Aliases for IZUMO1R Gene

Aliases for IZUMO1R Gene

  • IZUMO1 Receptor, JUNO 2 3 5
  • Folate Receptor 4, Delta (Putative) 2 3
  • Sperm-Egg Fusion Protein Juno 3 4
  • IZUMO1 Receptor Protein JUNO 3 4
  • Folate Receptor Delta 3 4
  • FR-Delta 3 4
  • FOLR4 3 4
  • JUNO 3 4
  • Folate Receptor 4 (Delta) Homolog (Mouse) 2
  • Folate Receptor 4 (Delta) Homolog 3
  • Probable Folate Receptor Delta 3
  • Folate Receptor 4 4
  • Folbp3 3

External Ids for IZUMO1R Gene

Previous HGNC Symbols for IZUMO1R Gene

  • FOLR4

Summaries for IZUMO1R Gene

GeneCards Summary for IZUMO1R Gene

IZUMO1R (IZUMO1 Receptor, JUNO) is a Protein Coding gene. Among its related pathways are Selenium Micronutrient Network and Antifolate resistance. Gene Ontology (GO) annotations related to this gene include folic acid binding. An important paralog of this gene is FOLR1.

UniProtKB/Swiss-Prot Summary for IZUMO1R Gene

  • Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.

Additional gene information for IZUMO1R Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IZUMO1R Gene

Genomics for IZUMO1R Gene

GeneHancer (GH) Regulatory Elements for IZUMO1R Gene

Promoters and enhancers for IZUMO1R Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J094303 Enhancer 0.4 Ensembl ENCODE 750.6 -0.5 -460 3.4 MNT IZUMO1R GPR83 MRE11 ENSG00000255893 CEP295 ENSG00000250519 lnc-IZUMO1R-2
GH11J094284 Enhancer 0.3 Ensembl 13.1 -20.3 -20260 0.6 ZNF335 IZUMO1R lnc-IZUMO1R-2 lnc-IZUMO1R-3
GH11J094188 Promoter 0.3 Ensembl 10.2 -115.7 -115660 0.2 ARPC3P3 ENSG00000256745 lnc-GPR83-5 ENSG00000250519 IZUMO1R
GH11J094278 Enhancer 0.2 Ensembl 12.1 -26.1 -26060 0.6 lnc-IZUMO1R-3 IZUMO1R ENSG00000250519 lnc-IZUMO1R-2 LOC105369435
GH11J093348 Enhancer 0.2 Ensembl 4.3 -956.0 -955960 0.4 DEUP1 SMCO4 IZUMO1R piR-32539-008
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IZUMO1R on UCSC Golden Path with GeneCards custom track

Genomic Locations for IZUMO1R Gene

Genomic Locations for IZUMO1R Gene
chr11:94,304,561-94,307,762
(GRCh38/hg38)
Size:
3,202 bases
Orientation:
Plus strand
chr11:94,038,759-94,040,887
(GRCh37/hg19)
Size:
2,129 bases
Orientation:
Plus strand

Genomic View for IZUMO1R Gene

Genes around IZUMO1R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IZUMO1R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IZUMO1R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IZUMO1R Gene

Proteins for IZUMO1R Gene

  • Protein details for IZUMO1R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6ND01-JUNO_HUMAN
    Recommended name:
    Sperm-egg fusion protein Juno
    Protein Accession:
    A6ND01

    Protein attributes for IZUMO1R Gene

    Size:
    250 amino acids
    Molecular mass:
    28672 Da
    Quaternary structure:
    • Monomer (PubMed:27309808). Interacts with IZUMO1; the interaction is direct. IZUMO1 and IZUMO1R/JUNO form a complex with 1:1 stoichiometry (PubMed:24739963, PubMed:27309818, PubMed:27309808).

    Three dimensional structures from OCA and Proteopedia for IZUMO1R Gene

    Alternative splice isoforms for IZUMO1R Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IZUMO1R Gene

Post-translational modifications for IZUMO1R Gene

  • The protein is rapidly cleaved following fertilization, being only weakly detectable in zona-intact fertilized eggs at telophase II and undetectable at the pronuclear stage. Sheding is probably required to block to polyspermy and ensuring egg fusion with a single sperm.
  • Glycosylation at Asn73

Other Protein References for IZUMO1R Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IZUMO1R Gene

Domains & Families for IZUMO1R Gene

Gene Families for IZUMO1R Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins
  • Transporters

Protein Domains for IZUMO1R Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IZUMO1R Gene

GenScript: Design optimal peptide antigens:
  • Folate receptor 4 (FOLR4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6ND01

UniProtKB/Swiss-Prot:

JUNO_HUMAN :
  • Belongs to the folate receptor family.
Family:
  • Belongs to the folate receptor family.
genes like me logo Genes that share domains with IZUMO1R: view

Function for IZUMO1R Gene

Molecular function for IZUMO1R Gene

UniProtKB/Swiss-Prot Function:
Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.

