ITGB3 Gene (Protein Coding)

Integrin Subunit Beta 3

GC17P047254
GIFtS:
49
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface ... See more...

Aliases for ITGB3 Gene

Aliases for ITGB3 Gene

  • Integrin Subunit Beta 3 2 3 5
  • GPIIIa 2 3 4
  • Integrin, Beta 3 (Platelet Glycoprotein IIIa, Antigen CD61) 2 3
  • Platelet Membrane Glycoprotein IIIa 3 4
  • Integrin Beta-3 3 4
  • Antigen CD61 2 3
  • CD61 2 3
  • GP3A 3 4
  • Integrin Beta Chain, Beta 3 3
  • Platelet Glycoprotein IIIa 2
  • Integrin Beta 3 3
  • CD61 Antigen 4
  • BDPLT16 3
  • BDPLT2 3
  • ITGB3 5
  • GT 3

External Ids for ITGB3 Gene

Previous HGNC Symbols for ITGB3 Gene

  • GP3A

Previous GeneCards Identifiers for ITGB3 Gene

  • GC17P044829
  • GC17P047729
  • GC17P045673
  • GC17P045805
  • GC17P042686
  • GC17P045331
  • GC17P040709

Summaries for ITGB3 Gene

Entrez Gene Summary for ITGB3 Gene

  • The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITGB3 Gene

ITGB3 (Integrin Subunit Beta 3) is a Protein Coding gene. Diseases associated with ITGB3 include Glanzmann Thrombasthenia and Bleeding Disorder, Platelet-Type, 16. Among its related pathways are Monoamine Transport and RET signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and protease binding. An important paralog of this gene is ENSG00000259753.

UniProtKB/Swiss-Prot Summary for ITGB3 Gene

  • Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887). In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (By similarity). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed:31331973).
  • (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8.
  • (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Coxsackievirus A9.
  • (Microbial infection) Acts as a receptor for Hantaan virus.
  • (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Cytomegalovirus/HHV-5.
  • (Microbial infection) Integrin ITGA5:ITGB3 acts as a receptor for Human metapneumovirus.
  • (Microbial infection) Integrin ITGAV:ITGB3 acts aP05556s a receptor for Human parechovirus 1.
  • (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus.
  • (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Tocris Summary for ITGB3 Gene

  • Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.

Gene Wiki entry for ITGB3 Gene

Additional gene information for ITGB3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ITGB3 Gene

Genomics for ITGB3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ITGB3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17J047274 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 616.1 +24.2 24194 7.4 SP1 PRDM10 ZNF629 RFX1 LEF1 IKZF1 ZNF692 JUND PRDM1 MTA2 ITGB3 EFCAB13 LRRC37A GOSR2 LRRC37A2 LRRC46 TBKBP1 CBX1 ENSG00000264701 ENSG00000263766
GH17J047251 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 610.5 -0.2 -209 4 GATAD2A HNRNPL TFE3 ZNF512 IKZF1 NFKBIZ CTCF ZNF692 RCOR2 ZNF7 ITGB3 ENSG00000259753 ARL17B ARL17A EFCAB13 ENSG00000253347 MRPL45P2 ENSG00000263412 CDC27 SP2
GH17J047285 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 610.3 +34.1 34092 4.2 LEF1 IKZF1 POLR2A BACH1 JUND MTA2 RELA PKNOX1 SMAD5 NR2C1 ITGB3 EFCAB13 MYL4 RNU7-186P ENSG00000266601 TBKBP1 SCRN2 CBX1 LOC107985029 RF00017-2423
GH17J047301 Promoter 0.6 EPDnew 600.3 +47.6 47568 0.1 GATA3 BATF ADNP GATA2 RF00017-2423 ITGB3 EFCAB13 RNU7-186P LOC107985029 ENSG00000259753
GH17J047299 Promoter/Enhancer 0.5 EPDnew dbSUPER 600.3 +45.4 45420 0.1 ITGB3 EFCAB13 RNU7-186P RF00017-2423 LOC107985029 ENSG00000259753
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ITGB3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ITGB3

