Aliases for ITGAM Gene
Aliases for ITGAM Gene
- Integrin Subunit Alpha M 2 3 5
- Integrin, Alpha M (Complement Component 3 Receptor 3 Subunit) 2 3
- Cell Surface Glycoprotein MAC-1 Subunit Alpha 3 4
- Complement Component 3 Receptor 3 Subunit 2 3
- CD11 Antigen-Like Family Member B 3 4
- Leukocyte Adhesion Receptor MO1 3 4
- CR-3 Alpha Chain 3 4
- CD11B 3 4
- CR3A 3 4
- Integrin, Alpha M (Complement Component Receptor 3, Alpha; Also Known As CD11b (P170), Macrophage Antigen Alpha Polypeptide) 2
- Neutrophil Adherence Receptor Alpha-M Subunit 3
External Ids for ITGAM Gene
- HGNC: 6149
- Entrez Gene: 3684
- Ensembl: ENSG00000169896
- OMIM: 120980
- UniProtKB: P11215
Previous HGNC Symbols for ITGAM Gene
- CR3A
- CD11B
Previous GeneCards Identifiers for ITGAM Gene
- GC16P030449
- GC16P031767
- GC16P031268
- GC16P031307
- GC16P031168
- GC16P028833
Summaries for ITGAM Gene
-
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
GeneCards Summary for ITGAM Gene
ITGAM (Integrin Subunit Alpha M) is a Protein Coding gene. Diseases associated with ITGAM include Systemic Lupus Erythematosus 6 and Granulocytopenia. Among its related pathways are Cytokine Signaling in Immune system and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is ITGAX.
UniProtKB/Swiss-Prot for ITGAM Gene
-
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity).
Additional gene information for ITGAM Gene
- Monarch Initiative
- Search for ITGAM at DataMed
- Search for ITGAM at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGAM Gene
Genomics for ITGAM Gene
GeneHancer (GH) Regulatory Elements for ITGAM Gene
Promoters and enhancers for ITGAM Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ITGAM on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ITGAM Gene
Genomic Locations for ITGAM Gene
- chr16:31,259,967-31,332,892
- (GRCh38/hg38)
- Size:
- 72,926 bases
- Orientation:
- Plus strand
- chr16:31,271,288-31,344,213
- (GRCh37/hg19)
Genomic View for ITGAM Gene
Genes around ITGAM on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by Ensembl
- 16p11.2 by Entrez Gene
- 16p11.2 by HGNC
ITGAM Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ITGAM Gene
Proteins for ITGAM Gene
-
Protein details for ITGAM Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P11215-ITAM_HUMAN
- Recommended name:
- Integrin alpha-M
- Protein Accession:
- P11215
- Q4VAK0
- Q4VAK1
- Q4VAK2
Protein attributes for ITGAM Gene
- Size:
- 1152 amino acids
- Molecular mass:
- 127179 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit. ITGAM associates with ITGB2. Found in a complex with CD177 and ITGB2/CD18 (PubMed:21193407). Interacts with JAM3 (PubMed:15194813, PubMed:12208882). Interacts with THBD (PubMed:27055590).
Three dimensional structures from OCA and Proteopedia for ITGAM Gene
Protein Expression for ITGAM Gene
Post-translational modifications for ITGAM Gene
- Glycosylation at posLast=8686, posLast=240240, isoforms=2391, isoforms=2469, isoforms=2692, isoforms=2696, isoforms=2734, posLast=801801, isoforms=2880, posLast=900900, isoforms=2911, posLast=940940, isoforms=2946, isoforms=2978, posLast=993993, isoforms=21021, posLast=10441044, isoforms=21050, and isoforms=21075
Other Protein References for ITGAM Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ITGAM (CD11b/Integrin alpha M)
- Cell Signaling Technology (CST) Antibodies for ITGAM (ITGAM)
-
Custom Antibody ServicesOriGene Antibodies for ITGAM
- CF807953
- TA807953
- CF807952
- TA807952
- TA353260
- TA336565
- TA336516
- TA323951
- TA323950
- TA320387
- TA320386
- TA320385
- TA303242
- SM3007R
- SM3007P
- SM3007F
- SM3007B
- SM3007AS
- SM3007AC
- SM1068RT
- SM1068R
- SM1068PT
- SM1068PS
- SM1068P
- SM1068FT
- SM1068F
- SM1068A
- BM4032B
- BM4032
- AP50837PU-N
- AP31807PU-N
- AM50206PU-T
- AM50206PU-S
- AM50206PU-N
- AM50205PU-T
- AM50205PU-S
- AM50205PU-N
- AM32402PU-N
- AM32402FC-N
- AM05517FC-N
- AM05208PU-N
- AM05208FC-N
- AM05208BT-N
- AM03120AF-N
- AM00640PU-N
- Novus Biologicals Antibodies for ITGAM
-
Abcam antibodies for ITGAM
-
Cloud-Clone Corp. Antibodies for ITGAM
- Invitrogen Antibodies for ITGAM
- antibodies-online: Search results for 1087 available CD11b Antibodies ranked by validation data
- Compare Top CD11b Antibodies
-
Recommended
- 19 IHC (p) Antibodies (anti-mouse)
- 6 IF Antibodies (anti-mouse)
- 4 ICFC Antibodies (anti-mouse)
- 2 Neut Antibodies (anti-mouse)
- 2 StM Antibodies (anti-mouse)
- 1 BCA Antibody (anti-mouse)
- 1 IC Antibody (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 1 ISt Antibody (anti-mouse)
- 1 in vitro Antibody (anti-mouse)
- 61 WB Antibodies (anti-rat)
- 52 FACS Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 19 IHC Antibodies (anti-rat)
- 14 IP Antibodies (anti-rat)
- 11 IHC (fro) Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 1 IHC (zinc) Antibody (anti-rat)
- 1 StM Antibody (anti-human)
- 1 MA Antibody (anti-human)
- 1 Func Antibody (anti-human)
- 3 IF/ICC Antibodies (anti-human)
- 3 ICC Antibodies (anti-human)
- 3 BCA Antibodies (anti-human)
- 4 Neut Antibodies (anti-human)
- 6 ICFC Antibodies (anti-human)
- 17 IHC (p) Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 25 IHC (fro) Antibodies (anti-human)
- 31 IF Antibodies (anti-human)
- 50 IHC Antibodies (anti-human)
- 99 IP Antibodies (anti-human)
- 135 WB Antibodies (anti-human)
- 264 FACS Antibodies (anti-human)
- 1 ICFC Antibody (anti-rat)
- 24 IF (p) Antibodies (anti-mouse)
- 64 IP Antibodies (anti-mouse)
- 68 IHC Antibodies (anti-mouse)
- 85 WB Antibodies (anti-mouse)
- 204 FACS Antibodies (anti-mouse)
- GeneTex ITGAM antibody for ITGAM
-
CrownBio Antibodies for ITGAM
-
Santa Cruz Biotechnology (SCBT) Antibodies for ITGAM
Protein Products
- R&D Systems Proteins and Enzymes for ITGAM (Integrin alpha M beta 2)
-
OriGene Purified Proteins for ITGAM
- Search Origene for MassSpec and Protein Over-expression Lysates for ITGAM
- Origene Custom Protein Services for ITGAM
- Novus Biologicals proteins for ITGAM
-
Cloud-Clone Corp. Proteins for ITGAM
- Search GeneTex for Proteins for ITGAM
-
Abcam proteins for ITGAM
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for ITGAM (CD11b/Integrin alpha M)
-
Cloud-Clone Corp. Assay Kits for ITGAM
No data available for DME Specific Peptides for ITGAM Gene
Domains & Families for ITGAM Gene
Gene Families for ITGAM Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Disease related genes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ITGAM Gene
Suggested Antigen Peptide Sequences for ITGAM Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P11215UniProtKB/Swiss-Prot:
ITAM_HUMAN :- The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
- Belongs to the integrin alpha chain family.
