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This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
ITGAM (Integrin Subunit Alpha M) is a Protein Coding gene. Diseases associated with ITGAM include Systemic Lupus Erythematosus 6 and Shwartzman Phenomenon. Among its related pathways are Neuroscience and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is ITGAX.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001540 | amyloid-beta binding | IC | -- |
GO:0001851 | complement component C3b binding | ISS | -- |
GO:0005178 | integrin binding | NAS | 20199584 |
GO:0005515 | protein binding | IPI | 12208882 |
GO:0031072 | heat shock protein binding | IPI | 12496435 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IDA | 25645918 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0008305 | integrin complex | TAS | 2563162 |
GO:0009897 | external side of plasma membrane | NAS | 20199584 |
GO:0009986 | cell surface | IDA | 19234460 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MAPK Erk Pathway |
.32
|
.32
|
2 | Apoptotic Pathways in Synovial Fibroblasts |
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
|
Actin-Based Motility by Rho Family GTPases
.62
Rap1 Pathway
.57
|
3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
4 | Integrin Pathway |
FAK1 Signaling
.67
Integrin Pathway
.67
GnRH Signaling
.56
|
UPA-UPAR Pathway
.56
Transendothelial Migration of Leukocytes
.38
|
5 | Actin Nucleation by ARP-WASP Complex |
Actin Nucleation and Branching
.66
Actin Nucleation by ARP-WASP Complex
.66
|
CDC42 Pathway
.41
RhoA Pathway
.35
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001774 | microglial cell activation | ISS | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0006898 | receptor-mediated endocytosis | ISS | -- |
GO:0006911 | phagocytosis, engulfment | ISS | -- |
GO:0007155 | cell adhesion | TAS | 2563162 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Leukadherin 1 | Pharma | CD11b/CD18 activator | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Leukadherin 1 | CD11b/CD18 activator | 344897-95-6 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
ExUns: | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||
SP2: | - | ||||||||||||||||||
SP3: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ITGAM 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ITGAM 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ITGAM 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Itgam 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Itgam 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | itgad 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC101882585 30 |
|
||
si:dkey-32n7.4 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
735533 | Likely Benign: not provided | 31,265,452(+) | C/T | SYNONYMOUS_VARIANT | |
741398 | Benign: not provided | 31,271,945(+) | G/A | SYNONYMOUS_VARIANT | |
768775 | Benign: not provided | 31,321,569(+) | C/T | SYNONYMOUS_VARIANT | |
777009 | Benign: not provided | 31,328,198(+) | G/A | SYNONYMOUS_VARIANT | |
786639 | Likely Benign: not provided | 31,325,329(+) | T/C | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv503e214 | CNV | gain | 21293372 |
esv1039007 | CNV | deletion | 17803354 |
esv2052288 | CNV | deletion | 18987734 |
esv2436135 | CNV | deletion | 19546169 |
esv2714193 | CNV | deletion | 23290073 |
esv3553318 | CNV | deletion | 23714750 |
esv3553319 | CNV | deletion | 23714750 |
nsv1061980 | CNV | gain | 25217958 |
nsv1071284 | CNV | deletion | 25765185 |
nsv1111132 | CNV | tandem duplication | 24896259 |
nsv1138424 | CNV | deletion | 24896259 |
nsv953803 | CNV | deletion | 24416366 |
nsv958208 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
systemic lupus erythematosus 6 |
|
|
shwartzman phenomenon |
|
|
systemic lupus erythematosus |
|
|
granulocytopenia |
|
|
leishmaniasis |
|
|