Top Transcription factor binding sites by QIAGEN in the ITGB3 gene promoter:
  • C/EBPalpha
  • ER-alpha
  • NF-kappaB
  • NF-kappaB1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for ITGB3 Gene

Genomic Locations for ITGB3 Gene
chr17:47,253,827-47,313,743
(GRCh38/hg38)
Size:
59,917 bases
Orientation:
Plus strand
chr17:45,331,208-45,421,658
(GRCh37/hg19)
Size:
90,451 bases
Orientation:
Plus strand

Genomic View for ITGB3 Gene

Genes around ITGB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGB3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ITGB3 Gene

Proteins for ITGB3 Gene

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  • Protein details for ITGB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05106-ITB3_HUMAN
    Recommended name:
    Integrin beta-3
    Protein Accession:
    P05106
    Secondary Accessions:
    • A0PJW2
    • D3DXJ8
    • O15495
    • Q12806
    • Q13413
    • Q14648
    • Q16499

    Protein attributes for ITGB3 Gene

    Size:
    788 amino acids
    Molecular mass:
    87058 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Beta-3 (ITGB3) associates with either alpha-IIb (ITGA2B) or alpha-V (ITGAV). Isoform Beta-3C interacts with FLNB. Interacts with COMP. Interacts with PDIA6 following platelet stimulation. Interacts with SYK; upon activation by ITGB3 promotes platelet adhesion. Interacts with MYO10. Interacts with DAB2. Interacts with FERMT2. Interacts with EMP2; regulates the levels of the heterodimer ITGA5:ITGB3 integrin expression on the plasma membrane (PubMed:16216233). Integrin ITGAV:ITGB3 interacts with FBLN5 (via N-terminus) (By similarity). ITGAV:ITGB3 interacts with CCN3 (PubMed:12695522). ITGAV:ITGB3 is found in a ternary complex with CX3CR1 and CX3CL1 (PubMed:23125415). ITGAV:ITGB3 is found in a ternary complex with NRG1 and ERBB3 (PubMed:20682778). ITGAV:ITGB3 is found in a ternary complex with FGF1 and FGFR1 (PubMed:18441324). ITGAV:ITGB3 interacts with FGF2; it is likely that FGF2 can simultaneously bind ITGAV:ITGB3 and FGF receptors (PubMed:28302677). ITGAV:ITGB3 binds to IL1B (PubMed:29030430). ITGAV:ITGB3 is found in a ternary complex with IGF1 and IGF1R (PubMed:19578119). ITGAV:ITGB3 interacts with IGF2 (PubMed:28873464). ITGAV:ITGB3 interacts with FBN1 (PubMed:12807887). ITGAV:ITGB3 interacts with CD9, CD81 and CD151 (via second extracellular domain) (PubMed:27993971). Interacts (via the allosteric site (site 2)) with CXCL12 in a CXCR4-independent manner (PubMed:29301984). Interacts with MXRA8/DICAM; the interaction inhibits ITGAV:ITGB3 heterodimer formation (PubMed:22492581). ITGAV:ITGB3 interacts with PTN (PubMed:19141530). Forms a complex with PTPRZ1 and PTN that stimulates endothelial cell migration through ITGB3 Tyr-773 phosphorylation (PubMed:19141530). ITGAV:ITGB3 interacts with SLC6A4 (By similarity).
    • (Microbial infection) Integrin ITGAV:ITGB3 interacts with herpes virus 8/HHV-8 glycoprotein B.
    • (Microbial infection) Integrin ITGAV:ITGB3 interacts with coxsackievirus A9 capsid proteins.
    • (Microbial infection) Interacts with Hantaan virus glycoprotein G.
    • (Microbial infection) Integrin ITGAV:ITGB3 interacts with cytomegalovirus/HHV-5 gH:gL proteins.
    • (Microbial infection) Integrin ITGA5:ITGB3 interacts with human metapneumovirus fusion protein.
    • (Microbial infection) Integrin ITGAV:ITGB3 interacts with human parechovirus 1 capsid proteins.
    • (Microbial infection) Integrin ITGAV:ITGB3 interacts with west nile virus envelope protein E.
    • (Microbial infection) Interacts with HIV-1 Tat (PubMed:10397733). ITGAV:ITGB3 interacts with AGRA2 (PubMed:16982628).

    Three dimensional structures from OCA and Proteopedia for ITGB3 Gene

    Alternative splice isoforms for ITGB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGB3 Gene

Protein Expression for ITGB3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ITGB3 Gene

  • Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding.
  • Glycosylation at Asn125, Asn346, Asn397, Asn478, Asn585, and Asn680
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for ITGB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ITGB3 Gene

Domains & Families for ITGB3 Gene

Gene Families for ITGB3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Disease related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ITGB3 Gene

InterPro:
Blocks:
  • Von Willebrand factor type A domain signature
  • Integrin beta, C-terminal
  • Integrin beta subunit signature
ProtoNet:

Suggested Antigen Peptide Sequences for ITGB3 Gene

GenScript: Design optimal peptide antigens:
  • Integrin beta (A7U833_HUMAN)
  • Platelet glycoprotein IIIa (F1C630_HUMAN)
  • Platelet glycoprotein IIIa (F1C632_HUMAN)
  • Platelet glycoprotein IIIa (F1C633_HUMAN)
  • Platelet glycoprotein IIIa (F1C634_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05106

UniProtKB/Swiss-Prot:

ITB3_HUMAN :
  • Belongs to the integrin beta chain family.
Family:
  • Belongs to the integrin beta chain family.
genes like me logo Genes that share domains with ITGB3: view

Function for ITGB3 Gene

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Molecular function for ITGB3 Gene

UniProtKB/Swiss-Prot Function:
Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887). In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (By similarity). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed:31331973).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Coxsackievirus A9.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Hantaan virus.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Cytomegalovirus/HHV-5.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Integrin ITGA5:ITGB3 acts as a receptor for Human metapneumovirus.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Integrin ITGAV:ITGB3 acts aP05556s a receptor for Human parechovirus 1.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus.
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
GENATLAS Biochemistry:
integrin,beta 3,platelet glycoprotein IIIa,Pen alloantigen,Sra alloantigen,involved in neonatal alloimmune thrombocytopenia and post-transfusion purpura,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,contributor,in association with PAI1 in susceptibility to myocardial infarction in Finnish population (see PAI1)

Phenotypes From GWAS Catalog for ITGB3 Gene

Gene Ontology (GO) - Molecular Function for ITGB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0001968 fibronectin binding IBA,IMP 24658351
GO:0002020 protease binding IDA 22505472
GO:0003756 protein disulfide isomerase activity IDA 12204115
GO:0005161 platelet-derived growth factor receptor binding TAS 19267251
genes like me logo Genes that share ontologies with ITGB3: view
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Human Phenotype Ontology for ITGB3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ITGB3 Gene

MGI Knock Outs for ITGB3:

Animal Model Products

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miRNA for ITGB3 Gene

miRTarBase miRNAs that target ITGB3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGB3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ITGB3 Gene

Localization for ITGB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGB3 Gene

Cell membrane. Single-pass type I membrane protein. Cell projection, lamellipodium membrane. Cell junction, focal adhesion. Cell junction, synapse, postsynaptic cell membrane. Single-pass type I membrane protein. Cell junction, synapse.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITGB3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytoskeleton 3
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ITGB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22027834
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2452834
GO:0005911 cell-cell junction IDA 19461049
genes like me logo Genes that share ontologies with ITGB3: view

Pathways & Interactions for ITGB3 Gene

PathCards logo

SuperPathways for ITGB3 Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Apoptotic Pathways in Synovial Fibroblasts
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
Rap1 Pathway
.57
3 ERK Signaling
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
4 Integrin Pathway
FAK1 Signaling
.67
Integrin Pathway
.67
GnRH Signaling
.56
UPA-UPAR Pathway
.56
Transendothelial Migration of Leukocytes
.38
5 Paradoxical activation of RAF signaling by kinase inactive BRAF
MAP2K and MAPK activation
.90
Paradoxical activation of RAF signaling by kinase inactive BRAF
.90
Signaling by high-kinase activity BRAF mutants
.90
Signaling by moderate kinase activity BRAF mutants
.90
Signaling by RAS mutants
.78
genes like me logo Genes that share pathways with ITGB3: view

