ITGAX Gene (Protein Coding)

Integrin Subunit Alpha X

GC16P031379
GIFtS:
45
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2... See more...

Aliases for ITGAX Gene

Aliases for ITGAX Gene

  • Integrin Subunit Alpha X 2 3 5
  • Integrin, Alpha X (Complement Component 3 Receptor 4 Subunit) 2 3
  • Integrin, Alpha X (Antigen CD11C (P150), Alpha Polypeptide) 2 3
  • Leukocyte Adhesion Glycoprotein P150,95 Alpha Chain 3 4
  • Complement Component 3 Receptor 4 Subunit 2 3
  • Leukocyte Adhesion Receptor P150,95 3 4
  • CD11 Antigen-Like Family Member C 3 4
  • Integrin Alpha-X 3 4
  • CD11C 3 4
  • Leukocyte Surface Antigen P150,95, Alpha Subunit 3
  • Myeloid Membrane Antigen, Alpha Subunit 3
  • P150 95 Integrin Alpha Chain 3
  • Leu M5, Alpha Subunit 3
  • Integrin Alpha X 3
  • CD11c Antigen 4
  • Leu M5 4
  • SLEB6 3

External Ids for ITGAX Gene

Previous HGNC Symbols for ITGAX Gene

  • CD11C

Previous GeneCards Identifiers for ITGAX Gene

  • GC16P030448
  • GC16P031863
  • GC16P031363
  • GC16P031402
  • GC16P031274
  • GC16P031366
  • GC16P028926

Summaries for ITGAX Gene

Entrez Gene Summary for ITGAX Gene

  • This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for ITGAX Gene

ITGAX (Integrin Subunit Alpha X) is a Protein Coding gene. Diseases associated with ITGAX include Hairy Cell Leukemia and Benign Cephalic Histiocytosis. Among its related pathways are MAPK-Erk Pathway and Cytokine Signaling in Immune system. An important paralog of this gene is ITGAD.

UniProtKB/Swiss-Prot Summary for ITGAX Gene

  • Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

Gene Wiki entry for ITGAX Gene

Additional gene information for ITGAX Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ITGAX Gene

Genomics for ITGAX Gene

GeneHancer (GH) Regulatory Elements for ITGAX Gene

Promoters and enhancers for ITGAX Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ITGAX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ITGAX gene promoter:
  • c-Myb
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • NRSF form 1
  • NRSF form 2
  • Sp1

Genomic Locations for ITGAX Gene

Genomic Locations for ITGAX Gene
chr16:31,355,134-31,382,997
(GRCh38/hg38)
Size:
27,864 bases
Orientation:
Plus strand
chr16:31,366,455-31,394,318
(GRCh37/hg19)
Size:
27,864 bases
Orientation:
Plus strand

Genomic View for ITGAX Gene

Genes around ITGAX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGAX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGAX Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ITGAX Gene

Proteins for ITGAX Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ITGAX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20702-ITAX_HUMAN
    Recommended name:
    Integrin alpha-X
    Protein Accession:
    P20702
    Secondary Accessions:
    • Q8IVA6

    Protein attributes for ITGAX Gene

    Size:
    1163 amino acids
    Molecular mass:
    127829 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2.

    Three dimensional structures from OCA and Proteopedia for ITGAX Gene

neXtProt entry for ITGAX Gene

Protein Expression for ITGAX Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ITGAX Gene

  • Glycosylation at Asn61, Asn89, Asn392, Asn697, Asn735, Asn899, Asn904, Asn939, and Asn1050
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for ITGAX Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ITGAX Gene

Domains & Families for ITGAX Gene

Gene Families for ITGAX Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for ITGAX Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ITGAX Gene

GenScript: Design optimal peptide antigens:
  • Leukocyte adhesion receptor p150,95 (ITAX_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P20702

UniProtKB/Swiss-Prot:

ITAX_HUMAN :
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Belongs to the integrin alpha chain family.
Domain:
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Family:
  • Belongs to the integrin alpha chain family.
genes like me logo Genes that share domains with ITGAX: view

