Aliases for ITGAX Gene
Aliases for ITGAX Gene
- Integrin Subunit Alpha X 2 3 5
- Integrin, Alpha X (Complement Component 3 Receptor 4 Subunit) 2 3
- Integrin, Alpha X (Antigen CD11C (P150), Alpha Polypeptide) 2 3
- Leukocyte Adhesion Glycoprotein P150,95 Alpha Chain 3 4
- Complement Component 3 Receptor 4 Subunit 2 3
- Leukocyte Adhesion Receptor P150,95 3 4
- CD11 Antigen-Like Family Member C 3 4
- CD11C 3 4
- Leukocyte Surface Antigen P150,95, Alpha Subunit 3
External Ids for ITGAX Gene
- HGNC: 6152
- Entrez Gene: 3687
- Ensembl: ENSG00000140678
- OMIM: 151510
- UniProtKB: P20702
Previous HGNC Symbols for ITGAX Gene
- CD11C
Previous GeneCards Identifiers for ITGAX Gene
- GC16P030448
- GC16P031863
- GC16P031363
- GC16P031402
- GC16P031274
- GC16P028926
Summaries for ITGAX Gene
-
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
GeneCards Summary for ITGAX Gene
ITGAX (Integrin Subunit Alpha X) is a Protein Coding gene. Diseases associated with ITGAX include Hairy Cell Leukemia and Benign Cephalic Histiocytosis. Among its related pathways are Cytokine Signaling in Immune system and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include receptor activity. An important paralog of this gene is ITGAD.
UniProtKB/Swiss-Prot for ITGAX Gene
-
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
Additional gene information for ITGAX Gene
- Monarch Initiative
- Search for ITGAX at DataMed
- Search for ITGAX at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGAX Gene
Genomics for ITGAX Gene
GeneHancer (GH) Regulatory Elements for ITGAX Gene
Promoters and enhancers for ITGAX Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ITGAX on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ITGAX gene promoter:
Regulatory Element Products
Genomic Locations for ITGAX Gene
Genomic Locations for ITGAX Gene
- chr16:31,355,134-31,382,997
- (GRCh38/hg38)
- Size:
- 27,864 bases
- Orientation:
- Plus strand
- chr16:31,366,455-31,394,318
- (GRCh37/hg19)
Genomic View for ITGAX Gene
Genes around ITGAX on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by Ensembl
- 16p11.2 by Entrez Gene
- 16p11.2 by HGNC
ITGAX Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ITGAX Gene
Proteins for ITGAX Gene
-
Protein details for ITGAX Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P20702-ITAX_HUMAN
- Recommended name:
- Integrin alpha-X
- Protein Accession:
- P20702
- Q8IVA6
Protein attributes for ITGAX Gene
- Size:
- 1163 amino acids
- Molecular mass:
- 127829 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2.
Protein Expression for ITGAX Gene
Post-translational modifications for ITGAX Gene
- Glycosylation at posLast=6161, isoforms=89, posLast=392392, isoforms=697, isoforms=735, isoforms=899, posLast=904904, isoforms=939, and isoforms=1050
Other Protein References for ITGAX Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ITGAX (CD11c)
-
Custom Antibody ServicesOriGene Antibodies for ITGAX
- Novus Biologicals Antibodies for ITGAX
