ITGB1 Gene (Protein Coding)

Integrin Subunit Beta 1

GC10M032900
GIFtS:
51
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene enc... See more...

Aliases for ITGB1 Gene

Aliases for ITGB1 Gene

  • Integrin Subunit Beta 1 2 3 5
  • Integrin, Beta 1 (Fibronectin Receptor, Beta Polypeptide, Antigen CD29 Includes MDF2, MSK12) 2 3
  • Glycoprotein IIa 3 4
  • Integrin Beta-1 3 4
  • MSK12 3 4
  • GPIIA 3 4
  • FNRB 3 4
  • MDF2 3 4
  • Very Late Activation Protein, Beta Polypeptide 3
  • Fibronectin Receptor Subunit Beta 4
  • Integrin VLA-4 Beta Subunit 3
  • VLA-4 Subunit Beta 4
  • Integrin Beta 1 3
  • CD29 Antigen 4
  • VLA-BETA 3
  • CD29 3
  • VLAB 3

External Ids for ITGB1 Gene

Previous HGNC Symbols for ITGB1 Gene

  • FNRB
  • MSK12
  • MDF2

Previous GeneCards Identifiers for ITGB1 Gene

  • GC10M032936
  • GC10M033339
  • GC10M033193
  • GC10M033164
  • GC10M033229
  • GC10M033189

Summaries for ITGB1 Gene

Entrez Gene Summary for ITGB1 Gene

  • Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITGB1 Gene

ITGB1 (Integrin Subunit Beta 1) is a Protein Coding gene. Diseases associated with ITGB1 include Gallbladder Cancer and Breast Cancer. Among its related pathways are ERK Signaling and Microglia Activation During Neuroinflammation: Overview. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and signaling receptor binding. An important paralog of this gene is ITGB2.

UniProtKB/Swiss-Prot Summary for ITGB1 Gene

  • Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).
  • [Isoform 5]: Isoform 5 displaces isoform 1 in striated muscles.
  • (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.
  • (Microbial infection) Acts as a receptor for Cytomegalovirus/HHV-5.
  • (Microbial infection) Acts as a receptor for Epstein-Barr virus/HHV-4.
  • (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human parvovirus B19.
  • (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus.
  • (Microbial infection) Acts as a receptor for Mammalian reovirus.
  • (Microbial infection) In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Tocris Summary for ITGB1 Gene

  • Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.

Gene Wiki entry for ITGB1 Gene

Additional gene information for ITGB1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ITGB1 Gene

Genomics for ITGB1 Gene

GeneHancer (GH) Regulatory Elements for ITGB1 Gene

Promoters and enhancers for ITGB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10J032947 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 512.1 +50.2 50235 17.1 HNRNPK ZNF217 EP300 ZSCAN5C TCF12 NRF1 USF1 POLR2G NCOR1 GTF2E2 ITGB1 KIF5B EPC1 ENSG00000226842 ENSG00000273038 AK3P5 RPS4XP11 CCDC7 ITGB1-DT lnc-NRP1-2
GH10J033003 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +0.3 250 4.4 ZNF217 TCF12 POLR2G JUND FOS ZNF639 ZIC2 POLR2A CLOCK ZNF423 ITGB1 ENSG00000273038 MF281430-010 lnc-CCDC7-14 ITGB1-DT
GH10J032445 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 7.3 +559.2 559222 3.1 HNRNPK ZBTB40 EP300 CTCF SIN3A NRF1 TCF12 POLR2G GTF2E2 PHF8 CCDC7 ENSG00000286409 LOC101929431 ENSG00000273038 EPC1 ITGB1 lnc-EPC1-4
GH10J033032 Enhancer 0.8 Ensembl ENCODE 11.7 -25.6 -25635 4.8 TCF12 JUND EP300 FOS FOSL2 ATF3 SIN3A MAFK MAX TCF7L2 RF00017-645 ITGB1 ENSG00000273038 NRP1 lnc-ITGB1-2 MTND4LP11 ITGB1-DT
GH10J032929 Enhancer 0.8 Ensembl ENCODE dbSUPER 11.4 +75.9 75925 0.3 GATA3 FOXA1 ZBTB40 RAD21 ITGB1 lnc-NRP1-6 piR-48553-032
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ITGB1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ITGB1

