This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2... See more...

Aliases for ITGAX Gene

Aliases for ITGAX Gene

  • Integrin Subunit Alpha X 2 3 5
  • Integrin, Alpha X (Complement Component 3 Receptor 4 Subunit) 2 3
  • Integrin, Alpha X (Antigen CD11C (P150), Alpha Polypeptide) 2 3
  • Leukocyte Adhesion Glycoprotein P150,95 Alpha Chain 3 4
  • Complement Component 3 Receptor 4 Subunit 2 3
  • Leukocyte Adhesion Receptor P150,95 3 4
  • CD11 Antigen-Like Family Member C 3 4
  • Integrin Alpha-X 3 4
  • CD11C 3 4
  • Leukocyte Surface Antigen P150,95, Alpha Subunit 3
  • Myeloid Membrane Antigen, Alpha Subunit 3
  • P150 95 Integrin Alpha Chain 3
  • Leu M5, Alpha Subunit 3
  • Integrin Alpha X 3
  • CD11c Antigen 4
  • Leu M5 4
  • SLEB6 3
  • ITGAX 5
  • CD11c 2

External Ids for ITGAX Gene

Previous HGNC Symbols for ITGAX Gene

  • CD11C

Previous GeneCards Identifiers for ITGAX Gene

  • GC16P030448
  • GC16P031863
  • GC16P031363
  • GC16P031402
  • GC16P031274
  • GC16P031366
  • GC16P028926
  • GC16P031379
  • GC16P031432

Summaries for ITGAX Gene

Entrez Gene Summary for ITGAX Gene

  • This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for ITGAX Gene

ITGAX (Integrin Subunit Alpha X) is a Protein Coding gene. Diseases associated with ITGAX include Hairy Cell Leukemia and Benign Cephalic Histiocytosis. Among its related pathways are Integrin Pathway and Degradation of the extracellular matrix. An important paralog of this gene is ITGAD.

UniProtKB/Swiss-Prot Summary for ITGAX Gene

  • Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

Gene Wiki entry for ITGAX Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ITGAX Gene

Genomics for ITGAX Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ITGAX Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ITGAX on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ITGAX

Top Transcription factor binding sites by QIAGEN in the ITGAX gene promoter:
  • c-Myb
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • NRSF form 1
  • NRSF form 2
  • Sp1

Genomic Locations for ITGAX Gene

Genomic Locations for ITGAX Gene
chr16:31,355,134-31,382,999
(GRCh38/hg38)
Size:
27,866 bases
Orientation:
Plus strand
chr16:31,366,455-31,394,318
(GRCh37/hg19)
Size:
27,864 bases
Orientation:
Plus strand

Genomic View for ITGAX Gene

Genes around ITGAX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGAX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGAX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGAX Gene

Proteins for ITGAX Gene

  • Protein details for ITGAX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20702-ITAX_HUMAN
    Recommended name:
    Integrin alpha-X
    Protein Accession:
    P20702
    Secondary Accessions:
    • Q8IVA6

    Protein attributes for ITGAX Gene

    Size:
    1163 amino acids
    Molecular mass:
    127829 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2.

    Three dimensional structures from OCA and Proteopedia for ITGAX Gene

neXtProt entry for ITGAX Gene

Post-translational modifications for ITGAX Gene

  • Glycosylation at Asn61, Asn89, Asn392, Asn697, Asn735, Asn899, Asn904, Asn939, and Asn1050
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for ITGAX Gene

Antibody Products

No data available for DME Specific Peptides for ITGAX Gene

Domains & Families for ITGAX Gene

Gene Families for ITGAX Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ITGAX Gene

InterPro:
Blocks:
  • Von Willebrand factor type A domain signature
  • Integrins alpha chain
  • Integrin alpha chain, C-terminal cytoplasmic region
  • FG-GAP
ProtoNet:

Suggested Antigen Peptide Sequences for ITGAX Gene

GenScript: Design optimal peptide antigens:
  • Leukocyte adhesion receptor p150,95 (ITAX_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P20702

