Aliases for IVNS1ABP Gene

Aliases for IVNS1ABP Gene

  • Influenza Virus NS1A Binding Protein 2 3 5
  • Aryl Hydrocarbon Receptor-Associated Protein 3 2 3 4
  • Influenza Virus NS1A-Binding Protein 3 4
  • Kelch-Like Family Member 39 2 3
  • Kelch-Like Protein 39 3 4
  • NS1-Binding Protein 3 4
  • FLARA3 3 4
  • KLHL39 3 4
  • NS1-BP 3 4
  • NS1BP 3 4
  • ARA3 3 4
  • Aryl Hydrocarbon Receptor-Associated 3 3
  • NCX Downstream Gene 1 3
  • KIAA0850 4
  • HSPC068 3
  • NS-1 3
  • ND1 3
  • NS1 4

External Ids for IVNS1ABP Gene

Previous GeneCards Identifiers for IVNS1ABP Gene

  • GC01M181785
  • GC01M182504
  • GC01M181997
  • GC01M183532
  • GC01M185265
  • GC01M156501

Summaries for IVNS1ABP Gene

GeneCards Summary for IVNS1ABP Gene

IVNS1ABP (Influenza Virus NS1A Binding Protein) is a Protein Coding gene. Diseases associated with IVNS1ABP include Influenza and Leber Optic Atrophy. An important paralog of this gene is KLHL17.

UniProtKB/Swiss-Prot Summary for IVNS1ABP Gene

  • Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811).
  • (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein.

Gene Wiki entry for IVNS1ABP Gene

Additional gene information for IVNS1ABP Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IVNS1ABP Gene

Genomics for IVNS1ABP Gene

GeneHancer (GH) Regulatory Elements for IVNS1ABP Gene

Promoters and enhancers for IVNS1ABP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IVNS1ABP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IVNS1ABP

Top Transcription factor binding sites by QIAGEN in the IVNS1ABP gene promoter:
  • AhR
  • Arnt
  • c-Myc
  • C/EBPbeta
  • CUTL1
  • FOXF2
  • HFH-1
  • HNF-3beta
  • Max1

Genomic Locations for IVNS1ABP Gene

Genomic Locations for IVNS1ABP Gene
chr1:185,296,388-185,317,343
(GRCh38/hg38)
Size:
20,956 bases
Orientation:
Minus strand
chr1:185,265,520-185,286,461
(GRCh37/hg19)
Size:
20,942 bases
Orientation:
Minus strand

Genomic View for IVNS1ABP Gene

Genes around IVNS1ABP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IVNS1ABP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IVNS1ABP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IVNS1ABP Gene

Proteins for IVNS1ABP Gene

  • Protein details for IVNS1ABP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6Y0-NS1BP_HUMAN
    Recommended name:
    Influenza virus NS1A-binding protein
    Protein Accession:
    Q9Y6Y0
    Secondary Accessions:
    • A8K8R6
    • Q1G4T6
    • Q1G4T7
    • Q5TF75
    • Q6NW38
    • Q7LCG2
    • Q9NZX0
    • Q9Y480

    Protein attributes for IVNS1ABP Gene

    Size:
    642 amino acids
    Molecular mass:
    71729 Da
    Quaternary structure:
    • Homodimer; through the BTB domain (By similarity). Interacts with AHR/Aryl hydrocarbon receptor (PubMed:16582008). Interacts with HNRNPK (PubMed:23825951). Interacts (via kelch repeats) with KLHL20 (via kelch repeats); this interaction blocks the assembly of Cul3-KLHL20 complex (PubMed:25619834).
    • (Microbial infection) Interacts with influenza A virus non-structural protein 1/NS (PubMed:9696811).
    SequenceCaution:
    • Sequence=AAF29040.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA74873.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA10029.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IVNS1ABP Gene

neXtProt entry for IVNS1ABP Gene

Post-translational modifications for IVNS1ABP Gene

  • Ubiquitination at Lys103, Lys197, Lys369, Lys464, and Lys477
  • Modification sites at PhosphoSitePlus

Other Protein References for IVNS1ABP Gene

No data available for DME Specific Peptides for IVNS1ABP Gene

Domains & Families for IVNS1ABP Gene

Gene Families for IVNS1ABP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IVNS1ABP Gene

Blocks:
  • BTB/POZ domain
  • BTB/Kelch-associated
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IVNS1ABP Gene

GenScript: Design optimal peptide antigens:
  • Aryl hydrocarbon receptor-associated protein 3 (NS1BP_HUMAN)
  • Influenza virus NS1A binding protein (Q5TF76_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6Y0

UniProtKB/Swiss-Prot:

NS1BP_HUMAN :
  • When the BTB domain is lacking, AHR signaling induction promoted by IVNS1ABP is massively increased; Thus, the BTB domain inhibits AHR signaling induced by IVNS1ABP.
Domain:
  • When the BTB domain is lacking, AHR signaling induction promoted by IVNS1ABP is massively increased; Thus, the BTB domain inhibits AHR signaling induced by IVNS1ABP.
genes like me logo Genes that share domains with IVNS1ABP: view

Function for IVNS1ABP Gene

Molecular function for IVNS1ABP Gene

UniProtKB/Swiss-Prot Function:
Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein.

Phenotypes From GWAS Catalog for IVNS1ABP Gene

Gene Ontology (GO) - Molecular Function for IVNS1ABP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23825951
genes like me logo Genes that share ontologies with IVNS1ABP: view
genes like me logo Genes that share phenotypes with IVNS1ABP: view

Animal Models for IVNS1ABP Gene

MGI Knock Outs for IVNS1ABP:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IVNS1ABP Gene

Localization for IVNS1ABP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IVNS1ABP Gene

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Note=Associated with actin filaments (By similarity). Localization related to speckle domains which correspond to interchromatin granules and are enriched in factors involved in pre-mRNA splicing (PubMed:9696811). Following influenza A virus infection, redistribution from speckles to a more diffuse distribution in the nucleoplasm (PubMed:9696811). {ECO:0000250 UniProtKB:Q920Q8, ECO:0000269 PubMed:9696811}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IVNS1ABP gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 3
plasma membrane 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IVNS1ABP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IEA --
GO:0005667 transcription factor complex TAS 9696811
GO:0005681 spliceosomal complex TAS 9696811
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IVNS1ABP: view

Pathways & Interactions for IVNS1ABP Gene

PathCards logo

SuperPathways for IVNS1ABP Gene

No Data Available

Gene Ontology (GO) - Biological Process for IVNS1ABP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006383 transcription by RNA polymerase III TAS 9696811
GO:0008380 RNA splicing IMP,TAS 23825951
GO:0009615 response to virus TAS,IMP 23825951
GO:0016032 viral process IEA --
GO:0031397 negative regulation of protein ubiquitination IMP 25619834
genes like me logo Genes that share ontologies with IVNS1ABP: view

No data available for Pathways by source and SIGNOR curated interactions for IVNS1ABP Gene

Drugs & Compounds for IVNS1ABP Gene

(1) Additional Compounds for IVNS1ABP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IVNS1ABP: view

Transcripts for IVNS1ABP Gene

mRNA/cDNA for IVNS1ABP Gene

2 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IVNS1ABP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b · 12c · 12d · 12e ^ 13a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7:
SP8: - - - - - -
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14: -
SP15:

ExUns: 13b · 13c ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c · 19d
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - - -
SP6: -
SP7: - -
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -

Relevant External Links for IVNS1ABP Gene

GeneLoc Exon Structure for
IVNS1ABP

Expression for IVNS1ABP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IVNS1ABP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IVNS1ABP Gene

This gene is overexpressed in Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for IVNS1ABP Gene

