Aliases for ITM2C Gene
External Ids for ITM2C Gene
Previous GeneCards Identifiers for ITM2C Gene
GeneCards Summary for ITM2C Gene
ITM2C (Integral Membrane Protein 2C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include amyloid-beta binding. An important paralog of this gene is ITM2B.
UniProtKB/Swiss-Prot for ITM2C Gene
Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).