Aliases for ITGB1 Gene
Aliases for ITGB1 Gene
External Ids for ITGB1 Gene
- HGNC: 6153
- Entrez Gene: 3688
- Ensembl: ENSG00000150093
- OMIM: 135630
- UniProtKB: P05556
Previous HGNC Symbols for ITGB1 Gene
- FNRB
- MSK12
- MDF2
Previous GeneCards Identifiers for ITGB1 Gene
- GC10M033339
- GC10M033193
- GC10M033164
- GC10M033229
- GC10M033189
Summaries for ITGB1 Gene
-
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ITGB1 Gene
ITGB1 (Integrin Subunit Beta 1) is a Protein Coding gene. Diseases associated with ITGB1 include Astrocytoma and Cerebral Hypoxia. Among its related pathways are Signaling events mediated by PRL and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and receptor binding. An important paralog of this gene is ITGB2.
UniProtKB/Swiss-Prot for ITGB1 Gene
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Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).
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Isoform 5: Isoform 5 displaces isoform 1 in striated muscles.
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(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387). Acts as a receptor for cytomegalovirus/HHV-5 (PubMed:20660204). Acts as a receptor for Epstein-Barr virus/HHV-4 (PubMed:17945327). Integrin ITGA5:ITGB1 acts as a receptor for human parvovirus B19 (PubMed:12907437). Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus (PubMed:12941907). Acts as a receptor for mammalian reovirus (PubMed:16501085). In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions (PubMed:10397733).
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Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.
Additional gene information for ITGB1 Gene
- Monarch Initiative
- Search for ITGB1 at DataMed
- Search for ITGB1 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGB1 Gene
Genomics for ITGB1 Gene
GeneHancer (GH) Regulatory Elements for ITGB1 Gene
Promoters and enhancers for ITGB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ITGB1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ITGB1 gene promoter:
Regulatory Element Products
Genomic Locations for ITGB1 Gene
Genomic Locations for ITGB1 Gene
- chr10:32,900,318-33,005,792
- (GRCh38/hg38)
- Size:
- 105,475 bases
- Orientation:
- Minus strand
- chr10:33,189,246-33,294,720
- (GRCh37/hg19)
Genomic View for ITGB1 Gene
Genes around ITGB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p11.22 by Ensembl
- 10p11.22 by Entrez Gene
- 10p11.22 by HGNC
ITGB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ITGB1 Gene
Proteins for ITGB1 Gene
-
Protein details for ITGB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05556-ITB1_HUMAN
- Recommended name:
- Integrin beta-1
- Protein Accession:
- P05556
- A8K6N2
- D3DRX9
- D3DRY3
- D3DRY4
- D3DRY5
- P78466
- P78467
- Q13089
- Q13090
- Q13091
- Q13212
- Q14622
- Q14647
- Q29RW2
- Q7Z3V1
- Q8WUM6
Protein attributes for ITGB1 Gene
- Size:
- 798 amino acids
- Molecular mass:
- 88415 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Interacts with seprase FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner. Binds LGALS3BP and NMRK2, when associated with alpha-7, but not with alpha-5. Interacts with FGR and HCK. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with RAB21. Interacts with KRT1 in the presence of RACK1 and SRC. Interacts with JAML; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. Interacts with FLNA, FLNB and RANBP9. Isoform 5 interacts with ACE2. Isoform 1 interacts with the C-terminal region of FLNC. Interacts with MYO10. Interacts with DAB2. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts with ITGB1BP1 (via C-terminal region); the interaction is a prerequisite for focal adhesion disassembly. Interacts with TLN1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with ACAP1; required for ITGB1 recycling. Interacts with ASAP3. Isoform 5 interacts with alpha-7A and alpha-7B in adult skeletal muscle. Isoform 5 interacts with alpha-7B in cardiomyocytes of adult heart. Interacts with EMP2; the interaction may be direct or indirect and ITGB1 has an heterodimer form (By similarity). ITGA5:ITGB1 interacts with NOV. ITGA4:ITGB1 is found in a ternary complex with CX3CR1 and CX3CL1 (PubMed:23125415). ITGA5:ITGB1 interacts with FBN1 (PubMed:12807887, PubMed:17158881).