Pathways by source for ITGB3 Gene

6 GeneGo (Thomson Reuters) pathways for ITGB3 Gene
  • Cell adhesion Integrin inside-out signaling
  • Cell adhesion_Endothelial cell contacts by non-junctional mechanisms
  • Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
  • Cytoskeleton remodeling Integrin outside-in signaling
  • Development VEGF signaling via VEGFR2 - generic cascades
35 Qiagen pathways for ITGB3 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Akt Signaling
  • Calpain Protease Regulates Cellular Mechanics
2 Cell Signaling Technology pathways for ITGB3 Gene

SIGNOR curated interactions for ITGB3 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ITGB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation TAS 19267251
GO:0001938 positive regulation of endothelial cell proliferation IMP 10022831
GO:0002576 platelet degranulation TAS --
GO:0007155 cell adhesion IEA,TAS 2452834
GO:0007160 cell-matrix adhesion IMP 7525578
genes like me logo Genes that share ontologies with ITGB3: view

Drugs & Compounds for ITGB3 Gene

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(50) Drugs for ITGB3 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Abciximab Approved Pharma Target, antagonist 66
Eptifibatide Approved, Investigational Pharma Target, antagonist 33
Tirofiban Approved Pharma Target, antagonist 44
Aspirin Approved, Vet_approved Pharma Channel blocker 1512
Antithymocyte immunoglobulin (rabbit) Approved Pharma Target 0

(13) Additional Compounds for ITGB3 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Echistatin, alpha1 isoform
154303-05-6

(5) Tocris Compounds for ITGB3 Gene

Compound Action Cas Number
A 205804 Selective inhibitor of E-selectin and ICAM-1 expression 251992-66-2
Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor 154303-05-6
GR 144053 trihydrochloride Glycoprotein IIb/IIIa (integrin alphaIIbbeta3) receptor antagonist. Antithrombotic 1215333-48-4
Obtustatin Potent and selective alpha1beta1 inhibitor
P11 Potent antagonist of alphavbeta3-vitronectin interaction; antiangiogenic 848644-86-0

(13) ApexBio Compounds for ITGB3 Gene

Compound Action Cas Number
Cilengitide Integrin inhibitor for αvβ3 and αvβ5 188968-51-6
CWHM-12 1564286-55-0
Cyclo (-RGDfK) Inhibitor of αvβ3 integrin 161552-03-0
Echistatin, α1 isoform 154303-05-6
GR 144053 trihydrochloride 1215333-48-4
LDV FITC 1207610-07-8
Obtustatin
P11 848644-86-0
RGD (Arg-Gly-Asp) Peptides Inhibits integrin binding to RGD motifs 99896-85-2
RGDS peptide 91037-65-9
SB273005 αvβ3 antagonist 205678-31-5
TC-I 15 916734-43-5
TCS 2314 317353-73-4
genes like me logo Genes that share compounds with ITGB3: view

Transcripts for ITGB3 Gene

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mRNA/cDNA for ITGB3 Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

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Alternative Splicing Database (ASD) splice patterns (SP) for ITGB3 Gene

No ASD Table

Relevant External Links for ITGB3 Gene

GeneLoc Exon Structure for
ITGB3

Expression for ITGB3 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ITGB3 Gene

mRNA expression in normal human tissues for ITGB3 Gene
mRNA expression by BioGPS for ITGB3 GenemRNA expression by GTEx for ITGB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGB3 Gene

This gene is overexpressed in Artery - Aorta (x5.6), Artery - Tibial (x4.8), Artery - Coronary (x4.1), and Colon - Sigmoid (x4.0).

Protein differential expression in normal tissues from HIPED for ITGB3 Gene

This gene is overexpressed in Platelet (28.4), Peripheral blood mononuclear cells (24.7), and Neutrophil (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ITGB3 Gene



Protein tissue co-expression partners for ITGB3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ITGB3

SOURCE GeneReport for Unigene cluster for ITGB3 Gene:

Hs.218040

mRNA Expression by UniProt/SwissProt for ITGB3 Gene:

P05106-ITB3_HUMAN
Tissue specificity: Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.

