Aliases for ITPRIPL1 Gene

Aliases for ITPRIPL1 Gene

  • ITPRIP Like 1 2 3 5
  • Inositol 1,4,5-Trisphosphate Receptor-Interacting Protein-Like 1 3 4
  • Inositol 1,4,5-Trisphosphate Receptor Interacting Protein-Like 1 2 3
  • KIAA1754L 3 4
  • Inositol 1,4,5-Triphosphate Receptor-Interacting Protein-Like 1 3
  • Inositol 1,4,5-Triphosphate Receptor Interacting Protein-Like 1 2
  • KIAA1754-Like 2

External Ids for ITPRIPL1 Gene

Previous HGNC Symbols for ITPRIPL1 Gene

  • KIAA1754L

Previous GeneCards Identifiers for ITPRIPL1 Gene

  • GC02P096991
  • GC02P090952

Summaries for ITPRIPL1 Gene

GeneCards Summary for ITPRIPL1 Gene

ITPRIPL1 (ITPRIP Like 1) is a Protein Coding gene. An important paralog of this gene is ITPRIP.

Additional gene information for ITPRIPL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ITPRIPL1 Gene

Genomics for ITPRIPL1 Gene

GeneHancer (GH) Regulatory Elements for ITPRIPL1 Gene

Promoters and enhancers for ITPRIPL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ITPRIPL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ITPRIPL1 gene promoter:
  • AREB6
  • c-Myb
  • Elk-1
  • LCR-F1
  • MyoD
  • RP58

Genomic Locations for ITPRIPL1 Gene

Genomic Locations for ITPRIPL1 Gene
chr2:96,325,324-96,330,517
(GRCh38/hg38)
Size:
5,194 bases
Orientation:
Plus strand
chr2:96,991,062-96,994,091
(GRCh37/hg19)
Size:
3,030 bases
Orientation:
Plus strand

Genomic View for ITPRIPL1 Gene

Genes around ITPRIPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITPRIPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITPRIPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITPRIPL1 Gene

Proteins for ITPRIPL1 Gene

  • Protein details for ITPRIPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6GPH6-IPIL1_HUMAN
    Recommended name:
    Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1
    Protein Accession:
    Q6GPH6
    Secondary Accessions:
    • F5H1L8
    • Q8NE61

    Protein attributes for ITPRIPL1 Gene

    Size:
    555 amino acids
    Molecular mass:
    63395 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ITPRIPL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITPRIPL1 Gene

Post-translational modifications for ITPRIPL1 Gene

  • Ubiquitination at Lys274
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ITPRIPL1 Gene

Domains & Families for ITPRIPL1 Gene

Gene Families for ITPRIPL1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for ITPRIPL1 Gene

Suggested Antigen Peptide Sequences for ITPRIPL1 Gene

GenScript: Design optimal peptide antigens:
  • Inositol 1,4,5-triphosphate receptor-interacting protein-like 1 (IPIL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6GPH6

UniProtKB/Swiss-Prot:

IPIL1_HUMAN :
  • Belongs to the ITPRIP family.
Family:
  • Belongs to the ITPRIP family.
genes like me logo Genes that share domains with ITPRIPL1: view

Function for ITPRIPL1 Gene

Phenotypes From GWAS Catalog for ITPRIPL1 Gene

Gene Ontology (GO) - Molecular Function for ITPRIPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ITPRIPL1: view
genes like me logo Genes that share phenotypes with ITPRIPL1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ITPRIPL1 Gene

Localization for ITPRIPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITPRIPL1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITPRIPL1 gene
Compartment Confidence
extracellular 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITPRIPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ITPRIPL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ITPRIPL1 Gene

Pathways & Interactions for ITPRIPL1 Gene

PathCards logo

SuperPathways for ITPRIPL1 Gene

No Data Available

SIGNOR curated interactions for ITPRIPL1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ITPRIPL1 Gene

None

No data available for Pathways by source for ITPRIPL1 Gene

Drugs & Compounds for ITPRIPL1 Gene

No Compound Related Data Available

Transcripts for ITPRIPL1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITPRIPL1 Gene

No ASD Table

Relevant External Links for ITPRIPL1 Gene

GeneLoc Exon Structure for
ITPRIPL1
ECgene alternative splicing isoforms for
ITPRIPL1

Expression for ITPRIPL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ITPRIPL1 Gene

mRNA differential expression in normal tissues according to GTEx for ITPRIPL1 Gene

This gene is overexpressed in Testis (x16.0).

NURSA nuclear receptor signaling pathways regulating expression of ITPRIPL1 Gene:

ITPRIPL1

SOURCE GeneReport for Unigene cluster for ITPRIPL1 Gene:

Hs.65009

Evidence on tissue expression from TISSUES for ITPRIPL1 Gene

  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with ITPRIPL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITPRIPL1 Gene

Orthologs for ITPRIPL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITPRIPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITPRIPL1 33 32
  • 99.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ITPRIPL1 33 32
  • 91 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ITPRIPL1 33 32
  • 88.03 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Itpripl1 17 33 32
  • 86.67 (n)
rat
(Rattus norvegicus)
Mammalia Itpripl1 32
  • 86.3 (n)
chicken
(Gallus gallus)
Aves -- 33
  • 24 (a)
OneToMany
-- 33
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ITPRIPL1 33
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-80c12.4 33
  • 20 (a)
ManyToMany
Species where no ortholog for ITPRIPL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITPRIPL1 Gene

ENSEMBL:
Gene Tree for ITPRIPL1 (if available)
TreeFam:
Gene Tree for ITPRIPL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ITPRIPL1: view image

Paralogs for ITPRIPL1 Gene

Paralogs for ITPRIPL1 Gene

(1) SIMAP similar genes for ITPRIPL1 Gene using alignment to 4 proteins:

  • IPIL1_HUMAN
  • C9JNT4_HUMAN
  • F5H1L8_HUMAN
  • H7C0T2_HUMAN
genes like me logo Genes that share paralogs with ITPRIPL1: view

Variants for ITPRIPL1 Gene

Sequence variations from dbSNP and Humsavar for ITPRIPL1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs193921120 uncertain-significance, Malignant tumor of prostate 96,327,946(+) G/A coding_sequence_variant, missense_variant
rs1000718882 -- 96,330,971(+) A/T downstream_transcript_variant
rs1001012022 -- 96,324,039(+) T/C upstream_transcript_variant
rs1001843075 -- 96,330,261(+) A/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1001937513 -- 96,330,510(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ITPRIPL1 Gene

Variant ID Type Subtype PubMed ID
dgv607e201 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv3591652 OTHER inversion 21293372
esv5003 OTHER complex 18987735
nsv1135873 CNV deletion 24896259
nsv508155 CNV deletion 20534489
nsv834305 CNV gain 17160897

Variation tolerance for ITPRIPL1 Gene

Residual Variation Intolerance Score: 77.6% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITPRIPL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITPRIPL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITPRIPL1 Gene

Disorders for ITPRIPL1 Gene

Additional Disease Information for ITPRIPL1

No disorders were found for ITPRIPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITPRIPL1 Gene

Publications for ITPRIPL1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 56
  2. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 56
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56

Products for ITPRIPL1 Gene

Sources for ITPRIPL1 Gene