Free for academic non-profit institutions. Other users need a Commercial license
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
ITGB3 (Integrin Subunit Beta 3) is a Protein Coding gene. Diseases associated with ITGB3 include Glanzmann Thrombasthenia and Bleeding Disorder, Platelet-Type, 16. Among its related pathways are Monoamine Transport and RET signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and protease binding. An important paralog of this gene is ENSG00000259753.
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001618 | virus receptor activity | IEA | -- |
GO:0001968 | fibronectin binding | IBA,IMP | 24658351 |
GO:0002020 | protease binding | IDA | 22505472 |
GO:0003756 | protein disulfide isomerase activity | IDA | 12204115 |
GO:0005161 | platelet-derived growth factor receptor binding | TAS | 19267251 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | 22027834 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 2452834 |
GO:0005911 | cell-cell junction | IDA | 19461049 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Apoptotic Pathways in Synovial Fibroblasts |
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
|
Actin-Based Motility by Rho Family GTPases
.62
Rap1 Pathway
.57
|
3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
4 | Integrin Pathway |
FAK1 Signaling
.67
Integrin Pathway
.67
GnRH Signaling
.56
|
UPA-UPAR Pathway
.56
Transendothelial Migration of Leukocytes
.38
|
5 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001934 | positive regulation of protein phosphorylation | TAS | 19267251 |
GO:0001938 | positive regulation of endothelial cell proliferation | IMP | 10022831 |
GO:0002576 | platelet degranulation | TAS | -- |
GO:0007155 | cell adhesion | IEA,TAS | 2452834 |
GO:0007160 | cell-matrix adhesion | IMP | 7525578 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Abciximab | Approved | Pharma | Target, antagonist | 66 | ||
Eptifibatide | Approved, Investigational | Pharma | Target, antagonist | 33 | ||
Tirofiban | Approved | Pharma | Target, antagonist | 44 | ||
Aspirin | Approved, Vet_approved | Pharma | Channel blocker | 1512 | ||
Antithymocyte immunoglobulin (rabbit) | Approved | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Echistatin, alpha1 isoform |
|
154303-05-6 |
|
|
Compound | Action | Cas Number |
---|---|---|
A 205804 | Selective inhibitor of E-selectin and ICAM-1 expression | 251992-66-2 |
Echistatin, alpha1 isoform | alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor | 154303-05-6 |
GR 144053 trihydrochloride | Glycoprotein IIb/IIIa (integrin alphaIIbbeta3) receptor antagonist. Antithrombotic | 1215333-48-4 |
Obtustatin | Potent and selective alpha1beta1 inhibitor | |
P11 | Potent antagonist of alphavbeta3-vitronectin interaction; antiangiogenic | 848644-86-0 |
Compound | Action | Cas Number |
---|---|---|
Cilengitide | Integrin inhibitor for αvβ3 and αvβ5 | 188968-51-6 |
CWHM-12 | 1564286-55-0 | |
Cyclo (-RGDfK) | Inhibitor of αvβ3 integrin | 161552-03-0 |
Echistatin, α1 isoform | 154303-05-6 | |
GR 144053 trihydrochloride | 1215333-48-4 | |
LDV FITC | 1207610-07-8 | |
Obtustatin | ||
P11 | 848644-86-0 | |
RGD (Arg-Gly-Asp) Peptides | Inhibits integrin binding to RGD motifs | 99896-85-2 |
RGDS peptide | 91037-65-9 | |
SB273005 | αvβ3 antagonist | 205678-31-5 |
TC-I 15 | 916734-43-5 | |
TCS 2314 | 317353-73-4 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ITGB3 30 |
|
||
Cow (Bos Taurus) |
Mammalia | INTB3 31 |
|
OneToMany | |
ITGB3 30 |
|
||||
Dog (Canis familiaris) |
Mammalia | GPIIIA 31 |
|
OneToMany | |
ITGB3 30 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Itgb3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Itgb3 30 17 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | ITGB3 30 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | itgb3 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | LOC397699 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | itgb3b 30 31 |
|
ManyToMany | |
itgb3a 31 |
|
ManyToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | mys 32 |
|
|
|
&bgr;Int-&ngr; 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | pat-3 32 |
|
|
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
626993 | Likely Pathogenic: Glanzmann thrombasthenia | 47,292,244(+) | A/C | MISSENSE_VARIANT | |
627066 | Pathogenic: Glanzmann thrombasthenia | 47,284,514(+) | G/A | MISSENSE_VARIANT | |
627094 | Likely Pathogenic: Glanzmann thrombasthenia | 47,253,911(+) | T/TG | FRAMESHIFT_VARIANT | |
627131 | Likely Pathogenic: Glanzmann thrombasthenia | 47,286,406(+) | A/G | MISSENSE_VARIANT | |
627151 | Likely Pathogenic: Abnormal bleeding | 47,287,148(+) | G/C | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3640696 | CNV | loss | 21293372 |
nsv1146669 | OTHER | inversion | 26484159 |
Disorder | Aliases | PubMed IDs |
---|---|---|
glanzmann thrombasthenia |
|
|
bleeding disorder, platelet-type, 16 |
|
|
myocardial infarction |
|
|
autosomal dominant macrothrombocytopenia |
|
|
fetal and neonatal alloimmune thrombocytopenia |
|
|