Aliases for ITIH5 Gene
External Ids for ITIH5 Gene
Previous GeneCards Identifiers for ITIH5 Gene
This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
GeneCards Summary for ITIH5 Gene
ITIH5 (Inter-Alpha-Trypsin Inhibitor Heavy Chain 5) is a Protein Coding gene. Diseases associated with ITIH5 include Chromosome 1P36 Deletion Syndrome. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is ITIH6.
UniProtKB/Swiss-Prot Summary for ITIH5 Gene
May act as a tumor suppressor.