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The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with ... See more...
Aliases for ITGA5 Gene
Aliases for ITGA5 Gene
External Ids for ITGA5 Gene
- HGNC: 6141
- NCBI Entrez Gene: 3678
- Ensembl: ENSG00000161638
- OMIM®: 135620
- UniProtKB/Swiss-Prot: P08648
Previous HGNC Symbols for ITGA5 Gene
- FNRA
Previous GeneCards Identifiers for ITGA5 Gene
- GC12M054915
- GC12M054505
- GC12M053075
- GC12M054789
- GC12M051828
Summaries for ITGA5 Gene
-
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
GeneCards Summary for ITGA5 Gene
ITGA5 (Integrin Subunit Alpha 5) is a Protein Coding gene. Diseases associated with ITGA5 include Colorectal Cancer, Hereditary Nonpolyposis, Type 8 and Lung Cancer. Among its related pathways are Integrin Pathway and Proteoglycans in cancer. Gene Ontology (GO) annotations related to this gene include integrin binding and epidermal growth factor receptor binding. An important paralog of this gene is ITGAV.
UniProtKB/Swiss-Prot Summary for ITGA5 Gene
-
Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).
-
(Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus.
-
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19.
-
(Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
-
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.
Additional gene information for ITGA5 Gene
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ITGA5 Gene
Genomics for ITGA5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ITGA5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ITGA5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ITGA5
- Top Transcription factor binding sites by QIAGEN in the ITGA5 gene promoter:
-
- AP-1
- AP-2alpha
- AP-2alpha isoform 2
- AP-2alpha isoform 3
- AP-2alpha isoform 4
- AP-2alphaA
- ATF-2
- c-Jun
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for ITGA5 Gene
Latest Assembly
- chr12:54,395,261-54,419,266
- (GRCh38/hg38)
- Size:
- 24,006 bases
- Orientation:
- Minus strand
Previous Assembly
- chr12:54,789,045-54,813,050
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 24,006 bases
- Orientation:
- Minus strand
Genomic View for ITGA5 Gene
Genes around ITGA5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by HGNC
- 12q13.13 by Entrez Gene
- 12q13.13 by Ensembl
ITGA5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ITGA5 Gene
Proteins for ITGA5 Gene
-
Protein details for ITGA5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08648-ITA5_HUMAN
- Recommended name:
- Integrin alpha-5
- Protein Accession:
- P08648
- Q96HA5
Protein attributes for ITGA5 Gene
- Size:
- 1049 amino acids
- Molecular mass:
- 114536 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with CIB1. ITGA5:ITGB1 interacts with CCN3. ITGA5:ITGB1 interacts with FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 interacts with IL1B (PubMed:29030430). ITGA5:ITGB1 interacts with ACE2 (PubMed:33102950).
- (Microbial infection) Integrin ITGA5:ITGB1 interacts with human metapneumovirus fusion protein.
- (Microbial infection) Integrin ITGA5:ITGB1 interacts with human parvovirus B19 capsid proteins.
- (Microbial infection) Interacts with HIV-1 Tat.
- (Microbial infection) ITGA5:ITGB1 interacts with SARS coronavirus-2/SARS-CoV-2 spike protein.
Protein Expression for ITGA5 Gene
Post-translational modifications for ITGA5 Gene
- Proteolytic cleavage by PCSK5 mediates activation of the precursor.
-
Glycosylation at Asn84, Asn182, Asn297, Asn307, Asn316, Asn524, Asn530, Asn593, Asn609, Asn675, Asn712, Asn724, Asn773, and Asn868
- NX_P08648 (NX_P08648-1)
-
Ubiquitination at Lys215
- NX_P08648 (NX_P08648-1)
- Modification sites at PhosphoSitePlus
- Glycosylation from GlyConnect
Other Protein References for ITGA5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences ITGA5/Integrin Alpha 5/CD49e Monoclonal Antibody and ITGA5/Integrin Alpha 5/CD49e Antibody
- G Biosciences Immunotag™ Integrin a5 (CD49e) Antibody
- NSJ Bioreagents Integrin alpha 5 Antibody (ITGA5)
-
Custom Antibody ServicesOriGene Antibodies for ITGA5
- Novus Biologicals Antibodies for ITGA5
-
Abcam antibodies for ITGA5
- Invitrogen Antibodies for ITGA5 (AFLGC-Itga5)
- antibodies-online: Show 119 available ITGA5 Antibodies ranked by validation data
- Compare Top ITGA5 Antibodies
-
Recommended
- 68 WB Antibodies (anti-mouse)
- 39 FACS Antibodies (anti-mouse)
- 26 IHC Antibodies (anti-mouse)
- 14 IHC (fro) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 10 IP Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 140 WB Antibodies (anti-human)
- 23 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 10 IP Antibodies (anti-human)
- 9 IHC Antibodies (anti-human)
- 7 IF Antibodies (anti-human)
- 5 IHC (fro) Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 35 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 7 IP Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for ITGA5
- integrin, alpha 5 (fibronectin receptor, alpha polypeptide) [22-054]
- integrin, alpha 5 (fibronectin receptor, alpha polypeptide) [51-385]
- Integrin alpha-5 [56-279]
- Integrin alpha-5 [61-961]
- Integrin alpha-5 [61-569]
- integrin alpha 5 (fibronectin receptor alpha) [98-807]
- integrin alpha 5 (fibronectin receptor alpha) [98-808]
- integrin alpha 5 (fibronectin receptor alpha) [98-810]
- integrin alpha 5 (fibronectin receptor alpha) [98-811]
-
Santa Cruz Biotechnology (SCBT) Antibodies for ITGA5
- Sino Biological Antibodies for ITGA5
Protein products for research
- G Biosciences Human Integrin alpha-5/CD49e, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for ITGA5
- Origene Custom Protein Services for ITGA5
-
ProSci Proteins for ITGA5
-
Abcam proteins for ITGA5
Assay products for research
No data available for DME Specific Peptides for ITGA5 Gene
Domains & Families for ITGA5 Gene
Gene Families for ITGA5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Plasma proteins
- Predicted membrane proteins
Protein Domains for ITGA5 Gene
- InterPro:
- Blocks:
-
- Integrins alpha chain
- Integrin alpha chain, C-terminal cytoplasmic region
- FG-GAP
Suggested Antigen Peptide Sequences for ITGA5 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ50382, moderately similar to Integrin alpha-5 (B4E3F4_HUMAN)
- VLA-5 (ITA5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P08648- Family:
-
- Belongs to the integrin alpha chain family.
Function for ITGA5 Gene
Molecular function for ITGA5 Gene
- UniProtKB/Swiss-Prot Function:
- Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
- GENATLAS Biochemistry:
- integrin,alpha 5 component of VLA-5 receptor,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,complexing with ITGB1 in fibronectin receptor
Phenotypes From GWAS Catalog for ITGA5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001618 | virus receptor activity | IEA | -- |
| GO:0005154 | epidermal growth factor receptor binding | IEA | -- |
| GO:0005161 | platelet-derived growth factor receptor binding | TAS | 19267251 |
| GO:0005178 | integrin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 12695522 |
Phenotypes for ITGA5 Gene
- MGI mutant phenotypes for ITGA5:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for ITGA5:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Synthetic lethal with Ras
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased viability in non-small-cell lung cancer (NSCLC) lineage
- Increased cell number in G1, small nuclei in G1
- Decreased cell migration
Animal Models for research
-
Taconic Biosciences Mouse Models for ITGA5
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ITGA5 - Starting at $85 >
- * ITGA5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ITGA5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ITGA5
-
Santa Cruz Biotechnology (SCBT) CRISPR for ITGA5
miRNA for ITGA5 Gene
- miRTarBase miRNAs that target ITGA5
-
- hsa-miR-92a-3p (MIRT003031)
- hsa-miR-31-5p (MIRT004976)
- hsa-miR-148b-3p (MIRT007314)
- mmu-miR-34b-5p (MIRT012761)
- hsa-miR-98-5p (MIRT027753)
- hsa-miR-1229-3p (MIRT036327)
- hsa-miR-484 (MIRT042174)
- hsa-miR-183-5p (MIRT047079)
- hsa-miR-152-3p (MIRT053040)
- hsa-miR-148a-3p (MIRT053480)
- hsa-miR-205-5p (MIRT054779)
- hsa-miR-30e-3p (MIRT702629)
- hsa-miR-30d-3p (MIRT702630)
- hsa-miR-30a-3p (MIRT702631)
- hsa-miR-222-5p (MIRT702632)
- hsa-miR-6846-3p (MIRT702633)
- hsa-miR-5585-5p (MIRT702634)
- hsa-miR-4667-3p (MIRT702635)
- hsa-miR-6887-3p (MIRT702636)
- hsa-miR-383-3p (MIRT702637)
- hsa-miR-3065-3p (MIRT702638)
- hsa-miR-4482-5p (MIRT702639)
- hsa-miR-3130-5p (MIRT702640)
- hsa-miR-1912 (MIRT702641)
- hsa-miR-1295b-5p (MIRT702642)
- hsa-miR-26a-5p (MIRT731168)
- hsa-miR-17-3p (MIRT731715)
- hsa-miR-330-5p (MIRT734133)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ITGA5
- Browse OriGene Inhibitory RNA Products For ITGA5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGA5
Clone products for research
- Applied Biological Materials (abm): Clones for ITGA5 - Starting at $45 >
- * ITGA5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ITGA5
- Addgene plasmids for ITGA5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ITGA5
Cell Lines for research
-
Horizon Cell Lines for ITGA5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGA5 Gene
Localization for ITGA5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ITGA5 Gene
- Membrane. Single-pass type I membrane protein. Cell junction, focal adhesion. Cell surface.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| nucleus | 3 |
| endoplasmic reticulum | 3 |
| cytosol | 3 |
| golgi apparatus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endosome | 2 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001726 | ruffle | TAS | 11919189 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005886 | plasma membrane | IEA,TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ITGA5 Gene
Pathways & Interactions for ITGA5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
|
Actin-Based Motility by Rho Family GTPases
.62
Rap1 Pathway
.57
|
| 2 | Integrin Pathway |
FAK1 Signaling
.67
Integrin Pathway
.67
GnRH Signaling
.56
|
UPA-UPAR Pathway
.56
Transendothelial Migration of Leukocytes
.38
|
| 3 | Focal Adhesion |
.61
.61
|
HGF Pathway
.33
|
| 4 | Actin Nucleation by ARP-WASP Complex |
Actin Nucleation and Branching
.66
Actin Nucleation by ARP-WASP Complex
.66
|
CDC42 Pathway
.41
RhoA Pathway
.35
|
| 5 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
MAPK Signaling
.58
Molecular Mechanisms of Cancer
.51
|
Pathways by source for ITGA5 Gene
6 Sino Biological pathways for ITGA5 Gene
8 BioSystems pathways for ITGA5 Gene
10 Reactome pathways for ITGA5 Gene
8 GeneGo (Thomson Reuters) pathways for ITGA5 Gene
- Cell adhesion Integrin inside-out signaling
- Cell adhesion Integrin-mediated cell adhesion and migration
- Cell adhesion_ECM remodeling
- Cell adhesion_Endothelial cell contacts by non-junctional mechanisms
- Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
3 R&D Systems pathways for ITGA5 Gene
33 Qiagen pathways for ITGA5 Gene
- Actin Nucleation and Branching
- Actin Nucleation by ARP-WASP Complex
- Actin-Based Motility by Rho Family GTPases
- Akt Signaling
- Calpain Protease Regulates Cellular Mechanics
3 Cell Signaling Technology pathways for ITGA5 Gene
Interacting Proteins for ITGA5 Gene
Selected Interacting proteins:
P08648-ITA5_HUMAN
ENSP00000293379
for ITGA5 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ITGA5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | TAS | 19267251 |
| GO:0007044 | cell-substrate junction assembly | IEA | -- |
| GO:0007155 | cell adhesion | TAS,IDA | 19703720 |
| GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | IEA | -- |
| GO:0007159 | leukocyte cell-cell adhesion | IEA | -- |
Drugs & Compounds for ITGA5 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cilengitide | Investigational | Pharma | inhibitor | Integrin inhibitor for αvβ3 and αvβ5, Integrins | 0 | |