Evidence on tissue expression from TISSUES for ITGB3 Gene

  • Blood(4.6)
  • Bone marrow(4.5)
  • Skin(4.5)
  • Muscle(4.5)
  • Liver(4.4)
  • Kidney(3.5)
  • Heart(3.1)
  • Intestine(2.8)
  • Spleen(2.8)
  • Nervous system(2.5)
  • Lung(2.5)
  • Bone(2.4)
  • Lymph node(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGB3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • reproductive
Regions:
Head and neck:
  • brain
  • face
  • head
  • mouth
  • nose
Abdomen:
  • intestine
  • large intestine
  • small intestine
  • stomach
Pelvis:
  • uterus
General:
  • blood
  • blood vessel
  • coagulation system
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with ITGB3: view

Orthologs for ITGB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGB3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ITGB3 30
  • 99.53 (n)
Cow
(Bos Taurus)
 Mammalia INTB3 31
  • 96 (a)
 OneToMany
ITGB3 30
  • 90.63 (n)
Dog
(Canis familiaris)
 Mammalia GPIIIA 31
  • 94 (a)
 OneToMany
ITGB3 30
  • 91.36 (n)
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 88 (a)
 OneToMany
Rat
(Rattus norvegicus)
 Mammalia Itgb3 30
  • 87.04 (n)
Mouse
(Mus musculus)
 Mammalia Itgb3 30 17 31
  • 86.62 (n)
 OneToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 84 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves ITGB3 30 31
  • 79.07 (n)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 82 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia itgb3 30
  • 70.4 (n)
African clawed frog
(Xenopus laevis)
 Amphibia LOC397699 30
Zebrafish
(Danio rerio)
 Actinopterygii itgb3b 30 31
  • 68.82 (n)
 ManyToMany
itgb3a 31
  • 60 (a)
 ManyToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta mys 32
  • 42 (a)
&bgr;Int-&ngr; 32
  • 30 (a)
Worm
(Caenorhabditis elegans)
 Secernentea pat-3 32
  • 38 (a)
Species where no ortholog for ITGB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ITGB3 Gene

ENSEMBL:
Gene Tree for ITGB3 (if available)
TreeFam:
Gene Tree for ITGB3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ITGB3: view image

Paralogs for ITGB3 Gene

Paralogs for ITGB3 Gene

(9) SIMAP similar genes for ITGB3 Gene using alignment to 14 proteins:

  • ITB3_HUMAN
  • A7U833_HUMAN
  • B4DTY9_HUMAN
  • F1C630_HUMAN
  • F1C632_HUMAN
  • F1C633_HUMAN
  • F1C634_HUMAN
  • F2X0U9_HUMAN
  • F2X0V0_HUMAN
  • I3L4X8_HUMAN
  • L7UUZ7_HUMAN
  • L7UW06_HUMAN
  • L7WKL1_HUMAN
  • Q1PBM2_HUMAN
genes like me logo Genes that share paralogs with ITGB3: view

Variants for ITGB3 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Polymorphic Variants from UniProtKB/Swiss-Prot for ITGB3 Gene

ITB3_HUMAN-P05106
Position 59 is associated with platelet-specific alloantigen HPA-1 (ZW or PL(A)). HPA-1A/ZW(A)/PL(A1) has Leu-59 and HPA-1B/ZW(B)/PL(A2) has Pro-59. HPA-1A is involved in fetal-maternal alloimmune thromobocytopenia (FMAIT) as well as in neonatal alloimmune thrombocytopenia (NAIT).
ITB3_HUMAN-P05106
Position 169 is associated with platelet-specific alloantigen HPA-4 (PEN or YUK). HPA-4A/PEN(A)/YUK(A) has Arg-169 and HPA-4B/PEN(B)/YUK(B) has Gln-169. HPA-4B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP).
ITB3_HUMAN-P05106
Position 433 is associated with platelet-specific alloantigen MO. MO(-) has Pro-433 and MO(+) has Ala-433. MO(+) is involved in NAIT.
ITB3_HUMAN-P05106
Position 515 is associated with platelet-specific alloantigen CA/TU. CA(-)/TU(-) has Arg-515 and CA(+)/TU(+) has Gln-515. CA(+) is involved in NAIT.
ITB3_HUMAN-P05106
Position 662 is associated with platelet-specific alloantigen SR(A). SR(A)(-) has Arg-662 and SR(A)(+) has Cys-662.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ITGB3 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
626993 Likely Pathogenic: Glanzmann thrombasthenia 47,292,244(+) A/C MISSENSE_VARIANT
627066 Pathogenic: Glanzmann thrombasthenia 47,284,514(+) G/A MISSENSE_VARIANT
627094 Likely Pathogenic: Glanzmann thrombasthenia 47,253,911(+) T/TG FRAMESHIFT_VARIANT
627131 Likely Pathogenic: Glanzmann thrombasthenia 47,286,406(+) A/G MISSENSE_VARIANT
627151 Likely Pathogenic: Abnormal bleeding 47,287,148(+) G/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ITGB3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ITGB3 Gene