-
Cloud-Clone Corp. Antibodies for ITGAX
- Invitrogen Antibodies for ITGAX
- antibodies-online: Search results for 672 available ITGAX Antibodies ranked by validation data
- Compare Top ITGAX Antibodies
-
Recommended
- 1 MA Antibody (anti-human)
- 1 ICFC Antibody (anti-human)
- 1 IHC (zinc) Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 2 BCA Antibodies (anti-human)
- 13 IF Antibodies (anti-human)
- 34 IP Antibodies (anti-human)
- 34 IHC Antibodies (anti-human)
- 49 IHC (fro) Antibodies (anti-human)
- 73 IHC (p) Antibodies (anti-human)
- 109 WB Antibodies (anti-human)
- 123 FACS Antibodies (anti-human)
- 1 IHC Antibody (anti-rat)
- 2 IP Antibodies (anti-rat)
- 5 WB Antibodies (anti-rat)
- 2 ICFC Antibodies (anti-mouse)
- 3 IF Antibodies (anti-mouse)
- 3 BCA Antibodies (anti-mouse)
- 7 IHC Antibodies (anti-mouse)
- 10 WB Antibodies (anti-mouse)
- 15 IHC (p) Antibodies (anti-mouse)
- 19 IHC (fro) Antibodies (anti-mouse)
- 30 IP Antibodies (anti-mouse)
- 107 FACS Antibodies (anti-mouse)
- 1 MA Antibody (anti-human)
- 1 ICFC Antibody (anti-human)
- 1 IHC (zinc) Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 2 BCA Antibodies (anti-human)
- 13 IF Antibodies (anti-human)
- 34 IP Antibodies (anti-human)
- 34 IHC Antibodies (anti-human)
- 49 IHC (fro) Antibodies (anti-human)
- 73 IHC (p) Antibodies (anti-human)
- 109 WB Antibodies (anti-human)
- 123 FACS Antibodies (anti-human)
- 1 IHC Antibody (anti-rat)
- 2 IP Antibodies (anti-rat)
- 5 WB Antibodies (anti-rat)
- 2 ICFC Antibodies (anti-mouse)
- 3 IF Antibodies (anti-mouse)
- 3 BCA Antibodies (anti-mouse)
- 7 IHC Antibodies (anti-mouse)
- 10 WB Antibodies (anti-mouse)
- 15 IHC (p) Antibodies (anti-mouse)
- 19 IHC (fro) Antibodies (anti-mouse)
- 30 IP Antibodies (anti-mouse)
- 107 FACS Antibodies (anti-mouse)
- GeneTex ITGAX antibody for ITGAX
-
Santa Cruz Biotechnology (SCBT) Antibodies for ITGAX
Protein Products
- R&D Systems Proteins and Enzymes for ITGAX (Integrin alpha X beta 2)
- R&D Systems Proteins and Enzymes for ITGAX (CD11c)
-
OriGene Purified Proteins for ITGAX
- Search Origene for MassSpec and Protein Over-expression Lysates for ITGAX
- Origene Custom Protein Services for ITGAX
- Novus Biologicals proteins for ITGAX
-
Cloud-Clone Corp. Proteins for ITGAX
- Search GeneTex for Proteins for ITGAX
-
Abcam proteins for ITGAX
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for ITGAX (CD11c)
No data available for DME Specific Peptides for ITGAX Gene
Domains & Families for ITGAX Gene
Gene Families for ITGAX Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for ITGAX Gene
Suggested Antigen Peptide Sequences for ITGAX Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P20702UniProtKB/Swiss-Prot:
ITAX_HUMAN :- The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
- Belongs to the integrin alpha chain family.
- Domain:
-
- The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
- Family:
-
- Belongs to the integrin alpha chain family.
Function for ITGAX Gene
Molecular function for ITGAX Gene
- GENATLAS Biochemistry:
- integrin,alpha X,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,dimerizing with ITGB2 in fibrinogen,C3b receptor
- UniProtKB/Swiss-Prot Function:
- Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
Phenotypes From GWAS Catalog for ITGAX Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004872 | receptor activity | TAS | 2303426 |
| GO:0005515 | protein binding | IPI | 17726152 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ITGAX Gene
- MGI mutant phenotypes for ITGAX:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for ITGAX:
Animal Models for ITGAX Gene
- MGI Knock Outs for ITGAX:
-
- Itgax tm1Bll
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ITGAX
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ITGAX gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGAX gene
- Search ViGene Biosciences for ITGAX
CRISPR Products
-
OriGene CRISPR knockouts for ITGAX
- genomics-online: gRNA clones - Search results for available ITGAX gene related products
- Applied Biological Materials CRISPR for ITGAX
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ITGAX
- GenScript: Design CRISPR guide RNA sequences for ITGAX
miRNA for ITGAX Gene
- miRTarBase miRNAs that target ITGAX
-
- hsa-mir-26b-5p (MIRT030204)
- hsa-mir-122-3p (MIRT761277)
- hsa-mir-1247-3p (MIRT761544)
- hsa-mir-25-5p (MIRT764229)
- hsa-mir-377-5p (MIRT767413)
- hsa-mir-4459 (MIRT769287)
- hsa-mir-4537 (MIRT770165)
- hsa-mir-455-3p (MIRT770343)
- hsa-mir-6086 (MIRT775544)
- hsa-mir-6087 (MIRT775670)
- hsa-mir-6499-3p (MIRT776282)
- hsa-mir-6516-5p (MIRT777141)
- hsa-mir-658 (MIRT777346)
miRNA Products
- Search ViGene Biosciences for ITGAX
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ITGAX
- Browse OriGene Inhibitory RNA Products For ITGAX
- genomics-online: shRNA clones - Search results for available ITGAX gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGAX gene
Clone Products
- Sino Biological Human cDNA Clone for ITGAX
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ITGAX
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ITGAX
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ITGAX
- genomics-online: cdna clones - Search results for available ITGAX gene related products
- orf clones - Search results for available ITGAX gene related products
- Applied Biological Materials Clones for ITGAX
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ITGAX (CD11c)
Cell Line Products
-
Horizon Cell Lines for ITGAX
-
ViGene Biosciences adenoviral particle packaged cDNA for ITGAX gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ITGAX gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGAX gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGAX Gene
Localization for ITGAX Gene
Subcellular locations from UniProtKB/Swiss-Prot for ITGAX Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| nucleus | 2 |
| lysosome | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0008305 | integrin complex | IEA | -- |
| GO:0009897 | external side of plasma membrane | IEA | -- |
| GO:0009986 | cell surface | IDA | 19234460 |
| GO:0016020 | membrane | HDA,IEA | 19946888 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ITGAX Gene
Pathways & Interactions for ITGAX Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MAPK-Erk Pathway |
.38
|
.38
.38
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
.66
.65
|
.57
|
| 3 | ERK Signaling |
.61
.58
|
.49
|
| 4 | Integrin Pathway |
.67
.67
.56
|
.56
|
| 5 | Actin Nucleation by ARP-WASP Complex |
.41
.35
|
|
Pathways by source for ITGAX Gene
8 Sino Biological pathways for ITGAX Gene
2 BioSystems pathways for ITGAX Gene
11 Reactome pathways for ITGAX Gene
3 KEGG pathways for ITGAX Gene
3 GeneGo (Thomson Reuters) pathways for ITGAX Gene
2 R&D Systems pathways for ITGAX Gene
Interacting Proteins for ITGAX Gene
Selected Interacting proteins:
P20702-ITAX_HUMAN
ENSP00000268296
for ITGAX Gene via
IID
UniProtKB
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | IEA,TAS | 2303426 |
| GO:0007229 | integrin-mediated signaling pathway | IEA | -- |
| GO:0009887 | animal organ morphogenesis | TAS | 3327687 |
| GO:0030198 | extracellular matrix organization | TAS | -- |
| GO:0034113 | heterotypic cell-cell adhesion | IMP | 20563599 |
Transcripts for ITGAX Gene
mRNA/cDNA for ITGAX Gene
- (4) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (45) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ITGAX Gene
CRISPR Products
-
OriGene CRISPR knockouts for ITGAX
- genomics-online: gRNA clones - Search results for available ITGAX gene related products
- Applied Biological Materials CRISPR for ITGAX
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ITGAX
- GenScript: Design CRISPR guide RNA sequences for ITGAX
miRNA Products
- Search ViGene Biosciences for ITGAX
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ITGAX
- Browse OriGene Inhibitory RNA Products For ITGAX
- genomics-online: shRNA clones - Search results for available ITGAX gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGAX gene
Clone Products
- Sino Biological Human cDNA Clone for ITGAX
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ITGAX
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ITGAX
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ITGAX
- genomics-online: cdna clones - Search results for available ITGAX gene related products
- orf clones - Search results for available ITGAX gene related products
- Applied Biological Materials Clones for ITGAX
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ITGAX (CD11c)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
| ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||
| SP5: |
Expression for ITGAX Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- pre Conventional Dendritic Cells Peripheral Blood
- Common Dendritic Cell Precursors Hematopoietic Bone Marrow
- Conventional Dendritic Cells I Spleen
- Conventional Dendritic Cells II Spleen
- Facilitating cells
- Spleen (Hematopoietic System)
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for ITGAX Gene
This gene is overexpressed in Whole Blood (x33.9) and Spleen (x4.7).