- (Microbial infection) Integrin ITGA2:ITGB1 interacts with human echoviruses 1 and 8 capsid proteins.
- (Microbial infection) Interacts with human cytomegalovirus/HHV-5 envelope glycoprotein B/gB.
- (Microbial infection) Interacts with Epstein-Barr virus/HHV-4 gB protein.
- (Microbial infection) Integrin ITGA5:ITGB1 interacts with human parvovirus B19 capsid protein.
- (Microbial infection) Integrin ITGA2:ITGB1 interacts with human rotavirus VP4 protein.
- (Microbial infection) Interacts with mammalian reovirus capsid proteins.
- (Microbial infection) Integrin ITGA5:ITGB1 interacts with HIV-1 Tat.
- SequenceCaution:
-
- Sequence=CAD97649.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for ITGB1 Gene
Protein Expression for ITGB1 Gene
Post-translational modifications for ITGB1 Gene
- The cysteine residues are involved in intrachain disulfide bonds.
- Ubiquitination at isoforms=794
- Glycosylation at posLast=5050, posLast=9494, posLast=9797, posLast=212212, posLast=269269, isoforms=2, 3, 4, 5363, posLast=394394, isoforms=2, 3, 4, 5403, isoforms=2, 3, 4, 5406, posLast=411411, posLast=417417, isoforms=2, 3, 4, 5481, isoforms=2, 3, 4, 5520, posLast=584584, and isoforms=2, 3, 4, 5669
- Modification sites at PhosphoSitePlus
Other Protein References for ITGB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ITGB1 (Integrin beta 1/CD29)
-
Custom Antibody ServicesOriGene Antibodies for ITGB1
- AP06431PU-N
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- CF807138
- TA807138
- CF806909
- TA806909
- TA353270
- TA353269
- TA349358
- TA347998
- TA341149
- TA341143
- TA328165
- TA320394
- TA320393
- TA320392
- TA311971
- TA311970
- TA311969
- SM3016R
- SM3016P
- SM3016F
- SM3016B
- SM3016APC
- SM2118P
- SM1740PT
- SM1740P
- SM1578PT
- SM1578PS
- SM1578P
- SM1578FT
- SM1578F
- BM6029P
- BM6028P
- BM2540
- AP55840PU-S
- AP55840PU-N
- AP55700PU-S
- AM32361PU-N
- AM32089PU-N
- AM32088PU-N
- AM31183RP-N
- AM31183PU-S
- AM31183PU-N
- AM31183FC-N
- AM31183AF-N
- AM09002PU-S
- AM09002PU-N
- AM06735PU-N
- AM06734PU-N
- Novus Biologicals Antibodies for ITGB1
-
Abcam antibodies for ITGB1
-
Cloud-Clone Corp. Antibodies for ITGB1
- Invitrogen Antibodies for ITGB1
- antibodies-online: Search results for 931 available LOC100009173 Antibodies ranked by validation data
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Recommended
- 1 BCA Antibody (anti-human)
- 2 RIA Antibodies (anti-human)
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- 15 IP Antibodies (anti-human)
- 23 IHC (p) Antibodies (anti-human)
- 24 IHC Antibodies (anti-human)
- 24 IF Antibodies (anti-human)
- 49 IHC (fro) Antibodies (anti-human)
- 161 FACS Antibodies (anti-human)
- 403 WB Antibodies (anti-human)
- 1 IHC Antibody (anti-rat)
- 2 Func Antibodies (anti-rat)
- 4 ICFC Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 15 IP Antibodies (anti-rat)
- 39 FACS Antibodies (anti-rat)
- 84 WB Antibodies (anti-rat)
- 1 IHC (zinc) Antibody (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 Func Antibodies (anti-mouse)
- 4 ICFC Antibodies (anti-mouse)
- 4 IHC (fro) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 23 IP Antibodies (anti-mouse)
- 102 FACS Antibodies (anti-mouse)
- 126 WB Antibodies (anti-mouse)
- 1 BCA Antibody (anti-human)
- 2 RIA Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 3 IF/ICC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 15 IP Antibodies (anti-human)
- 23 IHC (p) Antibodies (anti-human)
- 24 IHC Antibodies (anti-human)
- 24 IF Antibodies (anti-human)
- 49 IHC (fro) Antibodies (anti-human)
- 161 FACS Antibodies (anti-human)
