Aliases for ITGA5 Gene
Aliases for ITGA5 Gene
External Ids for ITGA5 Gene
- HGNC: 6141
- Entrez Gene: 3678
- Ensembl: ENSG00000161638
- OMIM: 135620
- UniProtKB: P08648
Previous HGNC Symbols for ITGA5 Gene
- FNRA
Previous GeneCards Identifiers for ITGA5 Gene
- GC12M054915
- GC12M054505
- GC12M053075
- GC12M054789
- GC12M051828
Summaries for ITGA5 Gene
-
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
GeneCards Summary for ITGA5 Gene
ITGA5 (Integrin Subunit Alpha 5) is a Protein Coding gene. Diseases associated with ITGA5 include Colon Carcinoma In Situ and Retinitis Pigmentosa 60. Among its related pathways are Focal Adhesion and Akt Signaling. Gene Ontology (GO) annotations related to this gene include integrin binding and epidermal growth factor receptor binding. An important paralog of this gene is ITGA8.
UniProtKB/Swiss-Prot for ITGA5 Gene
-
Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).
-
(Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus.
-
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19.
-
(Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions.
-
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.
Additional gene information for ITGA5 Gene
- Monarch Initiative
- Search for ITGA5 at DataMed
- Search for ITGA5 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGA5 Gene
Genomics for ITGA5 Gene
GeneHancer (GH) Regulatory Elements for ITGA5 Gene
Promoters and enhancers for ITGA5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around ITGA5 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ITGA5 gene promoter:
-
- AP-1
- AP-2alpha
- AP-2alphaA
- AP-2alpha isoform 4
- AP-2alpha isoform 3
- AP-2alpha isoform 2
- ATF-2
- c-Jun
- PPAR-gamma1
- PPAR-gamma2
Regulatory Element Products
Genomic Locations for ITGA5 Gene
Genomic Locations for ITGA5 Gene
- chr12:54,395,261-54,419,460
- (GRCh38/hg38)
- Size:
- 24,200 bases
- Orientation:
- Minus strand
- chr12:54,789,045-54,813,244
- (GRCh37/hg19)
- Size:
- 24,200 bases
- Orientation:
- Minus strand
Genomic View for ITGA5 Gene
Genes around ITGA5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by Entrez Gene
- 12q13.13 by HGNC
- 12q13.13 by Ensembl
ITGA5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ITGA5 Gene
Proteins for ITGA5 Gene
-
Protein details for ITGA5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08648-ITA5_HUMAN
- Recommended name:
- Integrin alpha-5
- Protein Accession:
- P08648
- Q96HA5
Protein attributes for ITGA5 Gene
- Size:
- 1049 amino acids
- Molecular mass:
- 114536 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with CIB1. ITGA5:ITGB1 interacts with NOV. ITGA5:ITGB1 interacts with FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 interacts with IL1B (PubMed:29030430).
- (Microbial infection) Integrin ITGA5:ITGB1 interacts with human metapneumovirus fusion protein.
- (Microbial infection) Integrin ITGA2:ITGB1 interacts with human parvovirus B19 capsid proteins.
- (Microbial infection) Interacts with HIV-1 Tat.
Protein Expression for ITGA5 Gene
Post-translational modifications for ITGA5 Gene
- Proteolytic cleavage by PCSK5 mediates activation of the precursor.
