Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms cont... See more...

Aliases for ITPKA Gene

Aliases for ITPKA Gene

  • Inositol-Trisphosphate 3-Kinase A 2 3 4 5
  • Inositol 1,4,5-Trisphosphate 3-Kinase A 2 3 4
  • InsP 3-Kinase A 3 4
  • IP3 3-Kinase A 3 4
  • EC 2.7.1.127 4 50
  • IP3-3KA 2 3
  • IP3K A 3 4
  • IP3KA 2 3
  • ITPKA 5

External Ids for ITPKA Gene

Previous GeneCards Identifiers for ITPKA Gene

  • GC15P037153
  • GC15P034681
  • GC15P039364
  • GC15P039502
  • GC15P039573
  • GC15P041786
  • GC15P018634

Summaries for ITPKA Gene

Entrez Gene Summary for ITPKA Gene

  • Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]

GeneCards Summary for ITPKA Gene

ITPKA (Inositol-Trisphosphate 3-Kinase A) is a Protein Coding gene. Among its related pathways are superpathway of inositol phosphate compounds and Metabolism. Gene Ontology (GO) annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is ITPKB.

Gene Wiki entry for ITPKA Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ITPKA Gene

Genomics for ITPKA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ITPKA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J041492 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.4 1427 5.1 SP1 MYC NCOR1 IKZF1 ZNF600 ZNF592 KLF9 ZBTB10 YY1 MXD4 HSALNG0105356-001 HSALNG0105356-002 ITPKA lnc-LTK-1 NDUFAF1 RPAP1 RTF1 MGA INO80 DNAJC17
GH15J041557 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.6 +68.0 68046 8.4 ZNF654 MYC ZNF600 NCOR1 IKZF1 SSRP1 ZNF592 ATF2 POLR2A NFIC TYRO3 LTK RPAP1 ITPKA RNU6-1169P SPTBN5 MAPKBP1 PLA2G4B JMJD7 ELOCP2
GH15J041588 Enhancer 0.3 ENCODE 11.6 +96.5 96457 1.7 NFIC NFIB piR-43536-012 JMJD7 SPTBN5 TYRO3 RPAP1 ITPKA MGA LTK MAPKBP1 RNU6-1169P
GH15J041530 Enhancer 0.3 Ensembl 11.7 +37.5 37508 0.6 CHD2 TYRO3 ITPKA RNU6-1169P HSALNG0105363 lnc-LTK-3 RPAP1 LTK
GH15J041512 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 0.4 +20.3 20295 1.7 MYC ZNF592 ZIC2 ZBTB10 ZNF341 MNT SIN3A KLF9 SP2 NKRF LTK RPAP1 NDUFAF1 HSALNG0105360 ITPKA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ITPKA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ITPKA

Top Transcription factor binding sites by QIAGEN in the ITPKA gene promoter:
  • AP-2gamma
  • Bach2
  • c-Fos
  • c-Jun
  • c-Myb
  • HTF
  • IRF-7A
  • POU3F2
  • RORalpha2

Genomic Locations for ITPKA Gene

Latest Assembly
chr15:41,493,393-41,503,555
(GRCh38/hg38)
Size:
10,163 bases
Orientation:
Plus strand

Previous Assembly
chr15:41,786,072-41,795,749
(GRCh37/hg19 by Entrez Gene)
Size:
9,678 bases
Orientation:
Plus strand

chr15:41,785,591-41,795,747
(GRCh37/hg19 by Ensembl)
Size:
10,157 bases
Orientation:
Plus strand

Genomic View for ITPKA Gene

Genes around ITPKA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITPKA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITPKA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITPKA Gene

Proteins for ITPKA Gene

  • Protein details for ITPKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23677-IP3KA_HUMAN
    Recommended name:
    Inositol-trisphosphate 3-kinase A
    Protein Accession:
    P23677
    Secondary Accessions:
    • Q8TAN3

    Protein attributes for ITPKA Gene

    Size:
    461 amino acids
    Molecular mass:
    51009 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ITPKA Gene

neXtProt entry for ITPKA Gene

Selected DME Specific Peptides for ITPKA Gene

P23677:
  • EGNREDGYL
  • IDFGKTTPLP
  • VDPEAPTEEE
  • RTYLEEELTKAR
  • TLGFRIEGIKK
  • HEVIGSSLLF

Post-translational modifications for ITPKA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ITPKA Gene

Antibodies for research

  • Abcam antibodies for ITPKA
  • Boster Bio Antibodies for ITPKA
  • Santa Cruz Biotechnology (SCBT) Antibodies for ITPKA

Domains & Families for ITPKA Gene

Gene Families for ITPKA Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ITPKA Gene

InterPro:
Blocks:
  • Inositol polyphosphate kinase

Suggested Antigen Peptide Sequences for ITPKA Gene

GenScript: Design optimal peptide antigens:
  • Inositol 1,4,5-trisphosphate 3-kinase A (IP3KA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P23677

UniProtKB/Swiss-Prot:

IP3KA_HUMAN :
  • Belongs to the inositol phosphokinase (IPK) family.
Family:
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with ITPKA: view

Function for ITPKA Gene

Molecular function for ITPKA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+); Xref=Rhea:RHEA:11020, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57895, ChEBI:CHEBI:203600, ChEBI:CHEBI:456216; EC=2.7.1.127;.
UniProtKB/Swiss-Prot EnzymeRegulation:
IP3K is activated by calmodulin.
GENATLAS Biochemistry:
inositol 1,4,5-triphosphate 3 kinase-A

Enzyme Numbers (IUBMB) for ITPKA Gene

Phenotypes From GWAS Catalog for ITPKA Gene

Gene Ontology (GO) - Molecular Function for ITPKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000828 inositol hexakisphosphate kinase activity IBA 21873635
GO:0004683 calmodulin-dependent protein kinase activity IEA --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ITPKA: view
genes like me logo Genes that share phenotypes with ITPKA: view

Animal Models for ITPKA Gene

MGI Knock Outs for ITPKA:

miRNA for ITPKA Gene

miRTarBase miRNAs that target ITPKA

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITPKA

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITPKA Gene

Localization for ITPKA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITPKA gene
Compartment Confidence
cytosol 4
nucleus 3
cytoskeleton 2
mitochondrion 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ITPKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0043197 dendritic spine IEA --
genes like me logo Genes that share ontologies with ITPKA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ITPKA Gene

Pathways & Interactions for ITPKA Gene

genes like me logo Genes that share pathways with ITPKA: view

SIGNOR curated interactions for ITPKA Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ITPKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006020 inositol metabolic process IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 1847047
GO:0016310 phosphorylation IEA --
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with ITPKA: view

Drugs & Compounds for ITPKA Gene

(7) Drugs for ITPKA Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
myo-Inositol 1,4,5-trisphosphate Experimental Pharma Target 0
inositol 1,3,4,5-tetrakisphosphate Experimental Pharma Target 0
Phosphoaminophosphonic Acid-Adenylate Ester Experimental Pharma Target 0
ATP Investigational Nutra 0
Calcium Nutra 6959

(3) Additional Compounds for ITPKA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
myo-Inositol 1,3,4,5-tetrakisphosphate
  • D-Myo-inositol 1,3,4,5-tetrakisphosphate
  • D-Myo-inositol 1,3,4,5-tetrakisphosphoric acid
  • Inositol 1,3,4,5-tetrakisphosphoric acid
  • Inositol 1,3,4,5-tetrakisphosphate
  • 1D-myo-Inositol 1,3,4,5-tetrakisphosphoric acid
99610-76-1

(1) ApexBio Compounds for ITPKA Gene

Compound Action Cas Number
BAMB-4 ITPKA inhibitor,membrane-permeable 891025-25-5
genes like me logo Genes that share compounds with ITPKA: view

Drug products for research

Transcripts for ITPKA Gene

mRNA/cDNA for ITPKA Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITPKA

Alternative Splicing Database (ASD) splice patterns (SP) for ITPKA Gene

No ASD Table

Relevant External Links for ITPKA Gene

GeneLoc Exon Structure for
ITPKA

Expression for ITPKA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ITPKA Gene

mRNA differential expression in normal tissues according to GTEx for ITPKA Gene

This gene is overexpressed in Brain - Cortex (x7.8), Brain - Frontal Cortex (BA9) (x6.0), Brain - Putamen (basal ganglia) (x5.6), Brain - Anterior cingulate cortex (BA24) (x5.2), Brain - Caudate (basal ganglia) (x4.5), and Brain - Nucleus accumbens (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for ITPKA Gene

This gene is overexpressed in Monocytes (28.5), Frontal cortex (21.2), Plasma (11.4), and Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ITPKA Gene



Protein tissue co-expression partners for ITPKA Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ITPKA

SOURCE GeneReport for Unigene cluster for ITPKA Gene:

Hs.2722

Evidence on tissue expression from TISSUES for ITPKA Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ITPKA: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITPKA Gene

Orthologs for ITPKA Gene

This gene was present in the common ancestor of animals.

Orthologs for ITPKA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ITPKA 29 30
  • 99.92 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ITPKA 29 30
  • 91.97 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ITPKA 29 30
  • 91.97 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ITPKA 30
  • 91 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Itpka 29 16 30
  • 87.94 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Itpka 29
  • 87.36 (n)
Oppossum
(Monodelphis domestica)
Mammalia ITPKA 30
  • 87 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ITPKA 29
  • 70.05 (n)
IP3KA 30
  • 69 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ITPKA 30
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100486229 29
  • 61.29 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC564528 29
  • 62.15 (n)
itpka 30
  • 48 (a)
OneToOne
wufi30c01 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002194 29
  • 57.89 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta IP3K1 31
  • 44 (a)
IP3K2 30 31
  • 30 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea lfe-2 30 31
  • 26 (a)
OneToMany
Species where no ortholog for ITPKA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ITPKA Gene

ENSEMBL:
Gene Tree for ITPKA (if available)
TreeFam:
Gene Tree for ITPKA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ITPKA: view image
Alliance of Genome Resources:
Additional Orthologs for ITPKA

Paralogs for ITPKA Gene

Paralogs for ITPKA Gene

(3) SIMAP similar genes for ITPKA Gene using alignment to 2 proteins:

  • IP3KA_HUMAN
  • C9JC74_HUMAN
genes like me logo Genes that share paralogs with ITPKA: view

Variants for ITPKA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ITPKA Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs190590881 Benign: not provided 41,493,975(+) G/C
NM_002220.3(ITPKA):c.48G>C (p.Ala16=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ITPKA Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ITPKA Gene

Variant ID Type Subtype PubMed ID
esv33378 CNV gain 17666407
nsv471241 CNV loss 18288195
nsv524476 CNV loss 19592680
nsv569233 CNV loss 21841781

Variation tolerance for ITPKA Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITPKA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITPKA
Leiden Open Variation Database (LOVD)
ITPKA

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITPKA Gene

Disorders for ITPKA Gene

Additional Disease Information for ITPKA

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for ITPKA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITPKA Gene

Publications for ITPKA Gene

  1. Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization. (PMID: 1330886) Erneux C … Mattei MG (Genomics 1992) 2 3 22
  2. Human brain inositol 1,4,5-trisphosphate 3-kinase cDNA sequence. (PMID: 2175886) Takazawa K … Erneux C (Nucleic acids research 1990) 2 3 4
  3. Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities. (PMID: 20022963) Windhorst S … Mayr GW (The Journal of biological chemistry 2010) 3 22
  4. Down-regulation of 1D-myo-inositol 1,4,5-trisphosphate 3-kinase A protein expression in oral squamous cell carcinoma. (PMID: 16525636) Kato H … Tanzawa H (International journal of oncology 2006) 3 22
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ITPKA Gene

  • Boster Bio Antibodies for ITPKA
  • Boster Bio ELISA Kits for ITPKA

Sources for ITPKA Gene