Top Transcription factor binding sites by QIAGEN in the ITGB1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun

Genomic Locations for ITGB1 Gene

Genomic Locations for ITGB1 Gene
chr10:32,900,318-33,005,792
(GRCh38/hg38)
Size:
105,475 bases
Orientation:
Minus strand
chr10:33,189,246-33,294,720
(GRCh37/hg19)
Size:
105,475 bases
Orientation:
Minus strand

Genomic View for ITGB1 Gene

Genes around ITGB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGB1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ITGB1 Gene

Proteins for ITGB1 Gene

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  • Protein details for ITGB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05556-ITB1_HUMAN
    Recommended name:
    Integrin beta-1
    Protein Accession:
    P05556
    Secondary Accessions:
    • A8K6N2
    • D3DRX9
    • D3DRY3
    • D3DRY4
    • D3DRY5
    • P78466
    • P78467
    • Q13089
    • Q13090
    • Q13091
    • Q13212
    • Q14622
    • Q14647
    • Q29RW2
    • Q7Z3V1
    • Q8WUM6

    Protein attributes for ITGB1 Gene

    Size:
    798 amino acids
    Molecular mass:
    88415 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. ITGA6:ITGB1 is found in a complex with CD9; interaction takes place in oocytes and is involved in sperm-egg fusion (By similarity). Interacts with seprase FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner. Binds LGALS3BP and NMRK2, when associated with alpha-7, but not with alpha-5. Interacts with FGR and HCK. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with RAB21. Interacts with KRT1 in the presence of RACK1 and SRC. Interacts with JAML; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. Interacts with FLNA, FLNB and RANBP9. Isoform 5 interacts with ACE2. Isoform 1 interacts with the C-terminal region of FLNC. Interacts with MYO10. Interacts with DAB2. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts with ITGB1BP1 (via C-terminal region); the interaction is a prerequisite for focal adhesion disassembly. Interacts with TLN1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with ACAP1; required for ITGB1 recycling. Interacts with ASAP3. Isoform 5 interacts with alpha-7A and alpha-7B in adult skeletal muscle. Isoform 5 interacts with alpha-7B in cardiomyocytes of adult heart. Interacts with EMP2; the interaction may be direct or indirect and ITGB1 has a heterodimer form (By similarity). ITGA5:ITGB1 interacts with CCN3. ITGA4:ITGB1 is found in a ternary complex with CX3CR1 and CX3CL1 (PubMed:23125415). ITGA5:ITGB1 interacts with FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 interacts with IL1B (PubMed:29030430). Interacts with MDK (PubMed:15466886). ITGA4:ITGB1 interacts with MDK; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). ITGA6:ITGB1 interacts with MDK; this interaction mediates MDK-induced neurite-outgrowth (PubMed:15466886).
    • (Microbial infection) Integrin ITGA2:ITGB1 interacts with human echoviruses 1 and 8 capsid proteins.
    • (Microbial infection) Interacts with human cytomegalovirus/HHV-5 envelope glycoprotein B/gB.
    • (Microbial infection) Interacts with Epstein-Barr virus/HHV-4 gB protein.
    • (Microbial infection) Integrin ITGA5:ITGB1 interacts with human parvovirus B19 capsid protein.
    • (Microbial infection) Integrin ITGA2:ITGB1 interacts with human rotavirus VP4 protein.
    • (Microbial infection) Interacts with mammalian reovirus capsid proteins.
    • (Microbial infection) Integrin ITGA5:ITGB1 interacts with HIV-1 Tat.
    SequenceCaution:
    • Sequence=CAD97649.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ITGB1 Gene

    Alternative splice isoforms for ITGB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGB1 Gene

Protein Expression for ITGB1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ITGB1 Gene

  • The cysteine residues are involved in intrachain disulfide bonds.
  • Glycosylation at Asn50, Asn94, Asn97, Asn212, Asn269, Asn363, Thr394, Asn406, Asn417, Asn481, Asn520, Asn584, and Asn669
  • Ubiquitination at Lys774, Lys784, and Lys794
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for ITGB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ITGB1 Gene

Domains & Families for ITGB1 Gene

Gene Families for ITGB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for ITGB1 Gene

Blocks:
  • Integrin beta, C-terminal
  • Integrin beta subunit signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ITGB1 Gene

GenScript: Design optimal peptide antigens:
  • Integrin beta (C9JPK5_HUMAN)
  • Integrin beta (E7EQW5_HUMAN)
  • Integrin beta (E7ERX5_HUMAN)
  • Integrin beta (E7EUI6_HUMAN)
  • Integrin beta (E9PLR6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05556

UniProtKB/Swiss-Prot:

ITB1_HUMAN :
  • Belongs to the integrin beta chain family.
Family:
  • Belongs to the integrin beta chain family.
genes like me logo Genes that share domains with ITGB1: view

Function for ITGB1 Gene

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  6. Cell Line

Molecular function for ITGB1 Gene

UniProtKB/Swiss-Prot Function:
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).
UniProtKB/Swiss-Prot Function:
[Isoform 5]: Isoform 5 displaces isoform 1 in striated muscles.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Cytomegalovirus/HHV-5.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Epstein-Barr virus/HHV-4.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human parvovirus B19.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Mammalian reovirus.
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
GENATLAS Biochemistry:
integrin,beta 1 chain,common beta subunit of very late antigens VLA1-6 and fibronectin/laminin/tenascin/vitronectin receptor,including MDF2,MSK2,identified by monoclonal antibodies A-1A5,AJ2,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,inducing an alternatively spliced isoform ITGB1C,inhibitor of cell proliferation,expressed in epidermal cells of the basal layer (stem,transit-amplifying,commited basal cells),inhibiting expression of suprabasal markers of terminal differentiation,coexpressed in human prostate epithelial cells with the cell cycle inhibitor p27/Kip1 (CDKN1B),involved in migration and survival in primary oligodendrocytes

Phenotypes From GWAS Catalog for ITGB1 Gene

Gene Ontology (GO) - Molecular Function for ITGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0001968 fibronectin binding IPI,IBA 11792823
GO:0002020 protease binding IPI 10455171
GO:0003779 actin binding IDA 16803572
GO:0005178 integrin binding IBA 21873635
genes like me logo Genes that share ontologies with ITGB1: view
genes like me logo Genes that share phenotypes with ITGB1: view

Animal Models for ITGB1 Gene

MGI Knock Outs for ITGB1:

Animal Model Products

CRISPR Products

miRNA for ITGB1 Gene

miRTarBase miRNAs that target ITGB1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGB1

Clone Products

  • Addgene plasmids for ITGB1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGB1 Gene

Localization for ITGB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGB1 Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, invadopodium membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Recycling endosome. Melanosome. Cleavage furrow. Cell projection, lamellipodium. Cell projection, ruffle. Cell junction, focal adhesion. Cell surface. Note=Isoform 2 does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a few intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells. Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions sites to fibrillar adhesions in a ITGB1BP1-dependent manner. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. {ECO:0000269 PubMed:10455171, ECO:0000303 PubMed:10455171}.
[Isoform 5]: Cell membrane, sarcolemma. Cell junction. Note=In cardiac muscle, isoform 5 is found in costameres and intercalated disks. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITGB1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
endosome 4
cytoskeleton 3
nucleus 3
endoplasmic reticulum 3
mitochondrion 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (3)
  • Plasma membrane (3)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ITGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle TAS 11919189
GO:0005623 cell IEA --
GO:0005737 cytoplasm IDA 16803572
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with ITGB1: view

