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Aliases for ITLN1 Gene

Aliases for ITLN1 Gene

  • Intelectin 1 2 3 5
  • Omentin 2 3 4
  • Intelectin 1 (Galactofuranose Binding) 2 3
  • Intestinal Lactoferrin Receptor 3 4
  • Galactofuranose-Binding Lectin 3 4
  • Endothelial Lectin HL-1 3 4
  • ITLN-1 3 4
  • INTL 3 4
  • ITLN 3 4
  • LFR 3 4
  • Intelectin-1 3
  • HIntL 3
  • HL-1 3
  • HL1 3

External Ids for ITLN1 Gene

Previous GeneCards Identifiers for ITLN1 Gene

  • GC01M156578
  • GC01M157624
  • GC01M158063
  • GC01M157659
  • GC01M159112
  • GC01M132202

Summaries for ITLN1 Gene

GeneCards Summary for ITLN1 Gene

ITLN1 (Intelectin 1) is a Protein Coding gene. Diseases associated with ITLN1 include Body Mass Index Quantitative Trait Locus 11 and Lipid-Rich Carcinoma. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Defensins. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is ITLN2.

UniProtKB/Swiss-Prot for ITLN1 Gene

  • Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499).

Gene Wiki entry for ITLN1 Gene

Additional gene information for ITLN1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITLN1 Gene

Genomics for ITLN1 Gene

GeneHancer (GH) Regulatory Elements for ITLN1 Gene

Promoters and enhancers for ITLN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J160885 Promoter 0.8 EPDnew 650.7 0.0 -20 0.1 KLF1 NFIC ZNF692 GLIS1 WT1 ITLN1 LY9 SLAMF1 ENSG00000228863 LOC646347
GH01J160884 Enhancer 0.6 ENCODE 656 +0.3 344 0.2 CTCF RFX1 ELF1 RAD21 GABPA TEAD3 CTBP1 SMC3 FOS ITLN1 CD244
GH01J161011 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.7 -132.0 -132043 11.7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 F11R DUSP12 USP21 ENSG00000228606 DEDD PPOX TSTD1 LOC148430 B4GALT3 ARHGAP30
GH01J160703 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 +175.6 175629 11.8 HDGF PKNOX1 SMAD1 STAT5A KLF5 IRF4 ZNF207 ATF7 ETV6 BCLAF1 CD48 SLAMF7 CD244 DEDD NCSTN ENSG00000228863 SLAMF1 LY9 LINC01133 ENSG00000256029
GH01J160794 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 +87.0 86980 6.8 HDGF PKNOX1 FOXA2 SMAD1 STAT5A BMI1 BATF KLF5 IRF4 ZNF143 LY9 SLAMF7 ENSG00000228863 ITLN1 SLAMF1 CD244 ATP1A4 SLAMF6 CD48 USF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ITLN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ITLN1 gene promoter:
  • CHOP-10
  • C/EBPalpha
  • Max1
  • c-Myc
  • Tal-1beta
  • ITF-2
  • HEN1
  • NCX
  • Zic1
  • JunD

Genomic Locations for ITLN1 Gene

Genomic Locations for ITLN1 Gene
chr1:160,876,539-160,885,170
(GRCh38/hg38)
Size:
8,632 bases
Orientation:
Minus strand
chr1:160,846,329-160,854,960
(GRCh37/hg19)
Size:
8,632 bases
Orientation:
Minus strand

Genomic View for ITLN1 Gene

Genes around ITLN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITLN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITLN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITLN1 Gene

Proteins for ITLN1 Gene

  • Protein details for ITLN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWA0-ITLN1_HUMAN
    Recommended name:
    Intelectin-1
    Protein Accession:
    Q8WWA0
    Secondary Accessions:
    • Q5IWS4
    • Q5VYI4
    • Q6YDJ3
    • Q9NP67

    Protein attributes for ITLN1 Gene

    Size:
    313 amino acids
    Molecular mass:
    34962 Da
    Quaternary structure:
    • Homotrimer; disulfide-linked (PubMed:11313366, PubMed:17621593, PubMed:26148048). May interact with LTF (PubMed:11747454, PubMed:23921499).