- Domain:
-
- The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
- Family:
-
- Belongs to the integrin alpha chain family.
Function for ITGAM Gene
Molecular function for ITGAM Gene
- GENATLAS Biochemistry:
- integrin,alpha M,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,dimerizing with ITGB2 in vitronectin,fibrinogen,von Willebrand factor,thrombospondin,fibronectin,osteopontin,collagen
- UniProtKB/Swiss-Prot Function:
- Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity).
Phenotypes From GWAS Catalog for ITGAM Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001851 | complement component C3b binding | ISS | -- |
| GO:0005515 | protein binding | IPI | 15004192 |
| GO:0031072 | heat shock protein binding | IPI | 12496435 |
| GO:0046872 | metal ion binding | IEA | -- |
| GO:0046982 | protein heterodimerization activity | NAS,IEA | 20199584 |
Phenotypes for ITGAM Gene
- MGI mutant phenotypes for ITGAM:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for ITGAM:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ITGAM
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ITGAM gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGAM gene
- Search ViGene Biosciences for ITGAM
CRISPR Products
-
OriGene CRISPR knockouts for ITGAM
- genomics-online: gRNA clones - Search results for 114 available CD11b gene related products
- Overview of 114 available CD11b gene related products
- Applied Biological Materials CRISPR for ITGAM
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ITGAM
- GenScript: Design CRISPR guide RNA sequences for ITGAM
miRNA for ITGAM Gene
- miRTarBase miRNAs that target ITGAM
miRNA Products
- Search ViGene Biosciences for ITGAM
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ITGAM
- Browse OriGene Inhibitory RNA Products For ITGAM
- genomics-online: shRNA clones - Search results for 114 available CD11b gene related products
- Overview of 114 available CD11b gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGAM gene
Clone Products
- Sino Biological Human cDNA Clone for ITGAM
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ITGAM
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ITGAM
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ITGAM
- Applied Biological Materials Clones for ITGAM
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ITGAM (CD11b/Integrin alpha M)
Cell Line Products
-
Horizon Cell Lines for ITGAM
-
ViGene Biosciences adenoviral particle packaged cDNA for ITGAM gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ITGAM gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGAM gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGAM Gene
Localization for ITGAM Gene
Subcellular locations from UniProtKB/Swiss-Prot for ITGAM Gene
- Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 25645918 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0008305 | integrin complex | TAS | 2563162 |
| GO:0009897 | external side of plasma membrane | NAS | 20199584 |
| GO:0009986 | cell surface | IDA | 19234460 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ITGAM Gene
Pathways & Interactions for ITGAM Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MAPK-Erk Pathway |
.38
|
.38
.38
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
.66
.65
|
.57
|
| 3 | ERK Signaling |
.61
.58
|
.49
|
| 4 | Integrin Pathway |
.67
.67
.56
|
.56
|
| 5 | Actin Nucleation by ARP-WASP Complex |
.41
.35
|
|
Pathways by source for ITGAM Gene
8 Sino Biological pathways for ITGAM Gene
1 Cell Signaling Technology pathway for ITGAM Gene
3 BioSystems pathways for ITGAM Gene
12 Reactome pathways for ITGAM Gene
15 KEGG pathways for ITGAM Gene
4 GeneGo (Thomson Reuters) pathways for ITGAM Gene
5 R&D Systems pathways for ITGAM Gene
Interacting Proteins for ITGAM Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001774 | microglial cell activation | ISS | -- |
| GO:0006911 | phagocytosis, engulfment | ISS | -- |
| GO:0007155 | cell adhesion | TAS | 2563162 |
| GO:0007229 | integrin-mediated signaling pathway | IEA | -- |
| GO:0010668 | ectodermal cell differentiation | IEP | 23154389 |
No data available for SIGNOR curated interactions for ITGAM Gene