Pathways & Interactions for ITGB1 Gene

genes like me logo Genes that share pathways with ITGB1: view

Pathways by source for ITGB1 Gene

14 GeneGo (Thomson Reuters) pathways for ITGB1 Gene
  • Cell adhesion Integrin inside-out signaling
  • Cell adhesion Integrin-mediated cell adhesion and migration
  • Cell adhesion PLAU signaling
  • Cell adhesion Tight junctions
  • Cell adhesion_Cell-matrix glycoconjugates
2 Tocris pathways for ITGB1 Gene
38 Qiagen pathways for ITGB1 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Agrin Interactions at Neuromuscular Junction
  • Akt Signaling
3 Cell Signaling Technology pathways for ITGB1 Gene

SIGNOR curated interactions for ITGB1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ITGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0000132 establishment of mitotic spindle orientation IMP 30992345
GO:0001701 in utero embryonic development IEA --
GO:0001708 cell fate specification IEA --
GO:0002042 cell migration involved in sprouting angiogenesis IEA --
genes like me logo Genes that share ontologies with ITGB1: view

Drugs & Compounds for ITGB1 Gene

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(62) Drugs for ITGB1 Gene - From: DrugBank, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antithymocyte immunoglobulin (rabbit) Approved Pharma Target 0
Firategrast Investigational Pharma antagonist α4β1/α4β7 integrin antagonist 0
ATL1102 Investigational Pharma antisense 0
R1295 Investigational Pharma antagonist 0
Volociximab Investigational Pharma Antibody Integrins 10

(30) Additional Compounds for ITGB1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Echistatin, alpha1 isoform
154303-05-6

(5) Tocris Compounds for ITGB1 Gene

Compound Action Cas Number
A 205804 Selective inhibitor of E-selectin and ICAM-1 expression 251992-66-2
Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor 154303-05-6
GR 144053 trihydrochloride Glycoprotein IIb/IIIa (integrin alphaIIbbeta3) receptor antagonist. Antithrombotic 1215333-48-4
Obtustatin Potent and selective alpha1beta1 inhibitor
P11 Potent antagonist of alphavbeta3-vitronectin interaction; antiangiogenic 848644-86-0

(15) ApexBio Compounds for ITGB1 Gene

Compound Action Cas Number
BIO 1211 α4β1 inhibitor,selective and high affinity 187735-94-0
BIO 5192 Integrin α4β1 inhibitor 327613-57-0
CWHM-12 1564286-55-0
Echistatin, α1 isoform 154303-05-6
Firategrast α4β1/α4β7 integrin antagonist 402567-16-2
GR 144053 trihydrochloride 1215333-48-4
LDV FITC 1207610-07-8
Obtustatin
P11 848644-86-0
RGD (Arg-Gly-Asp) Peptides Inhibits integrin binding to RGD motifs 99896-85-2
RGDS peptide 91037-65-9
TC-I 15 916734-43-5
TCS 2314 317353-73-4
TR-14035 α4β7 and α4β1 integrins antagonist 232271-19-1
Zaurategrast Integrin inhibitor 455264-31-0
genes like me logo Genes that share compounds with ITGB1: view

Drug Products

Transcripts for ITGB1 Gene

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  1. CRISPR
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mRNA/cDNA for ITGB1 Gene

6 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGB1

Clone Products

  • Addgene plasmids for ITGB1

Alternative Splicing Database (ASD) splice patterns (SP) for ITGB1 Gene

No ASD Table

Relevant External Links for ITGB1 Gene

GeneLoc Exon Structure for
ITGB1

Expression for ITGB1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ITGB1 Gene

mRNA expression in normal human tissues for ITGB1 Gene
mRNA expression by BioGPS for ITGB1 GenemRNA expression by GTEx for ITGB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery