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ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
ITGAL (Integrin Subunit Alpha L) is a Protein Coding gene. Diseases associated with ITGAL include Immune-Complex Glomerulonephritis and Chronic Venous Insufficiency. Among its related pathways are Integrin Pathway and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and cell adhesion molecule binding. An important paralog of this gene is ITGAM.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 11544294 |
GO:0030369 | ICAM-3 receptor activity | IMP | 19029120 |
GO:0044877 | protein-containing complex binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO:0050839 | cell adhesion molecule binding | IPI | 1448173 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0008305 | integrin complex | NAS | 8103515 |
GO:0009986 | cell surface | IDA | 19029120 |
GO:0016020 | membrane | IEA,HDA | 19946888 |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
|
Actin-Based Motility by Rho Family GTPases
.62
Rap1 Pathway
.57
|
2 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
3 | Integrin Pathway |
FAK1 Signaling
.67
Integrin Pathway
.67
GnRH Signaling
.56
|
UPA-UPAR Pathway
.56
Transendothelial Migration of Leukocytes
.38
|
4 | Actin Nucleation by ARP-WASP Complex |
Actin Nucleation and Branching
.66
Actin Nucleation by ARP-WASP Complex
.66
|
CDC42 Pathway
.41
RhoA Pathway
.35
|
5 | Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell | IMP | 2477710 |
GO:0006909 | phagocytosis | IEA | -- |
GO:0006954 | inflammatory response | NAS | 8103515 |
GO:0007155 | cell adhesion | NAS | 8103515 |
GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | IMP | 2477710 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Efalizumab | Approved, Investigational | Pharma | Target, antibody | 0 | ||
Lovastatin | Approved, Investigational | Pharma | Inhibitor, Competitive, Agonist, Full agonist, Target, inhibitory allosteric modulator | HMG-CoA reductase inhibitor, Potent HMG-CoA reductase inhibitor | 82 | |
Simvastatin | Approved | Pharma | Inhibitor, Competitive, Target, inhibitory allosteric modulator | HMG-CoA reductase inhibitor | 582 | |
Antithymocyte immunoglobulin (rabbit) | Approved | Pharma | Target | 0 | ||
Lifitegrast | Approved | Pharma | Target, antagonist | 22 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
A 286982 | LFA-1/ICAM-1 interaction inhibitor | 280749-17-9 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: |
ExUns: | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||||||
SP9: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ITGAL 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ITGAL 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ITGAL 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Itgal 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Itgal 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ITGAL 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ITGAL 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ITGAL 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | zmp:0000001082 30 |
|
||
ITGAL 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
714699 | Benign: not provided | 30,521,608(+) | C/T | SYNONYMOUS_VARIANT | |
717785 | Benign: not provided | 30,489,160(+) | G/A | INTRON_VARIANT | |
783065 | Benign: not provided | 30,489,395(+) | T/G | INTRON_VARIANT | |
783736 | Benign: not provided | 30,517,822(+) | G/A | MISSENSE_VARIANT | |
784337 | Benign: not provided | 30,479,194(+) | G/A | MISSENSE_VARIANT,INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1116127 | CNV | deletion | 24896259 |
nsv1127486 | CNV | deletion | 24896259 |
nsv1783 | CNV | deletion | 18451855 |
nsv1784 | CNV | insertion | 18451855 |
Disorder | Aliases | PubMed IDs |
---|---|---|
immune-complex glomerulonephritis |
|
|
chronic venous insufficiency |
|
|
benign cephalic histiocytosis |
|
|
lichen planus |
|
|
leukocyte adhesion deficiency, type i |
|
|