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The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
ITGA5 (Integrin Subunit Alpha 5) is a Protein Coding gene. Diseases associated with ITGA5 include Colorectal Cancer, Hereditary Nonpolyposis, Type 8 and Lung Cancer. Among its related pathways are Integrin Pathway and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include integrin binding and epidermal growth factor receptor binding. An important paralog of this gene is ITGAV.
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001618 | virus receptor activity | IEA | -- |
GO:0005154 | epidermal growth factor receptor binding | IEA | -- |
GO:0005161 | platelet-derived growth factor receptor binding | TAS | 19267251 |
GO:0005178 | integrin binding | IEA | -- |
GO:0005515 | protein binding | IPI | 12695522 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001726 | ruffle | TAS | 11919189 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0005886 | plasma membrane | IEA,TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MAPK Erk Pathway |
.32
|
.32
.32
|
2 | Apoptotic Pathways in Synovial Fibroblasts |
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
|
Actin-Based Motility by Rho Family GTPases
.62
Rap1 Pathway
.57
|
3 | Integrin Pathway |
FAK1 Signaling
.67
Integrin Pathway
.67
GnRH Signaling
.56
|
UPA-UPAR Pathway
.56
Transendothelial Migration of Leukocytes
.38
|
4 | Focal Adhesion |
.61
.61
|
HGF Pathway
.33
|
5 | Actin Nucleation by ARP-WASP Complex |
Actin Nucleation and Branching
.66
Actin Nucleation by ARP-WASP Complex
.66
|
CDC42 Pathway
.41
RhoA Pathway
.35
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001525 | angiogenesis | TAS | 19267251 |
GO:0007044 | cell-substrate junction assembly | IEA | -- |
GO:0007155 | cell adhesion | TAS,IDA | 19703720 |
GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | IEA | -- |
GO:0007159 | leukocyte cell-cell adhesion | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Cilengitide | Investigational | Pharma | inhibitor | Integrin inhibitor for αvβ3 and αvβ5, Integrins | 0 | |
Resveratrol | Investigational | Pharma | Target | Cyclooxygenase inhibitor | 156 | |
Volociximab | Investigational | Pharma | Antibody | Integrins | 10 | |
Cyclo (-RGDfK) | Pharma | Inhibitor of αvβ3 integrin | 0 | |||
RGD (Arg-Gly-Asp) Peptides | Pharma | Inhibits integrin binding to RGD motifs | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Echistatin, alpha1 isoform |
|
154303-05-6 |
|
|
Compound | Action | Cas Number |
---|---|---|
A 205804 | Selective inhibitor of E-selectin and ICAM-1 expression | 251992-66-2 |
Echistatin, alpha1 isoform | alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor | 154303-05-6 |
GR 144053 trihydrochloride | Glycoprotein IIb/IIIa (integrin alphaIIbbeta3) receptor antagonist. Antithrombotic | 1215333-48-4 |
Obtustatin | Potent and selective alpha1beta1 inhibitor | |
P11 | Potent antagonist of alphavbeta3-vitronectin interaction; antiangiogenic | 848644-86-0 |
Compound | Action | Cas Number |
---|---|---|
Cilengitide | Integrin inhibitor for αvβ3 and αvβ5 | 188968-51-6 |
Cyclo (-RGDfK) | Inhibitor of αvβ3 integrin | 161552-03-0 |
RGD (Arg-Gly-Asp) Peptides | Inhibits integrin binding to RGD motifs | 99896-85-2 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19a | · | 19b | · | 19c | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: |
ExUns: | 19d | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | · | 28c | ^ | 29 | ^ | 30a | · | 30b | ^ | 31a | · | 31b | · | 31c | ^ | 32a | · | 32b | · | 32c | · | 32d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||||||||||||||||||||||
SP10: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ITGA5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ITGA5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ITGA5 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Itga5 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Itga5 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ITGA5 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | ITGA5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | itga5 30 |
|
||
Str.3950 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | itga5-A 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | itga5 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | alphaPS4 32 |
|
|
|
alphaPS5 32 |
|
|
|||
if 31 32 |
|
OneToMany | |||
scb 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | F54F2.1 32 |
|
|
|
pat-2 31 |
|
OneToMany | |||
ina-1 32 |
|
|
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
718349 | Benign: not provided | 54,399,935(-) | C/G | MISSENSE_VARIANT | |
781075 | Benign: not provided | 54,399,717(-) | G/A | SYNONYMOUS_VARIANT | |
782560 | Benign: not provided | 54,404,227(-) | C/T | MISSENSE_VARIANT | |
783665 | Benign: not provided | 54,404,225(-) | A/G | SYNONYMOUS_VARIANT | |
783666 | Benign: not provided | 54,404,228(-) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2745915 | CNV | deletion | 23290073 |
esv3549239 | CNV | deletion | 23714750 |
nsv559000 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
colorectal cancer, hereditary nonpolyposis, type 8 |
|
|
lung cancer |
|
|
colon carcinoma in situ |
|
|
muscular dystrophy, congenital, due to integrin alpha-7 deficiency |
|
|
hepatocellular carcinoma |
|