The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1... See more...

Aliases for ITGA3 Gene

Aliases for ITGA3 Gene

  • Integrin Subunit Alpha 3 2 3 5
  • Integrin, Alpha 3 (Antigen CD49C, Alpha 3 Subunit Of VLA-3 Receptor) 2 3
  • Antigen Identified By Monoclonal Antibody J143 2 3
  • Alpha 3 Subunit Of VLA-3 Receptor 2 3
  • CD49 Antigen-Like Family Member C 3 4
  • Galactoprotein B3 3 4
  • Integrin Alpha-3 3 4
  • Antigen CD49C 2 3
  • MSK18 3 4
  • FRP-2 3 4
  • GAPB3 3 4
  • Very Late Activation Protein 3 Receptor, Alpha-3 Subunit 3
  • Testicular Tissue Protein Li 96 3
  • Testicular Tissue Protein Li 98 3
  • VLA-3 Subunit Alpha 4
  • Integrin Alpha 3 3
  • CD49c Antigen 4
  • GAP-B3 3
  • CD49C 3
  • ILNEB 3
  • VCA-2 3
  • VLA3a 3
  • VL3A 3

External Ids for ITGA3 Gene

Previous HGNC Symbols for ITGA3 Gene

  • MSK18

Previous GeneCards Identifiers for ITGA3 Gene

  • GC17P047940
  • GC17P050613
  • GC17P048475
  • GC17P048608
  • GC17P045488
  • GC17P048133
  • GC17P043500

Summaries for ITGA3 Gene

Entrez Gene Summary for ITGA3 Gene

  • The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]

GeneCards Summary for ITGA3 Gene

ITGA3 (Integrin Subunit Alpha 3) is a Protein Coding gene. Diseases associated with ITGA3 include Interstitial Lung Disease, Nephrotic Syndrome, And Epidermolysis Bullosa, Congenital and Interstitial Lung Disease. Among its related pathways are Hematopoietic cell lineage and ERK Signaling. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and integrin binding. An important paralog of this gene is ITGA7.

UniProtKB/Swiss-Prot Summary for ITGA3 Gene

  • Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.

Gene Wiki entry for ITGA3 Gene

Additional gene information for ITGA3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ITGA3 Gene

Genomics for ITGA3 Gene

GeneHancer (GH) Regulatory Elements for ITGA3 Gene

Promoters and enhancers for ITGA3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ITGA3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ITGA3

Top Transcription factor binding sites by QIAGEN in the ITGA3 gene promoter:
  • AP-4
  • GR
  • GR-alpha
  • GR-beta
  • HEN1
  • Nkx2-5
  • Sp1
  • STAT1beta
  • STAT5B

Genomic Locations for ITGA3 Gene

Genomic Locations for ITGA3 Gene
chr17:50,055,968-50,090,485
(GRCh38/hg38)
Size:
34,518 bases
Orientation:
Plus strand
chr17:48,133,332-48,167,849
(GRCh37/hg19)
Size:
34,518 bases
Orientation:
Plus strand

Genomic View for ITGA3 Gene

Genes around ITGA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA3 Gene

Proteins for ITGA3 Gene

  • Protein details for ITGA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26006-ITA3_HUMAN
    Recommended name:
    Integrin alpha-3
    Protein Accession:
    P26006
    Secondary Accessions:
    • A7E246
    • B7ZM80
    • B9EGQ1
    • D3DTX4
    • D3DTX5

    Protein attributes for ITGA3 Gene

    Size:
    1051 amino acids
    Molecular mass:
    116612 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner.

    Alternative splice isoforms for ITGA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGA3 Gene

Post-translational modifications for ITGA3 Gene

  • Isoform 1, but not isoform 2, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation.
  • Glycosylation at Asn86, Asn107, Asn265, Asn500, Asn511, Asn573, Asn605, Asn656, Asn697, Asn841, Asn857, Asn926, Asn935, and Asn969
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ITA3_HUMAN (738)

Antibody Products

No data available for DME Specific Peptides for ITGA3 Gene

Domains & Families for ITGA3 Gene

Gene Families for ITGA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ITGA3 Gene

Blocks:
  • Integrins alpha chain
  • Integrin alpha chain, C-terminal cytoplasmic region
  • FG-GAP
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ITGA3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59664, highly similar to Integrin alpha-3 (B4DDT0_HUMAN)
  • cDNA FLJ60385, highly similar to Integrin alpha-3 (B4E0H8_HUMAN)
  • VLA-3 subunit alpha (ITA3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P26006

UniProtKB/Swiss-Prot:

ITA3_HUMAN :
  • Belongs to the integrin alpha chain family.
Family:
  • Belongs to the integrin alpha chain family.
genes like me logo Genes that share domains with ITGA3: view

Function for ITGA3 Gene

Molecular function for ITGA3 Gene

UniProtKB/Swiss-Prot Function:
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
GENATLAS Biochemistry:
integrin,alpha 3,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,dimerizing with ITGB1 in fibronectin,laminin,collagen receptors

Phenotypes From GWAS Catalog for ITGA3 Gene

Gene Ontology (GO) - Molecular Function for ITGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IEA --
GO:0002020 protease binding IPI 10455171
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 1911778
GO:0005518 collagen binding IEA --
genes like me logo Genes that share ontologies with ITGA3: view
genes like me logo Genes that share phenotypes with ITGA3: view

Human Phenotype Ontology for ITGA3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ITGA3 Gene

MGI Knock Outs for ITGA3:

miRNA for ITGA3 Gene

miRTarBase miRNAs that target ITGA3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ITGA3 Gene

Localization for ITGA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA3 Gene

Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell projection, invadopodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Note=Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. {ECO:0000269 PubMed:10455171}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITGA3 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ITGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IDA --
GO:0005925 focal adhesion HDA 21423176
GO:0008305 integrin complex TAS,IEA 1655803
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 19933311
genes like me logo Genes that share ontologies with ITGA3: view

Pathways & Interactions for ITGA3 Gene

PathCards logo

SuperPathways for ITGA3 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.66
.65
.64
.62
.57
2 Integrin Pathway
.67
.67
.56
.56
.38
3 Focal Adhesion
.33
4 MAPK-Erk Pathway
5 Actin Nucleation by ARP-WASP Complex
.66
.66
.41
.35
genes like me logo Genes that share pathways with ITGA3: view

Pathways by source for ITGA3 Gene

4 GeneGo (Thomson Reuters) pathways for ITGA3 Gene
  • Cell adhesion Integrin-mediated cell adhesion and migration
  • Cell adhesion_Cell-matrix glycoconjugates
  • Cell adhesion_Endothelial cell contacts by non-junctional mechanisms
  • Cytoskeleton remodeling Integrin outside-in signaling
33 Qiagen pathways for ITGA3 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Akt Signaling
  • Calpain Protease Regulates Cellular Mechanics

SIGNOR curated interactions for ITGA3 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ITGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion TAS 1655803
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0007507 heart development IEA --
genes like me logo Genes that share ontologies with ITGA3: view

Drugs & Compounds for ITGA3 Gene

(2) Drugs for ITGA3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for ITGA3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ITGA3: view

Transcripts for ITGA3 Gene

mRNA/cDNA for ITGA3 Gene

2 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a ·
SP1: - - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6:
SP7: - - - - - - - - - - - - - - - - - - - - -
SP8:
SP9:
SP10:

ExUns: 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25
SP1: - -
SP2: - -
SP3: - - - - - - - - -
SP4:
SP5: -
SP6: -
SP7: - - - - - - - - - - -
SP8:
SP9:
SP10:

Relevant External Links for ITGA3 Gene

GeneLoc Exon Structure for
ITGA3

Expression for ITGA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ITGA3 Gene

Protein differential expression in normal tissues from HIPED for ITGA3 Gene

This gene is overexpressed in Liver (26.7), Bone (12.0), and Amniocyte (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ITGA3 Gene



Protein tissue co-expression partners for ITGA3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ITGA3

SOURCE GeneReport for Unigene cluster for ITGA3 Gene:

Hs.265829

mRNA Expression by UniProt/SwissProt for ITGA3 Gene:

P26006-ITA3_HUMAN
Tissue specificity: Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells.

Evidence on tissue expression from TISSUES for ITGA3 Gene

  • Nervous system(4.7)
  • Kidney(4.3)
  • Lung(3.5)
  • Pancreas(2.9)
  • Intestine(2.7)
  • Skin(2.6)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGA3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cheek
  • chin
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • outer ear
  • scalp
  • skull
Thorax:
  • breast
  • chest wall
  • heart
  • lung
  • rib
  • rib cage
  • sternum
Abdomen:
  • kidney
Pelvis:
  • ureter
  • urinary bladder
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • coagulation system
  • hair
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with ITGA3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ITGA3 Gene