UniProtKB/Swiss-Prot:

ITAX_HUMAN :
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Belongs to the integrin alpha chain family.
Domain:
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Family:
  • Belongs to the integrin alpha chain family.
genes like me logo Genes that share domains with ITGAX: view

Function for ITGAX Gene

Molecular function for ITGAX Gene

UniProtKB/Swiss-Prot Function:
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
GENATLAS Biochemistry:
integrin,alpha X,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,dimerizing with ITGB2 in fibrinogen,C3b receptor

Phenotypes From GWAS Catalog for ITGAX Gene

Gene Ontology (GO) - Molecular Function for ITGAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding TAS 8020569
GO:0005515 protein binding IPI 17726152
GO:0030971 receptor tyrosine kinase binding IPI 30873824
GO:0038023 signaling receptor activity TAS 2303426
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ITGAX: view
genes like me logo Genes that share phenotypes with ITGAX: view

Animal Models for ITGAX Gene

MGI Knock Outs for ITGAX:

Animal Model Products

  • Taconic Biosciences Mouse Models for ITGAX

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGAX

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGAX Gene

Localization for ITGAX Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGAX Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITGAX gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 4
nucleus 3
endosome 3
lysosome 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ITGAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008305 integrin complex IEA,TAS 2303426
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 19234460
GO:0016020 membrane IEA,HDA 19946888
genes like me logo Genes that share ontologies with ITGAX: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ITGAX Gene

Pathways & Interactions for ITGAX Gene

PathCards logo

SuperPathways for ITGAX Gene

SuperPathway Contained pathways
1 MAPK Erk Pathway
2 Apoptotic Pathways in Synovial Fibroblasts
.66
.65
.64
.62
.57
3 ERK Signaling
.61
.61
.58
.51
.49
4 Integrin Pathway
.67
.67
.56
.56
.38
5 Actin Nucleation by ARP-WASP Complex
.66
.66
.41
.35
genes like me logo Genes that share pathways with ITGAX: view

Pathways by source for ITGAX Gene

3 GeneGo (Thomson Reuters) pathways for ITGAX Gene
  • Immune response Alternative complement pathway
  • Immune response Classical complement pathway
  • Immune response Lectin induced complement pathway
35 Qiagen pathways for ITGAX Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Agrin Interactions at Neuromuscular Junction
  • Akt Signaling

SIGNOR curated interactions for ITGAX Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ITGAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA,TAS 2303426
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0008284 positive regulation of cell proliferation IMP 30873824
GO:0009887 animal organ morphogenesis TAS 3327687
GO:0010628 positive regulation of gene expression IEA,ISS --
genes like me logo Genes that share ontologies with ITGAX: view

Drugs & Compounds for ITGAX Gene

(10) Drugs for ITGAX Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Efalizumab Approved, Investigational Pharma Target, antibody 0

(10) Additional Compounds for ITGAX Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ITGAX: view

Transcripts for ITGAX Gene

mRNA/cDNA for ITGAX Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGAX

Alternative Splicing Database (ASD) splice patterns (SP) for ITGAX Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^
SP1: - -
SP2: - -
SP3: -
SP4:
SP5:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32
SP1: -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for ITGAX Gene

GeneLoc Exon Structure for
ITGAX

Expression for ITGAX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ITGAX Gene

mRNA differential expression in normal tissues according to GTEx for ITGAX Gene

This gene is overexpressed in Whole Blood (x33.9) and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for ITGAX Gene

This gene is overexpressed in Lymph node (18.9), Monocytes (15.7), and Lung (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ITGAX Gene



Protein tissue co-expression partners for ITGAX Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ITGAX

SOURCE GeneReport for Unigene cluster for ITGAX Gene:

Hs.248472

mRNA Expression by UniProt/SwissProt for ITGAX Gene:

P20702-ITAX_HUMAN
Tissue specificity: Predominantly expressed in monocytes and granulocytes.

