External Ids for ITGB8 Gene
Previous GeneCards Identifiers for ITGB8 Gene
This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for ITGB8 Gene
ITGB8 (Integrin Subunit Beta 8) is a Protein Coding gene. Diseases associated with ITGB8 include Hypoplastic Right Heart Syndrome and Arteriovenous Malformation. Among its related pathways are MAPK-Erk Pathway and Dilated cardiomyopathy (DCM). Gene Ontology (GO) annotations related to this gene include signaling receptor binding and extracellular matrix protein binding. An important paralog of this gene is ITGB6.
UniProtKB/Swiss-Prot Summary for ITGB8 Gene
Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (PubMed:1918072). It recognizes the sequence R-G-D in its ligands (PubMed:1918072). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity).