ITGA8 Gene (Protein Coding)

Integrin Subunit Alpha 8

GC10M015513
GIFtS:
43
Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1... See more...

Aliases for ITGA8 Gene

Aliases for ITGA8 Gene

  • Integrin Subunit Alpha 8 2 3 5
  • Integrin, Alpha 8 2 3
  • Integrin Alpha-8 3 4
  • ITGA8 5

External Ids for ITGA8 Gene

Previous GeneCards Identifiers for ITGA8 Gene

  • GC10M015541
  • GC10M015709
  • GC10M015563
  • GC10M015599
  • GC10M015555

Summaries for ITGA8 Gene

Entrez Gene Summary for ITGA8 Gene

  • Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]

GeneCards Summary for ITGA8 Gene

ITGA8 (Integrin Subunit Alpha 8) is a Protein Coding gene. Diseases associated with ITGA8 include Renal Hypodysplasia/Aplasia 1 and Renal Agenesis, Bilateral. Among its related pathways are Integrin Pathway and Degradation of the extracellular matrix. An important paralog of this gene is ITGAV.

UniProtKB/Swiss-Prot Summary for ITGA8 Gene

  • Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.

Gene Wiki entry for ITGA8 Gene

Additional gene information for ITGA8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ITGA8 Gene

Genomics for ITGA8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ITGA8 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10J015718 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +1.4 1373 2.7 ZNF600 ZIC2 FEZF1 ZNF639 ZNF341 CTCF ZNF513 ZNF843 BCL11B ZSCAN5A ITGA8 HSPA14 RPP38 piR-59297-038 FAM171A1
GH10J015747 Enhancer 0.5 ENCODE dbSUPER 12.7 -27.8 -27843 1.5 ATF4 SCRT2 ITGA8 piR-50444-038 lnc-RPP38-6 MINDY3
GH10J015751 Enhancer 0.4 dbSUPER 12.7 -31.1 -31082 0.7 ATF2 ZNF18 CREB1 SPI1 piR-50444-038 ITGA8 lnc-RPP38-6 MINDY3
GH10J015695 Enhancer 0.4 Ensembl 12.1 +24.3 24328 0.4 PKNOX1 ZBTB17 IKZF1 ITGA8 piR-59297-038 FAM171A1
GH10J015533 Enhancer 0.3 FANTOM5 6.7 +186.6 186624 0.3 EZH2 piR-31470-037 piR-58297-037 ITGA8 piR-57460-041 FAM171A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ITGA8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ITGA8

Top Transcription factor binding sites by QIAGEN in the ITGA8 gene promoter:
  • aMEF-2
  • AREB6
  • ATF-2
  • c-Myb
  • CRE-BP1
  • FOXD1
  • GR
  • GR-alpha
  • MEF-2A
  • RP58

Genomic Locations for ITGA8 Gene

Latest Assembly
chr10:15,513,954-15,720,329
(GRCh38/hg38)
Size:
206,376 bases
Orientation:
Minus strand

Previous Assembly
chr10:15,555,953-15,761,921
(GRCh37/hg19 by Entrez Gene)
Size:
205,969 bases
Orientation:
Minus strand

chr10:15,555,948-15,762,124
(GRCh37/hg19 by Ensembl)
Size:
206,177 bases
Orientation:
Minus strand

Genomic View for ITGA8 Gene

Genes around ITGA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGA8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ITGA8 Gene

Proteins for ITGA8 Gene

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  • Protein details for ITGA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53708-ITA8_HUMAN
    Recommended name:
    Integrin alpha-8
    Protein Accession:
    P53708
    Secondary Accessions:
    • B0YJ31
    • Q5VX94

    Protein attributes for ITGA8 Gene

    Size:
    1063 amino acids
    Molecular mass:
    117474 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-8 associates with beta-1.

neXtProt entry for ITGA8 Gene

Protein Expression for ITGA8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ITGA8 Gene

  • Glycosylation at Asn81, Asn122, Asn177, Asn239, Asn302, Asn311, Asn504, Asn601, Asn605, Asn719, Asn737, Asn753, Asn780, Asn896, Asn923, and Asn1005
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGA8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for ITGA8

No data available for DME Specific Peptides for ITGA8 Gene

Domains & Families for ITGA8 Gene

Gene Families for ITGA8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for ITGA8 Gene

InterPro:
Blocks:
  • Integrins alpha chain
  • Integrin alpha chain, C-terminal cytoplasmic region
  • FG-GAP

Suggested Antigen Peptide Sequences for ITGA8 Gene

GenScript: Design optimal peptide antigens:
  • Integrin alpha-8 (ITA8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P53708

UniProtKB/Swiss-Prot:

ITA8_HUMAN :
  • Belongs to the integrin alpha chain family.
Family:
  • Belongs to the integrin alpha chain family.
genes like me logo Genes that share domains with ITGA8: view

Function for ITGA8 Gene

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  6. Cell Lines for research

Molecular function for ITGA8 Gene

UniProtKB/Swiss-Prot Function:
Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.

