Aliases for ITIH1 Gene
External Ids for ITIH1 Gene
Previous GeneCards Identifiers for ITIH1 Gene
This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3. [provided by RefSeq, Nov 2015]
GeneCards Summary for ITIH1 Gene
ITIH1 (Inter-Alpha-Trypsin Inhibitor Heavy Chain 1) is a Protein Coding gene. Among its related pathways are Cell adhesion_Cell-matrix glycoconjugates. Gene Ontology (GO) annotations related to this gene include calcium ion binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is ITIH3.
UniProtKB/Swiss-Prot for ITIH1 Gene
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells.