This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix... See more...

Aliases for ITGA11 Gene

Aliases for ITGA11 Gene

  • Integrin Subunit Alpha 11 2 3 5
  • Integrin Alpha-11 3 4
  • Integrin, Alpha 11 2
  • HsT18964 3

External Ids for ITGA11 Gene

Previous GeneCards Identifiers for ITGA11 Gene

  • GC15M064434
  • GC15M061692
  • GC15M066172
  • GC15M066309
  • GC15M066381
  • GC15M068594
  • GC15M045424

Summaries for ITGA11 Gene

Entrez Gene Summary for ITGA11 Gene

  • This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITGA11 Gene

ITGA11 (Integrin Subunit Alpha 11) is a Protein Coding gene. Diseases associated with ITGA11 include Tick Infestation. Among its related pathways are MAPK-Erk Pathway and Dilated cardiomyopathy (DCM). Gene Ontology (GO) annotations related to this gene include collagen binding and collagen receptor activity. An important paralog of this gene is ITGA10.

UniProtKB/Swiss-Prot Summary for ITGA11 Gene

Gene Wiki entry for ITGA11 Gene

Additional gene information for ITGA11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ITGA11 Gene

Genomics for ITGA11 Gene

GeneHancer (GH) Regulatory Elements for ITGA11 Gene

Promoters and enhancers for ITGA11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J068428 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 758.9 +1.8 1762 4.4 MAX POLR2A KLF14 GLIS2 ZNF561 EZH2 SIN3A ZNF610 ZNF335 GLIS1 ITGA11 ENSG00000270964 piR-55036-033
GH15J068524 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 23.5 -93.6 -93638 2.8 CREM PRDM10 IKZF2 PKNOX1 SCRT2 EED BCL11A RUNX3 JUNB ZNF335 ITGA11 HSALNG0106803 CORO2B
GH15J068340 Enhancer 1.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.4 +89.5 89462 5 MNT CREB1 TARDBP CTBP1 ZNF629 JUN JUND ZBTB48 ESRRA ZNF580 ITGA11 piR-39222-001 lnc-CLN6-2
GH15J069125 Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.2 -698.0 -698038 10.4 ZBTB40 MLX RBPJ NR2F1 CREB1 MIXL1 HLF L3MBTL2 MAX RAD21 ITGA11 NOX5 EWSAT1 PAQR5 HSALNG0106839 HSALNG0106838 HSALNG0106840
GH15J068333 Promoter/Enhancer 1 Ensembl ENCODE dbSUPER 16.2 +97.5 97487 2.2 ZIC2 CEBPB ZNF316 STAT1 ZFHX2 ITGA11 FEM1B piR-39222-001 lnc-CLN6-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ITGA11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ITGA11 gene promoter:
  • C/EBPalpha
  • E2F
  • E2F-1
  • GATA-1
  • GR
  • GR-alpha
  • NF-1
  • NF-1/L
  • Pax-3
  • YY1

Genomic Locations for ITGA11 Gene

Genomic Locations for ITGA11 Gene
chr15:68,296,532-68,432,163
(GRCh38/hg38)
Size:
135,632 bases
Orientation:
Minus strand
chr15:68,594,042-68,724,501
(GRCh37/hg19)
Size:
130,460 bases
Orientation:
Minus strand

Genomic View for ITGA11 Gene

Genes around ITGA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA11 Gene

Proteins for ITGA11 Gene

  • Protein details for ITGA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKX5-ITA11_HUMAN
    Recommended name:
    Integrin alpha-11
    Protein Accession:
    Q9UKX5
    Secondary Accessions:
    • J3KQM2
    • Q8WYI8
    • Q9UKQ1

    Protein attributes for ITGA11 Gene

    Size:
    1188 amino acids
    Molecular mass:
    133470 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Alpha-11 associates with beta-1. Interacts with RAB21.
    SequenceCaution:
    • Sequence=AAL39001.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ITGA11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGA11 Gene

Post-translational modifications for ITGA11 Gene

  • Glycosylation at Asn82, Asn95, Asn291, Asn331, Asn358, Asn449, Asn462, Asn528, Asn642, Asn694, Asn857, Asn894, Asn973, Asn1031, Asn1039, and Asn1059
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGA11 Gene

No data available for DME Specific Peptides for ITGA11 Gene

Domains & Families for ITGA11 Gene

Gene Families for ITGA11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ITGA11 Gene

GenScript: Design optimal peptide antigens:
  • Integrin alpha-11 (ITA11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UKX5

UniProtKB/Swiss-Prot:

ITA11_HUMAN :
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Belongs to the integrin alpha chain family.
Domain:
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Family:
  • Belongs to the integrin alpha chain family.
genes like me logo Genes that share domains with ITGA11: view

Function for ITGA11 Gene

Molecular function for ITGA11 Gene

UniProtKB/Swiss-Prot Function:
Integrin alpha-11/beta-1 is a receptor for collagen.
GENATLAS Biochemistry:
integrin,alpha11,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,predominantly expressed in musculoskeletal tissues,uterus,heart,likely dimerizing with ITGB1

Phenotypes From GWAS Catalog for ITGA11 Gene

Gene Ontology (GO) - Molecular Function for ITGA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005518 collagen binding TAS,IMP 11518510
GO:0038064 collagen receptor activity IMP 11518510
GO:0046872 metal ion binding IEA --
GO:0098639 collagen binding involved in cell-matrix adhesion IMP 24823363
genes like me logo Genes that share ontologies with ITGA11: view
genes like me logo Genes that share phenotypes with ITGA11: view

Animal Models for ITGA11 Gene

MGI Knock Outs for ITGA11:

Animal Model Products

  • Taconic Biosciences Mouse Models for ITGA11

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGA11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGA11 Gene

Localization for ITGA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA11 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITGA11 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ITGA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 11518510
GO:0008305 integrin complex TAS 10486209
GO:0016020 membrane IEA,HDA 16210410
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ITGA11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ITGA11 Gene

Pathways & Interactions for ITGA11 Gene

PathCards logo

SuperPathways for ITGA11 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.66
.65
.64
.62
.57
2 Integrin Pathway
.67
.67
.56
.56
.38
3 Focal Adhesion
.33
4 MAPK-Erk Pathway
5 Actin Nucleation by ARP-WASP Complex
.66
.66
.41
.35
genes like me logo Genes that share pathways with ITGA11: view

Pathways by source for ITGA11 Gene

2 Tocris pathways for ITGA11 Gene
33 Qiagen pathways for ITGA11 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Akt Signaling
  • Calpain Protease Regulates Cellular Mechanics

SIGNOR curated interactions for ITGA11 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ITGA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation HDA 16210410
GO:0006929 substrate-dependent cell migration IMP 11518510
GO:0007155 cell adhesion TAS 10486209
GO:0007160 cell-matrix adhesion IMP,TAS 11518510
GO:0007229 integrin-mediated signaling pathway IMP 24823363
genes like me logo Genes that share ontologies with ITGA11: view

Drugs & Compounds for ITGA11 Gene

No Compound Related Data Available

Transcripts for ITGA11 Gene

mRNA/cDNA for ITGA11 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGA11

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20 ^ 21 ^
SP1: - - -
SP2:
SP3: -
SP4:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
SP1:
SP2:
SP3:
SP4:

Relevant External Links for ITGA11 Gene

GeneLoc Exon Structure for
ITGA11
ECgene alternative splicing isoforms for
ITGA11

Expression for ITGA11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ITGA11 Gene

mRNA differential expression in normal tissues according to GTEx for ITGA11 Gene

This gene is overexpressed in Artery - Aorta (x16.1), Uterus (x5.7), and Artery - Coronary (x5.2).

Protein differential expression in normal tissues from HIPED for ITGA11 Gene

This gene is overexpressed in Uterus (26.2), Bone marrow mesenchymal stem cell (22.1), and Cervix (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ITGA11 Gene



NURSA nuclear receptor signaling pathways regulating expression of ITGA11 Gene:

ITGA11

SOURCE GeneReport for Unigene cluster for ITGA11 Gene:

Hs.436416

mRNA Expression by UniProt/SwissProt for ITGA11 Gene:

Q9UKX5-ITA11_HUMAN
Tissue specificity: According to PubMed:10464311, highest levels of expression in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209, also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands and prostate. Very low levels in peripheral blood lymphocytes, fetal brain and fetal liver.

Evidence on tissue expression from TISSUES for ITGA11 Gene

  • Bone(4.3)
  • Muscle(4.3)
  • Heart(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ITGA11: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGA11 Gene

Orthologs for ITGA11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGA11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGA11 33 32
  • 98.99 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ITGA11 33 32
  • 90.32 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ITGA11 33 32
  • 89.68 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Itga11 17 33 32
  • 86.78 (n)
rat
(Rattus norvegicus)
Mammalia Itga11 32
  • 86.54 (n)
oppossum
(Monodelphis domestica)
Mammalia ITGA11 33
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGA11 33
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITGA11 33 32
  • 76.23 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITGA11 33
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itga11 32
  • 69.16 (n)
zebrafish
(Danio rerio)
Actinopterygii itga11a 33 32
  • 62.78 (n)
OneToMany
itga11b 33
  • 54 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 21 (a)
OneToMany
Species where no ortholog for ITGA11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGA11 Gene

ENSEMBL:
Gene Tree for ITGA11 (if available)
TreeFam:
Gene Tree for ITGA11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ITGA11: view image

Paralogs for ITGA11 Gene

(4) SIMAP similar genes for ITGA11 Gene using alignment to 1 proteins:

  • ITA11_HUMAN
genes like me logo Genes that share paralogs with ITGA11: view

Variants for ITGA11 Gene

Sequence variations from dbSNP and Humsavar for ITGA11 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs200576562 uncertain-significance, Inborn genetic diseases 68,303,824(-) C/A/T coding_sequence_variant, missense_variant
rs61729760 uncertain-significance, Inborn genetic diseases 68,320,339(-) G/A coding_sequence_variant, missense_variant
rs1000004062 -- 68,301,020(-) G/A 3_prime_UTR_variant
rs1000017215 -- 68,359,744(-) A/G intron_variant
rs1000035229 -- 68,301,307(-) G/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ITGA11 Gene

Variant ID Type Subtype PubMed ID
dgv1232n106 CNV deletion 24896259
dgv2616n100 CNV gain 25217958
esv1007510 CNV insertion 20482838
esv1045367 CNV insertion 17803354
esv1196404 CNV deletion 17803354
esv1977419 CNV deletion 18987734
esv2749816 CNV deletion 23290073
esv2760036 CNV loss 17122850
esv33024 CNV gain 17666407
esv3401926 CNV insertion 20981092
esv3552612 CNV deletion 23714750
esv3636804 CNV loss 21293372
esv5360 CNV loss 18987735
esv8981 CNV loss 19470904
esv999038 CNV deletion 20482838
nsv1043972 CNV gain 25217958
nsv1070709 CNV deletion 25765185
nsv1070710 CNV deletion 25765185
nsv1112280 CNV deletion 24896259
nsv1125608 CNV tandem duplication 24896259
nsv1149557 CNV deletion 26484159
nsv1582 CNV insertion 18451855
nsv471248 CNV gain 18288195
nsv569806 CNV loss 21841781
nsv9273 CNV loss 18304495
nsv957995 CNV deletion 24416366
nsv958027 CNV deletion 24416366

Variation tolerance for ITGA11 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.33; 88.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITGA11 Gene

Human Gene Mutation Database (HGMD)
ITGA11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGA11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA11 Gene

Disorders for ITGA11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ITGA11 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
tick infestation
  • tick infestations
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ITGA11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ITGA11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGA11 Gene

Publications for ITGA11 Gene

  1. Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11). (PMID: 10486209) Lehnert K … Krissansen GW (Genomics 1999) 2 3 4 23 56
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  3. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PMID: 19789190) Young RP … Gamble GD (Postgraduate medical journal 2009) 3 43 56
  4. Lung cancer susceptibility model based on age, family history and genetic variants. (PMID: 19390575) Young RP … Gamble GD (PloS one 2009) 3 43 56
  5. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl GR … Lerman C (Archives of general psychiatry 2008) 3 43 56

Products for ITGA11 Gene

Sources for ITGA11 Gene