- Glycosylation at isoforms=868, isoforms=773, Asn771, isoforms=724, isoforms=712, Asn675, isoforms=609, isoforms=593, Asn530, isoforms=524, isoforms=316, isoforms=307, Asn297, Asn182, and Asn84
- Ubiquitination at isoforms=215
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- ITA5_HUMAN (283)
Other Protein References for ITGA5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ITGA5 (Integrin alpha 5/CD49e)
-
Custom Antibody ServicesOriGene Antibodies for ITGA5
- Novus Biologicals Antibodies for ITGA5
-
Abcam antibodies for ITGA5
- Invitrogen Antibodies for ITGA5 (AFLGC-ITGA5)
- antibodies-online: Search results for 417 available ITGA5 Antibodies ranked by validation data
- Compare Top ITGA5 Antibodies
-
Recommended
- 62 WB Antibodies (anti-mouse)
- 52 FACS Antibodies (anti-mouse)
- 35 IHC Antibodies (anti-mouse)
- 34 IHC (fro) Antibodies (anti-mouse)
- 15 IP Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 141 WB Antibodies (anti-human)
- 34 FACS Antibodies (anti-human)
- 14 IHC (fro) Antibodies (anti-human)
- 12 IF Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 12 IP Antibodies (anti-human)
- 11 IHC Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 32 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 11 IP Antibodies (anti-rat)
- 6 FACS Antibodies (anti-rat)
- 1 IHC (fro) Antibody (anti-rat)
- GeneTex Itga5 Antibody for ITGA5
-
Santa Cruz Biotechnology (SCBT) Antibodies for ITGA5
Protein Products
- R&D Systems Proteins and Enzymes for ITGA5 (Integrin alpha 5 beta 1)
-
OriGene Purified Proteins for ITGA5
- Search Origene for MassSpec and Protein Over-expression Lysates for ITGA5
- Origene Custom Protein Services for ITGA5
- Search GeneTex for Proteins for ITGA5
-
ProSci Proteins for ITGA5
-
Abcam proteins for ITGA5
Assay Products
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for ITGA5 (Integrin alpha 5/CD49e)
No data available for DME Specific Peptides for ITGA5 Gene
Domains & Families for ITGA5 Gene
Gene Families for ITGA5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Plasma proteins
- Predicted membrane proteins
Protein Domains for ITGA5 Gene
Suggested Antigen Peptide Sequences for ITGA5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P08648- Family:
-
- Belongs to the integrin alpha chain family.
Function for ITGA5 Gene
Molecular function for ITGA5 Gene
- UniProtKB/Swiss-Prot Function:
- Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions.
- GENATLAS Biochemistry:
- integrin,alpha 5 component of VLA-5 receptor,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,complexing with ITGB1 in fibronectin receptor
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001618 | virus receptor activity | IEA | -- |
| GO:0005154 | epidermal growth factor receptor binding | IEA | -- |
| GO:0005161 | platelet-derived growth factor receptor binding | TAS | 19267251 |
| GO:0005178 | integrin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 12695522 |
Phenotypes for ITGA5 Gene
- MGI mutant phenotypes for ITGA5:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for ITGA5:
Animal Model Products
-
Taconic Biosciences Mouse Models for ITGA5
- Cyagen custom Knockout/knockin (KOKI) mouse models for ITGA5
-
CRISPR Products
-
OriGene CRISPR knockouts for ITGA5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ITGA5
- genomics-online: gRNA clones - Search results for 114 available ITGA5 gene related products
- Overview of 114 available ITGA5 gene related products
- Applied Biological Materials CRISPR for ITGA5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ITGA5
- GenScript: Design CRISPR guide RNA sequences for ITGA5
miRNA for ITGA5 Gene
- miRTarBase miRNAs that target ITGA5
-
- hsa-mir-92a-3p (MIRT003031)
- hsa-mir-31-5p (MIRT004976)
- hsa-mir-148b-3p (MIRT007314)
- hsa-mir-98-5p (MIRT027753)
- hsa-mir-1229-3p (MIRT036327)
- hsa-mir-484 (MIRT042174)
- hsa-mir-183-5p (MIRT047079)
- hsa-mir-152-3p (MIRT053040)
- hsa-mir-148a-3p (MIRT053480)
- hsa-mir-205-5p (MIRT054779)
- hsa-mir-30e-3p (MIRT702629)
- hsa-mir-30d-3p (MIRT702630)
- hsa-mir-30a-3p (MIRT702631)
- hsa-mir-222-5p (MIRT702632)
- hsa-mir-6846-3p (MIRT702633)
- hsa-mir-5585-5p (MIRT702634)
- hsa-mir-4667-3p (MIRT702635)
- hsa-mir-6887-3p (MIRT702636)
- hsa-mir-383-3p (MIRT702637)
- hsa-mir-3065-3p (MIRT702638)
- hsa-mir-4482-5p (MIRT702639)
- hsa-mir-3130-5p (MIRT702640)
- hsa-mir-1912 (MIRT702641)
- hsa-mir-1295b-5p (MIRT702642)
- hsa-mir-26a-5p (MIRT731168)
- hsa-mir-17-3p (MIRT731715)
- hsa-mir-330-5p (MIRT734133)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ITGA5
- Browse OriGene Inhibitory RNA Products For ITGA5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGA5
- genomics-online: shRNA clones - Search results for 114 available ITGA5 gene related products
- Overview of 114 available ITGA5 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ITGA5
