Aliases for IZUMO4 Gene

Aliases for IZUMO4 Gene

  • IZUMO Family Member 4 2 3 5
  • Izumo Sperm-Egg Fusion Protein 4 3 4
  • Sperm 22 KDa Protein C113 3 4
  • C19orf36 3 4
  • Putative SAMP14 Binding Protein Variant 1 3
  • Putative SAMP14 Binding Protein Variant 2 3
  • Chromosome 19 Open Reading Frame 36 2
  • IMAGE:4215339 3
  • IZUMO4 5

External Ids for IZUMO4 Gene

Previous HGNC Symbols for IZUMO4 Gene

  • C19orf36

Previous GeneCards Identifiers for IZUMO4 Gene

  • GC19P002085
  • GC19P001869

Summaries for IZUMO4 Gene

GeneCards Summary for IZUMO4 Gene

IZUMO4 (IZUMO Family Member 4) is a Protein Coding gene. Among its related pathways are Fertilization.

Additional gene information for IZUMO4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IZUMO4 Gene

Genomics for IZUMO4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IZUMO4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IZUMO4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IZUMO4

Genomic Locations for IZUMO4 Gene

Genomic Locations for IZUMO4 Gene
chr19:2,096,429-2,099,593
(GRCh38/hg38)
Size:
3,165 bases
Orientation:
Plus strand
chr19:2,096,380-2,099,592
(GRCh37/hg19)
Size:
3,213 bases
Orientation:
Plus strand

Genomic View for IZUMO4 Gene

Genes around IZUMO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IZUMO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IZUMO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IZUMO4 Gene

Proteins for IZUMO4 Gene

  • Protein details for IZUMO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1ZYL8-IZUM4_HUMAN
    Recommended name:
    Izumo sperm-egg fusion protein 4
    Protein Accession:
    Q1ZYL8
    Secondary Accessions:
    • A7RA93
    • A7RA94
    • Q6UXA2
    • Q96FT6
    • Q96L02

    Protein attributes for IZUMO4 Gene

    Size:
    232 amino acids
    Molecular mass:
    26510 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH10443.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • Izumo is the name of a Japanese shrine to marriage.

    Alternative splice isoforms for IZUMO4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IZUMO4 Gene

Post-translational modifications for IZUMO4 Gene

  • Glycosylation at Asn24 and Asn219
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IZUMO4 Gene

Domains & Families for IZUMO4 Gene

Gene Families for IZUMO4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for IZUMO4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IZUMO4 Gene

GenScript: Design optimal peptide antigens:
  • Sperm 22 kDa protein c113 (IZUM4_HUMAN)
  • R26660_2, (O75250_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q1ZYL8

UniProtKB/Swiss-Prot:

IZUM4_HUMAN :
  • Belongs to the Izumo family.
Family:
  • Belongs to the Izumo family.
genes like me logo Genes that share domains with IZUMO4: view

Function for IZUMO4 Gene

Phenotypes From GWAS Catalog for IZUMO4 Gene

Phenotypes for IZUMO4 Gene

genes like me logo Genes that share phenotypes with IZUMO4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IZUMO4

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IZUMO4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IZUMO4 Gene

Localization for IZUMO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IZUMO4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IZUMO4 gene
Compartment Confidence
extracellular 4
nucleus 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IZUMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus HDA 21630459
genes like me logo Genes that share ontologies with IZUMO4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IZUMO4 Gene

Pathways & Interactions for IZUMO4 Gene

PathCards logo

SuperPathways for IZUMO4 Gene

SuperPathway Contained pathways
1 Fertilization
genes like me logo Genes that share pathways with IZUMO4: view

Pathways by source for IZUMO4 Gene

3 Reactome pathways for IZUMO4 Gene

Interacting Proteins for IZUMO4 Gene

Gene Ontology (GO) - Biological Process for IZUMO4 Gene

None

No data available for SIGNOR curated interactions for IZUMO4 Gene

Drugs & Compounds for IZUMO4 Gene

No Compound Related Data Available

Transcripts for IZUMO4 Gene

mRNA/cDNA for IZUMO4 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IZUMO4

Alternative Splicing Database (ASD) splice patterns (SP) for IZUMO4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1:
SP2: -
SP3: -
SP4: -
SP5: -

Relevant External Links for IZUMO4 Gene

GeneLoc Exon Structure for
IZUMO4

Expression for IZUMO4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IZUMO4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IZUMO4 Gene

This gene is overexpressed in Testis (x24.5).

Protein differential expression in normal tissues from HIPED for IZUMO4 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IZUMO4 Gene



Protein tissue co-expression partners for IZUMO4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IZUMO4

SOURCE GeneReport for Unigene cluster for IZUMO4 Gene:

Hs.424049

mRNA Expression by UniProt/SwissProt for IZUMO4 Gene:

Q1ZYL8-IZUM4_HUMAN
Tissue specificity: Detected in sperm.

Evidence on tissue expression from TISSUES for IZUMO4 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with IZUMO4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IZUMO4 Gene

Orthologs for IZUMO4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IZUMO4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IZUMO4 30 31
  • 98.99 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IZUMO4 30 31
  • 87 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IZUMO4 30 31
  • 86.58 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Izumo4 30
  • 83.26 (n)
Mouse
(Mus musculus)
Mammalia Izumo4 30 17 31
  • 82.64 (n)
OneToOne
Species where no ortholog for IZUMO4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IZUMO4 Gene

ENSEMBL:
Gene Tree for IZUMO4 (if available)
TreeFam:
Gene Tree for IZUMO4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IZUMO4: view image

Paralogs for IZUMO4 Gene

(1) SIMAP similar genes for IZUMO4 Gene using alignment to 1 proteins:

  • IZUM4_HUMAN
genes like me logo Genes that share paralogs with IZUMO4: view

No data available for Paralogs for IZUMO4 Gene

Variants for IZUMO4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IZUMO4 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs17851210 - p.Ala2Thr
rs35585208 - p.Phe38Leu
rs45506200 - p.Tyr137Phe

Additional dbSNP identifiers (rs#s) for IZUMO4 Gene

Structural Variations from Database of Genomic Variants (DGV) for IZUMO4 Gene

Variant ID Type Subtype PubMed ID
esv3583205 CNV loss 25503493
esv3893156 CNV loss 25118596
nsv470107 CNV loss 18288195

Variation tolerance for IZUMO4 Gene

Residual Variation Intolerance Score: 76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IZUMO4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IZUMO4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IZUMO4 Gene

Disorders for IZUMO4 Gene

No disorders were found for IZUMO4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IZUMO4 Gene

Publications for IZUMO4 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4
  2. Positive Selection and the Evolution of izumo Genes in Mammals. (PMID: 22957301) Grayson P … Civetta A (International journal of evolutionary biology 2012) 2 3
  3. Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. (PMID: 19658160) Ellerman DA … Primakoff P (Molecular reproduction and development 2009) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies. (PMID: 30097533) Schiza C … Diamandis EP (Molecular & cellular proteomics : MCP 2018) 3

Products for IZUMO4 Gene

Sources for IZUMO4 Gene