Aliases for ITGA2B Gene
- Integrin Subunit Alpha 2b 2 3 5
- Integrin, Alpha 2b (Platelet Glycoprotein IIb Of IIb/IIIa Complex, Antigen CD41) 2 3
- Platelet Glycoprotein IIb Of IIb/IIIa Complex 2 3
- Protein Phosphatase 1, Regulatory Subunit 93 2 3
- Platelet Membrane Glycoprotein IIb 3 4
- Integrin Alpha-IIb 3 4
- GPalpha IIb 3 4
- PPP1R93 2 3
- CD41B 2 3
- GPIIb 3 4
- CD41 2 3
- GP2B 3 4
External Ids for ITGA2B Gene
Previous HGNC Symbols for ITGA2B Gene
Previous GeneCards Identifiers for ITGA2B Gene
This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]
GeneCards Summary for ITGA2B Gene
ITGA2B (Integrin Subunit Alpha 2b) is a Protein Coding gene. Diseases associated with ITGA2B include Glanzmann Thrombasthenia and Bleeding Disorder, Platelet-Type, 16. Among its related pathways are RET signaling and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and fibrinogen binding. An important paralog of this gene is ITGA8.
UniProtKB/Swiss-Prot Summary for ITGA2B Gene
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.