External Ids for IVL Gene
Previous GeneCards Identifiers for IVL Gene
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]
GeneCards Summary for IVL Gene
IVL (Involucrin) is a Protein Coding gene. Diseases associated with IVL include Discoid Lupus Erythematosus and Ichthyosis Vulgaris. Among its related pathways are Corticotropin-releasing hormone signaling pathway and Keratinization. Gene Ontology (GO) annotations related to this gene include structural molecule activity and protein binding, bridging.
UniProtKB/Swiss-Prot Summary for IVL Gene
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.