Aliases for ITLN1 Gene
External Ids for ITLN1 Gene
Previous GeneCards Identifiers for ITLN1 Gene
GeneCards Summary for ITLN1 Gene
ITLN1 (Intelectin 1) is a Protein Coding gene. Diseases associated with ITLN1 include Body Mass Index Quantitative Trait Locus 11 and Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is ITLN2.
UniProtKB/Swiss-Prot for ITLN1 Gene
Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499).