Aliases for ITGA1 Gene
External Ids for ITGA1 Gene
Previous GeneCards Identifiers for ITGA1 Gene
This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]
GeneCards Summary for ITGA1 Gene
ITGA1 (Integrin Subunit Alpha 1) is a Protein Coding gene. Diseases associated with ITGA1 include Intestine Carcinoma In Situ and Colon Carcinoma In Situ. Among its related pathways are MAPK-Erk Pathway and Developmental Biology. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and collagen binding. An important paralog of this gene is ITGA2.
UniProtKB/Swiss-Prot Summary for ITGA1 Gene
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.