Aliases for ITPR3 Gene
External Ids for ITPR3 Gene
Previous GeneCards Identifiers for ITPR3 Gene
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
GeneCards Summary for ITPR3 Gene
ITPR3 (Inositol 1,4,5-Trisphosphate Receptor Type 3) is a Protein Coding gene. Diseases associated with ITPR3 include Diabetes Mellitus, Insulin-Dependent and Peritoneum Cancer. Among its related pathways are Antigen activates B Cell Receptor (BCR) leading to generation of second messengers and G-protein signaling G-Protein alpha-i signaling cascades. Gene Ontology (GO) annotations related to this gene include binding and phosphatidylinositol binding. An important paralog of this gene is ITPR2.
UniProtKB/Swiss-Prot for ITPR3 Gene
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
Inositol 1,4,5-trisphosphate (IP3) receptors are a form of ligand-gated ion channels that are activated by cytosolic Ca2+ and IP3. They are localized to intracellular membranes, such as the endoplasmic reticulum, and mediate the mobilization of intracellular Ca2+ stores.