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This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
ITK (IL2 Inducible T Cell Kinase) is a Protein Coding gene. Diseases associated with ITK include Lymphoproliferative Syndrome 1 and Agammaglobulinemia, X-Linked. Among its related pathways are TCR Signaling (Qiagen) and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TEC.
ITK (IL-2-inducible T-cell kinase) is a member of the Tec family of nonreceptor tyrosine kinases that are critically important for the growth, differentiation and activation of myeloid-, mast- and B-cells. ITK has a critical role in T-cell growth, signaling and function.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004713 | protein tyrosine kinase activity | IEA | -- |
GO:0004715 | non-membrane spanning protein tyrosine kinase activity | TAS,IDA | 12186560 |
GO:0005515 | protein binding | IPI | 8892607 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | ISS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005911 | cell-cell junction | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Immune response NFAT in immune response |
Immune response ICOS pathway in T-helper cell
.56
Immune response NFAT in immune response
.56
|
Immune response T cell receptor signaling pathway
.52
Immune response CD28 signaling
.52
|
2 | T cell receptor signaling pathway | ||
3 | ICos-ICosL Pathway in T-Helper Cell |
CD28 Signaling in T-Helper Cell
.66
|
ICos-ICosL Pathway in T-Helper Cell
.66
|
4 | TCR Signaling (Qiagen) |
TCR Signaling
.68
|
ITK and TCR Signaling
.54
|
5 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001816 | cytokine production | IEA,ISS | -- |
GO:0001865 | NK T cell differentiation | IBA | 21873635 |
GO:0002250 | adaptive immune response | IBA,ISS | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0006468 | protein phosphorylation | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Pazopanib | Approved | Pharma | Target, inhibitor | VEFGR, c-Kit, and PDGFR inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
Zanubrutinib | Approved, Investigational | Pharma | Target, inhibitor | 33 | ||
Staurosporine | Experimental | Pharma | Allosteric regulator, Positive, Neutral, Target | Protein kinase inhibitor,potent and cell permeable | 9 | |
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Compound | Action | Cas Number |
---|---|---|
BMS-509744 | Itk inhibitor,potent and selective | 439575-02-7 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: |
ExUns: | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19a | · | 19b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||
SP2: | |||||||||||||||
SP3: | - | ||||||||||||||
SP4: | - | - | |||||||||||||
SP5: | |||||||||||||||
SP6: | - | - | |||||||||||||
SP7: | |||||||||||||||
SP8: | |||||||||||||||
SP9: | |||||||||||||||
SP10: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ITK 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ITK 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ITK 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ITK 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Itk 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Itk 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ITK 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ITK 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ITK 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | itk 30 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Btk29A 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | spe-8 32 |
|
|
|
F22B3.8 32 |
|
|
|||
kin-24 32 |
|
|
|||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.8009 30 |
|
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
638898 | Uncertain Significance: Lymphoproliferative syndrome 1 | 157,181,059(+) | G/T | MISSENSE_VARIANT | |
641419 | Uncertain Significance: Lymphoproliferative syndrome 1 | 157,244,311(+) | C/A | MISSENSE_VARIANT | |
642717 | Uncertain Significance: Lymphoproliferative syndrome 1 | 157,228,322(+) | A/G | MISSENSE_VARIANT | |
644968 | Uncertain Significance: Lymphoproliferative syndrome 1 | 157,249,012(+) | G/A | ||
646233 | Uncertain Significance: Lymphoproliferative syndrome 1 | 157,244,440(+) | G/A | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1662e212 | CNV | gain | 25503493 |
esv3575892 | CNV | gain | 25503493 |
esv3575895 | CNV | gain | 25503493 |
nsv1147442 | CNV | insertion | 26484159 |
Disorder | Aliases | PubMed IDs |
---|---|---|
lymphoproliferative syndrome 1 |
|
|
agammaglobulinemia, x-linked |
|
|
lymphoproliferative syndrome |
|
|
kaolin pneumoconiosis |
|
|
allergic asthma |
|