    Three dimensional structures from OCA and Proteopedia for ITLN1 Gene

neXtProt entry for ITLN1 Gene

Post-translational modifications for ITLN1 Gene

Other Protein References for ITLN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ITLN1 (Intelectin-1/2)
  • R&D Systems Antibodies for ITLN1 (Intelectin-1/Omentin)
  • Abcam antibodies for ITLN1
  • Boster Bio Antibodies for ITLN1

No data available for DME Specific Peptides for ITLN1 Gene

Domains & Families for ITLN1 Gene

Gene Families for ITLN1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for ITLN1 Gene

Suggested Antigen Peptide Sequences for ITLN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ITLN1: view

No data available for UniProtKB/Swiss-Prot for ITLN1 Gene

Function for ITLN1 Gene

Molecular function for ITLN1 Gene

UniProtKB/Swiss-Prot Function:
Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499).

Phenotypes From GWAS Catalog for ITLN1 Gene

Gene Ontology (GO) - Molecular Function for ITLN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 26148048
GO:0030246 carbohydrate binding IEA --
GO:0042802 identical protein binding IPI 26148048
GO:0046872 metal ion binding IEA --
GO:0070492 oligosaccharide binding IDA,IEA 26148048
genes like me logo Genes that share ontologies with ITLN1: view
genes like me logo Genes that share phenotypes with ITLN1: view

Animal Models for ITLN1 Gene

MGI Knock Outs for ITLN1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ITLN1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITLN1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ITLN1 Gene

Localization for ITLN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITLN1 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Enriched in lipid rafts. {ECO:0000250 UniProtKB:O88310}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITLN1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 1

Gene Ontology (GO) - Cellular Components for ITLN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
GO:0031526 brush border membrane IEA,ISS --
genes like me logo Genes that share ontologies with ITLN1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ITLN1 Gene

Pathways & Interactions for ITLN1 Gene

genes like me logo Genes that share pathways with ITLN1: view

Pathways by source for ITLN1 Gene

3 Reactome pathways for ITLN1 Gene
1 R&D Systems pathway for ITLN1 Gene

Gene Ontology (GO) - Biological Process for ITLN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 16531507
GO:0009624 response to nematode ISS,IEA --
GO:0019730 antimicrobial humoral response TAS --
GO:0046326 positive regulation of glucose import IDA 16531507
GO:0070207 protein homotrimerization IDA 26148048
genes like me logo Genes that share ontologies with ITLN1: view

No data available for SIGNOR curated interactions for ITLN1 Gene

Drugs & Compounds for ITLN1 Gene

(3) Drugs for ITLN1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0

(1) Additional Compounds for ITLN1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • FE (II) ion
  • Fe(II)
  • Fe(2+)
  • Ferrous ion
  • Iron ion(2+)
15438-31-0
genes like me logo Genes that share compounds with ITLN1: view

Transcripts for ITLN1 Gene

mRNA/cDNA for ITLN1 Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(97) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ITLN1 Gene

Intelectin 1 (galactofuranose binding):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITLN1

Alternative Splicing Database (ASD) splice patterns (SP) for ITLN1 Gene

No ASD Table

Relevant External Links for ITLN1 Gene

GeneLoc Exon Structure for
ITLN1
ECgene alternative splicing isoforms for
ITLN1

Expression for ITLN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ITLN1 Gene

mRNA differential expression in normal tissues according to GTEx for ITLN1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x20.0), Heart - Atrial Appendage (x15.9), and Colon - Transverse (x4.7).

Protein differential expression in normal tissues from HIPED for ITLN1 Gene

This gene is overexpressed in Pancreatic juice (43.6) and Rectum (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ITLN1 Gene



NURSA nuclear receptor signaling pathways regulating expression of ITLN1 Gene:

ITLN1

SOURCE GeneReport for Unigene cluster for ITLN1 Gene:

Hs.50813

mRNA Expression by UniProt/SwissProt for ITLN1 Gene:

Q8WWA0-ITLN1_HUMAN
Tissue specificity: Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level) (PubMed:16531507). Highly expressed in the small intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid and, to a lesser degree, in the uterus, spleen, prostate, lymph node and thymus.

