This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017] See more...

Aliases for ITGB5 Gene

Aliases for ITGB5 Gene

  • Integrin Subunit Beta 5 2 3 5
  • Integrin Beta-5 3 4
  • Testis Secretory Sperm-Binding Protein Li 217p 3
  • Integrin, Beta 5 2

External Ids for ITGB5 Gene

Previous GeneCards Identifiers for ITGB5 Gene

  • GC03M121191
  • GC03M124498
  • GC03M125763
  • GC03M125802
  • GC03M125964
  • GC03M121856
  • GC03M124480

Summaries for ITGB5 Gene

Entrez Gene Summary for ITGB5 Gene

  • This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017]

GeneCards Summary for ITGB5 Gene

ITGB5 (Integrin Subunit Beta 5) is a Protein Coding gene. Diseases associated with ITGB5 include Villous Adenocarcinoma and Arrhythmogenic Right Ventricular Cardiomyopathy. Among its related pathways are MAPK-Erk Pathway and Phagosome. Gene Ontology (GO) annotations related to this gene include integrin binding. An important paralog of this gene is ITGB3.

UniProtKB/Swiss-Prot Summary for ITGB5 Gene

  • Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.
  • (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.

Gene Wiki entry for ITGB5 Gene

Additional gene information for ITGB5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ITGB5 Gene

Genomics for ITGB5 Gene

GeneHancer (GH) Regulatory Elements for ITGB5 Gene

Promoters and enhancers for ITGB5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J124882 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 777.5 +15.3 15266 8 SIN3A ZBTB6 FOXA1 POLR2A L3MBTL2 RAD21 MNT ZNF652 ELF3 ZFX ITGB5 ITGB5-AS1 MUC13 piR-51671-060
GH03J124900 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 750.6 0.0 -4 1.2 CTCF CC2D1A RAD21 ELF3 PPARG HNF1A SP5 ARID2 REST TRIM22 ITGB5 ITGB5-AS1 UMPS lnc-ITGB5-2
GH03J124831 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 49.7 +65.6 65560 9.5 SIN3A GATA3 FOXA1 LCORL MLX SMARCE1 RBPJ POLR2A TCF7L2 USF2 ITGB5 ITGB5-AS1 UMPS KALRN ENO1P3 lnc-MUC13-5 piR-43105-473
GH03J124875 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 37.6 +23.3 23292 5.3 SIN3A ZBTB40 LCORL RBPJ SMARCE1 POLR2A NR2F1 NR2F6 ATF1 CREB1 ITGB5 UMPS ITGB5-AS1 MUC13 piR-51671-060 lnc-MUC13-5 ENO1P3
GH03J124925 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 25.2 -29.1 -29055 10.4 ZNF24 CTCF RAD21 NKRF MAFK MLLT1 ZNF687 PPARG IKZF1 REST MUC13 ITGB5 ITGB5-AS1 RNU6-232P UMPS lnc-ITGB5-2 lnc-MUC13-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ITGB5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ITGB5 gene promoter:
  • AML1a
  • Cdc5
  • ER-alpha
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • Nkx2-5
  • NRF-2
  • Pbx1a

Genomic Locations for ITGB5 Gene

Genomic Locations for ITGB5 Gene
chr3:124,761,948-124,901,418
(GRCh38/hg38)
Size:
139,471 bases
Orientation:
Minus strand
chr3:124,480,795-124,620,265
(GRCh37/hg19)
Size:
139,471 bases
Orientation:
Minus strand

Genomic View for ITGB5 Gene

Genes around ITGB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGB5 Gene

Proteins for ITGB5 Gene

  • Protein details for ITGB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18084-ITB5_HUMAN
    Recommended name:
    Integrin beta-5
    Protein Accession:
    P18084
    Secondary Accessions:
    • B0LPF8
    • B2RD70

    Protein attributes for ITGB5 Gene

    Size:
    799 amino acids
    Molecular mass:
    88054 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Beta-5 (ITGB5) associates with alpha-V (ITGAV). Interacts with MYO10 (PubMed:15156152). Interacts with DAB2. Integrin ITGAV:ITGB5 interacts with FBLN5 (via N-terminus) (By similarity). ITGAV:ITGB5 interacts with CCN3 (PubMed:15611078).
    • (Microbial infection) Integrin ITGAV:ITGB5 interacts with adenovirus type C penton protein.

neXtProt entry for ITGB5 Gene

Post-translational modifications for ITGB5 Gene

  • Glycosylation at Thr199, Asn347, Asn460, Asn477, Asn505, Asn552, Asn586, Asn654, and Asn705
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Antibody Products