Drugs & Compounds for ITGAM Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Leukadherin 1 | Pharma | CD11b/CD18 activator | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for ITGAM Gene
| Compound | Action | Cas Number |
|---|---|---|
| Leukadherin 1 | CD11b/CD18 activator | 344897-95-6 |
Transcripts for ITGAM Gene
mRNA/cDNA for ITGAM Gene
- (6) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (93) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ITGAM Gene
- Integrin, alpha M (complement component 3 receptor 3 subunit):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ITGAM
- genomics-online: gRNA clones - Search results for 114 available CD11b gene related products
- Overview of 114 available CD11b gene related products
- Applied Biological Materials CRISPR for ITGAM
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ITGAM
- GenScript: Design CRISPR guide RNA sequences for ITGAM
miRNA Products
- Search ViGene Biosciences for ITGAM
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ITGAM
- Browse OriGene Inhibitory RNA Products For ITGAM
- genomics-online: shRNA clones - Search results for 114 available CD11b gene related products
- Overview of 114 available CD11b gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGAM gene
Clone Products
- Sino Biological Human cDNA Clone for ITGAM
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ITGAM
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ITGAM
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ITGAM
- Applied Biological Materials Clones for ITGAM
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ITGAM (CD11b/Integrin alpha M)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ExUns: | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||
| SP2: | - | ||||||||||||||||||
| SP3: |
Expression for ITGAM Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
- Bone (Muscoskeletal System)
- Brain (Nervous System)
- Spleen (Hematopoietic System)
-
Chorion (Extraembryonic Tissues)
- Hofbauer Cells Chorionic Villus
-
Placenta (Extraembryonic Tissues)
- Hofbauer Cells Chorionic Villus
mRNA differential expression in normal tissues according to GTEx for ITGAM Gene
This gene is overexpressed in Whole Blood (x31.3).
This gene is overexpressed in Neutrophil (31.4), Nasal epithelium (9.4), and Monocytes (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ITGAM Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ITGAM Gene:
ITGAMSOURCE GeneReport for Unigene cluster for ITGAM Gene:
Hs.172631mRNA Expression by UniProt/SwissProt for ITGAM Gene:
P11215-ITAM_HUMAN
Tissue specificity:
Predominantly expressed in monocytes and granulocytes (PubMed:1346576). Expressed in neutrophils (at protein level) (PubMed:21193407).
Evidence on tissue expression from TISSUES for ITGAM Gene
- Blood(4.9)
- Liver(4.5)
- Spleen(4.3)
- Bone marrow(4.2)
- Lung(4)
- Lymph node(3.6)
- Heart(3.3)
- Nervous system(3)
- Intestine(2.9)
- Eye(2.3)
- Skin(2.2)
- Muscle(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGAM Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- ear
- eye
- face
- head
- mouth
Thorax:
- esophagus
- heart
- lung
Abdomen:
- intestine
- kidney
- large intestine
- pancreas
- small intestine
- spleen
- stomach
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- lymph node
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for ITGAM
- genomics-online: primer clones - Search results for 114 available CD11b gene related products
- Overview of 114 available CD11b gene related products
Orthologs for ITGAM Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ITGAM 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ITGAM 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ITGAM 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Itgam 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Itgam 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | itgad 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC101882585 33 |
|
||
| si:dkey-32n7.4 34 |
|
ManyToMany |
- Species where no ortholog for ITGAM was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ITGAM Gene
Paralogs for ITGAM Gene