- 403 WB Antibodies (anti-human)
- 1 IHC Antibody (anti-rat)
- 2 Func Antibodies (anti-rat)
- 4 ICFC Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 15 IP Antibodies (anti-rat)
- 39 FACS Antibodies (anti-rat)
- 84 WB Antibodies (anti-rat)
- 1 IHC (zinc) Antibody (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 Func Antibodies (anti-mouse)
- 4 ICFC Antibodies (anti-mouse)
- 4 IHC (fro) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 23 IP Antibodies (anti-mouse)
- 102 FACS Antibodies (anti-mouse)
- 126 WB Antibodies (anti-mouse)
- GeneTex ITGB1 antibody for ITGB1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ITGB1
- Integrin β1 (E-11)
- Integrin β1 (A-4)
- Integrin β1 (102DF5)
- Integrin α2/β1 (3H1472)
- Integrin α9/β1 (2Q954)
- Integrin β1 (3H1192)
- Integrin β1 (2Q837)
- Integrin βId (2B1)
- Integrin α9/β1 (Y9A2)
- Integrin β1 (JB1B)
- Integrin β1 (12G10)
- Integrin β1 (TS2/16)
- Integrin β1 (MEM-101A)
- Integrin β1 (K-20)
- Integrin β1 (P4G11)
- Integrin β1 (P5D2)
- Integrin α2 (P1H5)
- Integrin β1 (4B7R)
- Sino Biological Antibodies for ITGB1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ITGB1
- Origene Custom Protein Services for ITGB1
- Sino Biological Recombinant Proteins for ITGB1
- Sino Biological Cell Lysates for ITGB1
- ProSpec Recombinant Proteins for ITGB1
-
Cloud-Clone Corp. Proteins for ITGB1
- Search GeneTex for Proteins for ITGB1
-
Abcam proteins for ITGB1
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for ITGB1 (Integrin beta 1/CD29)
-
Cloud-Clone Corp. Assay Kits for ITGB1
- antibodies-online: Search results for 39 available LOC100009173 Elisa Kits ranked by validation data
- Compare Top LOC100009173 Elisa Kits
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Recommended
- 1 Sheep (Ovine) ELISA Kit
- 11 Rat (Rattus) ELISA Kits
- 1 Rabbit ELISA Kit
- 2 Pig (Porcine) ELISA Kits
- 13 Mouse (Murine) ELISA Kits
- 1 Monkey ELISA Kit
- 21 Human ELISA Kits
- 1 Guinea Pig ELISA Kit
- 1 Goat ELISA Kit
- 1 Dog (Canine) ELISA Kit
- 2 Cow (Bovine) ELISA Kits
- 2 Chicken ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 11 Rat (Rattus) ELISA Kits
- 1 Rabbit ELISA Kit
- 2 Pig (Porcine) ELISA Kits
- 13 Mouse (Murine) ELISA Kits
- 1 Monkey ELISA Kit
- 21 Human ELISA Kits
- 1 Guinea Pig ELISA Kit
- 1 Goat ELISA Kit
- 1 Dog (Canine) ELISA Kit
- 2 Cow (Bovine) ELISA Kits
- 2 Chicken ELISA Kits
No data available for DME Specific Peptides for ITGB1 Gene
Domains & Families for ITGB1 Gene
Gene Families for ITGB1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
- Transporters
Protein Domains for ITGB1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ITGB1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P05556- Family:
-
- Belongs to the integrin beta chain family.
Function for ITGB1 Gene
Molecular function for ITGB1 Gene
- GENATLAS Biochemistry:
- integrin,beta 1 chain,common beta subunit of very late antigens VLA1-6 and fibronectin/laminin/tenascin/vitronectin receptor,including MDF2,MSK2,identified by monoclonal antibodies A-1A5,AJ2,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,inducing an alternatively spliced isoform ITGB1C,inhibitor of cell proliferation,expressed in epidermal cells of the basal layer (stem,transit-amplifying,commited basal cells),inhibiting expression of suprabasal markers of terminal differentiation,coexpressed in human prostate epithelial cells with the cell cycle inhibitor p27/Kip1 (CDKN1B),involved in migration and survival in primary oligodendrocytes
- UniProtKB/Swiss-Prot Function:
- Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).
