This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role ... See more...

Aliases for ITGB7 Gene

Aliases for ITGB7 Gene

  • Integrin Subunit Beta 7 2 3 5
  • Gut Homing Receptor Beta Subunit 3 4
  • Integrin Beta-7 3 4
  • Integrin Beta 7 Subunit 3
  • Integrin, Beta 7 2
  • ITGB7 5

External Ids for ITGB7 Gene

Previous GeneCards Identifiers for ITGB7 Gene

  • GC12M053680
  • GC12M053498
  • GC12M053301
  • GC12M051871
  • GC12M053585
  • GC12M050628

Summaries for ITGB7 Gene

Entrez Gene Summary for ITGB7 Gene

  • This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

GeneCards Summary for ITGB7 Gene

ITGB7 (Integrin Subunit Beta 7) is a Protein Coding gene. Diseases associated with ITGB7 include Spongiotic Dermatitis and Inflammatory Bowel Disease 18. Among its related pathways are Transcriptional misregulation in cancer and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include virus receptor activity. An important paralog of this gene is ITGB2.

UniProtKB/Swiss-Prot Summary for ITGB7 Gene

  • Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Gene Wiki entry for ITGB7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ITGB7 Gene

Genomics for ITGB7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ITGB7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J053205 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 600.7 -0.2 -238 4.9 SP1 IKZF1 POLR2A BACH1 LARP7 STAT3 PRDM1 ZNF143 RELA RFX1 ITGB7 lnc-ITGB7-2 RARG
GH12J053199 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 600.4 +6.7 6737 1.8 RFX1 IKZF1 BACH1 FOXA1 PRDM1 ZNF143 RELA PKNOX1 TCF12 IKZF2 ITGB7 ZNF740 CSAD SOAT2 lnc-CSAD-1
GH12J053215 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16 -13.7 -13668 10.3 CEBPG SP1 HNRNPL GATAD2A CTCF ZBTB33 TEAD4 PRDM10 ZNF629 ZNF512 RARG lnc-ITGB7-3 ITGB7 MAP3K12 TNS2 SP1 IGFBP6 PFDN5 MYG1 TARBP2
GH12J053622 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 15.6 -417.8 -417760 5 BRCA1 ARHGAP35 CEBPG SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 ATF7 ATF7-NPFF lnc-ATP5MC2-1 SP1 EIF4B ENSG00000258344 ATP5MC2 AAAS ITGB7 PCBP2
GH12J053294 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 -90.5 -90538 7 CEBPG HNRNPL CREB1 GATAD2A TEAD4 PRDM10 ZNF629 TFE3 RFX1 IKZF1 MYG1 MYG1-AS1 PFDN5 piR-50035 piR-46958 ESPL1 AAAS ZNF740 ENSG00000257605 TARBP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ITGB7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ITGB7

Top Transcription factor binding sites by QIAGEN in the ITGB7 gene promoter:
  • c-Myb
  • ER-alpha
  • Pax-2
  • Pax-4a
  • POU3F1
  • PPAR-gamma1
  • PPAR-gamma2
  • RelA
  • RP58
  • Sp1

Genomic Locations for ITGB7 Gene

Genomic Locations for ITGB7 Gene
chr12:53,191,318-53,207,375
(GRCh38/hg38)
Size:
16,058 bases
Orientation:
Minus strand
chr12:53,585,102-53,601,091
(GRCh37/hg19)
Size:
15,990 bases
Orientation:
Minus strand

Genomic View for ITGB7 Gene

Genes around ITGB7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGB7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGB7 Gene

Proteins for ITGB7 Gene

  • Protein details for ITGB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26010-ITB7_HUMAN
    Recommended name:
    Integrin beta-7
    Protein Accession:
    P26010
    Secondary Accessions:
    • Q9UCP7
    • Q9UCS7

    Protein attributes for ITGB7 Gene

    Size:
    798 amino acids
    Molecular mass:
    86903 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E. Integrin alpha-4/beta-7 interacts with MADCAM1, VCAM1, fibronectin, and may also interact with HIV-1 gp120. Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23) (PubMed:19828450).