Evidence on tissue expression from TISSUES for ITLN1 Gene

  • Intestine(4.6)
  • Lung(4.5)
  • Heart(3.3)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with ITLN1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITLN1 Gene

Orthologs for ITLN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITLN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITLN1 34 33
  • 98.51 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Itln1 16 34 33
  • 82.32 (n)
Gm9765 34
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Itln1 33
  • 82.32 (n)
cow
(Bos Taurus)
Mammalia ITLN2 34 34
  • 78 (a)
ManyToMany
-- 34
  • 77 (a)
ManyToMany
-- 34
  • 77 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
ManyToMany
-- 34
  • 74 (a)
ManyToMany
-- 34
  • 73 (a)
ManyToMany
-- 34
  • 70 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100127565 33
  • 67.77 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC564958 33
  • 64.01 (n)
BX571811.1 34
  • 59 (a)
ManyToMany
BX927082.1 34
  • 56 (a)
ManyToMany
itln2 34 34
  • 56 (a)
ManyToMany
zgc:153219 34
  • 54 (a)
ManyToMany
ITLN4 34
  • 52 (a)
ManyToMany
BX571811.2 34
  • 51 (a)
ManyToMany
itln3 34
  • 47 (a)
ManyToMany
itln1 34
  • 45 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
ManyToMany
-- 34
  • 23 (a)
ManyToMany
-- 34
  • 22 (a)
ManyToMany
-- 34
  • 21 (a)
ManyToMany
-- 34
  • 14 (a)
ManyToMany
-- 34
  • 13 (a)
ManyToMany
-- 34
  • 12 (a)
ManyToMany
Species where no ortholog for ITLN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITLN1 Gene

ENSEMBL:
Gene Tree for ITLN1 (if available)
TreeFam:
Gene Tree for ITLN1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ITLN1: view image

Paralogs for ITLN1 Gene

Paralogs for ITLN1 Gene

(1) SIMAP similar genes for ITLN1 Gene using alignment to 2 proteins:

  • ITLN1_HUMAN
  • Q5IWS5_HUMAN
genes like me logo Genes that share paralogs with ITLN1: view

Variants for ITLN1 Gene

Sequence variations from dbSNP and Humsavar for ITLN1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000096441 -- 160,885,737(-) T/C upstream_transcript_variant
rs1000396540 -- 160,882,379(-) C/T intron_variant
rs1000719794 -- 160,883,382(-) A/G/T intron_variant
rs1000752735 -- 160,883,117(-) C/T intron_variant
rs1000985769 -- 160,886,633(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ITLN1 Gene

Variant ID Type Subtype PubMed ID
esv2672334 CNV deletion 23128226
esv3578225 CNV loss 25503493
esv3587719 CNV loss 21293372
nsv548057 CNV loss 21841781
nsv946457 CNV duplication 23825009

Variation tolerance for ITLN1 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITLN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITLN1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITLN1 Gene

Disorders for ITLN1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ITLN1 Gene - From: DISEASES and Novoseek

- elite association - COSMIC cancer census association via MalaCards
Search ITLN1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ITLN1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ITLN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITLN1 Gene

Publications for ITLN1 Gene

  1. Human homologs of the Xenopus oocyte cortical granule lectin XL35. (PMID: 11181563) Lee JK … Pierce M (Glycobiology 2001) 2 3 4 22 58
  2. Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall. (PMID: 11313366) Tsuji S … Seya T (The Journal of biological chemistry 2001) 2 3 4 22 58
  3. A single-nucleotide polymorphism in intelectin 1 is associated with increased asthma risk. (PMID: 19000584) Pemberton AD … Holgate ST (The Journal of allergy and clinical immunology 2008) 3 22 44 58
  4. Frequency and significance of the novel single nucleotide missense polymorphism Val109Asp in the human gene encoding omentin in Caucasian patients with type 2 diabetes mellitus or chronic inflammatory bowel diseases. (PMID: 17295929) Schäffler A … Herfarth H (Cardiovascular diabetology 2007) 3 22 44 58
  5. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. (PMID: 16531507) Yang RZ … Gong DW (American journal of physiology. Endocrinology and metabolism 2006) 3 4 22 58

Products for ITLN1 Gene

Sources for ITLN1 Gene

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