Free for academic non-profit institutions. Other users need a Commercial license
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
ITGB1 (Integrin Subunit Beta 1) is a Protein Coding gene. Diseases associated with ITGB1 include Gallbladder Cancer and Breast Cancer. Among its related pathways are Integrin Pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and signaling receptor binding. An important paralog of this gene is ITGB3.
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001618 | virus receptor activity | IEA | -- |
GO:0001968 | fibronectin binding | IDA,IPI | 11792823 |
GO:0002020 | protease binding | IPI | 10455171 |
GO:0003779 | actin binding | IDA | 16803572 |
GO:0005178 | integrin binding | IBA,TAS | 8020569 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001726 | ruffle | TAS | 11919189 |
GO:0005623 | cell | IEA | -- |
GO:0005737 | cytoplasm | IDA | 16803572 |
GO:0005768 | endosome | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MAPK Erk Pathway |
.32
|
.32
.32
.32
.32
|
2 | MET promotes cell motility |
.45
|
|
3 | AKT Siganaling Pathway | ||
4 | Autophagy Pathway | ||
5 | Apoptotic Pathways in Synovial Fibroblasts |
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
|
Actin-Based Motility by Rho Family GTPases
.62
Rap1 Pathway
.57
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000082 | G1/S transition of mitotic cell cycle | IEA | -- |
GO:0000132 | establishment of mitotic spindle orientation | IMP | 30992345 |
GO:0001701 | in utero embryonic development | IEA | -- |
GO:0001708 | cell fate specification | IEA | -- |
GO:0002042 | cell migration involved in sprouting angiogenesis | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Antithymocyte immunoglobulin (rabbit) | Approved | Pharma | Target | 0 | ||
Firategrast | Investigational | Pharma | antagonist | α4β1/α4β7 integrin antagonist | 0 | |
ATL1102 | Investigational | Pharma | antisense | 0 | ||
R1295 | Investigational | Pharma | antagonist | 0 | ||
Volociximab | Investigational | Pharma | Antibody | Integrins | 10 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Echistatin, alpha1 isoform |
|
154303-05-6 |
|
|
Compound | Action | Cas Number |
---|---|---|
A 205804 | Selective inhibitor of E-selectin and ICAM-1 expression | 251992-66-2 |
Echistatin, alpha1 isoform | alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor | 154303-05-6 |
GR 144053 trihydrochloride | Glycoprotein IIb/IIIa (integrin alphaIIbbeta3) receptor antagonist. Antithrombotic | 1215333-48-4 |
Obtustatin | Potent and selective alpha1beta1 inhibitor | |
P11 | Potent antagonist of alphavbeta3-vitronectin interaction; antiangiogenic | 848644-86-0 |
Compound | Action | Cas Number |
---|---|---|
BIO 1211 | α4β1 inhibitor,selective and high affinity | 187735-94-0 |
BIO 5192 | Integrin α4β1 inhibitor | 327613-57-0 |
CWHM-12 | 1564286-55-0 | |
Echistatin, α1 isoform | 154303-05-6 | |
Firategrast | α4β1/α4β7 integrin antagonist | 402567-16-2 |
GR 144053 trihydrochloride | 1215333-48-4 | |
LDV FITC | 1207610-07-8 | |
Obtustatin | ||
P11 | 848644-86-0 | |
RGD (Arg-Gly-Asp) Peptides | Inhibits integrin binding to RGD motifs | 99896-85-2 |
RGDS peptide | 91037-65-9 | |
TC-I 15 | 916734-43-5 | |
TCS 2314 | 317353-73-4 |