- UniProtKB/Swiss-Prot Function:
- Isoform 5: Isoform 5 displaces isoform 1 in striated muscles.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387). Acts as a receptor for cytomegalovirus/HHV-5 (PubMed:20660204). Acts as a receptor for Epstein-Barr virus/HHV-4 (PubMed:17945327). Integrin ITGA5:ITGB1 acts as a receptor for human parvovirus B19 (PubMed:12907437). Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus (PubMed:12941907). Acts as a receptor for mammalian reovirus (PubMed:16501085). In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions (PubMed:10397733).
Phenotypes From GWAS Catalog for ITGB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001618 | virus receptor activity | IEA | -- |
| GO:0001968 | fibronectin binding | IPI | 11792823 |
| GO:0002020 | protease binding | IPI | 10455171 |
| GO:0003779 | actin binding | IDA | 16803572 |
| GO:0004872 | receptor activity | IEA | -- |
Phenotypes for ITGB1 Gene
- MGI mutant phenotypes for ITGB1:
-
inferred from 26 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- pigmentation phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for ITGB1:
-
- Decreased viability in esophageal squamous lineage
- Decreased ionizing radiation sensitivity
- Decreased shRNA abundance (Z-score < -2)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- Increased number of mitotic cells
- Decreased Salmonella enterica Typhimurium invasion
- Decreased cell migration
- Increased HPV16-GFP infection
- Synthetic lethal with imatinib mesylate
Animal Models for ITGB1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ITGB1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ITGB1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGB1 gene
- Search ViGene Biosciences for ITGB1
CRISPR Products
-
OriGene CRISPR knockouts for ITGB1
- genomics-online: gRNA clones - Search results for available LOC100009173 gene related products
- Applied Biological Materials CRISPR for ITGB1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ITGB1
- GenScript: Design CRISPR guide RNA sequences for ITGB1
miRNA for ITGB1 Gene
- miRTarBase miRNAs that target ITGB1
-
- hsa-mir-124-3p (MIRT002731)
- gga-mir-124a-3p (MIRT003906)
- hsa-mir-183-5p (MIRT004015)
- hsa-mir-375 (MIRT019882)
- hsa-mir-215-5p (MIRT024365)
- hsa-mir-192-5p (MIRT026513)
- hsa-mir-9-3p (MIRT035520)
- hsa-mir-769-5p (MIRT039178)
- hsa-mir-186-5p (MIRT044978)
- hsa-mir-25-3p (MIRT050264)
- hsa-mir-134-5p (MIRT054591)
- hsa-mir-130b-3p (MIRT054592)
- hsa-mir-29b-3p (MIRT438919)
- hsa-mir-218-5p (MIRT440422)
- hsa-mir-183-3p (MIRT562097)
- hsa-mir-223-3p (MIRT562098)
- hsa-mir-4697-3p (MIRT562099)
- hsa-mir-3622b-5p (MIRT562100)
- hsa-mir-5588-5p (MIRT562101)
- hsa-mir-4799-3p (MIRT562102)
- hsa-mir-4720-5p (MIRT562103)
- hsa-mir-8073 (MIRT562104)
- hsa-mir-221-5p (MIRT562105)
- hsa-mir-4292 (MIRT562106)
- hsa-mir-6791-5p (MIRT562107)
- hsa-mir-4308 (MIRT562108)
- hsa-mir-1910-5p (MIRT562109)
- hsa-mir-2114-5p (MIRT562110)
- hsa-mir-3529-3p (MIRT562111)
- hsa-mir-455-3p (MIRT562112)
- hsa-mir-4452 (MIRT567105)
- hsa-mir-6126 (MIRT567106)
- hsa-mir-4493 (MIRT567107)
- hsa-mir-605-3p (MIRT567108)
- hsa-mir-4521 (MIRT567109)
- hsa-mir-3910 (MIRT567110)
- hsa-mir-548at-5p (MIRT567111)
- hsa-mir-4796-3p (MIRT567112)
- hsa-mir-93-5p (MIRT567113)
- hsa-mir-526b-3p (MIRT567114)
- hsa-mir-519d-3p (MIRT567115)
- hsa-mir-20b-5p (MIRT567116)
- hsa-mir-20a-5p (MIRT567117)
- hsa-mir-17-5p (MIRT567118)
- hsa-mir-106b-5p (MIRT567119)
- hsa-mir-106a-5p (MIRT567120)
- hsa-mir-548ah-5p (MIRT567121)
- hsa-mir-3609 (MIRT567122)
- hsa-mir-548t-5p (MIRT567123)
- hsa-mir-548az-5p (MIRT567124)
- hsa-mir-548n (MIRT567125)
- hsa-mir-29c-3p (MIRT731308)
- hsa-mir-29a-3p (MIRT731594)
- hsa-mir-143-3p (MIRT734788)
miRNA Products