This gene is overexpressed in Lymph node (18.9), Monocytes (15.7), and Lung (11.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ITGAX Gene
NURSA nuclear receptor signaling pathways regulating expression of ITGAX Gene:
ITGAXSOURCE GeneReport for Unigene cluster for ITGAX Gene:
Hs.248472mRNA Expression by UniProt/SwissProt for ITGAX Gene:
P20702-ITAX_HUMAN
Tissue specificity:
Predominantly expressed in monocytes and granulocytes.
Evidence on tissue expression from TISSUES for ITGAX Gene
- Blood(4.7)
- Liver(4.4)
- Spleen(4.1)
- Lymph node(4)
- Bone marrow(3.4)
- Intestine(3)
- Lung(2.9)
- Skin(2.5)
- Nervous system(2.4)
Primer Products
-
OriGene qPCR primer pairs for ITGAX
- genomics-online: primer clones - Search results for available ITGAX gene related products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGAX Gene
Orthologs for ITGAX Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ITGAX 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ITGAX 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Itgax 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Itgax 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | si:dkey-32n7.4 34 |
|
ManyToMany |
- Species where no ortholog for ITGAX was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ITGAX Gene
Paralogs for ITGAX Gene
(5) SIMAP similar genes for ITGAX Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for ITGAX Gene
Variants for ITGAX Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000145527 | -- | 31,376,223(+) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000200595 | -- | 31,373,783(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000211681 | -- | 31,368,603(+) | A/T | intron_variant | |
| rs1000391622 | -- | 31,370,154(+) | C/T | intron_variant | |
| rs1000404770 | -- | 31,379,529(+) | A/G | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv833194 | CNV | loss | 17160897 |
| nsv1061980 | CNV | gain | 25217958 |
| nsv1059610 | CNV | gain | 25217958 |
| esv2714194 | CNV | deletion | 23290073 |
| dgv503e214 | CNV | gain | 21293372 |
Residual Variation Intolerance Score:
15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
12.29;
94.09% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ITGAX Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ITGAX
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGAX Gene
Disorders for ITGAX Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hairy cell leukemia |
|
|
| benign cephalic histiocytosis |
|
|
| histiocytosis |
|
|
| lymphocytic vasculitis |
|
|
| mantle cell lymphoma |
|
|
Search ITGAX in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ITGAX
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ITGAX Gene
Publications for ITGAX Gene
- Haplotype analysis of the CD11 gene cluster in patients with chronic Helicobacter pylori infection and gastric ulcer disease. (PMID: 15730520) Hellmig S … Schreiber S (Tissue antigens 2005) 3 22 44 58
- Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule. (PMID: 2303426) Corbi AL … Springer TA (The Journal of biological chemistry 1990) 2 3 4 58
- A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PMID: 20962850) Budarf ML … Rioux JD (Genes and immunity 2011) 3 44 58
- Structure of an integrin with an alphaI domain, complement receptor type 4. (PMID: 20033057) Xie C … Springer TA (The EMBO journal 2010) 3 4 58
- Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c. (PMID: 19800635) Brummett BH … Williams RB (Journal of psychiatric research 2010) 3 22 58
Products for ITGAX Gene
- R&D Systems Antibodies for ITGAX (CD11c)
- R&D Systems Proteins and Enzymes for ITGAX (CD11c)
- R&D Systems Proteins and Enzymes for ITGAX (Integrin alpha X beta 2)
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for ITGAX (CD11c)
- R&D Systems cDNA Clones for ITGAX (CD11c)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for ITGAX
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ITGAX
- Search Origene for MassSpec and Protein Over-expression Lysates for ITGAX
- Origene Custom Protein Services for ITGAX
