ITGA5 Gene (Protein Coding)

Integrin Subunit Alpha 5

GC12M054396
GIFtS:
48
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with ... See more...

Aliases for ITGA5 Gene

Aliases for ITGA5 Gene

  • Integrin Subunit Alpha 5 2 3 5
  • Integrin, Alpha 5 (Fibronectin Receptor, Alpha Polypeptide) 2 3
  • Fibronectin Receptor, Alpha Polypeptide 2 3
  • Fibronectin Receptor Subunit Alpha 3 4
  • CD49 Antigen-Like Family Member E 3 4
  • Integrin Alpha-5 3 4
  • Integrin Alpha-F 3 4
  • CD49e 2 3
  • VLA-5 3 4
  • FNRA 3 4
  • Very Late Activation Protein 5, Alpha Subunit 3
  • Fibronectin Receptor, Alpha Subunit 3
  • ITGA5/SLC9B1 Fusion 3
  • CD49e Antigen 4
  • VLA5A 3
  • ITGA5 5

External Ids for ITGA5 Gene

Previous HGNC Symbols for ITGA5 Gene

  • FNRA

Previous GeneCards Identifiers for ITGA5 Gene

  • GC12M054915
  • GC12M054505
  • GC12M053075
  • GC12M054789
  • GC12M051828

Summaries for ITGA5 Gene

Entrez Gene Summary for ITGA5 Gene

  • The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

GeneCards Summary for ITGA5 Gene

ITGA5 (Integrin Subunit Alpha 5) is a Protein Coding gene. Diseases associated with ITGA5 include Colorectal Cancer, Hereditary Nonpolyposis, Type 8 and Lung Cancer. Among its related pathways are Integrin Pathway and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include integrin binding and epidermal growth factor receptor binding. An important paralog of this gene is ITGAV.

UniProtKB/Swiss-Prot Summary for ITGA5 Gene

  • Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).
  • (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus.
  • (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19.
  • (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Tocris Summary for ITGA5 Gene

  • Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.

Gene Wiki entry for ITGA5 Gene

Additional gene information for ITGA5 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ITGA5 Gene

Genomics for ITGA5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ITGA5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ITGA5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ITGA5

Top Transcription factor binding sites by QIAGEN in the ITGA5 gene promoter:
  • AP-1
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • ATF-2
  • c-Jun
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for ITGA5 Gene

Genomic Locations for ITGA5 Gene
chr12:54,395,261-54,419,266
(GRCh38/hg38)
Size:
24,006 bases
Orientation:
Minus strand
chr12:54,789,045-54,813,244
(GRCh37/hg19)
Size:
24,200 bases
Orientation:
Minus strand

Genomic View for ITGA5 Gene

Genes around ITGA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGA5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ITGA5 Gene

Proteins for ITGA5 Gene

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  • Protein details for ITGA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08648-ITA5_HUMAN
    Recommended name:
    Integrin alpha-5
    Protein Accession:
    P08648
    Secondary Accessions:
    • Q96HA5

    Protein attributes for ITGA5 Gene

    Size:
    1049 amino acids
    Molecular mass:
    114536 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with CIB1. ITGA5:ITGB1 interacts with CCN3. ITGA5:ITGB1 interacts with FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 interacts with IL1B (PubMed:29030430).
    • (Microbial infection) Integrin ITGA5:ITGB1 interacts with human metapneumovirus fusion protein.
    • (Microbial infection) Integrin ITGA2:ITGB1 interacts with human parvovirus B19 capsid proteins.
    • (Microbial infection) Interacts with HIV-1 Tat.

    Three dimensional structures from OCA and Proteopedia for ITGA5 Gene

neXtProt entry for ITGA5 Gene

Protein Expression for ITGA5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ITGA5 Gene

  • Proteolytic cleavage by PCSK5 mediates activation of the precursor.
  • Glycosylation at Asn84, Asn182, Asn297, Asn307, Asn316, Asn524, Asn530, Asn593, Asn609, Asn675, Asn712, Asn724, Asn773, and Asn868
  • Ubiquitination at Lys215
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for ITGA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ITGA5 Gene

Domains & Families for ITGA5 Gene

Gene Families for ITGA5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for ITGA5 Gene

InterPro:
Blocks:
  • Integrins alpha chain
  • Integrin alpha chain, C-terminal cytoplasmic region
  • FG-GAP
ProtoNet:

Suggested Antigen Peptide Sequences for ITGA5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50382, moderately similar to Integrin alpha-5 (B4E3F4_HUMAN)
  • VLA-5 (ITA5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08648

UniProtKB/Swiss-Prot:

ITA5_HUMAN :
  • Belongs to the integrin alpha chain family.
Family:
  • Belongs to the integrin alpha chain family.
genes like me logo Genes that share domains with ITGA5: view

Function for ITGA5 Gene

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Molecular function for ITGA5 Gene

UniProtKB/Swiss-Prot Function:
Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19.
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
GENATLAS Biochemistry:
integrin,alpha 5 component of VLA-5 receptor,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,complexing with ITGB1 in fibronectin receptor

Phenotypes From GWAS Catalog for ITGA5 Gene

Gene Ontology (GO) - Molecular Function for ITGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005154 epidermal growth factor receptor binding IEA --
GO:0005161 platelet-derived growth factor receptor binding TAS 19267251
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 12695522
genes like me logo Genes that share ontologies with ITGA5: view
genes like me logo Genes that share phenotypes with ITGA5: view

Animal Models for ITGA5 Gene

MGI Knock Outs for ITGA5:

Animal Model Products

  • Taconic Biosciences Mouse Models for ITGA5

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGA5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGA5 Gene

Localization for ITGA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA5 Gene

Membrane. Single-pass type I membrane protein. Cell junction, focal adhesion. Cell surface.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITGA5 gene
Compartment Confidence
plasma membrane 5
extracellular 3
nucleus 3
endoplasmic reticulum 3
cytosol 3
golgi apparatus 3
cytoskeleton 2
mitochondrion 2
endosome 2
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ITGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle TAS 11919189
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA,TAS --
genes like me logo Genes that share ontologies with ITGA5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ITGA5 Gene

Pathways & Interactions for ITGA5 Gene

PathCards logo

SuperPathways for ITGA5 Gene

SuperPathway Contained pathways
1 MAPK Erk Pathway
G Protein coupled Receptors Signaling
.32
G Protein coupled Receptors Signaling
.32
G Protein coupled Receptors Signaling
.32
MAPK Erk Pathway
.32
MAPK Erk Pathway
.32
MAPK Erk Pathway
.32
Actin Dynamics Signaling Pathway
.31
2 Apoptotic Pathways in Synovial Fibroblasts
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
Rap1 Pathway
.57
3 Integrin Pathway
FAK1 Signaling
.67
Integrin Pathway
.67
GnRH Signaling
.56
UPA-UPAR Pathway
.56
Transendothelial Migration of Leukocytes
.38
4 Focal Adhesion
Focal adhesion
.61
Focal Adhesion
.61
Integrin-mediated Cell Adhesion
.38
HGF Pathway
.33
5 Actin Nucleation by ARP-WASP Complex
Actin Nucleation and Branching
.66
Actin Nucleation by ARP-WASP Complex
.66
CDC42 Pathway
.41
RhoA Pathway
.35
genes like me logo Genes that share pathways with ITGA5: view

Pathways by source for ITGA5 Gene

8 GeneGo (Thomson Reuters) pathways for ITGA5 Gene
  • Cell adhesion Integrin inside-out signaling
  • Cell adhesion Integrin-mediated cell adhesion and migration
  • Cell adhesion_ECM remodeling
  • Cell adhesion_Endothelial cell contacts by non-junctional mechanisms
  • Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
33 Qiagen pathways for ITGA5 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Akt Signaling
  • Calpain Protease Regulates Cellular Mechanics
3 Cell Signaling Technology pathways for ITGA5 Gene