- Search ViGene Biosciences for ITGB1
- SwitchGear ITGB1 3' UTR sequence
- SwitchGear ITGB1 3' UTR sequence
- Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ITGB1
- Browse OriGene Inhibitory RNA Products For ITGB1
- genomics-online: shRNA clones - Search results for available LOC100009173 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGB1 gene
Clone Products
-
OriGene ORF clones in human for ITGB1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ITGB1
- VectorBuilder custom plasmid, inducible vectors for ITGB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ITGB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ITGB1
- genomics-online: cdna clones - Search results for available LOC100009173 gene related products
- orf clones - Search results for available LOC100009173 gene related products
- Applied Biological Materials Clones for ITGB1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ITGB1 (Integrin beta 1/CD29)
Cell Line Products
-
Horizon Cell Lines for ITGB1
-
ViGene Biosciences adenoviral particle packaged cDNA for ITGB1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ITGB1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGB1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGB1 Gene
Localization for ITGB1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ITGB1 Gene
- Cell membrane; Single-pass type I membrane protein. Cell projection, invadopodium membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Recycling endosome. Melanosome. Cleavage furrow. Cell projection, lamellipodium. Cell projection, ruffle. Cell junction, focal adhesion. Cell surface. Note=Isoform 2 does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a few intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells. Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions sites to fibrillar adhesions in a ITGB1BP1-dependent manner. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. {ECO:0000269 PubMed:10455171, ECO:0000303 PubMed:10455171}.
- Isoform 5: Cell membrane, sarcolemma. Cell junction. Note=In cardiac muscle, isoform 5 is found in costameres and intercalated disks. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endosome | 4 |
| cytoskeleton | 3 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| peroxisome | 1 |
- Focal adhesion sites (3)
- Plasma membrane (3)
- Endoplasmic reticulum (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001726 | ruffle | TAS | 11919189 |
| GO:0005737 | cytoplasm | IDA | 16803572 |
| GO:0005768 | endosome | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005925 | colocalizes_with focal adhesion | IEA,IDA | 14970227 |
Pathways & Interactions for ITGB1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MAPK-Erk Pathway |
.38
|
.38
.38
.38
.38
.38
|
| 2 | AKT Signaling Pathway | ||
| 3 | Apoptotic Pathways in Synovial Fibroblasts |
.66
.65
|
.57
|
| 4 | ERK Signaling |
.61
.58
|
.49
|
| 5 | Integrin Pathway |
.67
.67
.56
|
.56
|
Pathways by source for ITGB1 Gene
17 Sino Biological pathways for ITGB1 Gene
27 BioSystems pathways for ITGB1 Gene
38 Reactome pathways for ITGB1 Gene
24 KEGG pathways for ITGB1 Gene
14 GeneGo (Thomson Reuters) pathways for ITGB1 Gene
6 R&D Systems pathways for ITGB1 Gene
- Articular Cartilage Extracellular Matrix Pathway
- Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview
- Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways
- Blood-Brain Barrier Pathway: Anatomy
2 Tocris pathways for ITGB1 Gene
38 Qiagen pathways for ITGB1 Gene
3 Cell Signaling Technology pathways for ITGB1 Gene
Interacting Proteins for ITGB1 Gene
Selected Interacting proteins:
ENSP00000303351
P05556-ITB1_HUMAN
for ITGB1 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IEA | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001708 | cell fate specification | IEA | -- |
| GO:0002042 | cell migration involved in sprouting angiogenesis | IEA | -- |
| GO:0006968 | cellular defense response | TAS | 10201960 |
Drugs & Compounds for ITGB1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Antithymocyte immunoglobulin (rabbit) | Approved | Pharma | Target | 0 | ||
| Firategrast | Investigational | Pharma | antagonist | α4β1/α4β7 integrin antagonist | 0 | |
| ATL1102 | Investigational | Pharma | antisense | 0 | ||
| R1295 | Investigational | Pharma | antagonist | 0 | ||
| Obtustatin | Pharma | Potent and selective alpha1beta1 inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(5) Tocris Compounds for ITGB1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| A 205804 | Selective inhibitor of E-selectin and ICAM-1 expression | 251992-66-2 |
| Echistatin, alpha1 isoform | alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor | 154303-05-6 |
| GR 144053 trihydrochloride | Glycoprotein IIb/IIIa (integrin alphaIIbbeta3) receptor antagonist. Antithrombotic | 1215333-48-4 |
| Obtustatin | Potent and selective alpha1beta1 inhibitor | |
| P11 | Potent antagonist of alphavbeta3-vitronectin interaction; antiangiogenic | 848644-86-0 |
(15) ApexBio Compounds for ITGB1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BIO 1211 | α4β1 inhibitor,selective and high affinity | 187735-94-0 |
| BIO 5192 | Integrin α4β1 inhibitor | 327613-57-0 |
| CWHM-12 | 1564286-55-0 | |
| Echistatin, α1 isoform | 154303-05-6 | |
| Firategrast | α4β1/α4β7 integrin antagonist | 402567-16-2 |
| GR 144053 trihydrochloride | 1215333-48-4 | |
| LDV FITC | 1207610-07-8 | |
| Obtustatin | ||
| P11 | 848644-86-0 | |
| RGD (Arg-Gly-Asp) Peptides | Inhibits integrin binding to RGD motifs | 99896-85-2 |
| RGDS peptide | 91037-65-9 | |
| TC-I 15 | 916734-43-5 | |
| TCS 2314 | 317353-73-4 | |
| TR-14035 | α4β7 and α4β1 integrins antagonist | 232271-19-1 |
| Zaurategrast | Integrin inhibitor | 455264-31-0 |
Transcripts for ITGB1 Gene
mRNA/cDNA for ITGB1 Gene
- (6) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (1076) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ITGB1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ITGB1
- genomics-online: gRNA clones - Search results for available LOC100009173 gene related products
- Applied Biological Materials CRISPR for ITGB1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ITGB1
- GenScript: Design CRISPR guide RNA sequences for ITGB1
miRNA Products
- Search ViGene Biosciences for ITGB1
- SwitchGear ITGB1 3' UTR sequence
- SwitchGear ITGB1 3' UTR sequence
- Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ITGB1
- Browse OriGene Inhibitory RNA Products For ITGB1
- genomics-online: shRNA clones - Search results for available LOC100009173 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGB1 gene
Clone Products
-
OriGene ORF clones in human for ITGB1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ITGB1
- VectorBuilder custom plasmid, inducible vectors for ITGB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ITGB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ITGB1
- genomics-online: cdna clones - Search results for available LOC100009173 gene related products
- orf clones - Search results for available LOC100009173 gene related products
- Applied Biological Materials Clones for ITGB1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ITGB1 (Integrin beta 1/CD29)
Expression for ITGB1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Mesenchymal Stem Cells
- Mesenchymal Stem Cells Cord Blood
- Amniotic Mesenchymal Stromal Cells Amniotic Membrane
- Mesenchymal Stem Cells Amniotic Fluid
- Mesenchymal Stem Cells Whartons Jelly
- Mesenchymal Stem Cells Subcutaneous White Adipose
-
Epithelial Cells
- Fetal Matrix Cells Hair Follicle