This gene is overexpressed in Breast (18.4), Islet of Langerhans (10.2), Placenta (7.4), and Pancreas (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IVNS1ABP Gene



Protein tissue co-expression partners for IVNS1ABP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IVNS1ABP

SOURCE GeneReport for Unigene cluster for IVNS1ABP Gene:

Hs.497183

Evidence on tissue expression from TISSUES for IVNS1ABP Gene

  • Nervous system(4.9)
  • Blood(4.2)
  • Skin(3.1)
  • Intestine(2.4)
  • Bone marrow(2.3)
  • Kidney(2.3)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with IVNS1ABP: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IVNS1ABP Gene

Orthologs for IVNS1ABP Gene

This gene was present in the common ancestor of animals.

Orthologs for IVNS1ABP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IVNS1ABP 31 30
  • 99.79 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IVNS1ABP 31 30
  • 95.53 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IVNS1ABP 31 30
  • 94.39 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IVNS1ABP 31
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ivns1abp 17 31 30
  • 93.3 (n)
rat
(Rattus norvegicus)
Mammalia Ivns1abp 30
  • 91.83 (n)
oppossum
(Monodelphis domestica)
Mammalia IVNS1ABP 31
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves IVNS1ABP 31 30
  • 82.89 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IVNS1ABP 31
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100037891 30
  • 78.64 (n)
Str.6416 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.4940 30
zebrafish
(Danio rerio)
Actinopterygii ivns1abpb 31
  • 74 (a)
OneToMany
ivns1abpa 31 30
  • 71.52 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003823 30
  • 47.88 (n)
worm
(Caenorhabditis elegans)
Secernentea tag-147 31 30
  • 46.33 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6660 31
  • 27 (a)
ManyToMany
Species where no ortholog for IVNS1ABP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IVNS1ABP Gene

ENSEMBL:
Gene Tree for IVNS1ABP (if available)
TreeFam:
Gene Tree for IVNS1ABP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IVNS1ABP: view image

Paralogs for IVNS1ABP Gene

(18) SIMAP similar genes for IVNS1ABP Gene using alignment to 3 proteins:

  • NS1BP_HUMAN
  • A8MVR0_HUMAN
  • H0Y5Y2_HUMAN
genes like me logo Genes that share paralogs with IVNS1ABP: view

Variants for IVNS1ABP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IVNS1ABP Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
783014 Benign: not provided 185,301,203(-) G/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for IVNS1ABP Gene

Structural Variations from Database of Genomic Variants (DGV) for IVNS1ABP Gene

Variant ID Type Subtype PubMed ID
nsv548398 CNV gain 21841781

Variation tolerance for IVNS1ABP Gene

Residual Variation Intolerance Score: 44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IVNS1ABP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IVNS1ABP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IVNS1ABP Gene

Disorders for IVNS1ABP Gene

MalaCards: The human disease database

(10) MalaCards diseases for IVNS1ABP Gene - From: GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
influenza
  • flu
leber optic atrophy
  • leber optic atrophy, susceptibility to
tick-borne encephalitis
  • central european encephalitis
japanese encephalitis
  • japanese b encephalitis
avian influenza
  • avian flu
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IVNS1ABP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IVNS1ABP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IVNS1ABP Gene

Publications for IVNS1ABP Gene

  1. NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells. (PMID: 9696811) Wolff T … Palese P (Journal of virology 1998) 2 3 4 23 54
  2. The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein. (PMID: 16582008) Dunham EE … Bradfield CA (Molecular pharmacology 2006) 2 3 4 54
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 54
  4. Crystal structure of the Kelch domain of human NS1-binding protein at 1.98 Å resolution. (PMID: 29497022) Guo L … Liu Y (Acta crystallographica. Section F, Structural biology communications 2018) 3 4 54
  5. KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination. (PMID: 25619834) Chen HY … Chen RH (Oncogene 2015) 3 4 54

Products for IVNS1ABP Gene

Sources for IVNS1ABP Gene