    Three dimensional structures from OCA and Proteopedia for ITGB7 Gene

    Alternative splice isoforms for ITGB7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGB7 Gene

Post-translational modifications for ITGB7 Gene

  • Glycosylation at Asn68, Asn279, Asn434, Asn477, Asn665, Asn674, Asn531, and Asn590
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Boster Bio Antibodies for ITGB7

No data available for DME Specific Peptides for ITGB7 Gene

Domains & Families for ITGB7 Gene

Gene Families for ITGB7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ITGB7 Gene

InterPro:
Blocks:
  • Von Willebrand factor type A domain signature
  • Integrin beta, C-terminal
  • Integrin beta subunit signature
ProtoNet:

Suggested Antigen Peptide Sequences for ITGB7 Gene

GenScript: Design optimal peptide antigens:
  • Integrin beta (F5H6T4_HUMAN)
  • Gut homing receptor beta subunit (ITB7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P26010

UniProtKB/Swiss-Prot:

ITB7_HUMAN :
  • Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding.
  • Belongs to the integrin beta chain family.
Domain:
  • Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding.
Family:
  • Belongs to the integrin beta chain family.
genes like me logo Genes that share domains with ITGB7: view

Function for ITGB7 Gene

Molecular function for ITGB7 Gene

UniProtKB/Swiss-Prot Function:
Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
UniProtKB/Swiss-Prot Induction:
Integrin alpha-E/beta-7 is induced by TGFB1.
GENATLAS Biochemistry:
integrin,beta 7,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells

Phenotypes From GWAS Catalog for ITGB7 Gene

Gene Ontology (GO) - Molecular Function for ITGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005178 integrin binding IBA 21873635
GO:0005515 protein binding IPI 1542691
GO:0038023 signaling receptor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ITGB7: view
genes like me logo Genes that share phenotypes with ITGB7: view

Animal Models for ITGB7 Gene

MGI Knock Outs for ITGB7:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGB7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ITGB7 Gene

Localization for ITGB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGB7 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITGB7 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 3
cytoskeleton 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ITGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IBA 21873635
GO:0008305 integrin complex IEA,TAS 2040616
GO:0009986 cell surface IDA 18308860
GO:0016020 membrane IEA,HDA 19946888
genes like me logo Genes that share ontologies with ITGB7: view

Pathways & Interactions for ITGB7 Gene

PathCards logo

SuperPathways for ITGB7 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.66
.65
.64
.62
.57
2 ERK Signaling
.61
.61
.58
.51
.49
3 Integrin Pathway
.67
.67
.56
.56
.38
4 Focal Adhesion
.33
5 Actin Nucleation by ARP-WASP Complex
.66
.66
.41
.35
genes like me logo Genes that share pathways with ITGB7: view

SIGNOR curated interactions for ITGB7 Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for ITGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003366 cell-matrix adhesion involved in ameboidal cell migration IMP 23986478
GO:0007155 cell adhesion IEA,TAS 2040616
GO:0007160 cell-matrix adhesion IEA,IMP 18308860
GO:0007229 integrin-mediated signaling pathway IEA,IMP 23986478
GO:0016477 cell migration IBA 21873635
genes like me logo Genes that share ontologies with ITGB7: view

Drugs & Compounds for ITGB7 Gene

(8) Drugs for ITGB7 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vedolizumab Approved Pharma Target, antibody 110
Magnesium Approved, Experimental, Investigational Pharma 0
R1295 Investigational Pharma Target, antagonist 0
Firategrast Investigational Pharma α4β1/α4β7 integrin antagonist 0
Calcium Nutra 6556

(1) Additional Compounds for ITGB7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for ITGB7 Gene

Compound Action Cas Number
Firategrast α4β1/α4β7 integrin antagonist 402567-16-2
genes like me logo Genes that share compounds with ITGB7: view

Drug Products

Transcripts for ITGB7 Gene

mRNA/cDNA for ITGB7 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGB7

Alternative Splicing Database (ASD) splice patterns (SP) for ITGB7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6:
SP7:

ExUns: 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for ITGB7 Gene

GeneLoc Exon Structure for
ITGB7

Expression for ITGB7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ITGB7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGB7 Gene

This gene is overexpressed in Whole Blood (x12.6) and Spleen (x4.9).

Protein differential expression in normal tissues from HIPED for ITGB7 Gene

This gene is overexpressed in Pancreas (23.1), Peripheral blood mononuclear cells (14.9), and CD8 Tcells (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ITGB7 Gene



Protein tissue co-expression partners for ITGB7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ITGB7

SOURCE GeneReport for Unigene cluster for ITGB7 Gene:

Hs.654470

mRNA Expression by UniProt/SwissProt for ITGB7 Gene:

P26010-ITB7_HUMAN
Tissue specificity: Expressed in a variety of leukocyte lines.

