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Aliases for ITPKA Gene

Aliases for ITPKA Gene

  • Inositol-Trisphosphate 3-Kinase A 2 3 3 5
  • Inositol 1,4,5-Trisphosphate 3-Kinase A 2 3 4
  • InsP 3-Kinase A 3 4
  • IP3 3-Kinase A 3 4
  • IP3K A 3 4
  • EC 4
  • IP3-3KA 3
  • IP3KA 3

External Ids for ITPKA Gene

Previous GeneCards Identifiers for ITPKA Gene

  • GC15P037153
  • GC15P034681
  • GC15P039364
  • GC15P039502
  • GC15P039573
  • GC15P041786
  • GC15P018634

Summaries for ITPKA Gene

Entrez Gene Summary for ITPKA Gene

  • Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]

GeneCards Summary for ITPKA Gene

ITPKA (Inositol-Trisphosphate 3-Kinase A) is a Protein Coding gene. Among its related pathways are Metabolism and superpathway of inositol phosphate compounds. Gene Ontology (GO) annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is ITPKB.

Gene Wiki entry for ITPKA Gene

Additional gene information for ITPKA Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITPKA Gene

Genomics for ITPKA Gene

GeneHancer (GH) Regulatory Elements for ITPKA Gene

Promoters and enhancers for ITPKA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J041492 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.7 +1.4 1427 5.1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF766 ITPKA NDUFAF1 MGA INO80 DNAJC17 RPAP1 RTF1 RAD51-AS1 VPS39 LOC105370795
GH15J041560 Enhancer 1.2 ENCODE dbSUPER 11.2 +69.8 69787 4.9 ATF1 ARID4B ETS1 TCF12 GLIS2 GATA2 SP5 NCOA1 REST ZNF592 LTK RPAP1 ITPKA RNU6-1169P SPTBN5 PLA2G4B MAPKBP1 TYRO3 GC15M041574
GH15J041588 Enhancer 0.4 ENCODE 11.6 +96.5 96457 1.7 NFIC GATA3 NFIB JMJD7 SPTBN5 TYRO3 ITPKA RPAP1 MGA LTK MAPKBP1 RNU6-1169P GC15P041578
GH15J041557 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.6 +65.4 65425 3.2 SMAD1 ARID4B SIN3A ZNF2 ZNF48 GLIS2 ZNF143 DEK ZNF263 SP3 TYRO3 ELOCP2 VPS39 RPAP1 DNAJC17 RAD51-AS1 MGA INO80 LRRC57 MAPKBP1
GH15J041489 Enhancer 1.1 Ensembl ENCODE 0.7 -2.9 -2912 1.1 KLF17 BATF IRF4 RAD21 ZNF335 ZNF366 RCOR1 FOS ETV6 ATF7 NDUFAF1 RTF1 LOC105370790 ITPKA GC15M041410
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ITPKA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ITPKA gene promoter:
  • IRF-7A
  • HTF
  • AP-2gamma
  • c-Myb
  • Bach2
  • POU3F2
  • c-Fos
  • RORalpha2
  • c-Jun

Genomic Locations for ITPKA Gene

Genomic Locations for ITPKA Gene
10,167 bases
Plus strand
10,167 bases
Plus strand

Genomic View for ITPKA Gene

Genes around ITPKA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITPKA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITPKA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITPKA Gene

Proteins for ITPKA Gene

  • Protein details for ITPKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inositol-trisphosphate 3-kinase A
    Protein Accession:
    Secondary Accessions:
    • Q8TAN3

    Protein attributes for ITPKA Gene

    461 amino acids
    Molecular mass:
    51009 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ITPKA Gene

neXtProt entry for ITPKA Gene

Post-translational modifications for ITPKA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ITPKA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ITPKA Gene

Domains & Families for ITPKA Gene

Gene Families for ITPKA Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ITPKA Gene


Suggested Antigen Peptide Sequences for ITPKA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the inositol phosphokinase (IPK) family.
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with ITPKA: view

Function for ITPKA Gene

Molecular function for ITPKA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
IP3K is activated by calmodulin.
GENATLAS Biochemistry:
inositol 1,4,5-triphosphate 3 kinase-A

Enzyme Numbers (IUBMB) for ITPKA Gene

Phenotypes From GWAS Catalog for ITPKA Gene

Gene Ontology (GO) - Molecular Function for ITPKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004683 calmodulin-dependent protein kinase activity IEA --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity TAS,IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with ITPKA: view
genes like me logo Genes that share phenotypes with ITPKA: view

Animal Models for ITPKA Gene

MGI Knock Outs for ITPKA:

Animal Model Products

miRNA for ITPKA Gene

miRTarBase miRNAs that target ITPKA

Clone Products

  • Addgene plasmids for ITPKA

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITPKA Gene

Localization for ITPKA Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITPKA gene
Compartment Confidence
cytosol 4
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ITPKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0043197 dendritic spine IEA --
genes like me logo Genes that share ontologies with ITPKA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ITPKA Gene

Pathways & Interactions for ITPKA Gene

genes like me logo Genes that share pathways with ITPKA: view

SIGNOR curated interactions for ITPKA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ITPKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006020 inositol metabolic process IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 1847047
GO:0016310 phosphorylation IEA --
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with ITPKA: view

Drugs & Compounds for ITPKA Gene

(7) Drugs for ITPKA Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
1D-myo-inositol 1,4,5-trisphosphate Experimental Pharma Target 0
inositol 1,3,4,5-tetrakisphosphate Experimental Pharma Target 0
Phosphoaminophosphonic Acid-Adenylate Ester Experimental Pharma Target 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(4) Additional Compounds for ITPKA Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
Inositol 1,3,4,5-tetraphosphate
  • 1,3,4,5-Tetrakis(dihydrogen phosphate) myo-inositol
  • 1D-myo-Inositol 1,3,4,5-tetrakis(dihydrogen phosphate)
  • 1D-myo-Inositol 1,3,4,5-tetrakisphosphate
  • D-myo-Inositol 1,3,4,5-tetrakisphosphate
  • Inositol 1,3,4,5-tetrakis(phosphate)
Inositol 1,4,5-trisphosphate
  • 1,4,5-Insp3
  • D-myo-Inositol 1,4,5-trisphosphate
  • D-myo-INOSITOL-1,4,5-triphosphATE
  • Ins(1,4,5)P3
  • InsP3
genes like me logo Genes that share compounds with ITPKA: view

Transcripts for ITPKA Gene

mRNA/cDNA for ITPKA Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(41) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ITPKA Gene

Inositol-trisphosphate 3-kinase A:
Representative Sequences:

Clone Products

  • Addgene plasmids for ITPKA

Alternative Splicing Database (ASD) splice patterns (SP) for ITPKA Gene

No ASD Table

Relevant External Links for ITPKA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ITPKA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ITPKA Gene

mRNA differential expression in normal tissues according to GTEx for ITPKA Gene

This gene is overexpressed in Brain - Cortex (x7.8), Brain - Frontal Cortex (BA9) (x6.0), Brain - Putamen (basal ganglia) (x5.6), Brain - Anterior cingulate cortex (BA24) (x5.2), Brain - Caudate (basal ganglia) (x4.5), and Brain - Nucleus accumbens (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for ITPKA Gene

This gene is overexpressed in Monocytes (28.5), Frontal cortex (21.2), Plasma (11.4), and Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ITPKA Gene

Protein tissue co-expression partners for ITPKA Gene

NURSA nuclear receptor signaling pathways regulating expression of ITPKA Gene:


SOURCE GeneReport for Unigene cluster for ITPKA Gene:


Evidence on tissue expression from TISSUES for ITPKA Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ITPKA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITPKA Gene

Orthologs for ITPKA Gene

This gene was present in the common ancestor of animals.

Orthologs for ITPKA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ITPKA 34 33
  • 99.92 (n)
(Bos Taurus)
Mammalia ITPKA 34 33
  • 91.97 (n)
(Canis familiaris)
Mammalia ITPKA 34 33
  • 91.97 (n)
(Ornithorhynchus anatinus)
Mammalia ITPKA 34
  • 91 (a)
(Mus musculus)
Mammalia Itpka 16 34 33
  • 87.94 (n)
(Rattus norvegicus)
Mammalia Itpka 33
  • 87.36 (n)
(Monodelphis domestica)
Mammalia ITPKA 34
  • 87 (a)
(Gallus gallus)
Aves ITPKA 33
  • 70.05 (n)
IP3KA 34
  • 69 (a)
(Anolis carolinensis)
Reptilia ITPKA 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486229 33
  • 61.29 (n)
(Danio rerio)
Actinopterygii LOC564528 33
  • 62.15 (n)
itpka 34
  • 48 (a)
wufi30c01 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002194 33
  • 57.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta IP3K1 35
  • 44 (a)
IP3K2 34 35
  • 30 (a)
(Caenorhabditis elegans)
Secernentea lfe-2 34 35
  • 26 (a)
Species where no ortholog for ITPKA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITPKA Gene

Gene Tree for ITPKA (if available)
Gene Tree for ITPKA (if available)
Evolutionary constrained regions (ECRs) for ITPKA: view image

Paralogs for ITPKA Gene

Paralogs for ITPKA Gene

(3) SIMAP similar genes for ITPKA Gene using alignment to 2 proteins:

  • C9JC74_HUMAN
genes like me logo Genes that share paralogs with ITPKA: view

Variants for ITPKA Gene

Sequence variations from dbSNP and Humsavar for ITPKA Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000100232 -- 41,493,215(+) G/A upstream_transcript_variant
rs1000264681 -- 41,492,106(+) G/A upstream_transcript_variant
rs1000837280 -- 41,493,686(+) G/A upstream_transcript_variant
rs1001057275 -- 41,499,690(+) TGTG/TG intron_variant
rs1001238390 -- 41,499,860(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ITPKA Gene

Variant ID Type Subtype PubMed ID
esv33378 CNV gain 17666407
nsv471241 CNV loss 18288195
nsv524476 CNV loss 19592680
nsv569233 CNV loss 21841781

Variation tolerance for ITPKA Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITPKA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITPKA Gene

Disorders for ITPKA Gene

Additional Disease Information for ITPKA

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ITPKA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITPKA Gene

Publications for ITPKA Gene

  1. Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization. (PMID: 1330886) Erneux C … Mattei MG (Genomics 1992) 2 3 22 58
  2. Human brain inositol 1,4,5-trisphosphate 3-kinase cDNA sequence. (PMID: 2175886) Takazawa K … Erneux C (Nucleic acids research 1990) 2 3 4 58
  3. Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities. (PMID: 20022963) Windhorst S … Mayr GW (The Journal of biological chemistry 2010) 3 22 58
  4. Down-regulation of 1D-myo-inositol 1,4,5-trisphosphate 3-kinase A protein expression in oral squamous cell carcinoma. (PMID: 16525636) Kato H … Tanzawa H (International journal of oncology 2006) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ITPKA Gene

Sources for ITPKA Gene

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