Variant ID Type Subtype PubMed ID
esv3640696 CNV loss 21293372
nsv1146669 OTHER inversion 26484159

Variation tolerance for ITGB3 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 48.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITGB3 Gene

Human Gene Mutation Database (HGMD)
ITGB3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGB3

SNP Genotyping and Copy Number Assay Products

Disorders for ITGB3 Gene

MalaCards: The human disease database

(49) MalaCards diseases for ITGB3 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ITGB3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ITB3_HUMAN
  • Glanzmann thrombasthenia (GT) [MIM:273800]: A common inherited disease of platelet aggregation. It is characterized by mucocutaneous bleeding of mild-to-moderate severity. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. {ECO:0000269 PubMed:10233432, ECO:0000269 PubMed:11588040, ECO:0000269 PubMed:11897046, ECO:0000269 PubMed:12083483, ECO:0000269 PubMed:12353082, ECO:0000269 PubMed:1371279, ECO:0000269 PubMed:1438206, ECO:0000269 PubMed:15583747, ECO:0000269 PubMed:15634267, ECO:0000269 PubMed:15748237, ECO:0000269 PubMed:1602006, ECO:0000269 PubMed:20020534, ECO:0000269 PubMed:2392682, ECO:0000269 PubMed:29084015, ECO:0000269 PubMed:8781422, ECO:0000269 PubMed:9215749, ECO:0000269 PubMed:9376589, ECO:0000269 PubMed:9684783, ECO:0000269 PubMed:9790984}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Bleeding disorder, platelet-type 16 (BDPLT16) [MIM:187800]: An autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet functional abnormalities. {ECO:0000269 PubMed:18065693, ECO:0000269 PubMed:29380037}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for ITGB3 Gene

Glanzmann thrombasthenia (GpIIb-GpIIIa complex deficiency)

Additional Disease Information for ITGB3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ITGB3: view

Publications for ITGB3 Gene

  1. AlphaIIbbeta3 integrin: new allelic variants in Glanzmann thrombasthenia, effects on ITGA2B and ITGB3 mRNA splicing, expression, and structure-function. (PMID: 20020534) Jallu V … Kaplan C (Human mutation 2010) 3 4 23
  2. The Leu33Pro polymorphism in the ITGB3 gene does not modify BRCA1/2-associated breast or ovarian cancer risks: results from a multicenter study among 15,542 BRCA1 and BRCA2 mutation carriers. (PMID: 19876733) Jakubowska A … Lubinski J (Breast cancer research and treatment 2010) 3 23 41
  3. Association and gene-gene interaction of SLC6A4 and ITGB3 in autism. (PMID: 19588468) Ma DQ … Martin ER (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 23 41
  4. Molecular defects in ITGA2B and ITGB3 genes in patients with Glanzmann thrombasthenia. (PMID: 19691478) Kannan M … Saxena R (Journal of thrombosis and haemostasis : JTH 2009) 3 23 41
  5. [Association of the integrin gene polymorphisms with ischemic stroke and plasma lipid levels]. (PMID: 19350519) Wei YS … Xie HY (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2009) 3 23 41

ExternalLinks

View latest publications for ITGB3 gene in Mastermind

Products for ITGB3 Gene

  • Addgene plasmids for ITGB3