Function for ITGAX Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ITGAX Gene

UniProtKB/Swiss-Prot Function:
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
GENATLAS Biochemistry:
integrin,alpha X,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,dimerizing with ITGB2 in fibrinogen,C3b receptor

Phenotypes From GWAS Catalog for ITGAX Gene

Gene Ontology (GO) - Molecular Function for ITGAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17726152
GO:0030971 receptor tyrosine kinase binding IPI 30873824
GO:0038023 signaling receptor activity TAS 2303426
GO:0046872 metal ion binding IEA --
GO:0046982 protein heterodimerization activity TAS 8020569
genes like me logo Genes that share ontologies with ITGAX: view
genes like me logo Genes that share phenotypes with ITGAX: view

Animal Models for ITGAX Gene

MGI Knock Outs for ITGAX:

Animal Model Products

  • Taconic Biosciences Mouse Models for ITGAX

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGAX

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGAX Gene

Localization for ITGAX Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGAX Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITGAX gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 3
nucleus 2
lysosome 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for ITGAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008305 integrin complex IEA --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 19234460
GO:0016020 membrane HDA,IEA 19946888
genes like me logo Genes that share ontologies with ITGAX: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ITGAX Gene

Pathways & Interactions for ITGAX Gene

PathCards logo

SuperPathways for ITGAX Gene

SuperPathway Contained pathways
1 MAPK-Erk Pathway
G Protein-coupled Receptors Signaling
.38
G Protein-coupled Receptors Signaling
.38
MAPK-Erk Pathway
.38
MAPK-Erk Pathway
.38
MAPK-Erk Pathway
.38
Actin Dynamics Signaling Pathway
.35
2 Apoptotic Pathways in Synovial Fibroblasts
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
Rap1 Pathway
.57
3 ERK Signaling
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
4 Integrin Pathway
FAK1 Signaling
.67
Integrin Pathway
.67
GnRH Signaling
.56
UPA-UPAR Pathway
.56
Transendothelial Migration of Leukocytes
.38
5 Actin Nucleation by ARP-WASP Complex
Actin Nucleation and Branching
.66
Actin Nucleation by ARP-WASP Complex
.66
CDC42 Pathway
.41
RhoA Pathway
.35
genes like me logo Genes that share pathways with ITGAX: view

Pathways by source for ITGAX Gene

2 BioSystems pathways for ITGAX Gene
35 Qiagen pathways for ITGAX Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Agrin Interactions at Neuromuscular Junction
  • Akt Signaling

SIGNOR curated interactions for ITGAX Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ITGAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS,IEA 2303426
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0008284 positive regulation of cell proliferation IMP 30873824
GO:0009887 animal organ morphogenesis TAS 3327687
GO:0010628 positive regulation of gene expression ISS,IEA --
genes like me logo Genes that share ontologies with ITGAX: view

Drugs & Compounds for ITGAX Gene

Products:

  1. Drug

(9) Drugs for ITGAX Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for ITGAX Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ITGAX: view

Transcripts for ITGAX Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ITGAX Gene

(2) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(45) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGAX

Alternative Splicing Database (ASD) splice patterns (SP) for ITGAX Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^
SP1: - -
SP2: - -
SP3: -
SP4:
SP5:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32
SP1: -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for ITGAX Gene

GeneLoc Exon Structure for
ITGAX
ECgene alternative splicing isoforms for
ITGAX

Expression for ITGAX Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ITGAX Gene

mRNA expression in normal human tissues for ITGAX Gene
mRNA expression by BioGPS for ITGAX GenemRNA expression by GTEx for ITGAX Gene

mRNA differential expression in normal tissues according to GTEx for ITGAX Gene

This gene is overexpressed in Whole Blood (x33.9) and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for ITGAX Gene

This gene is overexpressed in Lymph node (18.9), Monocytes (15.7), and Lung (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ITGAX Gene



Protein tissue co-expression partners for ITGAX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ITGAX Gene:

ITGAX

SOURCE GeneReport for Unigene cluster for ITGAX Gene:

Hs.248472

mRNA Expression by UniProt/SwissProt for ITGAX Gene:

P20702-ITAX_HUMAN
Tissue specificity: Predominantly expressed in monocytes and granulocytes.