- Anterior Lens Epithelial Cells Lens
- Primary Hair Placode Cells Hair Follicle
- Outer Enamel Epithelial Cells Dental Enamel
- Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
- Umbilical Cord (Extraembryonic Tissues)
-
Skeletal Muscle (Muscoskeletal System)
- Multinuclear Myocytes Thoracic Vertebral Colomn Muscles
- Multinuclear Myocytes Thoracic Back Muscles
- Multinuclear Myocytes Posterior Neck Muscles
- Multinuclear Myocytes Hindlimb Dorsal Muscle
- Multinuclear Myocytes Forelimb Ventral Muscles
-
Tooth (Integumentary System)
- Outer Enamel Epithelial Cells Dental Enamel
- Stellate Reticulum Cells Dental Core
- Inner Enamel Epithelial Cells Dental Enamel
- Primary Enamel Knot Cells Enamel Knot
- Dental Papilla Cells Dental Papilla
- Bone (Muscoskeletal System)
-
Adipose (Muscoskeletal System)
- Stromal Cells Subcutaneous White Adipose
- Mesenchymal Stem Cells Subcutaneous White Adipose
- Visceral White Preadipocytes Visceral White Adipose
- Adipose-derived stem cells (StemGenex)
- Adipose-derived mesenchymal stem cells
- Hair (Integumentary System)
-
Placenta (Extraembryonic Tissues)
- Chorionic Mesenchymal Stromal Cells Chorionic Villus
- Extravillous Cytotrophoblast Cells Extravillous Cytotrophoblast Layer
- placenta ; decidual cells
- placenta ; trophoblastic cells
- Placenta-derived mesenchymal stem cells
-
Eye (Sensory Organs)
- Anterior Lens Epithelial Cells Lens
- Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
- Limbal Basal Epithelial Cells Limbus Epithelium
- Limbal epithelial stem cells (family)
- Limbal epithelial stem cells
- Blood (Hematopoietic System)
-
Limb (Muscoskeletal System)
- Interzone Cells Zeugopod Synovial Joint
- Interzone Cells Stylopod Synovial Joint
- Multinuclear Myocytes Hindlimb Dorsal Muscle
- Multinuclear Myocytes Forelimb Ventral Muscles
- Multinuclear Myocytes Hindlimb Ventral Muscle
-
Peripheral Nervous System (Nervous System)
- Myelinating Schwann Cells Peripheral Nerve Domain
- Schwann Precursor Cells Peripheral Nerve Domain
- Immature Schwann Cells Peripheral Nerve Domain
- Non-myelinating Schwann Cells Peripheral Nerve Domain
- Pro-myelinating Schwann Cells Peripheral Nerve Domain
-
Trophoblast (Extraembryonic Tissues)
- 4-Cell Embryo Zygote
- 8-Cell Embryo Morula
- Morula Cells Morula
- 2-Cell Embryo Zygote
- Zygote Zygote
-
Inner Cell Mass (Early Embryo)
- 4-Cell Embryo Zygote
- 8-Cell Embryo Morula
- Morula Cells Morula
- 2-Cell Embryo Zygote
- Zygote Zygote
-
Zygote (Early Embryonic Tissues)
- 4-Cell Embryo Zygote
- 8-Cell Embryo Morula
- Morula Cells Morula
- 2-Cell Embryo Zygote
- Zygote Zygote
- Brain (Nervous System)
- NULL (Uncategorized)
-
Amnion (Extraembryonic Tissues)
- Amniotic Mesenchymal Stromal Cells Amniotic Membrane
- Mesenchymal Stem Cells Amniotic Fluid
- Amnion-derived mesenchymal stem cells
- Amniotic Epithelial Cells Amniotic Membrane
-
Cartilage (Muscoskeletal System)
- Interzone Cells Zeugopod Synovial Joint
- Interzone Cells Stylopod Synovial Joint
- Interzone Cells Autopod Synovial Joint
- Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
-
Dermis (Integumentary System)
- Dermal Fibroblasts Ventral Dermis
- Dermal Fibroblasts Cranial Dermis
- Dermal Fibroblasts Dorsal Dermis
-
Fibroblasts
- Dermal Fibroblasts Ventral Dermis
- Dermal Fibroblasts Cranial Dermis
- Dermal Fibroblasts Dorsal Dermis
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Fetal liver cells
- Hepatoblasts Liver Bud
-
Paraxial Mesoderm (Gastrulation Derivatives)
- Presomitic Mesoderm Cells Presomitic Mesoderm
- Presegmented Somitic Mesenchyme Cells Presomitic Mesoderm
- Paraxial Mesoderm Cells Trunk Mesoderm
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
- Spermatogonial Stem Cells Seminiferous Tubules
- Leydig Cells Testis Interstitium