(4) SIMAP similar genes for ITGAM Gene using alignment to 3 proteins:
Variants for ITGAM Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs372291727 | uncertain-significance, not provided | 31,276,977(+) | T/C | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs41321249 | benign, not specified | 31,330,103(+) | C/A | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs1000068561 | -- | 31,284,488(+) | C/T | intron_variant | |
| rs1000069240 | -- | 31,261,515(+) | T/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000120561 | -- | 31,305,458(+) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv958208 | CNV | deletion | 24416366 |
| nsv953803 | CNV | deletion | 24416366 |
| nsv1138424 | CNV | deletion | 24896259 |
| nsv1111132 | CNV | tandem duplication | 24896259 |
| nsv1071284 | CNV | deletion | 25765185 |
| nsv1061980 | CNV | gain | 25217958 |
| esv3553319 | CNV | deletion | 23714750 |
| esv3553318 | CNV | deletion | 23714750 |
| esv2714193 | CNV | deletion | 23290073 |
| esv2436135 | CNV | deletion | 19546169 |
| esv2052288 | CNV | deletion | 18987734 |
| esv1039007 | CNV | deletion | 17803354 |
| dgv503e214 | CNV | gain | 21293372 |
Residual Variation Intolerance Score:
26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.35;
81.59% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ITGAM Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGAM Gene
Disorders for ITGAM Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| systemic lupus erythematosus 6 |
|
|
| granulocytopenia |
|
|
| shwartzman phenomenon |
|
|
| systemic lupus erythematosus 5 |
|
|
| lymphocytic vasculitis |
|
|
Search ITGAM in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ITAM_HUMAN- Systemic lupus erythematosus 6 (SLEB6) [MIM:609939]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:18204446, ECO:0000269 PubMed:18204448}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Additional Disease Information for ITGAM
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for ITGAM Gene
Publications for ITGAM Gene
- A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. (PMID: 18204448) Nath SK … Harley JB (Nature genetics 2008) 3 4 44 58
- Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. (PMID: 18204446) International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN) … Kelly JA (Nature genetics 2008) 3 4 44 58
- The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression. (PMID: 1683702) Shelley CS … Arnaout MA (Proceedings of the National Academy of Sciences of the United States of America 1991) 3 4 22 58
- CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. (PMID: 28807980) Bai M … Nigrovic PA (Blood 2017) 3 4 58
- A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PMID: 20962850) Budarf ML … Rioux JD (Genes and immunity 2011) 3 44 58
Products for ITGAM Gene
- R&D Systems Antibodies for ITGAM (CD11b/Integrin alpha M)
- R&D Systems Proteins and Enzymes for ITGAM (Integrin alpha M beta 2)
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for ITGAM (CD11b/Integrin alpha M)
- R&D Systems cDNA Clones for ITGAM (CD11b/Integrin alpha M)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for ITGAM
- AM00640PU-N
- AM03120AF-N
- AM05208BT-N
- AM05208FC-N
- AM05208PU-N
- AM05517FC-N
- AM32402FC-N
- AM32402PU-N
- AM50205PU-N
- AM50205PU-S
- AM50205PU-T
- AM50206PU-N
- AM50206PU-S
- AM50206PU-T
- AP31807PU-N
- AP50837PU-N
- BM4032
- BM4032B
- SM1068A
- SM1068F
- SM1068FT
- SM1068P
- SM1068PS
- SM1068PT
- SM1068R
- SM1068RT
- SM3007AC
- SM3007AS
- SM3007B
- SM3007F
- SM3007P
- SM3007R
- TA303242
- TA320385
- TA320386
- TA320387
- TA323950
- TA323951
- TA336516
- TA336565
- TA353260
- TA807952
- CF807952
- TA807953
- CF807953
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ITGAM
- Search Origene for MassSpec and Protein Over-expression Lysates for ITGAM
- Origene Custom Protein Services for ITGAM
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ITGAM
- Browse OriGene Inhibitory RNA Products For ITGAM
- OriGene qPCR primer pairs for ITGAM
- OriGene CRISPR knockouts for ITGAM
- OriGene ORF clones in human for ITGAM
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ITGAM