- Addgene plasmids for ITGA5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ITGA5
- Applied Biological Materials Clones for ITGA5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ITGA5 (Integrin alpha 5/CD49e)
Cell Line Products
-
Horizon Cell Lines for ITGA5
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGA5 Gene
Localization for ITGA5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ITGA5 Gene
- Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion. Cell surface.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 3 |
| endoplasmic reticulum | 3 |
| golgi apparatus | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001726 | ruffle | TAS | 11919189 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005886 | plasma membrane | IEA,TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ITGA5 Gene
Pathways & Interactions for ITGA5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MAPK-Erk Pathway |
.38
|
.38
.38
.38
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
.66
.65
|
.57
|
| 3 | Integrin Pathway |
.67
.67
.56
|
.56
|
| 4 | Focal Adhesion |
.62
.62
|
.33
|
| 5 | Actin Nucleation by ARP-WASP Complex |
.41
.35
|
|
Pathways by source for ITGA5 Gene
10 Sino Biological pathways for ITGA5 Gene
8 BioSystems pathways for ITGA5 Gene
10 Reactome pathways for ITGA5 Gene
8 GeneGo (Thomson Reuters) pathways for ITGA5 Gene
3 R&D Systems pathways for ITGA5 Gene
33 Qiagen pathways for ITGA5 Gene
3 Cell Signaling Technology pathways for ITGA5 Gene
Interacting Proteins for ITGA5 Gene
Selected Interacting proteins:
P08648-ITA5_HUMAN
ENSP00000293379
for ITGA5 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ITGA5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | TAS | 19267251 |
| GO:0007044 | cell-substrate junction assembly | IEA | -- |
| GO:0007155 | cell adhesion | TAS | 2454952 |
| GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | IEA | -- |
| GO:0007159 | leukocyte cell-cell adhesion | IEA | -- |
Drugs & Compounds for ITGA5 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Resveratrol | Approved, Experimental, Investigational | Pharma | Target | Cyclooxygenase inhibitor | 126 | |
| Cilengitide | Investigational | Pharma | inhibitor | Integrin inhibitor for αvβ3 and αvβ5, Integrins | 0 | |
| Volociximab | Investigational | Pharma | Antibody | Integrins | 0 | |
| Cyclo (-RGDfK) | Pharma | Inhibitor of αvβ3 integrin | 0 | |||
| RGD (Arg-Gly-Asp) Peptides | Pharma | Inhibits integrin binding to RGD motifs | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Echistatin, alpha1 isoform |
|
154303-05-6 |
|
|
(5) Tocris Compounds for ITGA5 Gene
| Compound | Action | Cas Number |
|---|---|---|
| A 205804 | Selective inhibitor of E-selectin and ICAM-1 expression | 251992-66-2 |
| Echistatin, alpha1 isoform | alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor | 154303-05-6 |
| GR 144053 trihydrochloride | Glycoprotein IIb/IIIa (integrin alphaIIbbeta3) receptor antagonist. Antithrombotic | 1215333-48-4 |
| Obtustatin | Potent and selective alpha1beta1 inhibitor | |
| P11 | Potent antagonist of alphavbeta3-vitronectin interaction; antiangiogenic | 848644-86-0 |
Drug Products
Transcripts for ITGA5 Gene
mRNA/cDNA for ITGA5 Gene
- (2) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (464) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000435631 1240 bps (uc058oxl.1)
- ENST00000553071 1013 bps (uc058oxm.1)
- ENST00000547744 547 bps (uc058oxn.1)
- ENST00000551861 536 bps (uc058oxk.1)
- ENST00000293379 4444 bps (uc001sga.4)
Unigene Clusters for ITGA5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ITGA5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ITGA5
- genomics-online: gRNA clones - Search results for 114 available ITGA5 gene related products
- Overview of 114 available ITGA5 gene related products
- Applied Biological Materials CRISPR for ITGA5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ITGA5
- GenScript: Design CRISPR guide RNA sequences for ITGA5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ITGA5
- Browse OriGene Inhibitory RNA Products For ITGA5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGA5
- genomics-online: shRNA clones - Search results for 114 available ITGA5 gene related products
- Overview of 114 available ITGA5 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ITGA5
- Addgene plasmids for ITGA5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ITGA5
- Applied Biological Materials Clones for ITGA5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ITGA5 (Integrin alpha 5/CD49e)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19a | · | 19b | · | 19c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
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| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