Phenotypes From GWAS Catalog for ITGA8 Gene

Gene Ontology (GO) - Molecular Function for ITGA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ITGA8: view
genes like me logo Genes that share phenotypes with ITGA8: view

Human Phenotype Ontology for ITGA8 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ITGA8 Gene

MGI Knock Outs for ITGA8:

Animal Models for research

miRNA for ITGA8 Gene

miRTarBase miRNAs that target ITGA8

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGA8

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ITGA8 Gene

Localization for ITGA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA8 Gene

Membrane. Single-pass type I membrane protein. Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITGA8 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
extracellular 2
cytoskeleton 2
mitochondrion 1
nucleus 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ITGA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 24439109
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion HDA 21423176
GO:0008305 integrin complex TAS 7768999
GO:0009986 cell surface IDA 24439109
genes like me logo Genes that share ontologies with ITGA8: view

Pathways & Interactions for ITGA8 Gene

PathCards logo

SuperPathways for ITGA8 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
Rap1 Pathway
.57
2 Integrin Pathway
FAK1 Signaling
.67
Integrin Pathway
.67
GnRH Signaling
.56
UPA-UPAR Pathway
.56
Transendothelial Migration of Leukocytes
.38
3 Focal Adhesion
Focal adhesion
.61
Focal Adhesion
.61
Integrin-mediated Cell Adhesion
.38
HGF Pathway
.33
4 Actin Nucleation by ARP-WASP Complex
Actin Nucleation and Branching
.66
Actin Nucleation by ARP-WASP Complex
.66
CDC42 Pathway
.41
RhoA Pathway
.35
5 ERK Signaling
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
Molecular Mechanisms of Cancer
.51
genes like me logo Genes that share pathways with ITGA8: view

Pathways by source for ITGA8 Gene

2 GeneGo (Thomson Reuters) pathways for ITGA8 Gene
  • Cell adhesion PLAU signaling
  • Cytoskeleton remodeling Integrin outside-in signaling
33 Qiagen pathways for ITGA8 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Akt Signaling
  • Calpain Protease Regulates Cellular Mechanics

Gene Ontology (GO) - Biological Process for ITGA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IMP 24439109
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion NAS 7768999
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with ITGA8: view

No data available for SIGNOR curated interactions for ITGA8 Gene

Drugs & Compounds for ITGA8 Gene

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No Compound Related Data Available

Transcripts for ITGA8 Gene

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mRNA/cDNA for ITGA8 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGA8

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA8 Gene

No ASD Table

Relevant External Links for ITGA8 Gene

GeneLoc Exon Structure for
ITGA8

Expression for ITGA8 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ITGA8 Gene

mRNA expression in normal human tissues for ITGA8 Gene
mRNA expression by GTEx for ITGA8 GenemRNA expression by BioGPS for ITGA8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGA8 Gene

This gene is overexpressed in Artery - Aorta (x18.0), Artery - Coronary (x9.1), Artery - Tibial (x6.0), and Esophagus - Gastroesophageal Junction (x5.1).

Protein differential expression in normal tissues from HIPED for ITGA8 Gene

This gene is overexpressed in Liver (24.6), Urinary Bladder (9.3), Fetal gut (7.8), and Prostate (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ITGA8 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ITGA8

SOURCE GeneReport for Unigene cluster for ITGA8 Gene:

Hs.171311

mRNA Expression by UniProt/SwissProt for ITGA8 Gene:

P53708-ITA8_HUMAN
Tissue specificity: Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).

Evidence on tissue expression from TISSUES for ITGA8 Gene

  • Heart(2.7)
  • Kidney(2.4)
  • Lung(2.3)
  • Spleen(2.2)
  • Muscle(2.1)
  • Nervous system(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGA8 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeleton
  • urinary
Regions:
Head and neck:
  • chin
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • nose
  • outer ear
  • pituitary gland
  • skull
Thorax:
  • breast
  • esophagus
  • heart
  • lung
  • trachea
Abdomen:
  • intestine
  • kidney
  • large intestine
  • small intestine
  • stomach
Pelvis:
  • ovary
  • pelvis
  • placenta
  • ureter
  • urethra
  • urinary bladder
  • uterus
  • vagina
Limb:
  • foot
  • lower limb
General:
  • blood
  • blood vessel
  • coagulation system
  • skin
genes like me logo Genes that share expression patterns with ITGA8: view

Primer products for research

No data available for Protein tissue co-expression partners for ITGA8 Gene

Orthologs for ITGA8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGA8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ITGA8 29 30
  • 99.44 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ITGA8 29 30
  • 89.36 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ITGA8 29 30
  • 88.97 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Itga8 29 16 30
  • 86.03 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Itga8 29
  • 85.84 (n)
Oppossum
(Monodelphis domestica)
 Mammalia ITGA8 30
  • 85 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia ITGA8 30
  • 76 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves ITGA8 29 30
  • 76.16 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia ITGA8 30
  • 71 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia itga8 29
  • 70.86 (n)
Zebrafish
(Danio rerio)
 Actinopterygii itga8 30
  • 62 (a)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta if 29 30
  • 45.31 (n)
 OneToMany
scb 31
  • 27 (a)
alphaPS4 31
  • 26 (a)
alphaPS5 31
  • 26 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP000032 29
  • 45.09 (n)
Worm
(Caenorhabditis elegans)
 Secernentea pat-2 29 30
  • 45.93 (n)
 OneToMany
Species where no ortholog for ITGA8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ITGA8 Gene

ENSEMBL:
Gene Tree for ITGA8 (if available)
TreeFam:
Gene Tree for ITGA8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ITGA8: view image
Alliance of Genome Resources:
Additional Orthologs for ITGA8

Paralogs for ITGA8 Gene

Paralogs for ITGA8 Gene

(3) SIMAP similar genes for ITGA8 Gene using alignment to 1 proteins:

  • ITA8_HUMAN
genes like me logo Genes that share paralogs with ITGA8: view

Variants for ITGA8 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ITGA8 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
1012551 Uncertain Significance: not provided 15,608,252(-) C/T
NM_003638.3(ITGA8):c.1592G>A (p.Ser531Asn) 		MISSENSE
1012552 Likely Pathogenic: not provided 15,646,929(-) T/TG
NM_003638.3(ITGA8):c.1123dup (p.Gln375fs) 		FRAMESHIFT
1012553 Likely Pathogenic: not provided 15,672,704(-) G/T
NM_003638.3(ITGA8):c.722C>A (p.Ser241Ter) 		NONSENSE
1029736 Uncertain Significance: Renal hypodysplasia/aplasia 1 15,719,614(-) T/C
NM_003638.3(ITGA8):c.158A>G (p.Lys53Arg) 		MISSENSE
1030692 Pathogenic: Renal hypodysplasia/aplasia 1 15,684,104(-) C/T
NM_003638.3(ITGA8):c.468G>A (p.Trp156Ter) 		NONSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ITGA8 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ITGA8 Gene

Variant ID Type Subtype PubMed ID
dgv38n21 CNV gain 19592680
dgv679n100 CNV gain 25217958
dgv680n100 CNV gain 25217958
dgv98e214 CNV gain 21293372
esv2498205 CNV deletion 19546169
esv2656916 CNV deletion 23128226
esv2760135 CNV loss 21179565
esv32914 CNV gain 17666407
esv3622450 CNV loss 21293372
nsv1069025 CNV deletion 25765185
nsv516700 CNV loss 19592680
nsv523569 CNV gain 19592680
nsv524808 CNV gain 19592680
nsv831795 CNV gain 17160897

Variation tolerance for ITGA8 Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.97; 68.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITGA8 Gene

Human Gene Mutation Database (HGMD)
ITGA8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGA8
Leiden Open Variation Database (LOVD)
ITGA8

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA8 Gene

Disorders for ITGA8 Gene

MalaCards: The human disease database

(11) MalaCards diseases for ITGA8 Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search ITGA8 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ITA8_HUMAN
  • Renal hypodysplasia/aplasia 1 (RHDA1) [MIM:191830]: A perinatally lethal renal disease encompassing a spectrum of kidney development defects, including renal agenesis, bilateral renal aplasia, hypoplasia, (cystic) dysplasia, and severe obstructive uropathy. {ECO:0000269 PubMed:24439109}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for ITGA8

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ITGA8: view

No data available for Genatlas for ITGA8 Gene

Publications for ITGA8 Gene

  1. Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells. (PMID: 7768999) Schnapp LM … Pytela R (Journal of cell science 1995) 2 3 4 22
  2. Integrin alpha 8 recessive mutations are responsible for bilateral renal agenesis in humans. (PMID: 24439109) Humbert C … Jeanpierre C (American journal of human genetics 2014) 3 4 72
  3. A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease. (PMID: 18277079) Zeltner R … Hartner A (Nephron. Clinical practice 2008) 3 22 40
  4. Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8). (PMID: 15579315) Ekwa-Ekoka C … Schnapp LM (Matrix biology : journal of the International Society for Matrix Biology 2004) 3 4 22
  5. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PMID: 19197348) Lowe JK … Friedman JM (PLoS genetics 2009) 3 40

ExternalLinks

View latest publications for ITGA8 gene in Mastermind

Products for ITGA8 Gene

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