No data available for DME Specific Peptides for ITGB5 Gene

Domains & Families for ITGB5 Gene

Gene Families for ITGB5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ITGB5 Gene

GenScript: Design optimal peptide antigens:
  • Integrin beta (D3DNA1_HUMAN)
  • Integrin beta-5 (ITB5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P18084

UniProtKB/Swiss-Prot:

ITB5_HUMAN :
  • Belongs to the integrin beta chain family.
Family:
  • Belongs to the integrin beta chain family.
genes like me logo Genes that share domains with ITGB5: view

Function for ITGB5 Gene

Molecular function for ITGB5 Gene

UniProtKB/Swiss-Prot Function:
Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.

Phenotypes From GWAS Catalog for ITGB5 Gene

Gene Ontology (GO) - Molecular Function for ITGB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005178 integrin binding IBA 21873635
GO:0005515 protein binding IPI 1694173
GO:0038023 signaling receptor activity IEA --
genes like me logo Genes that share ontologies with ITGB5: view
genes like me logo Genes that share phenotypes with ITGB5: view

Animal Models for ITGB5 Gene

MGI Knock Outs for ITGB5:
  • Itgb5 Itgb5<tm1Des>
  • Itgb5 Itgb5<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for ITGB5 Gene

miRTarBase miRNAs that target ITGB5

Clone Products

  • Addgene plasmids for ITGB5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGB5 Gene

Localization for ITGB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGB5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITGB5 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 1
mitochondrion 1
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ITGB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IBA 21873635
GO:0008305 integrin complex IBA,IEA 21873635
GO:0009986 cell surface IBA,IDA 7525578
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ITGB5: view

Pathways & Interactions for ITGB5 Gene

PathCards logo

SuperPathways for ITGB5 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.66
.65
.64
.62
.57
2 ERK Signaling
.61
.61
.58
.51
.49
3 Integrin Pathway
.67
.67
.56
.56
.38
4 Focal Adhesion
.33
5 MAPK-Erk Pathway
genes like me logo Genes that share pathways with ITGB5: view

Pathways by source for ITGB5 Gene

SIGNOR curated interactions for ITGB5 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ITGB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006936 muscle contraction TAS --
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion IMP 24036928
GO:0007179 transforming growth factor beta receptor signaling pathway IMP 24036928
genes like me logo Genes that share ontologies with ITGB5: view

Drugs & Compounds for ITGB5 Gene

(4) Drugs for ITGB5 Gene - From: ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cilengitide Investigational Pharma inhibitor Integrin inhibitor for αvβ3 and αvβ5, Integrins 0
CNTO-95 Pharma 0
GLPG0187 Pharma 0

(1) ApexBio Compounds for ITGB5 Gene

Compound Action Cas Number
Cilengitide Integrin inhibitor for αvβ3 and αvβ5 188968-51-6
genes like me logo Genes that share compounds with ITGB5: view

Transcripts for ITGB5 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for ITGB5

Alternative Splicing Database (ASD) splice patterns (SP) for ITGB5 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ·
SP1: - - - -
SP2: - - - - -
SP3:
SP4: - - -
SP5: -
SP6: - - - -
SP7: -
SP8:
SP9: - - - - - -
SP10: - - -
SP11: - - - - - - -
SP12: - - -
SP13: -
SP14:

ExUns: 16d ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:

Relevant External Links for ITGB5 Gene

GeneLoc Exon Structure for
ITGB5
ECgene alternative splicing isoforms for
ITGB5

Expression for ITGB5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ITGB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGB5 Gene

This gene is overexpressed in Artery - Aorta (x5.6).

Protein differential expression in normal tissues from HIPED for ITGB5 Gene

This gene is overexpressed in Liver (16.8) and Monocytes (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ITGB5 Gene



Protein tissue co-expression partners for ITGB5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ITGB5 Gene:

ITGB5

SOURCE GeneReport for Unigene cluster for ITGB5 Gene:

Hs.536663

Evidence on tissue expression from TISSUES for ITGB5 Gene

  • Nervous system(4.6)
  • Kidney(4.5)
  • Liver(4.3)
  • Lung(4)
  • Skin(2.5)
  • Heart(2.2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with ITGB5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGB5 Gene