Evidence on tissue expression from TISSUES for ITGB7 Gene

  • Blood(4.7)
  • Intestine(4.6)
  • Spleen(3.9)
  • Lymph node(2.9)
  • Bone marrow(2.6)
  • Skin(2.3)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with ITGB7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGB7 Gene

Orthologs for ITGB7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGB7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ITGB7 30 31
  • 99.54 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ITGB7 30 31
  • 87.68 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ITGB7 30 31
  • 86.93 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Itgb7 30
  • 84.64 (n)
Mouse
(Mus musculus)
Mammalia Itgb7 30 17 31
  • 84.46 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ITGB7 31
  • 58 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ITGB7 31
  • 55 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia itgb7 30
  • 57.79 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC797491 30
  • 53.18 (n)
itgb7 31
  • 44 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta mys 31 32
  • 34 (a)
OneToMany
&bgr;Int-&ngr; 32
  • 30 (a)
Worm
(Caenorhabditis elegans)
Secernentea pat-3 31 32
  • 36 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.871 31
  • 34 (a)
OneToMany
Species where no ortholog for ITGB7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ITGB7 Gene

ENSEMBL:
Gene Tree for ITGB7 (if available)
TreeFam:
Gene Tree for ITGB7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ITGB7: view image

Paralogs for ITGB7 Gene

(7) SIMAP similar genes for ITGB7 Gene using alignment to 6 proteins:

  • ITB7_HUMAN
  • F5H6T4_HUMAN
  • F8VNX4_HUMAN
  • F8W186_HUMAN
  • H3BRM2_HUMAN
  • H3BRX4_HUMAN
genes like me logo Genes that share paralogs with ITGB7: view

Variants for ITGB7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ITGB7 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
707897 Benign: not provided 53,192,490(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
708809 Benign: not provided 53,193,812(-) C/G SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
714539 Benign: not provided 53,193,802(-) A/G SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
725617 Benign: not provided 53,192,735(-) T/C SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
771458 Benign: not provided 53,192,752(-) C/T MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for ITGB7 Gene

Structural Variations from Database of Genomic Variants (DGV) for ITGB7 Gene

Variant ID Type Subtype PubMed ID
dgv2644n54 CNV loss 21841781
dgv2645n54 CNV loss 21841781
dgv27n6 CNV deletion 16902084
nsv469404 CNV loss 19166990
nsv470295 CNV gain 18288195
nsv517066 CNV loss 19592680
nsv52501 CNV deletion 16902084
nsv52510 CNV deletion 16902084
nsv52860 CNV deletion 16902084
nsv558994 CNV loss 21841781
nsv832417 CNV gain 17160897

Variation tolerance for ITGB7 Gene

Residual Variation Intolerance Score: 6.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITGB7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGB7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGB7 Gene

Disorders for ITGB7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ITGB7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
spongiotic dermatitis
inflammatory bowel disease 18
  • ibd18
exfoliative ichthyosis
  • autosomal recessive exfoliative ichthyosis
- elite association - COSMIC cancer census association via MalaCards
Search ITGB7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ITGB7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ITGB7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGB7 Gene

Publications for ITGB7 Gene

  1. Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes. (PMID: 2040616) Erle DJ … Pytela R (The Journal of biological chemistry 1991) 2 3 4 23
  2. Single nucleotide polymorphism screening and association analysis--exclusion of integrin beta 7 and vitamin D receptor (chromosome 12q) as candidate genes for asthma. (PMID: 15663557) Vollmert C … Wjst M (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2004) 3 23 41
  3. The role of alpha and beta chains in ligand recognition by beta 7 integrins. (PMID: 10837471) Higgins JM … Brenner MB (The Journal of biological chemistry 2000) 3 4 23
  4. A family of beta 7 integrins on human mucosal lymphocytes. (PMID: 1542691) Parker CM … Brenner MB (Proceedings of the National Academy of Sciences of the United States of America 1992) 3 4 23
  5. The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1. (PMID: 1382574) Jiang WM … Krissansen GW (International immunology 1992) 3 4 23

Products for ITGB7 Gene

Sources for ITGB7 Gene