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ITGAX
- Browse OriGene Inhibitory RNA Products For ITGAX
- OriGene qPCR primer pairs for ITGAX
- OriGene CRISPR knockouts for ITGAX
- OriGene ORF clones in human for ITGAX
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ITGAX
- GenScript: Next-day shipping of latest version cDNA ORF clones for ITGAX in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ITGAX
- GenScript Custom Assay Services for ITGAX
- GenScript Custom overexpressing Cell Line Services for ITGAX
- GenScript: Design CRISPR guide RNA sequences for ITGAX
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ITGAX
- Sino Biological Human cDNA Clone for ITGAX
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for ITGAX
- Novus Biologicals proteins for ITGAX
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for ITGAX
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for ITGAX
- Cloud-Clone Corp. Proteins for ITGAX
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for ITGAX
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for ITGAX
- VectorBuilder custom plasmid, inducible vectors for ITGAX
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ITGAX
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ITGAX
- antibodies-online: Search results for 672 available ITGAX Antibodies ranked by validation data
- Compare Top ITGAX Antibodies
- Recommended
- 107 FACS Antibodies (anti-mouse)
- 30 IP Antibodies (anti-mouse)
- 19 IHC (fro) Antibodies (anti-mouse)
- 15 IHC (p) Antibodies (anti-mouse)
- 10 WB Antibodies (anti-mouse)
- 7 IHC Antibodies (anti-mouse)
- 3 BCA Antibodies (anti-mouse)
- 3 IF Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 5 WB Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 123 FACS Antibodies (anti-human)
- 109 WB Antibodies (anti-human)
- 73 IHC (p) Antibodies (anti-human)
- 49 IHC (fro) Antibodies (anti-human)
- 34 IHC Antibodies (anti-human)
- 34 IP Antibodies (anti-human)
- 13 IF Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC (zinc) Antibody (anti-human)
- 1 ICFC Antibody (anti-human)
- 1 MA Antibody (anti-human)
- 107 FACS Antibodies (anti-mouse)
- 30 IP Antibodies (anti-mouse)
- 19 IHC (fro) Antibodies (anti-mouse)
- 15 IHC (p) Antibodies (anti-mouse)
- 10 WB Antibodies (anti-mouse)
- 7 IHC Antibodies (anti-mouse)
- 3 BCA Antibodies (anti-mouse)
- 3 IF Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 5 WB Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 123 FACS Antibodies (anti-human)
- 109 WB Antibodies (anti-human)
- 73 IHC (p) Antibodies (anti-human)
- 49 IHC (fro) Antibodies (anti-human)
- 34 IHC Antibodies (anti-human)
- 34 IP Antibodies (anti-human)
- 13 IF Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC (zinc) Antibody (anti-human)
- 1 ICFC Antibody (anti-human)
- 1 MA Antibody (anti-human)
- antibodies-online: Search results for 1 available ITGAX Elisa Kits ranked by validation data
- Compare Top ITGAX Elisa Kits
- antibodies-online: Search results for 7 available ITGAX Proteins ranked by validation data
- Compare Top ITGAX Proteins
- GeneTex ITGAX antibody for ITGAX
- Search GeneTex for Proteins for ITGAX
- ViGene Biosciences adenoviral particle packaged cDNA for ITGAX gene
- ViGene Biosciences lentiviral particle packaged cDNA for ITGAX gene
- ViGene Biosciences ready-to-package AAV shRNAs for ITGAX gene
- Search ViGene Biosciences for ITGAX
- Santa Cruz Biotechnology (SCBT) Antibodies for ITGAX
- Search Santa Cruz Biotechnology (SCBT) for ITGAX siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ITGAX
- Horizon Cell Lines for ITGAX
- genomics-online: cdna clones - Search results for available ITGAX gene related products
- orf clones - Search results for available ITGAX gene related products
- genomics-online: gRNA clones - Search results for available ITGAX gene related products
- genomics-online: primer clones - Search results for available ITGAX gene related products
- genomics-online: shRNA clones - Search results for available ITGAX gene related products
Sources for ITGAX Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew