G Biosciences Immunotag™ JAG2 Antibody
- BioLegend Jagged 2 Antibody (346904) and Jagged 2 Antibody (346902)
-
Custom Antibody ServicesOriGene Antibodies for JAG2
- Novus Biologicals Antibodies for JAG2
-
Abcam antibodies for JAG2
- Invitrogen Antibodies for JAG2 (AFLGC-Jag2)
- antibodies-online: Show 30 available JAG2 Antibodies ranked by validation data
- Compare Top JAG2 Antibodies
-
Recommended
- 18 WB Antibodies (anti-mouse)
- 15 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 1 EIA Antibody (anti-mouse)
- 1 IHC (fro) Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 55 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 FACS Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 13 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 EIA Antibody (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IHC (fro) Antibody (anti-rat)
-
Boster Bio Antibodies for JAG2
-
Custom Antibody ServicesProSci Antibodies for JAG2
-
Santa Cruz Biotechnology (SCBT) Antibodies for JAG2
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for JAG2
- Origene Custom Protein Services for JAG2
- Novus Biologicals proteins for JAG2
-
ProSci Proteins for JAG2
-
Abcam proteins for JAG2
No data available for DME Specific Peptides for JAG2 Gene
Domains & Families for JAG2 Gene
Gene Families for JAG2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for JAG2 Gene
- InterPro:
- Blocks:
-
- Aspartic acid and asparagine hydroxylation site
- Delta/Serrate/lag-2 (DSL) protein
- EGF-like calcium-binding
- Notch ligand, N-terminal
- von Willebrand factor, type C
- ProtoNet:
Suggested Antigen Peptide Sequences for JAG2 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein jagged-2 (JAG2_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for JAG2 Gene
Function for JAG2 Gene
Molecular function for JAG2 Gene
- UniProtKB/Swiss-Prot Function:
- Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).
- GENATLAS Biochemistry:
- NOTCH1 ligand,homolog to rat jagged 2 and Drosophila serrate,Dres30,mouse homolog,expressed in high levels in embryonic limb buds,first branchial arch,developing cochlea and the organ of Corti,central and peripheral nervous system,retina,tooth buds,thymus,submandilas gland,stomach
Phenotypes From GWAS Catalog for JAG2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005112 | Notch binding | IBA,IPI | 9315665 |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16713569 |
| GO:0008083 | growth factor activity | IDA | 10383933 |
Phenotypes for JAG2 Gene
- MGI mutant phenotypes for JAG2:
-
inferred from 5 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- hematopoietic system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for JAG2:
-
- Increased gamma-H2AX phosphorylation
- no effect
- Decreased viability
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased shRNA abundance (Z-score > 2)
- Increased number of mitotic cells
- Increased IL-8 secretion
- Increased S DNA content
- Decreased cell number
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased shRNA abundance (Z-score < -2)
- Many micronuclei (grape), dynamic nuclei (hole, folded or small irregular), decreased viability (cell death)
Animal Models for JAG2 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for JAG2 - Starting at $85 >
- * JAG2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for JAG2
-
Santa Cruz Biotechnology (SCBT) CRISPR for JAG2
miRNA for JAG2 Gene
- miRTarBase miRNAs that target JAG2
-
- hsa-miR-335-5p (MIRT016805)
- hsa-miR-124-3p (MIRT022161)
- hsa-miR-484 (MIRT042161)
- hsa-miR-92a-3p (MIRT049515)
- hsa-miR-624-3p (MIRT053421)
- mmu-miR-466m-3p (MIRT591296)
- mmu-miR-466o-3p (MIRT591297)
- mmu-miR-466f-3p (MIRT591298)
- mmu-miR-362-3p (MIRT591299)
- mmu-miR-329-3p (MIRT591300)
- mmu-miR-466i-3p (MIRT591301)
- mmu-miR-1197-3p (MIRT592269)
- hsa-miR-6809-3p (MIRT647278)
- hsa-miR-6832-3p (MIRT647279)
- hsa-miR-6833-3p (MIRT647280)
- hsa-miR-4768-5p (MIRT647281)
- hsa-miR-493-5p (MIRT647282)
- hsa-let-7g-3p (MIRT647283)
- hsa-let-7a-2-3p (MIRT647284)
- hsa-let-7c-3p (MIRT647285)
- hsa-miR-4753-3p (MIRT647286)
- hsa-miR-1286 (MIRT647287)
- hsa-miR-130b-5p (MIRT647288)
- hsa-miR-761 (MIRT647289)
- hsa-miR-3619-5p (MIRT647290)
- hsa-miR-214-3p (MIRT647291)
- hsa-miR-8083 (MIRT647292)
- hsa-miR-6165 (MIRT647293)
- hsa-miR-410-3p (MIRT731729)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for JAG2