| Resveratrol | Investigational | Pharma | Target | Cyclooxygenase inhibitor | 170 | |
| Volociximab | Investigational | Pharma | Antibody | Integrins | 10 | |
| Cyclo (-RGDfK) | Pharma | Inhibitor of αvβ3 integrin | 0 | |||
| RGD (Arg-Gly-Asp) Peptides | Pharma | Inhibits integrin binding to RGD motifs | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Echistatin, alpha1 isoform |
|
154303-05-6 |
|
|
(5) Tocris Compounds for ITGA5 Gene
| Compound | Action | Cas Number |
|---|---|---|
| A 205804 | Selective inhibitor of E-selectin and ICAM-1 expression | 251992-66-2 |
| Echistatin, alpha1 isoform | alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor | 154303-05-6 |
| GR 144053 trihydrochloride | Glycoprotein IIb/IIIa (integrin alphaIIbbeta3) receptor antagonist. Antithrombotic | 1215333-48-4 |
| Obtustatin | Potent and selective alpha1beta1 inhibitor | |
| P11 | Potent antagonist of alphavbeta3-vitronectin interaction; antiangiogenic | 848644-86-0 |
(3) ApexBio Compounds for ITGA5 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Cilengitide | Integrin inhibitor for αvβ3 and αvβ5 | 188968-51-6 |
| Cyclo (-RGDfK) | Inhibitor of αvβ3 integrin | 161552-03-0 |
| RGD (Arg-Gly-Asp) Peptides | Inhibits integrin binding to RGD motifs | 99896-85-2 |
Drug products for research
- G Biosciences Human Integrin alpha-5/CD49e, Lyophilized
- ApexBio compounds for ITGA5
Transcripts for ITGA5 Gene
mRNA/cDNA for ITGA5 Gene
- 1 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000293379 4250 nts (view in UCSC)
- ENST00000435631 1240 nts (view in UCSC)
- ENST00000547197 757 nts (view in UCSC)
- ENST00000547744 547 nts (view in UCSC)
- ENST00000549601 505 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ITGA5 - Starting at $85 >
- * ITGA5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ITGA5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ITGA5
-
Santa Cruz Biotechnology (SCBT) CRISPR for ITGA5
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ITGA5
- Browse OriGene Inhibitory RNA Products For ITGA5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGA5
Clone products for research
- Applied Biological Materials (abm): Clones for ITGA5 - Starting at $45 >
- * ITGA5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ITGA5
- Addgene plasmids for ITGA5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ITGA5
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19a | · | 19b | · | 19c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
| ExUns: | 19d | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | · | 28c | ^ | 29 | ^ | 30a | · | 30b | ^ | 31a | · | 31b | · | 31c | ^ | 32a | · | 32b | · | 32c | · | 32d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
Relevant External Links for ITGA5 Gene
- GeneLoc Exon Structure for
- ITGA5
Expression for ITGA5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Cartilage (Muscoskeletal System)
- Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
- Interzone Cells Autopod Synovial Joint
- Interzone Cells Stylopod Synovial Joint
- Interzone Cells Zeugopod Synovial Joint
-
Paraxial Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm Cells Trunk Mesoderm
- Presegmented Somitic Mesenchyme Cells Presomitic Mesoderm
- Presomitic Mesoderm Cells Presomitic Mesoderm
- Bone (Muscoskeletal System)
-
Limb (Muscoskeletal System)
- Interzone Cells Autopod Synovial Joint
- Interzone Cells Stylopod Synovial Joint
- Interzone Cells Zeugopod Synovial Joint
- Gut Tube (Gastrointestinal Tract)
-
Somite (Muscoskeletal System)
- Presegmented Somitic Mesenchyme Cells Presomitic Mesoderm
- Presomitic Mesoderm Cells Presomitic Mesoderm
- Mesenchymal Stem Cells
-
Adipose (Muscoskeletal System)
- Stromal Cells Subcutaneous White Adipose
-
Lung (Respiratory System)
- Basal Cells Respiratory Bronchioles
-
Epithelial Cells
- Basal Cells Respiratory Bronchioles
-
Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm Cells Trunk Mesoderm
- Brain (Nervous System)
- Umbilical Cord (Extraembryonic Tissues)
-
Placenta (Extraembryonic Tissues)
-
Gall Bladder (Hepatobiliary System)
-
Fibroblasts (Uncategorized)
-
Esophagus (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for ITGA5 Gene
This gene is overexpressed in Artery - Tibial (x8.6) and Colon - Sigmoid (x6.1).
This gene is overexpressed in Urinary Bladder (22.7), Seminal vesicle (10.5), and Colon muscle (10.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ITGA5 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ITGA5
SOURCE GeneReport for Unigene cluster for ITGA5 Gene:
Hs.505654Evidence on tissue expression from TISSUES for ITGA5 Gene
- Liver(4.5)
- Lung(4.2)
- Nervous system(3.8)
- Kidney(3.1)
- Blood(3.1)
- Intestine(3)
- Bone marrow(2.9)
- Heart(2.9)
- Skin(2.8)
- Muscle(2.8)
- Bone(2.5)
- Lymph node(2.4)
- Eye(2.3)
- Spleen(2.2)
- Pancreas(2.1)
- Stomach(2.1)
- Thyroid gland(2.1)
Primer products for research
-
OriGene qPCR primer pairs for ITGA5
-
OriGene qPCR primer pairs and template standards for ITGA5
Gene Expression Assays for research
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGA5 Gene
Orthologs for ITGA5 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ITGA5 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ITGA5 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ITGA5 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Itga5 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Itga5 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ITGA5 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | -- 30 |
|
ManyToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | ITGA5 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | itga5 29 |
|
||
| Str.3950 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | itga5-A 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | itga5 29 30 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | alphaPS4 31 |
|
|
|
| alphaPS5 31 |
|
|
|||
| if 30 31 |
|
OneToMany | |||
| scb 31 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | F54F2.1 31 |
|
|
|
| pat-2 30 |
|
OneToMany | |||
| ina-1 31 |
|
|
- Species where no ortholog for ITGA5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ITGA5 Gene
- ENSEMBL:
- Gene Tree for ITGA5 (if available)
- TreeFam:
- Gene Tree for ITGA5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ITGA5: view image
- Alliance of Genome Resources:
- Additional Orthologs for ITGA5
Paralogs for ITGA5 Gene
Paralogs for ITGA5 Gene
(5) SIMAP similar genes for ITGA5 Gene using alignment to 4 proteins:
- ITA5_HUMAN
- B4E3F4_HUMAN
- H0YHL9_HUMAN
- H0YIV7_HUMAN
Variants for ITGA5 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ITGA5 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs112896207 | Benign: not provided | 54,404,227(-) |
C/T NM_002205.5(ITGA5):c.1483G>A (p.Ala495Thr) |
MISSENSE | |
| rs116004551 | Benign: not provided | 54,399,717(-) |
G/A NM_002205.5(ITGA5):c.2769C>T (p.Leu923=) |
SYNONYMOUS | |
| rs141408484 | Benign: not provided | 54,402,061(-) |
G/A NM_002205.5(ITGA5):c.2166C>T (p.Ala722=) |
SYNONYMOUS | |
| rs144650038 | Benign: not provided | 54,403,258(-) |
G/T NM_002205.5(ITGA5):c.1843C>A (p.Gln615Lys) |
MISSENSE | |
| rs186738212 | Benign: not provided | 54,399,935(-) |
C/G NM_002205.5(ITGA5):c.2656G>C (p.Gly886Arg) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2745915 | CNV | deletion | 23290073 |
| esv3549239 | CNV | deletion | 23714750 |
| nsv559000 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.58;
56.14% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ITGA5 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA5 Gene
Disorders for ITGA5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| colorectal cancer, hereditary nonpolyposis, type 8 |
|
|
| lung cancer |
|
|
| prolapse of urethra |
|
|
| muscular dystrophy, congenital, due to integrin alpha-7 deficiency |
|
|
| colorectal cancer |
|
|
Search ITGA5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ITGA5
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ITGA5 Gene
Publications for ITGA5 Gene
- The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection. (PMID: 33102950) Beddingfield BJ … Bix GJ (JACC. Basic to translational science 2021) 3 4
- Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling. (PMID: 31331973) Takada YK … Takada Y (Journal of immunology (Baltimore, Md. : 1950) 2019) 3 4
- Roles of the putative integrin-binding motif of the human metapneumovirus fusion (f) protein in cell-cell fusion, viral infectivity, and pathogenesis. (PMID: 24478423) Wei Y … Li J (Journal of virology 2014) 3 4
- Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity. (PMID: 24011356) Freeman TC … Parise LV (Biochemistry 2013) 3 4
- Crystal structure of α5β1 integrin ectodomain: atomic details of the fibronectin receptor. (PMID: 22451694) Nagae M … Takagi J (The Journal of cell biology 2012) 3 4
ExternalLinks
Products for ITGA5 Gene
- View all R&D Systems ITGA5 (Integrin alpha 5 beta 1) Products
- View all 25 R&D Systems ITGA5 (Integrin alpha 5/CD49e) Products
- View all R&D Systems ITGA5 (Integrin alpha 5 beta 1) Proteins and Enzymes
- View all 22 R&D Systems ITGA5 (Integrin alpha 5/CD49e) Primary Antibodies
- View all R&D Systems ITGA5 (Integrin alpha 5/CD49e) ELISAs
- View all R&D Systems ITGA5 (Integrin alpha 5/CD49e) Proteome Profiler Antibody Arrays
- View all R&D Systems ITGA5 (Integrin alpha 5/CD49e) cDNA Clones
- Learn more about R&D Systems custom ITGA5 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for ITGA5
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for ITGA5
- Origene Custom Protein Services for ITGA5
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ITGA5
- Browse OriGene Inhibitory RNA Products For ITGA5
- OriGene qPCR primer pairs for ITGA5
- OriGene qPCR primer pairs and template standards for ITGA5
- OriGene CRISPR knockouts for ITGA5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ITGA5
- Sino Biological Human cDNA Clone for ITGA5
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for ITGA5
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ITGA5
- Novus Biologicals proteins and lysates for ITGA5
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ITGA5
- Abcam proteins for ITGA5
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for ITGA5
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ITGA5 (AFLGC-Itga5)
- ApexBio compounds for ITGA5
- VectorBuilder Custom and pre-made DNA vectors for ITGA5 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ITGA5 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ITGA5 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ITGA5 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ITGA5
- Addgene plasmids for ITGA5
- antibodies-online: Show 119 available ITGA5 Antibodies ranked by validation data
- Compare Top ITGA5 Antibodies
- Recommended
- 68 WB Antibodies (anti-mouse)
- 39 FACS Antibodies (anti-mouse)
- 26 IHC Antibodies (anti-mouse)
- 14 IHC (fro) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 10 IP Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 140 WB Antibodies (anti-human)
- 23 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 10 IP Antibodies (anti-human)
- 9 IHC Antibodies (anti-human)
- 7 IF Antibodies (anti-human)
- 5 IHC (fro) Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 35 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 7 IP Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- antibodies-online: Show 15 available ITGA5 Elisa Kits ranked by validation data
- Compare Top ITGA5 Elisa Kits
- antibodies-online: Show 18 available ITGA5 Proteins ranked by validation data
- Compare Top ITGA5 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for ITGA5