Gene Ontology (GO) - Biological Process for ITGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis TAS 19267251
GO:0007044 cell-substrate junction assembly IEA --
GO:0007155 cell adhesion TAS,IDA 19703720
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
GO:0007159 leukocyte cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with ITGA5: view

No data available for SIGNOR curated interactions for ITGA5 Gene

Drugs & Compounds for ITGA5 Gene

Products:

  1. Drug

(17) Drugs for ITGA5 Gene - From: DrugBank, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cilengitide Investigational Pharma inhibitor Integrin inhibitor for αvβ3 and αvβ5, Integrins 0
Resveratrol Investigational Pharma Target Cyclooxygenase inhibitor 156
Volociximab Investigational Pharma Antibody Integrins 10
Cyclo (-RGDfK) Pharma Inhibitor of αvβ3 integrin 0
RGD (Arg-Gly-Asp) Peptides Pharma Inhibits integrin binding to RGD motifs 0

(5) Additional Compounds for ITGA5 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Echistatin, alpha1 isoform
154303-05-6

(5) Tocris Compounds for ITGA5 Gene

Compound Action Cas Number
A 205804 Selective inhibitor of E-selectin and ICAM-1 expression 251992-66-2
Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor 154303-05-6
GR 144053 trihydrochloride Glycoprotein IIb/IIIa (integrin alphaIIbbeta3) receptor antagonist. Antithrombotic 1215333-48-4
Obtustatin Potent and selective alpha1beta1 inhibitor
P11 Potent antagonist of alphavbeta3-vitronectin interaction; antiangiogenic 848644-86-0

(3) ApexBio Compounds for ITGA5 Gene

Compound Action Cas Number
Cilengitide Integrin inhibitor for αvβ3 and αvβ5 188968-51-6
Cyclo (-RGDfK) Inhibitor of αvβ3 integrin 161552-03-0
RGD (Arg-Gly-Asp) Peptides Inhibits integrin binding to RGD motifs 99896-85-2
genes like me logo Genes that share compounds with ITGA5: view

Transcripts for ITGA5 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ITGA5 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGA5

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c ·
SP1: - - - - -
SP2: - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

ExUns: 19d ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c ^ 29 ^ 30a · 30b ^ 31a · 31b · 31c ^ 32a · 32b · 32c · 32d
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6:
SP7: -
SP8: -
SP9:
SP10:

Relevant External Links for ITGA5 Gene

GeneLoc Exon Structure for
ITGA5

Expression for ITGA5 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ITGA5 Gene

mRNA expression in normal human tissues for ITGA5 Gene
mRNA expression by BioGPS for ITGA5 GenemRNA expression by GTEx for ITGA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGA5 Gene

This gene is overexpressed in Artery - Tibial (x8.6) and Colon - Sigmoid (x6.1).

Protein differential expression in normal tissues from HIPED for ITGA5 Gene

This gene is overexpressed in Urinary Bladder (22.7), Seminal vesicle (10.5), and Colon muscle (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ITGA5 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ITGA5

SOURCE GeneReport for Unigene cluster for ITGA5 Gene:

Hs.505654

Evidence on tissue expression from TISSUES for ITGA5 Gene

  • Liver(4.5)
  • Lung(4.2)
  • Nervous system(3.9)
  • Blood(3.3)
  • Kidney(3.2)
  • Intestine(3.2)
  • Bone marrow(3.1)
  • Heart(3.1)
  • Skin(3)
  • Muscle(2.9)
  • Bone(2.7)
  • Lymph node(2.6)
  • Eye(2.4)
  • Spleen(2.3)
  • Pancreas(2.2)
  • Thyroid gland(2.2)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with ITGA5: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGA5 Gene

Orthologs for ITGA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGA5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ITGA5 30 31
  • 99.49 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ITGA5 30 31
  • 90.44 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ITGA5 30 31
  • 88.37 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Itga5 30 17 31
  • 87.45 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Itga5 30
  • 87.22 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia ITGA5 31
  • 78 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves -- 31
  • 20 (a)
 ManyToMany
Lizard
(Anolis carolinensis)
 Reptilia ITGA5 31
  • 66 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia itga5 30
  • 65.84 (n)
Str.3950 30
African clawed frog
(Xenopus laevis)
 Amphibia itga5-A 30
Zebrafish
(Danio rerio)
 Actinopterygii itga5 30 31
  • 61.05 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta alphaPS4 32
  • 26 (a)
alphaPS5 32
  • 26 (a)
if 31 32
  • 24 (a)
 OneToMany
scb 32
  • 24 (a)
Worm
(Caenorhabditis elegans)
 Secernentea F54F2.1 32
  • 30 (a)
pat-2 31
  • 26 (a)
 OneToMany
ina-1 32
  • 25 (a)
Species where no ortholog for ITGA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ITGA5 Gene

ENSEMBL:
Gene Tree for ITGA5 (if available)
TreeFam:
Gene Tree for ITGA5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ITGA5: view image

Paralogs for ITGA5 Gene

Paralogs for ITGA5 Gene

(5) SIMAP similar genes for ITGA5 Gene using alignment to 4 proteins:

  • ITA5_HUMAN
  • B4E3F4_HUMAN
  • H0YHL9_HUMAN
  • H0YIV7_HUMAN
genes like me logo Genes that share paralogs with ITGA5: view

Variants for ITGA5 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ITGA5 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
718349 Benign: not provided 54,399,935(-) C/G MISSENSE_VARIANT
781075 Benign: not provided 54,399,717(-) G/A SYNONYMOUS_VARIANT
782560 Benign: not provided 54,404,227(-) C/T MISSENSE_VARIANT
783665 Benign: not provided 54,404,225(-) A/G SYNONYMOUS_VARIANT
783666 Benign: not provided 54,404,228(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ITGA5 Gene

Structural Variations from Database of Genomic Variants (DGV) for ITGA5 Gene

Variant ID Type Subtype PubMed ID
esv2745915 CNV deletion 23290073
esv3549239 CNV deletion 23714750
nsv559000 CNV loss 21841781

Variation tolerance for ITGA5 Gene

Residual Variation Intolerance Score: 5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITGA5 Gene

Human Gene Mutation Database (HGMD)
ITGA5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGA5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA5 Gene

Disorders for ITGA5 Gene

MalaCards: The human disease database

(7) MalaCards diseases for ITGA5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer, hereditary nonpolyposis, type 8
  • hnpcc8
lung cancer
  • adenocarcinoma of lung
colon carcinoma in situ
  • carcinoma in situ of colon
muscular dystrophy, congenital, due to integrin alpha-7 deficiency
  • myopathy, congenital, due to integrin alpha-7 deficiency
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search ITGA5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ITGA5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ITGA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGA5 Gene

Publications for ITGA5 Gene

  1. Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling. (PMID: 31331973) Takada YK … Takada Y (Journal of immunology (Baltimore, Md. : 1950) 2019) 3 4
  2. Roles of the putative integrin-binding motif of the human metapneumovirus fusion (f) protein in cell-cell fusion, viral infectivity, and pathogenesis. (PMID: 24478423) Wei Y … Li J (Journal of virology 2014) 3 4
  3. Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity. (PMID: 24011356) Freeman TC … Parise LV (Biochemistry 2013) 3 4
  4. Crystal structure of α5β1 integrin ectodomain: atomic details of the fibronectin receptor. (PMID: 22451694) Nagae M … Takagi J (The Journal of cell biology 2012) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41

ExternalLinks

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