This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlyi... See more...

Aliases for ITPR3 Gene

Aliases for ITPR3 Gene

  • Inositol 1,4,5-Trisphosphate Receptor Type 3 2 3 4 5
  • Inositol 1,4,5-Triphosphate Receptor, Type 3 2 3
  • Type 3 InsP3 Receptor 3 4
  • InsP3R3 3 4
  • IP3R3 2 3
  • Inositol 1,4,5-Trisphosphate Receptor, Type 3 2
  • Type 3 Inositol 1,4,5-Trisphosphate Receptor 4
  • IP3 Receptor Isoform 3 4
  • IP3 Receptor 3
  • IP3R 3 4
  • ITPR3 5
  • IP3R 3

External Ids for ITPR3 Gene

Previous GeneCards Identifiers for ITPR3 Gene

  • GC06P033591
  • GC06P033636
  • GC06P033697
  • GC06P033330
  • GC06P033588

Summaries for ITPR3 Gene

Entrez Gene Summary for ITPR3 Gene

  • This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]

GeneCards Summary for ITPR3 Gene

ITPR3 (Inositol 1,4,5-Trisphosphate Receptor Type 3) is a Protein Coding gene. Diseases associated with ITPR3 include Diabetes Mellitus, Type I and Anhidrosis, Isolated, With Normal Sweat Glands. Among its related pathways are DAG and IP3 signaling and Translation Translation regulation by Alpha-1 adrenergic receptors. Gene Ontology (GO) annotations related to this gene include binding and phosphatidylinositol binding. An important paralog of this gene is ITPR2.

UniProtKB/Swiss-Prot Summary for ITPR3 Gene

  • Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.

Tocris Summary for ITPR3 Gene

  • Inositol 1,4,5-trisphosphate (IP3) receptors are a form of ligand-gated ion channels that are activated by cytosolic Ca2+ and IP3. They are localized to intracellular membranes, such as the endoplasmic reticulum, and mediate the mobilization of intracellular Ca2+ stores.

Gene Wiki entry for ITPR3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ITPR3 Gene

Genomics for ITPR3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ITPR3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ITPR3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ITPR3

Top Transcription factor binding sites by QIAGEN in the ITPR3 gene promoter:
  • c-Myb
  • E47
  • GCNF
  • GCNF-1
  • Gfi-1
  • MyoD
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • Tal-1beta

Genomic Locations for ITPR3 Gene

Genomic Locations for ITPR3 Gene
chr6:33,620,365-33,696,574
(GRCh38/hg38)
Size:
76,210 bases
Orientation:
Plus strand
chr6:33,588,142-33,664,351
(GRCh37/hg19)
Size:
76,210 bases
Orientation:
Plus strand

Genomic View for ITPR3 Gene

Genes around ITPR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITPR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITPR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITPR3 Gene

Proteins for ITPR3 Gene

  • Protein details for ITPR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14573-ITPR3_HUMAN
    Recommended name:
    Inositol 1,4,5-trisphosphate receptor type 3
    Protein Accession:
    Q14573
    Secondary Accessions:
    • Q14649
    • Q5TAQ2

    Protein attributes for ITPR3 Gene

    Size:
    2671 amino acids
    Molecular mass:
    304106 Da
    Quaternary structure:
    • Homotetramer. Interacts with TRPC1, TRPC3 and TRPC4. Interacts with TRPV4 (PubMed:18826956). Interacts with SIGMAR1 (By similarity). Interacts with PML and AKT1 (By similarity). Interacts with IRAG2 (via coiled-coil domain) (By similarity). Interacts with CABP1 (PubMed:12032348). Interacts with TMBIM4/LFG4 (PubMed:19553469). Interacts with CEMIP (PubMed:23936024). Interacts with TESPA1 (By similarity). Interacts with TMEM203 (PubMed:25996873). Interacts with BOK; regulates ITPR3 expression (By similarity).

    Three dimensional structures from OCA and Proteopedia for ITPR3 Gene

neXtProt entry for ITPR3 Gene

Post-translational modifications for ITPR3 Gene

  • Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues (By similarity).
  • Glycosylation at Asn2405
  • Ubiquitination at Lys1589
  • Modification sites at PhosphoSitePlus

Other Protein References for ITPR3 Gene

No data available for DME Specific Peptides for ITPR3 Gene

Domains & Families for ITPR3 Gene

Gene Families for ITPR3 Gene

Protein Domains for ITPR3 Gene

InterPro:
Blocks:
  • Intracellular calcium-release channel
  • MIR domain
  • RyR and IP3R Homology associated
  • Inositol 1,4,5-trisphosphate-binding protein receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for ITPR3 Gene