-
Glial Cells
- Non-myelinating Schwann Cells Peripheral Nerve Domain
- Bergmann Glia Purkinje Cell Layer
- Myelinating Schwann Cells Peripheral Nerve Domain
- Kidney (Urinary System)
- Epidermis (Integumentary System)
- Heart (Cardiovascular System)
-
Somite (Muscoskeletal System)
- Presomitic Mesoderm Cells Presomitic Mesoderm
- Presegmented Somitic Mesenchyme Cells Presomitic Mesoderm
-
Pancreas (Endocrine System)
- Islets of Langerhans
- Mature Beta Cells Islets of Langerhans
- Neural Crest (Gastrulation Derivatives)
-
Neurons
- Dopaminergic neuron-like cells (Sundberg M et. al. 2013)
- Type1 Off Cone Bipolar Cells Inner Nuclear Layer
-
Chorion (Extraembryonic Tissues)
- Chorionic Mesenchymal Stromal Cells Chorionic Villus
-
Gonad
- Spermatogonial Stem Cells Seminiferous Tubules
-
Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm Cells Trunk Mesoderm
- Ovary (Reproductive System)
- Thyroid (Endocrine System)
- Uterus (Reproductive System)
- Smooth Muscle (Muscoskeletal System)
- Dopaminergic Neurons (Nervous System)
- Oral Cavity (Gastrointestinal Tract)
- Intestine (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Esophagus (Gastrointestinal Tract)
-
Adrenal Gland (Endocrine System)
-
Lung (Respiratory System)
-
Gall Bladder (Hepatobiliary System)
-
Spleen (Hematopoietic System)
-
Prostate (Endocrine System)
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for ITGB1 Gene
This gene is overexpressed in Artery - Aorta (x4.1).
This gene is overexpressed in Amniocyte (7.7) and Seminal vesicle (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ITGB1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ITGB1 Gene:
ITGB1SOURCE GeneReport for Unigene cluster for ITGB1 Gene:
Hs.643813mRNA Expression by UniProt/SwissProt for ITGB1 Gene:
P05556-ITB1_HUMAN
Tissue specificity:
Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform 4, rather than isoform 3, is selectively expressed in peripheral T-cells. Isoform 3 is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle).
Evidence on tissue expression from TISSUES for ITGB1 Gene
- Muscle(4.9)
- Skin(4.9)
- Liver(4.8)
- Bone marrow(4.7)
- Heart(4.7)
- Nervous system(4.7)
- Lung(4.3)
- Intestine(4)
- Pancreas(3.8)
- Kidney(3.7)
- Bone(3.5)
- Blood(3.2)
- Spleen(3.1)
- Lymph node(2.8)
- Eye(2.7)
- Adrenal gland(2.3)
- Gall bladder(2.3)
- Stomach(2.2)
Primer Products
-
OriGene qPCR primer pairs for ITGB1
-
OriGene qPCR primer pairs and template standards for ITGB1
- genomics-online: primer clones - Search results for available LOC100009173 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGB1 Gene
Orthologs for ITGB1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ITGB1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ITGB1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ITGB1 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ITGB1 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Itgb1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Itgb1 33 |
|
||
| chicken (Gallus gallus) |
Aves | ITGB1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ITGB1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | itgb1 33 |
|
||
| MGC76178 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7623 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | itgb1b 34 |
|
OneToMany | |
| itgb1a 33 34 |
|
||||
| itgb1b.1 34 |
|
OneToMany | |||
| itgb1b.2 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | mys 35 33 34 |
|
||
| bgrInt-ngr 35 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | INTB 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | pat-3 35 33 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.871 34 |
|
OneToMany |
- Species where no ortholog for ITGB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
