Aliases for IWS1 Gene
External Ids for IWS1 Gene
Previous GeneCards Identifiers for IWS1 Gene
GeneCards Summary for IWS1 Gene
IWS1 (Interacts With SUPT6H, CTD Assembly Factor 1) is a Protein Coding gene. Diseases associated with IWS1 include Granulomatous Disease, Chronic, Autosomal Recessive, 1 and Atrial Septal Defect 1. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and Translational Control. An important paralog of this gene is MDN1.
UniProtKB/Swiss-Prot Summary for IWS1 Gene
Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.