GenScript: Design optimal peptide antigens:
  • ITPR3 protein (A6H8K3_HUMAN)
  • Type 3 inositol 1,4,5-trisphosphate receptor (ITPR3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14573

UniProtKB/Swiss-Prot:

ITPR3_HUMAN :
  • The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
  • Belongs to the InsP3 receptor family.
Domain:
  • The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
Family:
  • Belongs to the InsP3 receptor family.
genes like me logo Genes that share domains with ITPR3: view

Function for ITPR3 Gene

Molecular function for ITPR3 Gene

UniProtKB/Swiss-Prot Function:
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
GENATLAS Biochemistry:
inositol 1,4,5-triphosphate receptor,type 3,coexpressed with RYR3 in neurons and smooth muscle cells forming heterotetrameric channel with ITPR1 and ITPR2,involved in Ca++ mobilization from the endoplastic reticulum,poorly sensitive to IP3 and CA++,mediating monophasic Ca++ transients

Phenotypes From GWAS Catalog for ITPR3 Gene

Gene Ontology (GO) - Molecular Function for ITPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000822 inositol hexakisphosphate binding ISS --
GO:0005216 ion channel activity IEA --
GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IBA,ISS --
GO:0005262 calcium channel activity IEA --
GO:0005509 calcium ion binding IBA 21873635
genes like me logo Genes that share ontologies with ITPR3: view
genes like me logo Genes that share phenotypes with ITPR3: view

Human Phenotype Ontology for ITPR3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ITPR3 Gene

MGI Knock Outs for ITPR3:

Animal Model Products

  • Taconic Biosciences Mouse Models for ITPR3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITPR3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ITPR3 Gene

Localization for ITPR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITPR3 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITPR3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
nucleus 4
mitochondrion 3
cytosol 3
extracellular 2
cytoskeleton 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ITPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IEA --
GO:0005640 nuclear outer membrane ISS --
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with ITPR3: view

Pathways & Interactions for ITPR3 Gene

PathCards logo

SuperPathways for ITPR3 Gene

SuperPathway Contained pathways
1 RET signaling
2 Development Angiotensin activation of ERK
.73
.73
.68
.65
.54
.48
.45
.40
3 DAG and IP3 signaling
.35
4 fMLP Pathway
.44
.43
.42
.39
.38
.31
5 Aldosterone synthesis and secretion
genes like me logo Genes that share pathways with ITPR3: view

Pathways by source for ITPR3 Gene

41 GeneGo (Thomson Reuters) pathways for ITPR3 Gene
  • Cell adhesion Integrin inside-out signaling
  • CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
  • Cytoskeleton remodeling FAK signaling
  • Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
  • Development A1 receptor signaling
47 Qiagen pathways for ITPR3 Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
  • Alpha-Adrenergic Signaling
  • BDNF Pathway
1 GeneTex pathway for ITPR3 Gene

Gene Ontology (GO) - Biological Process for ITPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport IEA --
GO:0007186 G protein-coupled receptor signaling pathway ISS --
GO:0007204 positive regulation of cytosolic calcium ion concentration ISS --
GO:0007613 memory IEA --
genes like me logo Genes that share ontologies with ITPR3: view

No data available for SIGNOR curated interactions for ITPR3 Gene

Drugs & Compounds for ITPR3 Gene

(10) Drugs for ITPR3 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist, cofactor 1058
Caffeine Approved Pharma Antagonist, Activator, Target, inhibitor 603
Ca<sup>2+</sup> Pharma Activator, Agonist, Full agonist, Inhibitor, Antagonist, Channel blocker 0
DECAVANADATE Pharma Antagonist, Activator, Agonist 0
IP<sub>3</sub> Pharma Activator 0

(4) Additional Compounds for ITPR3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Inositol 1,4,5-trisphosphate
  • 1,4,5-Insp3
  • D-myo-Inositol 1,4,5-trisphosphate
  • D-myo-INOSITOL-1,4,5-triphosphATE
  • Ins(1,4,5)P3
  • InsP3
88269-39-0

(1) Tocris Compounds for ITPR3 Gene

Compound Action Cas Number
2-APB IP3 receptor antagonist. Also TRP channel modulator 524-95-8
genes like me logo Genes that share compounds with ITPR3: view

Transcripts for ITPR3 Gene

mRNA/cDNA for ITPR3 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITPR3

Alternative Splicing Database (ASD) splice patterns (SP) for ITPR3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22a · 22b ^
SP1: - - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40a · 40b ^ 41 ^ 42a · 42b ·
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 42c ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^ 49a · 49b · 49c ^ 50 ^ 51 ^ 52 ^ 53a · 53b · 53c ^ 54a · 54b ^ 55a · 55b · 55c ^ 56 ^ 57a · 57b ^ 58 ^ 59a ·
SP1: - - -
SP2:
SP3:
SP4: - -
SP5: -
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:

