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Aliases for ITPRIPL2 Gene

Aliases for ITPRIPL2 Gene

  • ITPRIP Like 2 2 3 5
  • Inositol 1,4,5-Trisphosphate Receptor Interacting Protein Like 2 2

External Ids for ITPRIPL2 Gene

Previous GeneCards Identifiers for ITPRIPL2 Gene

  • GC16P019032
  • GC16P019125
  • GC16P017662

Summaries for ITPRIPL2 Gene

GeneCards Summary for ITPRIPL2 Gene

ITPRIPL2 (ITPRIP Like 2) is a Protein Coding gene. An important paralog of this gene is ITPRIP.

Additional gene information for ITPRIPL2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITPRIPL2 Gene

Genomics for ITPRIPL2 Gene

GeneHancer (GH) Regulatory Elements for ITPRIPL2 Gene

Promoters and enhancers for ITPRIPL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I019110 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.5 -468 6 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000261427 ENSG00000278389 ITPRIPL2 SYT17 COQ7 RNU4-46P GC16P019109
GH16I019123 Enhancer 1 ENCODE dbSUPER 4.9 +9.8 9812 0.2 FOXA2 ARID4B RAD21 RARA ETS1 YY1 SLC30A9 ATF7 MIXL1 RXRA SYT17 COQ7 ITPRIPL2 ENSG00000261759 ENSG00000261427 GC16P019109
GH16I019116 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 0.8 +4.7 4732 3.8 HDGF PKNOX1 ARNT FEZF1 POLR2B ARID2 FOS RUNX3 RXRA NCOA1 SYT17 COQ7 ENSG00000261427 ENSG00000261759 ITPRIPL2 GC16P019121 GC16P019109
GH16I019121 Enhancer 0.9 ENCODE dbSUPER 0.4 +8.2 8205 1.1 GATA3 SCRT2 RCOR1 SCRT1 SMARCE1 ZNF687 CEBPB DPF2 GATAD2B REST ENSG00000261759 GC16P019121 SYT17 COQ7 ENSG00000261427 ITPRIPL2 GC16P019109
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ITPRIPL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ITPRIPL2 gene promoter:

Genomic Locations for ITPRIPL2 Gene

Genomic Locations for ITPRIPL2 Gene
chr16:19,113,932-19,121,630
(GRCh38/hg38)
Size:
7,699 bases
Orientation:
Plus strand
chr16:19,125,254-19,132,952
(GRCh37/hg19)

Genomic View for ITPRIPL2 Gene

Genes around ITPRIPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITPRIPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITPRIPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITPRIPL2 Gene

Proteins for ITPRIPL2 Gene

  • Protein details for ITPRIPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3MIP1-IPIL2_HUMAN
    Recommended name:
    Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2
    Protein Accession:
    Q3MIP1

    Protein attributes for ITPRIPL2 Gene

    Size:
    535 amino acids
    Molecular mass:
    58446 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ITPRIPL2 Gene

Post-translational modifications for ITPRIPL2 Gene

No Post-translational modifications

Other Protein References for ITPRIPL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ITPRIPL2 Gene

Domains & Families for ITPRIPL2 Gene

Gene Families for ITPRIPL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ITPRIPL2 Gene

Suggested Antigen Peptide Sequences for ITPRIPL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q3MIP1

UniProtKB/Swiss-Prot:

IPIL2_HUMAN :
  • Belongs to the ITPRIP family.
Family:
  • Belongs to the ITPRIP family.
genes like me logo Genes that share domains with ITPRIPL2: view

Function for ITPRIPL2 Gene

Phenotypes From GWAS Catalog for ITPRIPL2 Gene

Phenotypes for ITPRIPL2 Gene

GenomeRNAi human phenotypes for ITPRIPL2:
genes like me logo Genes that share phenotypes with ITPRIPL2: view

Animal Model Products

miRNA for ITPRIPL2 Gene

miRTarBase miRNAs that target ITPRIPL2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ITPRIPL2 Gene

Localization for ITPRIPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITPRIPL2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITPRIPL2 gene
Compartment Confidence
plasma membrane 2
cytosol 2
golgi apparatus 2
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ITPRIPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ITPRIPL2: view

