External Ids for IVL Gene
Previous GeneCards Identifiers for IVL Gene
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]
GeneCards Summary for IVL Gene
IVL (Involucrin) is a Protein Coding gene. Diseases associated with IVL include Ichthyosis Vulgaris and Cholesteatoma Of Middle Ear. Among its related pathways are Keratinization and Validated transcriptional targets of AP1 family members Fra1 and Fra2. Gene Ontology (GO) annotations related to this gene include structural molecule activity and protein binding, bridging.
UniProtKB/Swiss-Prot Summary for IVL Gene
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.