Aliases for ITGA1 Gene
External Ids for ITGA1 Gene
Previous GeneCards Identifiers for ITGA1 Gene
This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]
GeneCards Summary for ITGA1 Gene
ITGA1 (Integrin Subunit Alpha 1) is a Protein Coding gene. Diseases associated with ITGA1 include Colon Carcinoma In Situ and Phimosis. Among its related pathways are Integrin Pathway and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and collagen binding. An important paralog of this gene is ITGA2.
UniProtKB/Swiss-Prot Summary for ITGA1 Gene
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.