Orthologs for ITGB5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGB5 33 32
  • 99.29 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ITGB5 33 32
  • 89.45 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ITGB5 33 32
  • 87.44 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Itgb5 17 33 32
  • 86.82 (n)
rat
(Rattus norvegicus)
Mammalia Itgb5 32
  • 86.82 (n)
oppossum
(Monodelphis domestica)
Mammalia ITGB5 33
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGB5 33
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITGB5 33 32
  • 74.58 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITGB5 33
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100216279 32
  • 68.14 (n)
zebrafish
(Danio rerio)
Actinopterygii itgb5 33 32
  • 67.79 (n)
OneToOne
wufi30h12 32
fruit fly
(Drosophila melanogaster)
Insecta mys 34
  • 40 (a)
&bgr;Int-&ngr; 34
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea pat-3 34
  • 38 (a)
Species where no ortholog for ITGB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGB5 Gene

ENSEMBL:
Gene Tree for ITGB5 (if available)
TreeFam:
Gene Tree for ITGB5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ITGB5: view image

Paralogs for ITGB5 Gene

(7) SIMAP similar genes for ITGB5 Gene using alignment to 10 proteins:

  • ITB5_HUMAN
  • D3DNA1_HUMAN
  • F8WBG2_HUMAN
  • H7C4W1_HUMAN
  • H7C580_HUMAN
  • H7C5U2_HUMAN
  • L7RT22_HUMAN
  • V9GYD8_HUMAN
  • V9GYZ1_HUMAN
  • V9GZ57_HUMAN
genes like me logo Genes that share paralogs with ITGB5: view

Variants for ITGB5 Gene

Sequence variations from dbSNP and Humsavar for ITGB5 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs201926531 uncertain-significance, not provided 124,841,442(-) G/A/T coding_sequence_variant, missense_variant, synonymous_variant
rs1000059302 -- 124,769,915(-) T/C/G intron_variant
rs1000066849 -- 124,813,341(-) A/G intron_variant
rs1000097821 -- 124,851,535(-) T/A intron_variant
rs1000098532 -- 124,817,982(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ITGB5 Gene

Variant ID Type Subtype PubMed ID
dgv8533n54 CNV gain+loss 21841781
dgv8534n54 CNV gain 21841781
dgv8535n54 CNV gain 21841781
dgv8536n54 CNV gain+loss 21841781
dgv8537n54 CNV gain 21841781
dgv8538n54 CNV loss 21841781
esv22852 CNV gain+loss 19812545
esv23075 CNV loss 19812545
esv2454361 CNV deletion 19546169
esv2607536 CNV insertion 19546169
esv2725850 CNV deletion 23290073
esv2725852 CNV deletion 23290073
esv3307663 CNV mobile element insertion 20981092
esv3332098 CNV duplication 20981092
esv3376769 CNV insertion 20981092
esv3398319 CNV insertion 20981092
esv3406650 CNV insertion 20981092
esv3562486 CNV deletion 23714750
esv9373 CNV loss 19470904
nsv1001677 CNV loss 25217958
nsv1012242 CNV gain 25217958
nsv1136770 CNV deletion 24896259
nsv1142370 CNV tandem duplication 24896259
nsv1144998 CNV deletion 24896259
nsv1160974 CNV duplication 26073780
nsv3981 CNV insertion 18451855
nsv591432 CNV loss 21841781
nsv591440 CNV gain 21841781
nsv591456 CNV loss 21841781
nsv820971 CNV deletion 20802225

Variation tolerance for ITGB5 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.87; 83.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITGB5 Gene

Human Gene Mutation Database (HGMD)
ITGB5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGB5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGB5 Gene

Disorders for ITGB5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ITGB5 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
villous adenocarcinoma
arrhythmogenic right ventricular cardiomyopathy
  • arrhythmogenic right ventricular dysplasia
- elite association - COSMIC cancer census association via MalaCards
Search ITGB5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ITGB5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ITGB5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGB5 Gene

Publications for ITGB5 Gene

  1. Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. (PMID: 18550570) Brendle A … Försti A (Carcinogenesis 2008) 3 23 43 56
  2. cDNA sequence of the human integrin beta 5 subunit. (PMID: 2211615) McLean JW … Bodary SC (The Journal of biological chemistry 1990) 2 3 4 56
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  4. Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells. (PMID: 20615244) Lyle C … McCormick F (Virology journal 2010) 3 4 56
  5. Role of genetic susceptibility to latent adenoviral infection and decreased lung function. (PMID: 19502044) Kasuga I … Sandford AJ (Respiratory medicine 2009) 3 43 56

Products for ITGB5 Gene

Sources for ITGB5 Gene

  • (121) HPO
  • (122)