- Browse OriGene Inhibitory RNA Products For JAG2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JAG2
Clone products for research
- Applied Biological Materials (abm): Clones for JAG2 - Starting at $45 >
- * JAG2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for JAG2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for JAG2
Cell Lines for research
-
Horizon Cell Lines for JAG2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for JAG2 Gene
Localization for JAG2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for JAG2 Gene
- Membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| nucleus | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
- Cytosol (3)
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | ISS | 10910909 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for JAG2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by NOTCH1 | ||
| 2 | NOTCH2 Activation and Transmission of Signal to the Nucleus | ||
| 3 | Notch Signaling Pathway (WikiPathways) | ||
| 4 | HIV Life Cycle |
.45
|
|
| 5 | Wnt / Hedgehog / Notch | ||
Pathways by source for JAG2 Gene
5 BioSystems pathways for JAG2 Gene
19 Reactome pathways for JAG2 Gene
5 KEGG pathways for JAG2 Gene
1 GeneGo (Thomson Reuters) pathway for JAG2 Gene
- Development Notch Signaling Pathway
2 R&D Systems pathways for JAG2 Gene
1 Cell Signaling Technology pathway for JAG2 Gene
Interacting Proteins for JAG2 Gene
Selected Interacting proteins:
Q9Y219-JAG2_HUMAN
ENSP00000328169
for JAG2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for JAG2
SIGNOR curated interactions for JAG2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | IEA | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0003016 | respiratory system process | IEA | -- |
| GO:0007154 | cell communication | IEA | -- |
| GO:0007219 | Notch signaling pathway | TAS | -- |
Transcripts for JAG2 Gene
mRNA/cDNA for JAG2 Gene
- 2 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000331782 5773 nts (view in UCSC)
- ENST00000347004 5720 nts (view in UCSC)
- ENST00000546616 2275 nts (view in UCSC)
- ENST00000553051 768 nts (view in UCSC)
- ENST00000553244 866 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for JAG2 - Starting at $85 >
- * JAG2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for JAG2
-
Santa Cruz Biotechnology (SCBT) CRISPR for JAG2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for JAG2
- Browse OriGene Inhibitory RNA Products For JAG2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for JAG2
Clone products for research
- Applied Biological Materials (abm): Clones for JAG2 - Starting at $45 >
- * JAG2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for JAG2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for JAG2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - |
| ExUns: | 20b | ^ | 21 | ^ | 22 | ^ | 23 |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: | |||||||
| SP7: | |||||||
| SP8: |
Relevant External Links for JAG2 Gene
- GeneLoc Exon Structure for
- JAG2
Expression for JAG2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
- Fetal Matrix Cells Hair Follicle
- Basal Cells Trachea
- Inner Enamel Epithelial Cells Dental Enamel
- Fetal Medulla Cells Hair Shaft
- Brain (Nervous System)
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
- Fetal Matrix Cells Hair Follicle
- Fetal Medulla Cells Hair Shaft
- Basal Keratinocytes Embryonic Epidermis
-
Tooth (Integumentary System)
- Primary Enamel Knot Cells Enamel Knot
- Inner Enamel Epithelial Cells Dental Enamel
- Stellate Reticulum Cells Dental Core
- Outer Enamel Epithelial Cells Dental Enamel
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Primitive Streak (Early Embryonic Tissues)
- Notochord Cells Notochord
-
Cartilage (Muscoskeletal System)
- Notochord Cells Notochord
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Umbilical Cord (Extraembryonic Tissues)
This gene is overexpressed in Platelet (48.8) and Heart (20.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for JAG2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for JAG2
SOURCE GeneReport for Unigene cluster for JAG2 Gene:
Hs.433445mRNA Expression by UniProt/SwissProt for JAG2 Gene:
Q9Y219-JAG2_HUMAN
Tissue specificity:
Expressed in heart, placenta and skeletal muscle and to a lesser extent in pancreas. Very low expression in brain, lung, liver and kidney.
Evidence on tissue expression from TISSUES for JAG2 Gene
- Nervous system(4.6)
- Heart(4.5)
- Bone marrow(4.4)
- Skin(3)
- Lung(2.6)
- Kidney(2.4)
- Liver(2.4)
- Muscle(2.4)
- Intestine(2.2)
- Blood(2.1)
- Spleen(2)
- Pancreas(2)
Primer products for research
-
OriGene qPCR primer pairs for JAG2
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for JAG2 Gene
Orthologs for JAG2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | JAG2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Jag2 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | JAG2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Jag2 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | JAG2 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | JAG2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | JAG2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | JAG2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | JAG2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | jag2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | jag2b 30 31 |
|
OneToMany | |
| JAG2 (1 of 3) 31 |
|
OneToMany | |||
| CABZ01041002.1 31 |
|
OneToMany | |||
| jag2 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Dl 32 |
|
|
|
| SP1070 32 |
|
|
|||
| Ser 31 32 |
|
OneToMany | |||
| C901 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | W02C12.1 32 |
|
|
|
| apx-1 32 |
|
|
|||
| R05G6.9 32 |
|
|
|||
| Y69H2.11 32 |
|
|
|||
| clec-78 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for JAG2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for JAG2 Gene
- ENSEMBL:
- Gene Tree for JAG2 (if available)
- TreeFam:
- Gene Tree for JAG2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for JAG2: view image
Paralogs for JAG2 Gene
Variants for JAG2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for JAG2 Gene
| SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs114828659 | Benign: not provided | 105,150,661(-) |
G/A NM_002226.5(JAG2):c.1545C>T (p.Asp515=) |
SYNONYMOUS | |
| rs117007108 | Benign: not provided | 105,143,591(-) |
G/A NM_002226.5(JAG2):c.3132C>T (p.Gly1044=) |
SYNONYMOUS | |
| rs138204105 | Benign: not provided | 105,143,043(-) |
G/A NM_002226.5(JAG2):c.3369C>T (p.Ser1123=) |
SYNONYMOUS | |
| rs139751287 | Benign: not provided | 105,146,681(-) |
C/T NM_002226.5(JAG2):c.2523G>A (p.Thr841=) |
SYNONYMOUS | |
| rs141925862 | Benign: not provided | 105,147,800(-) |
G/A NM_002226.5(JAG2):c.2337C>T (p.Asp779=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
8.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.13;
75.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for JAG2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JAG2 Gene
Disorders for JAG2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ossifying fibroma |
|
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| tongue carcinoma |
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| alagille syndrome 1 |
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| hajdu-cheney syndrome |
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| cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 |
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|
Search JAG2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for JAG2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for JAG2 Gene
Publications for JAG2 Gene
- Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene. (PMID: 10662552) Deng Y … Li L (Genomics 2000) 2 3 4 23
- Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. (PMID: 9315665) Luo B … Sklar J (Molecular and cellular biology 1997) 2 3 4 23
- Detection of Notch signaling molecules in cemento-ossifying fibroma of the jaws. (PMID: 20040020) Zhang TH … Zheng GS (Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2010) 3 23
- Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. (PMID: 20133585) Yustein JT … Dang CV (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 23
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41
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Products for JAG2 Gene
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