Pathways & Interactions for ITPRIPL2 Gene

SuperPathways for ITPRIPL2 Gene

No Data Available

Interacting Proteins for ITPRIPL2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000370849%0d%0a9606.ENSP00000348634%0d%0a
Selected Interacting proteins: Q3MIP1-IPIL2_HUMAN ENSP00000370849 for ITPRIPL2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ITPRIPL2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ITPRIPL2 Gene

Drugs & Compounds for ITPRIPL2 Gene

No Compound Related Data Available

Transcripts for ITPRIPL2 Gene

mRNA/cDNA for ITPRIPL2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ITPRIPL2 Gene

Inositol 1,4,5-trisphosphate receptor interacting protein-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITPRIPL2 Gene

No ASD Table

Relevant External Links for ITPRIPL2 Gene

GeneLoc Exon Structure for
ITPRIPL2
ECgene alternative splicing isoforms for
ITPRIPL2

Expression for ITPRIPL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ITPRIPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ITPRIPL2 Gene

This gene is overexpressed in Placenta (59.8) and Urine (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ITPRIPL2 Gene



Protein tissue co-expression partners for ITPRIPL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ITPRIPL2 Gene:

ITPRIPL2

SOURCE GeneReport for Unigene cluster for ITPRIPL2 Gene:

Hs.530899

Evidence on tissue expression from TISSUES for ITPRIPL2 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with ITPRIPL2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITPRIPL2 Gene

Orthologs for ITPRIPL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITPRIPL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITPRIPL2 33 34
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia ITPRIPL2 33 34
  • 87.03 (n)
dog
(Canis familiaris)
Mammalia ITPRIPL2 33 34
  • 86.65 (n)
mouse
(Mus musculus)
Mammalia Itpripl2 33 16 34
  • 83.55 (n)
rat
(Rattus norvegicus)
Mammalia Itpripl2 33
  • 82.49 (n)
oppossum
(Monodelphis domestica)
Mammalia ITPRIPL2 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITPRIPL2 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITPRIPL2 33
  • 64.81 (n)
lizard
(Anolis carolinensis)
Reptilia ITPRIPL2 34
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itpripl2 33
  • 51.87 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC555628 33
  • 51.88 (n)
ITPRIPL2 34
  • 40 (a)
OneToOne
Species where no ortholog for ITPRIPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITPRIPL2 Gene

ENSEMBL:
Gene Tree for ITPRIPL2 (if available)
TreeFam:
Gene Tree for ITPRIPL2 (if available)

Paralogs for ITPRIPL2 Gene

Paralogs for ITPRIPL2 Gene

genes like me logo Genes that share paralogs with ITPRIPL2: view

Variants for ITPRIPL2 Gene

Sequence variations from dbSNP and Humsavar for ITPRIPL2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1001106931 -- 19,112,311(+) G/A upstream_transcript_variant
rs1001245434 -- 19,120,213(+) C/G 3_prime_UTR_variant, non_coding_transcript_variant
rs1001349097 -- 19,113,590(+) A/G upstream_transcript_variant
rs1001413993 -- 19,112,027(+) AACAAACAAACAAACAAACAAA/AACAAACAAACAAACAAA upstream_transcript_variant
rs1001842487 -- 19,113,947(+) A/G 5_prime_UTR_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ITPRIPL2 Gene

Variant ID Type Subtype PubMed ID
dgv2787n100 CNV gain 25217958
esv2758634 CNV gain+loss 17122850
esv3570409 CNV gain 25503493
esv3582072 CNV loss 25503493
nsv1045019 CNV gain 25217958
nsv1051531 CNV gain 25217958
nsv436835 CNV insertion 17901297
nsv571579 CNV gain 21841781
nsv571582 CNV gain 21841781

Variation tolerance for ITPRIPL2 Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.53; 64.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITPRIPL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITPRIPL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITPRIPL2 Gene

Disorders for ITPRIPL2 Gene

Additional Disease Information for ITPRIPL2

No disorders were found for ITPRIPL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITPRIPL2 Gene

Publications for ITPRIPL2 Gene

  1. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  2. Confirmation of prior evidence of genetic susceptibility to alcoholism in a genome-wide association study of comorbid alcoholism and bipolar disorder. (PMID: 21876473) Lydall GJ … Gurling HM (Psychiatric genetics 2011) 44 58
  3. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen JV … Mann M (Science signaling 2010) 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 58

Products for ITPRIPL2 Gene

Sources for ITPRIPL2 Gene

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