Evidence on tissue expression from TISSUES for ITGAX Gene

  • Blood(4.7)
  • Liver(4.4)
  • Spleen(4.1)
  • Lymph node(4)
  • Bone marrow(3.4)
  • Intestine(3)
  • Lung(2.9)
  • Skin(2.5)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with ITGAX: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGAX Gene

Orthologs for ITGAX Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGAX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ITGAX 33 32
  • 98.56 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia ITGAX 33 32
  • 81.47 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Itgax 17 33 32
  • 76.94 (n)
rat
(Rattus norvegicus)
 Mammalia Itgax 32
  • 76.59 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 33
  • 60 (a)
 ManyToMany
-- 33
  • 60 (a)
 ManyToMany
-- 33
  • 56 (a)
 ManyToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 33
  • 56 (a)
 ManyToMany
-- 33
  • 54 (a)
 ManyToMany
-- 33
  • 52 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 33
  • 47 (a)
 ManyToMany
-- 33
  • 46 (a)
 ManyToMany
-- 33
  • 45 (a)
 ManyToMany
zebrafish
(Danio rerio)
 Actinopterygii si:dkey-32n7.4 33
  • 36 (a)
 ManyToMany
Species where no ortholog for ITGAX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGAX Gene

ENSEMBL:
Gene Tree for ITGAX (if available)
TreeFam:
Gene Tree for ITGAX (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ITGAX: view image

Paralogs for ITGAX Gene

Paralogs for ITGAX Gene

(5) SIMAP similar genes for ITGAX Gene using alignment to 2 proteins:

  • ITAX_HUMAN
  • H3BN02_HUMAN

Pseudogenes.org Pseudogenes for ITGAX Gene

genes like me logo Genes that share paralogs with ITGAX: view

Variants for ITGAX Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for ITGAX Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000145527 -- 31,376,223(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000200595 -- 31,373,783(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000211681 -- 31,368,603(+) A/G/T intron_variant
rs1000391622 -- 31,370,154(+) C/T intron_variant
rs1000404770 -- 31,379,529(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ITGAX Gene

Variant ID Type Subtype PubMed ID
dgv503e214 CNV gain 21293372
esv2714194 CNV deletion 23290073
nsv1059610 CNV gain 25217958
nsv1061980 CNV gain 25217958
nsv833194 CNV loss 17160897

Variation tolerance for ITGAX Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.29; 94.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITGAX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGAX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGAX Gene

Disorders for ITGAX Gene

MalaCards: The human disease database

(12) MalaCards diseases for ITGAX Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hairy cell leukemia
  • hcl-v
benign cephalic histiocytosis
lymphocytic vasculitis
  • vasculitis lymphocytic, nodular
mantle cell lymphoma
  • mcl
bladder lymphoma
  • lymphoma of the urinary bladder
- elite association - COSMIC cancer census association via MalaCards
Search ITGAX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ITGAX

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ITGAX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGAX Gene

Publications for ITGAX Gene

  1. Haplotype analysis of the CD11 gene cluster in patients with chronic Helicobacter pylori infection and gastric ulcer disease. (PMID: 15730520) Hellmig S … Schreiber S (Tissue antigens 2005) 3 23 43 56
  2. Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule. (PMID: 2303426) Corbi AL … Springer TA (The Journal of biological chemistry 1990) 2 3 4 56
  3. A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PMID: 20962850) Budarf ML … Rioux JD (Genes and immunity 2011) 3 43 56
  4. Structure of an integrin with an alphaI domain, complement receptor type 4. (PMID: 20033057) Xie C … Springer TA (The EMBO journal 2010) 3 4 56
  5. Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c. (PMID: 19800635) Brummett BH … Williams RB (Journal of psychiatric research 2010) 3 23 56

ExternalLinks

View latest publications for ITGAX gene in Mastermind

Products for ITGAX Gene

  • Addgene plasmids for ITGAX

Sources for ITGAX Gene