Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene bind... See more...

Aliases for ITGA10 Gene

Aliases for ITGA10 Gene

  • Integrin Subunit Alpha 10 2 3 5
  • Integrin Alpha-10 3 4
  • Integrin, Alpha 10 2
  • PRO827 3
  • ITGA10 5

External Ids for ITGA10 Gene

Previous GeneCards Identifiers for ITGA10 Gene

  • GC01P144045
  • GC01P142112
  • GC01P143252
  • GC01P143273
  • GC01P143014
  • GC01P144236
  • GC01P145524
  • GC01P119488

Summaries for ITGA10 Gene

Entrez Gene Summary for ITGA10 Gene

  • Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for ITGA10 Gene

ITGA10 (Integrin Subunit Alpha 10) is a Protein Coding gene. Diseases associated with ITGA10 include Colon Mucinous Adenocarcinoma. Among its related pathways are Integrin Pathway and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include collagen binding and collagen binding involved in cell-matrix adhesion. An important paralog of this gene is ITGA11.

UniProtKB/Swiss-Prot Summary for ITGA10 Gene

Gene Wiki entry for ITGA10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ITGA10 Gene

Genomics for ITGA10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ITGA10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J145908 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE 255.5 +0.5 521 2.4 CTCF REST TRIM22 ZNF217 RAD21 SMC3 ZNF384 ZNF362 TEAD4 ZNF143 ITGA10 lnc-PEX11B-2 HSALNG0006712 ANKRD35
GH01J145954 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.9 -50.3 -50254 11.3 SP1 MYC ZNF600 KLF9 POLR2A CEBPA ZNF10 ATF3 ZIC2 NFIC LIX1L ENSG00000278431 POLR3GL POLR3C ANKRD35 NBPF20 LIX1L-AS1 RBM8A TXNIP PEX11B
GH01J145858 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.9 +51.0 50987 2.6 SP1 MYC IKZF1 ZNF600 KLF9 ZNF223 POLR2A ZBTB10 YY1 MXD4 PIAS3 lnc-ANKRD35-2 piR-32683 GPR89A NBPF20 ANKRD35 POLR3C ITGA10 PEX11B GNRHR2
GH01J145844 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 12.5 +64.3 64297 2 ZNF207 MYC ZNF600 SSRP1 ZNF592 POLR2A ZBTB10 YY1 MXD4 NONO NUDT17 HSALNG0006718 HSALNG0006719 HSALNG0006720-001 HSALNG0006720-002 NBPF20 POLR3C GPR89A PIAS3 ITGA10
GH01J146005 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 11.2 -96.8 -96763 2.4 ZNF654 NCOR1 MYC ZNF592 CEBPA ATF3 YY1 CTCF REST CEBPB PEX11B GNRHR2 ITGA10 ANKRD35 LINC01719 HSALNG0006699 TXNIP HJV
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ITGA10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ITGA10

Top Transcription factor binding sites by QIAGEN in the ITGA10 gene promoter:
  • AML1a
  • Cart-1
  • Egr-2
  • HTF
  • NRF-2
  • POU3F1
  • RP58
  • Sox9
  • USF1

Genomic Locations for ITGA10 Gene

Latest Assembly
chr1:145,891,208-145,910,111
(GRCh38/hg38)
Size:
18,904 bases
Orientation:
Minus strand

Previous Assembly
chr1:145,525,030-145,543,868
(GRCh37/hg19 by Entrez Gene)
Size:
18,839 bases
Orientation:
Plus strand

chr1:145,524,891-145,543,868
(GRCh37/hg19 by Ensembl)
Size:
18,978 bases
Orientation:
Plus strand

Genomic View for ITGA10 Gene

Genes around ITGA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA10 Gene

Proteins for ITGA10 Gene

  • Protein details for ITGA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75578-ITA10_HUMAN
    Recommended name:
    Integrin alpha-10
    Protein Accession:
    O75578
    Secondary Accessions:
    • B2RAM4
    • B2RTV5
    • Q6UXJ6
    • Q9UHZ8

    Protein attributes for ITGA10 Gene

    Size:
    1167 amino acids
    Molecular mass:
    127602 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Alpha-10 associates with beta-1.

    Alternative splice isoforms for ITGA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGA10 Gene

Post-translational modifications for ITGA10 Gene

  • Glycosylation at Asn234, Asn98, Asn336, Asn364, Asn733, Asn763, Asn839, Asn921, Asn1011, Asn1018, and Asn1039
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ITGA10 Gene

Domains & Families for ITGA10 Gene

Gene Families for ITGA10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for ITGA10 Gene

InterPro:
Blocks:
  • Von Willebrand factor type A domain signature
  • Integrins alpha chain
  • Integrin alpha chain, C-terminal cytoplasmic region
  • FG-GAP

Suggested Antigen Peptide Sequences for ITGA10 Gene

GenScript: Design optimal peptide antigens:
  • Integrin alpha-10 (ITA10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75578

UniProtKB/Swiss-Prot:

ITA10_HUMAN :
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Belongs to the integrin alpha chain family.
Domain:
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Family:
  • Belongs to the integrin alpha chain family.
genes like me logo Genes that share domains with ITGA10: view

Function for ITGA10 Gene

Molecular function for ITGA10 Gene

UniProtKB/Swiss-Prot Function:
Integrin alpha-10/beta-1 is a receptor for collagen.

Phenotypes From GWAS Catalog for ITGA10 Gene

Gene Ontology (GO) - Molecular Function for ITGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005518 collagen binding TAS 9685391
GO:0046872 metal ion binding IEA --
GO:0098639 collagen binding involved in cell-matrix adhesion IMP 24823363
genes like me logo Genes that share ontologies with ITGA10: view
genes like me logo Genes that share phenotypes with ITGA10: view

Animal Models for ITGA10 Gene

MGI Knock Outs for ITGA10:

Animal Models for research

  • Taconic Biosciences Mouse Models for ITGA10

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGA10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGA10 Gene

Localization for ITGA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA10 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITGA10 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ITGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008305 integrin complex TAS 9685391
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0034680 integrin alpha10-beta1 complex IDA 24823363
genes like me logo Genes that share ontologies with ITGA10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ITGA10 Gene

Pathways & Interactions for ITGA10 Gene

PathCards logo

SuperPathways for ITGA10 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.66
.65
.64
.62
.57
2 Integrin Pathway
.67
.67
.56
.56
.38
3 Focal Adhesion
.33
4 Actin Nucleation by ARP-WASP Complex
.66
.66
.41
.35
5 ERK Signaling
.61
.61
.58
.51
genes like me logo Genes that share pathways with ITGA10: view

Pathways by source for ITGA10 Gene

3 GeneGo (Thomson Reuters) pathways for ITGA10 Gene
  • Cell adhesion Integrin inside-out signaling
  • Cell adhesion Integrin-mediated cell adhesion and migration
  • Cytoskeleton remodeling Integrin outside-in signaling
1 R&D Systems pathway for ITGA10 Gene
33 Qiagen pathways for ITGA10 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Akt Signaling
  • Calpain Protease Regulates Cellular Mechanics

SIGNOR curated interactions for ITGA10 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ITGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion TAS,IMP 24823363
GO:0007229 integrin-mediated signaling pathway IMP 24823363
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with ITGA10: view

Drugs & Compounds for ITGA10 Gene

No Compound Related Data Available

Transcripts for ITGA10 Gene

mRNA/cDNA for ITGA10 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITGA10

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA10 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: -
SP2:
SP3:
SP4:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1:
SP2:
SP3:
SP4:

Relevant External Links for ITGA10 Gene

GeneLoc Exon Structure for
ITGA10

Expression for ITGA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ITGA10 Gene

mRNA differential expression in normal tissues according to GTEx for ITGA10 Gene

This gene is overexpressed in Artery - Aorta (x13.5), Artery - Coronary (x7.2), and Artery - Tibial (x5.0).

Protein differential expression in normal tissues from HIPED for ITGA10 Gene

This gene is overexpressed in Breast (37.2) and Blymphocyte (26.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ITGA10 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ITGA10

SOURCE GeneReport for Unigene cluster for ITGA10 Gene:

Hs.158237

mRNA Expression by UniProt/SwissProt for ITGA10 Gene:

O75578-ITA10_HUMAN
Tissue specificity: Widely expressed with highest expression in muscle and heart. Found in articular cartilage.

Evidence on tissue expression from TISSUES for ITGA10 Gene

  • Heart(4.4)
  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ITGA10: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGA10 Gene

Orthologs for ITGA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGA10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ITGA10 29 30
  • 99.51 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ITGA10 29 30
  • 90.03 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ITGA10 29 30
  • 89.79 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Itga10 29
  • 86.61 (n)
Mouse
(Mus musculus)
Mammalia Itga10 29 16 30
  • 86.55 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ITGA10 30
  • 64 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 25 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia ITGA10 30
  • 66 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii itga10 29 30
  • 59.08 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 23 (a)
OneToMany
Species where no ortholog for ITGA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ITGA10 Gene

ENSEMBL:
Gene Tree for ITGA10 (if available)
TreeFam:
Gene Tree for ITGA10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ITGA10: view image
Alliance of Genome Resources:
Additional Orthologs for ITGA10

Paralogs for ITGA10 Gene

(5) SIMAP similar genes for ITGA10 Gene using alignment to 3 proteins:

  • ITA10_HUMAN
  • B2RTV5_HUMAN
  • F5GY13_HUMAN
genes like me logo Genes that share paralogs with ITGA10: view

Variants for ITGA10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ITGA10 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs2274616 -- p.Arg725Gln
rs2274618 -- p.Arg691His
rs35515885 -- p.Ala702Thr
rs36073645 -- p.Arg668Trp
rs6665210 -- p.Arg381Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ITGA10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ITGA10 Gene

Variant ID Type Subtype PubMed ID
esv3587419 CNV gain 21293372
esv3587420 CNV gain 21293372
nsv1005055 CNV loss 25217958
nsv2710 CNV insertion 18451855
nsv831381 CNV gain 17160897

Variation tolerance for ITGA10 Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.64; 82.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITGA10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGA10
Leiden Open Variation Database (LOVD)
ITGA10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA10 Gene

Disorders for ITGA10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ITGA10 Gene - From: COP

Disorder Aliases PubMed IDs
colon mucinous adenocarcinoma
  • colonic mucinous adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ITGA10

genes like me logo Genes that share disorders with ITGA10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGA10 Gene

Publications for ITGA10 Gene

  1. The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization. (PMID: 10702680) Lehnert K … Krissansen GW (Cytogenetics and cell genetics 1999) 2 3 4 22
  2. Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes. (PMID: 9685391) Camper L … Lundgren-Akerlund E (The Journal of biological chemistry 1998) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  4. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3
  5. Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier. (PMID: 31541017) Nakamura K … Yamada Y (The Journal of cell biology 2019) 3

Products for ITGA10 Gene

Sources for ITGA10 Gene