Relevant External Links for ITPR3 Gene

GeneLoc Exon Structure for
ITPR3

Expression for ITPR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ITPR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ITPR3 Gene

This gene is overexpressed in Nasal epithelium (47.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ITPR3 Gene



Protein tissue co-expression partners for ITPR3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ITPR3

SOURCE GeneReport for Unigene cluster for ITPR3 Gene:

Hs.65758

mRNA Expression by UniProt/SwissProt for ITPR3 Gene:

Q14573-ITPR3_HUMAN
Tissue specificity: Expressed in intestinal crypt and villus epithelial cells.

Evidence on tissue expression from TISSUES for ITPR3 Gene

  • Liver(4.6)
  • Intestine(4.1)
  • Lung(3.7)
  • Nervous system(3.6)
  • Blood(3.2)
  • Pancreas(3.1)
  • Skin(3)
  • Muscle(2.9)
  • Heart(2.9)
  • Stomach(2.8)
  • Thyroid gland(2.7)
  • Eye(2.7)
  • Adrenal gland(2.6)
  • Kidney(2.6)
  • Spleen(2.4)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with ITPR3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITPR3 Gene

Orthologs for ITPR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITPR3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ITPR3 30 31
  • 98.45 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ITPR3 30 31
  • 92.77 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ITPR3 30 31
  • 92.61 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ITPR3 31
  • 90 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Itpr3 30
  • 89.7 (n)
Mouse
(Mus musculus)
Mammalia Itpr3 30 17 31
  • 89.41 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ITPR3 31
  • 66 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ITPR3 30 31
  • 83.53 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ITPR3 31
  • 88 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii itpr3 31
  • 73 (a)
OneToOne
Dr.23369 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.660 30
Fruit Fly
(Drosophila melanogaster)
Insecta Itp-r83A 31 32
  • 51 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea itr-1 31 32
  • 37 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 51 (a)
OneToMany
Species where no ortholog for ITPR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ITPR3 Gene

ENSEMBL:
Gene Tree for ITPR3 (if available)
TreeFam:
Gene Tree for ITPR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ITPR3: view image

Paralogs for ITPR3 Gene

Paralogs for ITPR3 Gene

(2) SIMAP similar genes for ITPR3 Gene using alignment to 2 proteins:

  • ITPR3_HUMAN
  • A6H8K3_HUMAN
genes like me logo Genes that share paralogs with ITPR3: view

Variants for ITPR3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ITPR3 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
691360 Uncertain Significance: Pyloric stenosis; Esophageal atresia 33,662,590(+) G/C MISSENSE_VARIANT
709049 Likely Benign: not provided 33,685,684(+) T/C MISSENSE_VARIANT
709410 Benign: not provided 33,678,725(+) C/T SYNONYMOUS_VARIANT
712371 Likely Benign: not provided 33,673,710(+) C/T SYNONYMOUS_VARIANT
712618 Likely Benign: not provided 33,680,326(+) C/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ITPR3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ITPR3 Gene

Variant ID Type Subtype PubMed ID
dgv85n68 CNV loss 17160897
esv3435549 CNV duplication 20981092
esv3571003 CNV loss 25503493
esv3608630 CNV gain 21293372
esv8764 CNV gain 19470904
nsv470811 CNV loss 18288195
nsv522906 CNV loss 19592680
nsv5250 CNV deletion 18451855
nsv602838 CNV loss 21841781
nsv950158 CNV deletion 24416366

Variation tolerance for ITPR3 Gene

Residual Variation Intolerance Score: 0.44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.98; 68.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITPR3 Gene

Human Gene Mutation Database (HGMD)
ITPR3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITPR3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITPR3 Gene

Disorders for ITPR3 Gene

MalaCards: The human disease database

(9) MalaCards diseases for ITPR3 Gene - From: GTR, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ITPR3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ITPR3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ITPR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITPR3 Gene

Publications for ITPR3 Gene

  1. Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors. (PMID: 8081734) Yamamoto-Hino M … Hasegawa M (Receptors & channels 1994) 2 3 4 23
  2. Primary structure, ligand binding, and localization of the human type 3 inositol 1,4,5-trisphosphate receptor expressed in intestinal epithelium. (PMID: 8288584) Maranto AR (The Journal of biological chemistry 1994) 2 3 4 23
  3. IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site. (PMID: 18826956) Garcia-Elias A … Valverde MA (The Journal of biological chemistry 2008) 3 4 23
  4. A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population. (PMID: 18219441) Oishi T … Matsuda K (Journal of human genetics 2008)