Evidence on tissue expression from TISSUES for ITGAX Gene

  • Blood(4.8)
  • Liver(4.6)
  • Spleen(4.3)
  • Lymph node(4.2)
  • Bone marrow(3.9)
  • Intestine(3.6)
  • Lung(3.3)
  • Nervous system(3.2)
  • Skin(3)
  • Kidney(2.9)
  • Heart(2.8)
  • Bone(2.8)
  • Pancreas(2.6)
  • Muscle(2.6)
  • Eye(2.4)
  • Thyroid gland(2.4)
  • Stomach(2.4)
genes like me logo Genes that share expression patterns with ITGAX: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGAX Gene

Orthologs for ITGAX Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGAX Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ITGAX 30 31
  • 98.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ITGAX 30 31
  • 81.47 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Itgax 30 17 31
  • 76.94 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Itgax 30
  • 76.59 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 60 (a)
ManyToMany
-- 31
  • 60 (a)
ManyToMany
-- 31
  • 56 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 56 (a)
ManyToMany
-- 31
  • 54 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 47 (a)
ManyToMany
-- 31
  • 46 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-32n7.4 31
  • 36 (a)
ManyToMany
Species where no ortholog for ITGAX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ITGAX Gene

ENSEMBL:
Gene Tree for ITGAX (if available)
TreeFam:
Gene Tree for ITGAX (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ITGAX: view image

Paralogs for ITGAX Gene

(5) SIMAP similar genes for ITGAX Gene using alignment to 2 proteins:

  • ITAX_HUMAN
  • H3BN02_HUMAN

Pseudogenes.org Pseudogenes for ITGAX Gene

genes like me logo Genes that share paralogs with ITGAX: view

Variants for ITGAX Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ITGAX Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
708897 Benign: not provided 31,363,009(+) C/T SYNONYMOUS_VARIANT
718239 Likely Benign: not provided 31,362,633(+) C/T SYNONYMOUS_VARIANT
725689 Benign: not provided 31,362,967(+) C/T SYNONYMOUS_VARIANT
729197 Likely Benign: not provided 31,363,038(+) G/A MISSENSE_VARIANT
735739 Likely Benign: not provided 31,380,304(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ITGAX Gene

Structural Variations from Database of Genomic Variants (DGV) for ITGAX Gene

Variant ID Type Subtype PubMed ID
dgv503e214 CNV gain 21293372
esv2714194 CNV deletion 23290073
nsv1059610 CNV gain 25217958
nsv1061980 CNV gain 25217958
nsv833194 CNV loss 17160897

Variation tolerance for ITGAX Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.29; 94.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITGAX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGAX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGAX Gene

Disorders for ITGAX Gene

MalaCards: The human disease database

(39) MalaCards diseases for ITGAX Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hairy cell leukemia
  • hcl-v
benign cephalic histiocytosis
sporotrichosis
  • rose gardener's disease
leukocyte adhesion deficiency, type i
  • lad
histiocytosis
  • chronic histiocytosis x
- elite association - COSMIC cancer census association via MalaCards
Search ITGAX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ITGAX

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ITGAX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGAX Gene

Publications for ITGAX Gene

  1. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. (PMID: 18204098) Hom G … Behrens TW (The New England journal of medicine 2008) 3 23 41
  2. Haplotype analysis of the CD11 gene cluster in patients with chronic Helicobacter pylori infection and gastric ulcer disease. (PMID: 15730520) Hellmig S … Schreiber S (Tissue antigens 2005) 3 23 41
  3. Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule. (PMID: 2303426) Corbi AL … Springer TA (The Journal of biological chemistry 1990) 2 3 4
  4. A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PMID: 20962850) Budarf ML … Rioux JD (Genes and immunity 2011) 3 41
  5. Structure of an integrin with an alphaI domain, complement receptor type 4. (PMID: 20033057) Xie C … Springer TA (The EMBO journal 2010) 3 4

Products for ITGAX Gene

  • Addgene plasmids for ITGAX

Sources for ITGAX Gene