| ExUns: | 19d | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | · | 28c | ^ | 29 | ^ | 30a | · | 30b | ^ | 31a | · | 31b | · | 31c | ^ | 32a | · | 32b | · | 32c | · | 32d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
Expression for ITGA5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Cartilage (Muscoskeletal System)
- Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
- Interzone Cells Autopod Synovial Joint
- Interzone Cells Stylopod Synovial Joint
- Interzone Cells Zeugopod Synovial Joint
-
Paraxial Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm Cells Trunk Mesoderm
- Presegmented Somitic Mesenchyme Cells Presomitic Mesoderm
- Presomitic Mesoderm Cells Presomitic Mesoderm
- Bone (Muscoskeletal System)
-
Limb (Muscoskeletal System)
- Interzone Cells Autopod Synovial Joint
- Interzone Cells Stylopod Synovial Joint
- Interzone Cells Zeugopod Synovial Joint
- Gut Tube (Gastrointestinal Tract)
-
Somite (Muscoskeletal System)
- Presegmented Somitic Mesenchyme Cells Presomitic Mesoderm
- Presomitic Mesoderm Cells Presomitic Mesoderm
- Mesenchymal Stem Cells
-
Adipose (Muscoskeletal System)
- Stromal Cells Subcutaneous White Adipose
-
Lung (Respiratory System)
- Basal Cells Respiratory Bronchioles
-
Epithelial Cells
- Basal Cells Respiratory Bronchioles
-
Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm Cells Trunk Mesoderm
- Brain (Nervous System)
- Umbilical Cord (Extraembryonic Tissues)
-
Placenta (Extraembryonic Tissues)
-
Gall Bladder (Hepatobiliary System)
-
Fibroblasts (Uncategorized)
-
Esophagus (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for ITGA5 Gene
This gene is overexpressed in Artery - Tibial (x8.6) and Colon - Sigmoid (x6.1).
This gene is overexpressed in Urinary Bladder (22.7), Seminal vesicle (10.5), and Colon muscle (10.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ITGA5 Gene
NURSA nuclear receptor signaling pathways regulating expression of ITGA5 Gene:
ITGA5SOURCE GeneReport for Unigene cluster for ITGA5 Gene:
Hs.505654Evidence on tissue expression from TISSUES for ITGA5 Gene
- Liver(4.3)
- Lung(4)
- Nervous system(3.3)
- Bone marrow(2.9)
- Blood(2.8)
- Intestine(2.5)
- Heart(2.2)
- Kidney(2.1)
- Muscle(2.1)
- Skin(2.1)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for ITGA5
-
OriGene qPCR primer pairs and template standards for ITGA5
- genomics-online: primer clones - Search results for 114 available ITGA5 gene related products
- Overview of 114 available ITGA5 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGA5 Gene
Orthologs for ITGA5 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ITGA5 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ITGA5 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ITGA5 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Itga5 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Itga5 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ITGA5 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | ITGA5 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | itga5 33 |
|
||
| Str.3950 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | itga5-A 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | itga5 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | alphaPS4 35 |
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| alphaPS5 35 |
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| if 34 35 |
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OneToMany | |||
| scb 35 |
|
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| worm (Caenorhabditis elegans) |
Secernentea | F54F2.1 35 |
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| pat-2 34 |
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OneToMany | |||
| ina-1 35 |
|
|
- Species where no ortholog for ITGA5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ITGA5 Gene
- ENSEMBL:
- Gene Tree for ITGA5 (if available)
- TreeFam:
- Gene Tree for ITGA5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ITGA5: view image
Paralogs for ITGA5 Gene
Paralogs for ITGA5 Gene
(5) SIMAP similar genes for ITGA5 Gene using alignment to 4 proteins:
- ITA5_HUMAN
- B4E3F4_HUMAN
- H0YHL9_HUMAN
- H0YIV7_HUMAN
Variants for ITGA5 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000212357 | -- | 54,411,113(-) | C/T | intron_variant | |
| rs1000214590 | -- | 54,420,616(-) | A/G | upstream_transcript_variant | |
| rs1000378670 | -- | 54,414,220(-) | C/T | intron_variant | |
| rs1000676153 | -- | 54,415,108(-) | A/G | intron_variant | |
| rs1000791619 | -- | 54,400,232(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2745915 | CNV | deletion | 23290073 |
| esv3549239 | CNV | deletion | 23714750 |
| nsv559000 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.58;
56.14% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ITGA5 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA5 Gene
Disorders for ITGA5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| colon carcinoma in situ |
|
|
| retinitis pigmentosa 60 |
|
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| congenital epulis |
|
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| melanoma metastasis |
|
|
Search ITGA5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ITGA5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ITGA5 Gene
Publications for ITGA5 Gene
- Roles of the putative integrin-binding motif of the human metapneumovirus fusion (f) protein in cell-cell fusion, viral infectivity, and pathogenesis. (PMID: 24478423) Wei Y … Li J (Journal of virology 2014) 3 4 58
- Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity. (PMID: 24011356) Freeman TC … Parise LV (Biochemistry 2013) 3 4 58
- Crystal structure of α5β1 integrin ectodomain: atomic details of the fibronectin receptor. (PMID: 22451694) Nagae M … Takagi J (The Journal of cell biology 2012) 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- VLA-5-mediated adhesion to fibronectin accelerates hemin-stimulated erythroid differentiation of K562 cells through induction of VLA-4 expression. (PMID: 19460753) Tanaka R … Fukai F (The Journal of biological chemistry 2009) 3 22 58
Products for ITGA5 Gene
- R&D Systems Antibodies for ITGA5 (Integrin alpha 5/CD49e)
- R&D Systems Proteins and Enzymes for ITGA5 (Integrin alpha 5 beta 1)
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for ITGA5 (Integrin alpha 5/CD49e)
- R&D Systems cDNA Clones for ITGA5 (Integrin alpha 5/CD49e)
- Browse Human Proteins and Enzymes
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for ITGA5
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ITGA5
- Search Origene for MassSpec and Protein Over-expression Lysates for ITGA5
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- Browse OriGene Inhibitory RNA Products For ITGA5
- OriGene qPCR primer pairs for ITGA5
- OriGene qPCR primer pairs and template standards for ITGA5
- OriGene CRISPR knockouts for ITGA5
- OriGene ORF clones in human for ITGA5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ITGA5
- GenScript: Next-day shipping of latest version cDNA ORF clones for ITGA5 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ITGA5
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- Design optimal peptide antigens
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- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Sino Biological Human cDNA Clone for ITGA5
- Browse Sino Biological Recombinant Proteins
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- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ITGA5
- Novus Biologicals proteins and lysates for ITGA5
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ITGA5
- Abcam proteins for ITGA5
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for ITGA5
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ITGA5 (AFLGC-ITGA5)
- Cyagen custom Knockout/knockin (KOKI) mouse models for ITGA5
- Addgene plasmids for ITGA5
- antibodies-online: Search results for 417 available ITGA5 Antibodies ranked by validation data
- Compare Top ITGA5 Antibodies
- Recommended
- 62 WB Antibodies (anti-mouse)
- 52 FACS Antibodies (anti-mouse)
- 35 IHC Antibodies (anti-mouse)
- 34 IHC (fro) Antibodies (anti-mouse)
- 15 IP Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 141 WB Antibodies (anti-human)
- 34 FACS Antibodies (anti-human)
- 14 IHC (fro) Antibodies (anti-human)
- 12 IF Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 12 IP Antibodies (anti-human)
- 11 IHC Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 32 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 11 IP Antibodies (anti-rat)
- 6 FACS Antibodies (anti-rat)
- 1 IHC (fro) Antibody (anti-rat)
- antibodies-online: Search results for 14 available ITGA5 Elisa Kits ranked by validation data
- Compare Top ITGA5 Elisa Kits
- antibodies-online: Search results for 18 available ITGA5 Proteins ranked by validation data
- Compare Top ITGA5 Proteins
- GeneTex Itga5 Antibody for ITGA5
- Search GeneTex for Proteins for ITGA5
- Santa Cruz Biotechnology (SCBT) Antibodies for ITGA5
- Search Santa Cruz Biotechnology (SCBT) for ITGA5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ITGA5
- Search for ITGA5 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for ITGA5
- Horizon Cell Lines for ITGA5
- genomics-online: cdna clones - Search results for 114 available ITGA5 gene related products
- Overview of 114 available ITGA5 gene related products
- orf clones - Search results for 114 available ITGA5 gene related products
- Overview of 114 available ITGA5 gene related products
- genomics-online: gRNA clones - Search results for 114 available ITGA5 gene related products
- Overview of 114 available ITGA5 gene related products
- Recommended