Aliases for ITPR3 Gene
External Ids for ITPR3 Gene
Previous GeneCards Identifiers for ITPR3 Gene
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
GeneCards Summary for ITPR3 Gene
ITPR3 (Inositol 1,4,5-Trisphosphate Receptor Type 3) is a Protein Coding gene. Diseases associated with ITPR3 include Diabetes Mellitus, Insulin-Dependent and Anhidrosis, Isolated, With Normal Sweat Glands. Among its related pathways are Signaling by GPCR and Oxytocin signaling pathway. Gene Ontology (GO) annotations related to this gene include binding and phosphatidylinositol binding. An important paralog of this gene is ITPR2.
UniProtKB/Swiss-Prot Summary for ITPR3 Gene
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
Inositol 1,4,5-trisphosphate (IP3) receptors are a form of ligand-gated ion channels that are activated by cytosolic Ca2+ and IP3. They are localized to intracellular membranes, such as the endoplasmic reticulum, and mediate the mobilization of intracellular Ca2+ stores.