Aliases for ITIH3 Gene
External Ids for ITIH3 Gene
Previous GeneCards Identifiers for ITIH3 Gene
This gene encodes the heavy chain subunit of the pre-alpha-trypsin inhibitor complex. This complex may stabilize the extracellular matrix through its ability to bind hyaluronic acid. Polymorphisms of this gene may be associated with increased risk for schizophrenia and major depressive disorder. This gene is present in an inter-alpha-trypsin inhibitor family gene cluster on chromosome 3. [provided by RefSeq, Jul 2015]
GeneCards Summary for ITIH3 Gene
ITIH3 (Inter-Alpha-Trypsin Inhibitor Heavy Chain 3) is a Protein Coding gene. Diseases associated with ITIH3 include Schizophrenia and Major Depressive Disorder. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Cell adhesion_Cell-matrix glycoconjugates. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity. An important paralog of this gene is ITIH1.
UniProtKB/Swiss-Prot Summary for ITIH3 Gene
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.