- GenScript: Next-day shipping of latest version cDNA ORF clones for ITGAM in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ITGAM
- GenScript Custom Assay Services for ITGAM
- GenScript Custom overexpressing Cell Line Services for ITGAM
- GenScript: Design CRISPR guide RNA sequences for ITGAM
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ITGAM
- Cell Signaling Technology (CST) Antibodies for ITGAM (ITGAM)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for ITGAM
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for ITGAM
- Novus Biologicals proteins for ITGAM
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ITGAM
- Abcam proteins for ITGAM
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for ITGAM
- Cloud-Clone Corp. Proteins for ITGAM
- Cloud-Clone Corp. Assay Kits for ITGAM
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for ITGAM
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for ITGAM
- Cyagen custom Knockout/knockin (KOKI) mouse models for ITGAM
- VectorBuilder custom plasmid, inducible vectors for ITGAM
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ITGAM
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ITGAM
- antibodies-online: Search results for 1087 available CD11b Antibodies ranked by validation data
- Compare Top CD11b Antibodies
- Recommended
- 204 FACS Antibodies (anti-mouse)
- 85 WB Antibodies (anti-mouse)
- 68 IHC Antibodies (anti-mouse)
- 64 IP Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 19 IHC (p) Antibodies (anti-mouse)
- 6 IF Antibodies (anti-mouse)
- 4 ICFC Antibodies (anti-mouse)
- 2 Neut Antibodies (anti-mouse)
- 2 StM Antibodies (anti-mouse)
- 1 BCA Antibody (anti-mouse)
- 1 IC Antibody (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 1 ISt Antibody (anti-mouse)
- 1 in vitro Antibody (anti-mouse)
- 61 WB Antibodies (anti-rat)
- 52 FACS Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 19 IHC Antibodies (anti-rat)
- 14 IP Antibodies (anti-rat)
- 11 IHC (fro) Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 1 IHC (zinc) Antibody (anti-rat)
- 1 ICFC Antibody (anti-rat)
- 264 FACS Antibodies (anti-human)
- 135 WB Antibodies (anti-human)
- 99 IP Antibodies (anti-human)
- 50 IHC Antibodies (anti-human)
- 31 IF Antibodies (anti-human)
- 25 IHC (fro) Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 17 IHC (p) Antibodies (anti-human)
- 6 ICFC Antibodies (anti-human)
- 4 Neut Antibodies (anti-human)
- 3 BCA Antibodies (anti-human)
- 3 ICC Antibodies (anti-human)
- 3 IF/ICC Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 MA Antibody (anti-human)
- 1 StM Antibody (anti-human)
- antibodies-online: Search results for 22 available CD11b Elisa Kits ranked by validation data
- Compare Top CD11b Elisa Kits
- antibodies-online: Search results for 21 available CD11b Proteins ranked by validation data
- Compare Top CD11b Proteins
- GeneTex ITGAM antibody for ITGAM
- Search GeneTex for Proteins for ITGAM
- ViGene Biosciences adenoviral particle packaged cDNA for ITGAM gene
- ViGene Biosciences lentiviral particle packaged cDNA for ITGAM gene
- ViGene Biosciences ready-to-package AAV shRNAs for ITGAM gene
- Search ViGene Biosciences for ITGAM
- Santa Cruz Biotechnology (SCBT) Antibodies for ITGAM
- Search Santa Cruz Biotechnology (SCBT) for ITGAM siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ITGAM
- Horizon Cell Lines for ITGAM
- genomics-online: cdna clones - Search results for 114 available CD11b gene related products
- Overview of 114 available CD11b gene related products
- orf clones - Search results for 114 available CD11b gene related products
- Overview of 114 available CD11b gene related products
- genomics-online: gRNA clones - Search results for 114 available CD11b gene related products
- Overview of 114 available CD11b gene related products
- genomics-online: primer clones - Search results for 114 available CD11b gene related products
- Overview of 114 available CD11b gene related products
- genomics-online: shRNA clones - Search results for 114 available CD11b gene related products
- Overview of 114 available CD11b gene related products
Sources for ITGAM Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew