Aliases for ITGAL Gene
Aliases for ITGAL Gene
- Integrin Subunit Alpha L 2 3 5
- Integrin, Alpha L (Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1; Alpha Polypeptide) 2 3
- Lymphocyte Function-Associated Antigen 1, Alpha Polypeptide 2 3
- Leukocyte Function-Associated Molecule 1 Alpha Chain 3 4
- Leukocyte Adhesion Glycoprotein LFA-1 Alpha Chain 3 4
- CD11 Antigen-Like Family Member A 3 4
- LFA-1A 3 4
- CD11A 3 4
- Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1, Alpha Polypeptide 3
External Ids for ITGAL Gene
- HGNC: 6148
- Entrez Gene: 3683
- Ensembl: ENSG00000005844
- OMIM: 153370
- UniProtKB: P20701
Previous HGNC Symbols for ITGAL Gene
- CD11A
Previous GeneCards Identifiers for ITGAL Gene
- GC16P029766
- GC16P030972
- GC16P030480
- GC16P030520
- GC16P030391
- GC16P028046
Summaries for ITGAL Gene
-
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ITGAL Gene
ITGAL (Integrin Subunit Alpha L) is a Protein Coding gene. Diseases associated with ITGAL include Benign Cephalic Histiocytosis and Lichen Planus. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and cell adhesion molecule binding. An important paralog of this gene is ITGAM.
UniProtKB/Swiss-Prot for ITGAL Gene
-
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R (PubMed:11812992, PubMed:15528364). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Additional gene information for ITGAL Gene
- Monarch Initiative
- Search for ITGAL at DataMed
- Search for ITGAL at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGAL Gene
Genomics for ITGAL Gene
GeneHancer (GH) Regulatory Elements for ITGAL Gene
Promoters and enhancers for ITGAL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ITGAL on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ITGAL gene promoter:
Regulatory Element Products
Genomic Locations for ITGAL Gene
Genomic Locations for ITGAL Gene
- chr16:30,472,658-30,523,185
- (GRCh38/hg38)
- Size:
- 50,528 bases
- Orientation:
- Plus strand
- chr16:30,483,979-30,534,506
- (GRCh37/hg19)
Genomic View for ITGAL Gene
Genes around ITGAL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by Ensembl
- 16p11.2 by Entrez Gene
- 16p11.2 by HGNC
ITGAL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ITGAL Gene
Proteins for ITGAL Gene
-
Protein details for ITGAL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P20701-ITAL_HUMAN
- Recommended name:
- Integrin alpha-L
- Protein Accession:
- P20701
- O43746
- Q45H73
- Q96HB1
- Q9UBC8
Protein attributes for ITGAL Gene
- Size:
- 1170 amino acids
- Molecular mass:
- 128770 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit (PubMed:12526797). Alpha-L associates with beta-2 (PubMed:12526797). Interacts with THBD (PubMed:27055590).
Three dimensional structures from OCA and Proteopedia for ITGAL Gene
Protein Expression for ITGAL Gene
Post-translational modifications for ITGAL Gene
- In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.
- Ubiquitination at posLast=9393, isoforms=2, 3321, posLast=371371, isoforms=2, 3416, posLast=776776, isoforms=2, 3831, isoforms=2, 3836, posLast=950950, and isoforms=664
- Glycosylation at posLast=6565, posLast=8989, isoforms=2188, posLast=649649, posLast=670670, isoforms=2, 3726, posLast=730730, isoforms=2, 3862, isoforms=2, 3885, isoforms=2, 3897, isoforms=2, 31060, and posLast=10711071
- Modification sites at PhosphoSitePlus
Other Protein References for ITGAL Gene
Antibody Products
- R&D Systems Antibodies for ITGAL (Integrin alpha L/CD11a)
-
Custom Antibody ServicesOriGene Antibodies for ITGAL
- TA332416
- TA321452
- TA320384
- TA320383
- TA305639
- SM3100P
- SM3100LE
- SM3100AS
- SM1080RT
- SM1080R
- SM1080PT
- SM1080PS
- SM1080P
- SM1080A
- BM4046S
- BM4046R
- BM4046LE
- BM4046B
- BM4046AS
- BM4046
- AM50204PU-T
- AM50204PU-S
- AM50204PU-N
- AM39012RP-N
- AM39012PU-N
- AM33386PU-N
- AM33011PU-N
- AM33009PU-N
- AM32401PU-N
- AM32398PU-N
- AM31182RP-N
- AM31182PU-N
- AM31182FC-N
- AM31182AF-N
- AM26392PU-L
- AM05882FC-N
- AM05207RP-N
- AM05207PU-N
- AM05207FC-N
- AM05207BT-N
- Novus Biologicals Antibodies for ITGAL
-
Cloud-Clone Corp. Antibodies for ITGAL
- Invitrogen Antibodies for ITGAL
- antibodies-online: Search results for 829 available ITGAL Antibodies ranked by validation data
- Compare Top ITGAL Antibodies
-
Recommended
- 209 FACS Antibodies (anti-human)
- 85 WB Antibodies (anti-human)
- 81 IP Antibodies (anti-human)
- 55 IHC Antibodies (anti-human)
- 32 IHC (fro) Antibodies (anti-human)
- 19 IF Antibodies (anti-human)
- 10 Neut Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 3 IF/ICC Antibodies (anti-human)
- 3 ICFC Antibodies (anti-human)
- 1 BCA Antibody (anti-human)
- 77 FACS Antibodies (anti-mouse)
- 34 IHC (fro) Antibodies (anti-mouse)
- 31 WB Antibodies (anti-mouse)
- 28 IP Antibodies (anti-mouse)
- 25 IHC Antibodies (anti-mouse)
- 5 Neut Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 IC Antibody (anti-mouse)
- 1 ISt Antibody (anti-mouse)
- 1 ICFC Antibody (anti-mouse)
- 16 FACS Antibodies (anti-rat)
- 10 IHC (fro) Antibodies (anti-rat)
- 9 IP Antibodies (anti-rat)
- 6 WB Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- GeneTex ITGAL antibody for ITGAL
-
Santa Cruz Biotechnology (SCBT) Antibodies for ITGAL
- Sino Biological Antibodies for ITGAL
Protein Products
- R&D Systems Proteins and Enzymes for ITGAL (Integrin alpha L beta 2)
-
OriGene Purified Proteins for ITGAL
- Search Origene for MassSpec and Protein Over-expression Lysates for ITGAL
- Origene Custom Protein Services for ITGAL
- Novus Biologicals lysates for ITGAL
-
Cloud-Clone Corp. Proteins for ITGAL
- Search GeneTex for Proteins for ITGAL
-
Abcam proteins for ITGAL
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for ITGAL (Integrin alpha L/CD11a)
-
Cloud-Clone Corp. Assay Kits for ITGAL
No data available for DME Specific Peptides for ITGAL Gene
Domains & Families for ITGAL Gene
Gene Families for ITGAL Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- FDA approved drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for ITGAL Gene
Suggested Antigen Peptide Sequences for ITGAL Gene
Graphical View of Domain Structure for InterPro Entry
P20701UniProtKB/Swiss-Prot:
ITAL_HUMAN :- The integrin I-domain (insert) is a VWFA domain (PubMed:2537322). Integrins with I-domains do not undergo protease cleavage. The I-domain is necessary and sufficient for interaction with ICAM1 and F11R (PubMed:15528364).
- Belongs to the integrin alpha chain family.
- Domain:
-
- The integrin I-domain (insert) is a VWFA domain (PubMed:2537322). Integrins with I-domains do not undergo protease cleavage. The I-domain is necessary and sufficient for interaction with ICAM1 and F11R (PubMed:15528364).
- Family:
-
- Belongs to the integrin alpha chain family.
Function for ITGAL Gene
Molecular function for ITGAL Gene
- GENATLAS Biochemistry:
- integrin,alpha L,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,dimerizing with ITGB2 in ICAM1/ICAM2 receptor
- UniProtKB/Swiss-Prot Function:
- Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R (PubMed:11812992, PubMed:15528364). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Phenotypes From GWAS Catalog for ITGAL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11544294 |
| GO:0030369 | ICAM-3 receptor activity | IMP | 19029120 |
| GO:0032403 | protein complex binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for ITGAL Gene
- MGI mutant phenotypes for ITGAL:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for ITGAL:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance (Z-score > 2)
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Increased G1 DNA content
- G0/1 arrest
- Decreased shRNA abundance (Z-score < -2)
- Increased cell size
Animal Models for ITGAL Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ITGAL
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ITGAL gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGAL gene
- Search ViGene Biosciences for ITGAL
CRISPR Products
-
OriGene CRISPR knockouts for ITGAL
- genomics-online: gRNA clones - Search results for 143 available ITGAL gene related products
- Overview of 143 available ITGAL gene related products
- Applied Biological Materials CRISPR for ITGAL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ITGAL
- GenScript: Design CRISPR guide RNA sequences for ITGAL
miRNA for ITGAL Gene
- miRTarBase miRNAs that target ITGAL
-
- hsa-mir-6878-3p (MIRT631579)
- hsa-mir-640 (MIRT631580)
- hsa-mir-378a-5p (MIRT631581)
- hsa-mir-4764-3p (MIRT631582)
- hsa-mir-6821-3p (MIRT631583)
- hsa-mir-6790-3p (MIRT631584)
- hsa-mir-3653-5p (MIRT631585)
- hsa-mir-3189-3p (MIRT631586)
- hsa-mir-212-5p (MIRT631587)
- hsa-mir-4667-3p (MIRT631588)
- hsa-mir-3934-5p (MIRT631589)
- hsa-mir-764 (MIRT631590)
- hsa-mir-125a-3p (MIRT631591)
- hsa-mir-6865-3p (MIRT631592)
miRNA Products
- Search ViGene Biosciences for ITGAL
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ITGAL
- Browse OriGene Inhibitory RNA Products For ITGAL
- genomics-online: shRNA clones - Search results for 143 available ITGAL gene related products
- Overview of 143 available ITGAL gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGAL gene
Clone Products
- Sino Biological Human cDNA Clone for ITGAL
- VectorBuilder custom plasmid, inducible vectors for ITGAL
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ITGAL
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ITGAL
- Applied Biological Materials Clones for ITGAL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ITGAL (Integrin alpha L/CD11a)
Cell Line Products
-
Horizon Cell Lines for ITGAL
-
ViGene Biosciences adenoviral particle packaged cDNA for ITGAL gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ITGAL gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGAL gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGAL Gene
Localization for ITGAL Gene
Subcellular locations from UniProtKB/Swiss-Prot for ITGAL Gene
- Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0008305 | integrin complex | NAS | 8103515 |
| GO:0009986 | cell surface | IDA | 19029120 |
| GO:0016020 | membrane | IEA,HDA | 19946888 |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ITGAL Gene
Pathways & Interactions for ITGAL Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
.66
.65
|
.57
|
| 2 | ERK Signaling |
.61
.58
|
.49
|
| 3 | Integrin Pathway |
.67
.67
.56
|
.56
|
| 4 | MAPK-Erk Pathway |
.38
|
.38
|
| 5 | Actin Nucleation by ARP-WASP Complex |
.41
.35
|
|
Pathways by source for ITGAL Gene
5 Sino Biological pathways for ITGAL Gene
4 BioSystems pathways for ITGAL Gene
9 Reactome pathways for ITGAL Gene
11 KEGG pathways for ITGAL Gene
3 GeneGo (Thomson Reuters) pathways for ITGAL Gene
5 R&D Systems pathways for ITGAL Gene
- Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview
- Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways
- Blood-Brain Barrier Pathway: Anatomy
- Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers
Interacting Proteins for ITGAL Gene
Selected Interacting proteins:
P20701-ITAL_HUMAN
ENSP00000349252
for ITGAL Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell | IMP | 2477710 |
| GO:0006909 | phagocytosis | IEA | -- |
| GO:0006928 | movement of cell or subcellular component | TAS | 10477596 |
| GO:0006954 | inflammatory response | NAS | 8103515 |
| GO:0007155 | cell adhesion | NAS | 8103515 |
No data available for SIGNOR curated interactions for ITGAL Gene
Drugs & Compounds for ITGAL Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Efalizumab | Approved, Investigational | Pharma | Target, antibody | 0 | ||
| Lovastatin | Approved, Investigational | Pharma | Competitive, Inhibitor, Target, other/unknown | HMG-CoA reductase inhibitor, Potent HMG-CoA reductase inhibitor | 68 | |
| Simvastatin | Approved | Pharma | Competitive, Inhibitor, Target, inhibitor | HMG-CoA reductase inhibitor | 537 | |
| Antithymocyte immunoglobulin (rabbit) | Approved | Pharma | Target | 0 | ||
| Lifitegrast | Approved | Pharma | Target, antagonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for ITGAL Gene
| Compound | Action | Cas Number |
|---|---|---|
| A 286982 | LFA-1/ICAM-1 interaction inhibitor | 280749-17-9 |
Transcripts for ITGAL Gene
mRNA/cDNA for ITGAL Gene
- (5) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (121) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ITGAL Gene
CRISPR Products
-
OriGene CRISPR knockouts for ITGAL
- genomics-online: gRNA clones - Search results for 143 available ITGAL gene related products
- Overview of 143 available ITGAL gene related products
- Applied Biological Materials CRISPR for ITGAL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ITGAL
- GenScript: Design CRISPR guide RNA sequences for ITGAL
miRNA Products
- Search ViGene Biosciences for ITGAL
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ITGAL
- Browse OriGene Inhibitory RNA Products For ITGAL
- genomics-online: shRNA clones - Search results for 143 available ITGAL gene related products
- Overview of 143 available ITGAL gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGAL gene
Clone Products
- Sino Biological Human cDNA Clone for ITGAL
- VectorBuilder custom plasmid, inducible vectors for ITGAL
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ITGAL
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ITGAL
- Applied Biological Materials Clones for ITGAL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ITGAL (Integrin alpha L/CD11a)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||
| SP9: |
Expression for ITGAL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for ITGAL Gene
This gene is overexpressed in Whole Blood (x25.6) and Spleen (x7.2).
This gene is overexpressed in Lymph node (20.7), Tlymphocyte (13.6), Peripheral blood mononuclear cells (8.2), CD8 Tcells (7.4), and NK cells (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ITGAL Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ITGAL Gene:
ITGALSOURCE GeneReport for Unigene cluster for ITGAL Gene:
Hs.174103mRNA Expression by UniProt/SwissProt for ITGAL Gene:
P20701-ITAL_HUMAN
Tissue specificity:
Leukocytes.
Evidence on tissue expression from TISSUES for ITGAL Gene
- Blood(3.5)
- Lymph node(3)
- Spleen(3)
- Bone marrow(2.8)
- Heart(2.6)
- Intestine(2.4)
- Lung(2.4)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs for ITGAL
- genomics-online: primer clones - Search results for 143 available ITGAL gene related products
- Overview of 143 available ITGAL gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGAL Gene
Orthologs for ITGAL Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ITGAL 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ITGAL 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ITGAL 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Itgal 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Itgal 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ITGAL 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ITGAL 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ITGAL 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | zmp:0000001082 33 |
|
||
| ITGAL 34 |
|
OneToOne |
- Species where no ortholog for ITGAL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ITGAL Gene
Paralogs for ITGAL Gene
(3) SIMAP similar genes for ITGAL Gene using alignment to 9 proteins:
Variants for ITGAL Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000015257 | -- | 30,479,537(+) | T/A | intron_variant | |
| rs1000136272 | -- | 30,508,510(+) | A/G | intron_variant | |
| rs1000167609 | -- | 30,483,628(+) | G/C | intron_variant | |
| rs1000215271 | -- | 30,472,385(+) | T/C | upstream_transcript_variant | |
| rs1000217833 | -- | 30,519,160(+) | T/C | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1116127 | CNV | deletion | 24896259 |
| nsv1127486 | CNV | deletion | 24896259 |
| nsv1783 | CNV | deletion | 18451855 |
| nsv1784 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
3.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.16;
84.72% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ITGAL Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ITGAL
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGAL Gene
Disorders for ITGAL Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| benign cephalic histiocytosis |
|
|
| lichen planus |
|
|
| rheumatoid arthritis |
|
|
| mycosis fungoides |
|
|
| psoriasis |
|
Search ITGAL in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ITGAL
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ITGAL Gene
Publications for ITGAL Gene
- Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain. (PMID: 10493852) Kallen J … Hommel U (Journal of molecular biology 1999) 3 4 22 25 58
- Description of the leukocyte function-associated antigen 1 (LFA-1 or CD11a) promoter. (PMID: 8097887) Cornwell RD … Hickstein DD (Proceedings of the National Academy of Sciences of the United States of America 1993) 3 4 22 58
- Characterization of the CD11a (alpha L, LFA-1 alpha) integrin gene promoter. (PMID: 8103515) Nueda A … Corbí AL (The Journal of biological chemistry 1993) 3 4 22 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms. (PMID: 16301335) Fagerholm SC … Gahmberg CG (The Journal of cell biology 2005) 3 4 58
Products for ITGAL Gene
- R&D Systems Antibodies for ITGAL (Integrin alpha L/CD11a)
- R&D Systems Proteins and Enzymes for ITGAL (Integrin alpha L beta 2)
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for ITGAL (Integrin alpha L/CD11a)
- R&D Systems cDNA Clones for ITGAL (Integrin alpha L/CD11a)
- Browse Human Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for ITGAL
- AM05207BT-N
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- BM4046
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- TA305639
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- TA332416
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ITGAL
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for ITGAL
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping of latest version cDNA ORF clones for ITGAL in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ITGAL
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- GenScript: Design CRISPR guide RNA sequences for ITGAL
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Sino Biological Human cDNA Clone for ITGAL
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- Sino Biological Antibodies for ITGAL
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- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for ITGAL
- Novus Biologicals lysates for ITGAL
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
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- Abcam proteins for ITGAL
- Find your target
- Browse Primary Antibodies
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for ITGAL
- Cloud-Clone Corp. Proteins for ITGAL
- Cloud-Clone Corp. Assay Kits for ITGAL
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- ApexBio compounds for ITGAL
- Cyagen custom Knockout/knockin (KOKI) mouse models for ITGAL
- VectorBuilder custom plasmid, inducible vectors for ITGAL
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ITGAL
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ITGAL
- antibodies-online: Search results for 829 available ITGAL Antibodies ranked by validation data
- Compare Top ITGAL Antibodies
- Recommended
- 209 FACS Antibodies (anti-human)
- 85 WB Antibodies (anti-human)
- 81 IP Antibodies (anti-human)
- 55 IHC Antibodies (anti-human)
- 32 IHC (fro) Antibodies (anti-human)
- 19 IF Antibodies (anti-human)
- 10 Neut Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 3 IF/ICC Antibodies (anti-human)
- 3 ICFC Antibodies (anti-human)
- 1 BCA Antibody (anti-human)
- 77 FACS Antibodies (anti-mouse)
- 34 IHC (fro) Antibodies (anti-mouse)
- 31 WB Antibodies (anti-mouse)
- 28 IP Antibodies (anti-mouse)
- 25 IHC Antibodies (anti-mouse)
- 5 Neut Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 IC Antibody (anti-mouse)
- 1 ISt Antibody (anti-mouse)
- 1 ICFC Antibody (anti-mouse)
- 16 FACS Antibodies (anti-rat)
- 10 IHC (fro) Antibodies (anti-rat)
- 9 IP Antibodies (anti-rat)
- 6 WB Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 28 available ITGAL Elisa Kits ranked by validation data
- Compare Top ITGAL Elisa Kits
- antibodies-online: Search results for 11 available ITGAL Proteins ranked by validation data
- Compare Top ITGAL Proteins
- GeneTex ITGAL antibody for ITGAL
- Search GeneTex for Proteins for ITGAL
- ViGene Biosciences adenoviral particle packaged cDNA for ITGAL gene
- ViGene Biosciences lentiviral particle packaged cDNA for ITGAL gene
- ViGene Biosciences ready-to-package AAV shRNAs for ITGAL gene
- Search ViGene Biosciences for ITGAL
- Santa Cruz Biotechnology (SCBT) Antibodies for ITGAL
- Search Santa Cruz Biotechnology (SCBT) for ITGAL siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ITGAL
- Horizon Cell Lines for ITGAL
- genomics-online: cdna clones - Search results for 143 available ITGAL gene related products
- Overview of 143 available ITGAL gene related products
- orf clones - Search results for 143 available ITGAL gene related products
- Overview of 143 available ITGAL gene related products
- genomics-online: gRNA clones - Search results for 143 available ITGAL gene related products
- Overview of 143 available ITGAL gene related products
- genomics-online: primer clones - Search results for 143 available ITGAL gene related products
- Overview of 143 available ITGAL gene related products
- genomics-online: shRNA clones - Search results for 143 available ITGAL gene related products
- Overview of 143 available ITGAL gene related products
Sources for ITGAL Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152)