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Aliases for ITLN2 Gene

Aliases for ITLN2 Gene

  • Intelectin 2 2 3 5
  • Endothelial Lectin HL-2 3 4
  • Intelectin-2 3 4
  • HL-2 3
  • HL2 3

External Ids for ITLN2 Gene

Previous GeneCards Identifiers for ITLN2 Gene

  • GC01M157692
  • GC01M158131
  • GC01M157727
  • GC01M159181
  • GC01M132271

Summaries for ITLN2 Gene

GeneCards Summary for ITLN2 Gene

ITLN2 (Intelectin 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is ITLN1.

UniProtKB/Swiss-Prot for ITLN2 Gene

Additional gene information for ITLN2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITLN2 Gene

Genomics for ITLN2 Gene

GeneHancer (GH) Regulatory Elements for ITLN2 Gene

Promoters and enhancers for ITLN2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J160954 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 600.7 +2.9 2877 1 ELF3 CTCF ELF1 RAD21 ZNF143 REST TRIM22 NR2C1 SOX13 ESRRA ITLN2 ENSG00000233691
GH01J160986 Enhancer 0.7 Ensembl ENCODE 13 -30.3 -30323 2.6 NFIC ZNF18 NANOG POU5F1 F11R ITLN2 ENSG00000232879 TSTD1 SLAMF7 KLHDC9 ITLN1 ARHGAP30 ENSG00000228917 NECTIN4
GH01J160946 Enhancer 1.1 Ensembl ENCODE 5.7 +8.8 8782 3.6 CC2D1A CBFA2T2 ZNF148 MLLT1 GTF2F1 TRIM24 PPARG EGR1 SMARCA4 MTA1 ITLN1 LY9 SLAMF7 ENSG00000228863 LOC101928372 ENSG00000232188 CD244 ITLN2 ENSG00000233691
GH01J160810 Enhancer 0.7 Ensembl dbSUPER 5.6 +146.8 146777 1.6 SP1 MAFK ZNF316 MAFF SLAMF7 ITLN1 SLAMF1 ITLN2 PIR60624 LY9
GH01J160805 Enhancer 0.5 dbSUPER 5.1 +150.9 150919 1.4 TRIM24 TRIM28 KLF8 HLTF ATF7 ARNT SMARCA5 SLAMF7 ITLN1 ENSG00000228863 SLAMF1 ENSG00000228917 CD244 ITLN2 TSTD1 LY9 PIR60624
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ITLN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ITLN2 gene promoter:
  • AhR
  • Arnt
  • C/EBPalpha
  • CHOP-10
  • Gfi-1
  • LUN-1
  • Pax-5
  • USF-1
  • USF1
  • YY1

Genomic Locations for ITLN2 Gene

Genomic Locations for ITLN2 Gene
12,359 bases
Minus strand
9,775 bases
Minus strand

Genomic View for ITLN2 Gene

Genes around ITLN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITLN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITLN2 Gene

Proteins for ITLN2 Gene

  • Protein details for ITLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q17RR2
    • Q5VYI0

    Protein attributes for ITLN2 Gene

    325 amino acids
    Molecular mass:
    36212 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ITLN2 Gene


neXtProt entry for ITLN2 Gene

Post-translational modifications for ITLN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ITLN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ITLN2 Gene

Domains & Families for ITLN2 Gene

Gene Families for ITLN2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for ITLN2 Gene

Suggested Antigen Peptide Sequences for ITLN2 Gene

GenScript: Design optimal peptide antigens:
  • Endothelial lectin HL-2 (ITLN2_HUMAN)
  • Intelectin 2 (Q17RR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ITLN2: view

No data available for UniProtKB/Swiss-Prot for ITLN2 Gene

Function for ITLN2 Gene

Molecular function for ITLN2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the defense system against pathogens.

Phenotypes From GWAS Catalog for ITLN2 Gene

Gene Ontology (GO) - Molecular Function for ITLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ITLN2: view
genes like me logo Genes that share phenotypes with ITLN2: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ITLN2 - Now 50% OFF >
  • * ITLN2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ITLN2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ITLN2 Gene

Localization for ITLN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITLN2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITLN2 gene
Compartment Confidence
extracellular 4
golgi apparatus 1
lysosome 0

Gene Ontology (GO) - Cellular Components for ITLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ITLN2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ITLN2 Gene

Pathways & Interactions for ITLN2 Gene

PathCards logo

SuperPathways for ITLN2 Gene

No Data Available

Interacting Proteins for ITLN2 Gene

Gene Ontology (GO) - Biological Process for ITLN2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ITLN2 Gene

Drugs & Compounds for ITLN2 Gene

No Compound Related Data Available

Transcripts for ITLN2 Gene

mRNA/cDNA for ITLN2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ITLN2 Gene

Intelectin 2:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ITLN2 - Now 50% OFF >
  • * ITLN2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ITLN2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ITLN2 Gene

No ASD Table

Relevant External Links for ITLN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ITLN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ITLN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITLN2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x40.2) and Lung (x4.5).

Protein differential expression in normal tissues from HIPED for ITLN2 Gene

This gene is overexpressed in Pancreatic juice (62.8) and Spinal cord (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ITLN2 Gene

Protein tissue co-expression partners for ITLN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ITLN2 Gene:


SOURCE GeneReport for Unigene cluster for ITLN2 Gene:


mRNA Expression by UniProt/SwissProt for ITLN2 Gene:

Tissue specificity: Expressed only in the small intestine.

Evidence on tissue expression from TISSUES for ITLN2 Gene

  • Intestine(4.3)
  • Nervous system(4.1)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with ITLN2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ITLN2 Gene

Orthologs for ITLN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITLN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ITLN2 35 34
  • 98.97 (n)
(Bos Taurus)
Mammalia LOC100300695 34
  • 83.23 (n)
-- 35
  • 81 (a)
-- 35
  • 81 (a)
ITLN2 35 35
  • 80 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 79 (a)
-- 35
  • 74 (a)
-- 35
  • 73 (a)
-- 35
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145536 34
  • 65.58 (n)
MGC76330 34
African clawed frog
(Xenopus laevis)
Amphibia XEEL 34
(Danio rerio)
Actinopterygii BX571811.1 35
  • 57 (a)
BX927082.1 35
  • 55 (a)
itln2 35 35
  • 54 (a)
zgc:153219 35
  • 54 (a)
ITLN4 35
  • 51 (a)
BX571811.2 35
  • 50 (a)
itln3 35
  • 49 (a)
itln1 35
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
-- 35
  • 25 (a)
-- 35
  • 23 (a)
-- 35
  • 21 (a)
-- 35
  • 15 (a)
-- 35
  • 15 (a)
-- 35
  • 12 (a)
Species where no ortholog for ITLN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITLN2 Gene

Gene Tree for ITLN2 (if available)
Gene Tree for ITLN2 (if available)
Evolutionary constrained regions (ECRs) for ITLN2: view image

Paralogs for ITLN2 Gene

Paralogs for ITLN2 Gene

(1) SIMAP similar genes for ITLN2 Gene using alignment to 3 proteins:

  • L8E943_HUMAN
  • Q17RR2_HUMAN
genes like me logo Genes that share paralogs with ITLN2: view

Variants for ITLN2 Gene

Sequence variations from dbSNP and Humsavar for ITLN2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000068043 -- 160,952,901(-) C/T intron_variant
rs1000078008 -- 160,952,560(-) G/T intron_variant
rs1000229895 -- 160,958,922(-) C/T upstream_transcript_variant
rs1000421685 -- 160,954,944(-) T/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000683597 -- 160,958,632(-) T/C upstream_transcript_variant

Variation tolerance for ITLN2 Gene

Residual Variation Intolerance Score: 85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.33; 63.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITLN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ITLN2 Gene

Disorders for ITLN2 Gene

Additional Disease Information for ITLN2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ITLN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITLN2 Gene

Publications for ITLN2 Gene

  1. Human homologs of the Xenopus oocyte cortical granule lectin XL35. (PMID: 11181563) Lee JK … Pierce M (Glycobiology 2001) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 58
  3. Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. (PMID: 20682687) Jablonski KA … Diabetes Prevention Program Research Group (Diabetes 2010) 3 45 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ITLN2 Gene

Sources for ITLN2 Gene

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