Orthologs for ITGA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGA3 31 30
  • 99.16 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ITGA3 31 30
  • 89.55 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ITGA3 31 30
  • 89.52 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Itga3 17 31 30
  • 85.14 (n)
rat
(Rattus norvegicus)
Mammalia Itga3 30
  • 84.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ITGA3 31
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ITGA3 31
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITGA3 30
  • 67.85 (n)
lizard
(Anolis carolinensis)
Reptilia ITGA3 31
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494331 30
  • 58.37 (n)
African clawed frog
(Xenopus laevis)
Amphibia itga3-A 30
zebrafish
(Danio rerio)
Actinopterygii itga3b 31
  • 46 (a)
OneToMany
itga3a 31
  • 40 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mew 31 32
  • 27 (a)
OneToMany
alphaPS5 32
  • 25 (a)
worm
(Caenorhabditis elegans)
Secernentea ina-1 31 32
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6547 31
  • 29 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
Species where no ortholog for ITGA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGA3 Gene

ENSEMBL:
Gene Tree for ITGA3 (if available)
TreeFam:
Gene Tree for ITGA3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ITGA3: view image

Paralogs for ITGA3 Gene

(7) SIMAP similar genes for ITGA3 Gene using alignment to 7 proteins:

  • ITA3_HUMAN
  • B4DDT0_HUMAN
  • D6R9X8_HUMAN
  • H0YA32_HUMAN
  • H0YA49_HUMAN
  • K7EMU3_HUMAN
  • K7EQJ2_HUMAN

Pseudogenes.org Pseudogenes for ITGA3 Gene

genes like me logo Genes that share paralogs with ITGA3: view

Variants for ITGA3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ITGA3 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
708030 Likely Benign: not provided 50,078,276(+) G/T SYNONYMOUS_VARIANT
708150 Likely Benign: not provided 50,078,852(+) G/T MISSENSE_VARIANT
708230 Benign: not provided 50,075,729(+) C/G SYNONYMOUS_VARIANT
714736 Benign: not provided 50,074,283(+) G/A INTRON_VARIANT
717271 Likely Benign: not provided 50,056,523(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ITGA3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ITGA3 Gene

Variant ID Type Subtype PubMed ID
esv1740779 CNV insertion 17803354
esv3418171 CNV duplication 20981092
esv993321 CNV insertion 20482838
nsv1142222 CNV tandem duplication 24896259
nsv509660 CNV insertion 20534489
nsv833474 CNV loss 17160897
nsv954572 CNV deletion 24416366

Variation tolerance for ITGA3 Gene

Residual Variation Intolerance Score: 56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.09; 80.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITGA3 Gene

Human Gene Mutation Database (HGMD)
ITGA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGA3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA3 Gene

Disorders for ITGA3 Gene

MalaCards: The human disease database

(14) MalaCards diseases for ITGA3 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital
  • ilneb
interstitial lung disease
  • ild
lung disease
  • lung diseases
epidermolysis bullosa
  • acantholysis bullosa
nephrotic syndrome
  • finnish congenital nephrotic syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ITGA3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ITA3_HUMAN
  • Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital (ILNEB) [MIM:614748]: A multiorgan disorder characterized by congenital nephrotic syndrome, interstitial lung disease, and epidermolysis bullosa. The respiratory and renal features predominate, and lung involvement accounts for the lethal course of the disease. {ECO:0000269 PubMed:22512483, ECO:0000269 PubMed:27717396}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ITGA3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ITGA3: view

No data available for Genatlas for ITGA3 Gene

Publications for ITGA3 Gene

  1. Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. (PMID: 1655803) Takada Y … Hemler ME (The Journal of cell biology 1991) 2 3 4 23 54
  2. The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization. (PMID: 9111516) de Melker AA … Sonnenberg A (Laboratory investigation; a journal of technical methods and pathology 1997) 3 4 23 54
  3. Identification of human galactoprotein b3, an oncogenic transformation-induced membrane glycoprotein, as VLA-3 alpha subunit: the primary structure of human integrin alpha 3. (PMID: 1714443) Tsuji T … Osawa T (Journal of biochemistry 1991) 3 4 23 54
  4. Viable phenotype of ILNEB syndrome without nephrotic impairment in siblings heterozygous for unreported integrin alpha3 mutations. (PMID: 27717396) Colombo EA … Larizza L (Orphanet journal of rare diseases 2016) 3 4 54
  5. Integrin α3 mutations with kidney, lung, and skin disease. (PMID: 22512483) Has C … Laube GF (The New England journal of medicine 2012) 3 4 54

Products for ITGA3 Gene