Phenotypes From GWAS Catalog for IZUMO1R Gene

Gene Ontology (GO) - Molecular Function for IZUMO1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IEA --
GO:0005515 protein binding IPI 24739963
GO:0005542 NOT folic acid binding ISS --
GO:0038023 signaling receptor activity IPI 24739963
genes like me logo Genes that share ontologies with IZUMO1R: view
genes like me logo Genes that share phenotypes with IZUMO1R: view

Animal Models for IZUMO1R Gene

MGI Knock Outs for IZUMO1R:

Animal Model Products

  • Taconic Biosciences Mouse Models for IZUMO1R

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IZUMO1R Gene

Localization for IZUMO1R Gene

Subcellular locations from UniProtKB/Swiss-Prot for IZUMO1R Gene

Cell membrane; Lipid-anchor, GPI-anchor. Note=GPI-anchored at the oolemma. {ECO:0000250 UniProtKB:Q9EQF4}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IZUMO1R gene
Compartment Confidence
extracellular 5
plasma membrane 4
mitochondrion 1
nucleus 0
cytosol 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for IZUMO1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
GO:0031362 anchored component of external side of plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with IZUMO1R: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IZUMO1R Gene

Pathways & Interactions for IZUMO1R Gene

genes like me logo Genes that share pathways with IZUMO1R: view

Pathways by source for IZUMO1R Gene

Gene Ontology (GO) - Biological Process for IZUMO1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA,ISS --
GO:0007338 single fertilization ISS --
GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization ISS,IBA --
GO:0035036 sperm-egg recognition IBA,ISS --
genes like me logo Genes that share ontologies with IZUMO1R: view

No data available for SIGNOR curated interactions for IZUMO1R Gene

Drugs & Compounds for IZUMO1R Gene

(1) Drugs for IZUMO1R Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Folic acid Approved, Vet_approved Nutra 4687
genes like me logo Genes that share compounds with IZUMO1R: view

Transcripts for IZUMO1R Gene

mRNA/cDNA for IZUMO1R Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IZUMO1R Gene

No ASD Table

Relevant External Links for IZUMO1R Gene

GeneLoc Exon Structure for
IZUMO1R
ECgene alternative splicing isoforms for
IZUMO1R

Expression for IZUMO1R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IZUMO1R Gene

NURSA nuclear receptor signaling pathways regulating expression of IZUMO1R Gene:

IZUMO1R
genes like me logo Genes that share expression patterns with IZUMO1R: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IZUMO1R Gene

Orthologs for IZUMO1R Gene

This gene was present in the common ancestor of chordates.

Orthologs for IZUMO1R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOLR4 33 32
  • 99.73 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Folr4 32
  • 78.06 (n)
mouse
(Mus musculus)
Mammalia Folr4 33 32
  • 77.87 (n)
OneToOne
Izumo1r 17
oppossum
(Monodelphis domestica)
Mammalia FOLR4 33
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOLR4 33
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 21 (a)
ManyToMany
chicken
(Gallus gallus)
Aves FOLR1 33
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 59 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FOLR1 33
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 40 (a)
ManyToMany
-- 33
  • 30 (a)
ManyToMany
Species where no ortholog for IZUMO1R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IZUMO1R Gene

ENSEMBL:
Gene Tree for IZUMO1R (if available)
TreeFam:
Gene Tree for IZUMO1R (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IZUMO1R: view image

Paralogs for IZUMO1R Gene

Paralogs for IZUMO1R Gene

genes like me logo Genes that share paralogs with IZUMO1R: view

Variants for IZUMO1R Gene

Sequence variations from dbSNP and Humsavar for IZUMO1R Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000008389 -- 94,307,016(+) G/A intron_variant
rs1000679709 -- 94,307,836(+) C/A downstream_transcript_variant
rs1000682192 -- 94,305,978(+) G/A intron_variant
rs1001134329 -- 94,307,396(+) T/G intron_variant
rs1001220646 -- 94,305,769(+) G/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for IZUMO1R Gene

Variant ID Type Subtype PubMed ID
esv3627315 CNV gain 21293372
esv3627317 CNV gain 21293372
esv3892069 CNV loss 25118596
esv3892072 CNV gain 25118596
esv3892073 CNV loss 25118596
nsv523083 CNV gain 19592680
nsv832233 CNV gain 17160897

Variation tolerance for IZUMO1R Gene

Gene Damage Index Score: 5.15; 69.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IZUMO1R Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IZUMO1R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IZUMO1R Gene

Disorders for IZUMO1R Gene

Additional Disease Information for IZUMO1R

No disorders were found for IZUMO1R Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IZUMO1R Gene

Publications for IZUMO1R Gene

  1. Juno is the egg Izumo receptor and is essential for mammalian fertilization. (PMID: 24739963) Bianchi E … Wright GJ (Nature 2014) 2 3 4 56
  2. Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization. (PMID: 27309808) Ohto U … Shimizu T (Nature 2016) 3 4 56
  3. Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex. (PMID: 27309818) Aydin H … Lee JE (Nature 2016) 3 4 56
  4. Identification of two putative novel folate receptor genes in humans and mouse. (PMID: 11111049) Spiegelstein O … Finnell RH (Gene 2000) 2 3 56
  5. JUNO, the receptor of sperm IZUMO1, is expressed by the human oocyte and is essential for human fertilisation. (PMID: 30517645) Jean C … Barraud-Lange V (Human reproduction (Oxford, England) 2019) 3 56

Products for IZUMO1R Gene

Sources for IZUMO1R Gene