Aliases for ITFG2 Gene
External Ids for ITFG2 Gene
Previous HGNC Symbols for ITFG2 Gene
Previous GeneCards Identifiers for ITFG2 Gene
GeneCards Summary for ITFG2 Gene
ITFG2 (Integrin Alpha FG-GAP Repeat Containing 2) is a Protein Coding gene.
UniProtKB/Swiss-Prot for ITFG2 Gene
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.