External Ids for ITGB8 Gene
Previous GeneCards Identifiers for ITGB8 Gene
This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for ITGB8 Gene
ITGB8 (Integrin Subunit Beta 8) is a Protein Coding gene. Diseases associated with ITGB8 include Arteriovenous Malformation and Arrhythmogenic Right Ventricular Cardiomyopathy. Among its related pathways are Integrin Pathway and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and extracellular matrix protein binding. An important paralog of this gene is ITGB5.
UniProtKB/Swiss-Prot Summary for ITGB8 Gene
Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (PubMed:1918072). It recognizes the sequence R-G-D in its ligands (PubMed:1918072). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity).