Aliases for ITFG1 Gene

Aliases for ITFG1 Gene

  • Integrin Alpha FG-GAP Repeat Containing 1 2 3 5
  • LNKN-1 2 3 4
  • TIP 2 3 4
  • Integrin-Alpha FG-GAP Repeat-Containing Protein 1 3 4
  • T-Cell Immunomodulatory Protein 3 4
  • LINKIN 2 3
  • CDA08 2 3
  • T Cell Immunomodulatory Protein 2
  • 2310047C21Rik 3
  • Protein TIP 4
  • Linkin 4
  • ITFG1 5

External Ids for ITFG1 Gene

Previous GeneCards Identifiers for ITFG1 Gene

  • GC16M045747
  • GC16M047188
  • GC16M033078

Summaries for ITFG1 Gene

GeneCards Summary for ITFG1 Gene

ITFG1 (Integrin Alpha FG-GAP Repeat Containing 1) is a Protein Coding gene. Diseases associated with ITFG1 include Podoconiosis and Griscelli Syndrome, Type 1.

UniProtKB/Swiss-Prot Summary for ITFG1 Gene

  • Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ITFG1 Gene

Genomics for ITFG1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ITFG1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J047460 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +2.4 2443 5 TBP SP1 MXD4 MNT IKZF1 SMAD5 ETS1 MBD2 POLR2A ELF1 HSALNG0111197 ITFG1 PHKB ENSG00000261131 SIAH1 SHCBP1 GPT2 LONP2 lnc-NETO2-4
GH16J047459 Promoter/Enhancer 0.6 EPDnew dbSUPER 250.7 +5.0 4954 0.1 DACH1 ITFG1 PHKB hsa-miR-5095-195 lnc-NETO2-4 NETO2
GH16J047523 Enhancer 1 Ensembl ENCODE 10.5 -59.7 -59651 1.6 MXD4 HOMEZ THAP11 FOXA2 ZNF511 IRF4 SMAD4 MAFF SAP130 ETV4 ITFG1 PHKB SHCBP1 ENSG00000262038 RNA5SP425 ABCC12
GH16J047565 Enhancer 0.8 Ensembl ENCODE 10.8 -101.6 -101552 7.4 GABPA FOXA2 FOSL1 SPI1 POLR2A JUND ZNF584 GABPB1 ATF3 EED EIF4BP5 ITFG1 PHKB GPT2 ENSG00000259866 LOC100420642 lnc-ITFG1-1 ABCC12
GH16J047617 Enhancer 0.8 Ensembl ENCODE 10.7 -154.3 -154252 1.6 MAFF ZNF316 SPI1 HDAC2 MAFK TCF12 MAFG KDM1A CBFA2T2 SOX13 lnc-ITFG1-3 lnc-LONP2-12 ITFG1 PHKB ABCC12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ITFG1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ITFG1

Top Transcription factor binding sites by QIAGEN in the ITFG1 gene promoter:
  • AML1a
  • CREB
  • CUTL1
  • deltaCREB
  • GATA-1
  • Gfi-1
  • NRF-2
  • Sox5
  • Sox9
  • Zic1

Genomic Locations for ITFG1 Gene

Latest Assembly
309,763 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
306,856 bases
Minus strand

(GRCh37/hg19 by Ensembl)
309,763 bases
Minus strand

Genomic View for ITFG1 Gene

Genes around ITFG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITFG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITFG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITFG1 Gene

Proteins for ITFG1 Gene

  • Protein details for ITFG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell immunomodulatory protein
    Protein Accession:
    Secondary Accessions:
    • Q96SR4
    • Q9BRE2
    • Q9H2V9

    Protein attributes for ITFG1 Gene

    612 amino acids
    Molecular mass:
    68108 Da
    Quaternary structure:
    • Interacts with RUVBL1, RUVBL2 and alpha-tubulin.
    • Sequence=AAG41782.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for ITFG1 Gene

Post-translational modifications for ITFG1 Gene

  • Glycosylation at Asn36, Asn95, Asn139, Asn146, Asn151, Asn176, Asn188, Asn226, Asn243, Asn353, Asn371, and Asn482
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for ITFG1 Gene

No data available for DME Specific Peptides for ITFG1 Gene

Domains & Families for ITFG1 Gene

Gene Families for ITFG1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ITFG1 Gene


Suggested Antigen Peptide Sequences for ITFG1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51850, highly similar to T-cell immunomodulatory protein (B4DHQ9_HUMAN)
  • cDNA FLJ50638, highly similar to T-cell immunomodulatory protein (B4DSA2_HUMAN)
  • Integrin-alpha FG-GAP repeat-containing protein 1 (TIP_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TIP family.
  • Belongs to the TIP family.
genes like me logo Genes that share domains with ITFG1: view

Function for ITFG1 Gene

Molecular function for ITFG1 Gene

UniProtKB/Swiss-Prot Function:
Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity).

Phenotypes From GWAS Catalog for ITFG1 Gene

genes like me logo Genes that share phenotypes with ITFG1: view

Animal Models for research

  • Taconic Biosciences Mouse Models for ITFG1

miRNA for ITFG1 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITFG1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ITFG1 Gene

Localization for ITFG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITFG1 Gene

Secreted. Membrane. Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITFG1 gene
Compartment Confidence
extracellular 4
plasma membrane 3
nucleus 3
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1
peroxisome 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Aggresome (2)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ITFG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with ITFG1: view

Pathways & Interactions for ITFG1 Gene

PathCards logo

SuperPathways for ITFG1 Gene

No Data Available

Interacting Proteins for ITFG1 Gene

STRING Interaction Network Preview (showing top 4 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q8TB96-TIP_HUMAN ENSP00000319918 for ITFG1 Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for ITFG1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ITFG1 Gene

Drugs & Compounds for ITFG1 Gene

(1) Drugs for ITFG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ITFG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ITFG1: view

Transcripts for ITFG1 Gene

mRNA/cDNA for ITFG1 Gene

14 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ITFG1

Alternative Splicing Database (ASD) splice patterns (SP) for ITFG1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP2: -

Relevant External Links for ITFG1 Gene

GeneLoc Exon Structure for

Expression for ITFG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ITFG1 Gene

Protein differential expression in normal tissues from HIPED for ITFG1 Gene

This gene is overexpressed in Islet of Langerhans (13.3), Fetal Brain (8.8), Brain (7.1), Salivary gland (6.9), and Heart (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ITFG1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ITFG1

SOURCE GeneReport for Unigene cluster for ITFG1 Gene:


mRNA Expression by UniProt/SwissProt for ITFG1 Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for ITFG1 Gene

  • Nervous system(4.7)
  • Muscle(4.5)
  • Skin(4.4)
  • Liver(4.3)
  • Kidney(2.1)
  • Intestine(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with ITFG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITFG1 Gene

Orthologs for ITFG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITFG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ITFG1 30 31
  • 99.62 (n)
(Canis familiaris)
Mammalia ITFG1 30 31
  • 92.58 (n)
(Bos Taurus)
Mammalia ITFG1 30 31
  • 90.83 (n)
(Mus musculus)
Mammalia Itfg1 30 17 31
  • 86.81 (n)
(Rattus norvegicus)
Mammalia Itfg1 30
  • 85.82 (n)
(Monodelphis domestica)
Mammalia ITFG1 31
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia ITFG1 31
  • 76 (a)
(Gallus gallus)
Aves ITFG1 30 31
  • 76.49 (n)
(Anolis carolinensis)
Reptilia ITFG1 31
  • 74 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia itfg1 30
  • 66.1 (n)
Str.10543 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.32852 30
(Danio rerio)
Actinopterygii ITFG1 31
  • 67 (a)
itfg1 30
  • 62.99 (n)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4814 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG7739 30 31
  • 49.08 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011964 30
  • 47.37 (n)
(Caenorhabditis elegans)
Secernentea tag-256 30 31
  • 46.86 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 46 (a)
-- 31
  • 36 (a)
Species where no ortholog for ITFG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ITFG1 Gene

Gene Tree for ITFG1 (if available)
Gene Tree for ITFG1 (if available)
Evolutionary constrained regions (ECRs) for ITFG1: view image

Paralogs for ITFG1 Gene

No data available for Paralogs for ITFG1 Gene

Variants for ITFG1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ITFG1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ITFG1 Gene

Variant ID Type Subtype PubMed ID
dgv518e214 CNV loss 21293372
esv2671280 CNV deletion 23128226
esv2758644 CNV gain 17122850
esv3359649 CNV insertion 20981092
esv34317 CNV gain 17911159
esv3638551 CNV loss 21293372
esv3638553 CNV gain 21293372
esv3638554 CNV loss 21293372
esv3638555 CNV loss 21293372
esv3638556 CNV loss 21293372
esv3638557 CNV gain 21293372
esv3638558 CNV loss 21293372
nsv1066115 CNV gain 25217958
nsv1138449 CNV deletion 24896259
nsv1796 CNV insertion 18451855
nsv472719 CNV novel sequence insertion 20440878
nsv474668 CNV novel sequence insertion 20440878
nsv510418 OTHER sequence alteration 20534489
nsv520355 CNV gain 19592680
nsv525170 CNV gain 19592680
nsv528423 CNV loss 19592680
nsv572537 CNV loss 21841781
nsv833217 CNV gain 17160897

Variation tolerance for ITFG1 Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITFG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ITFG1 Gene

Disorders for ITFG1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ITFG1 Gene - From: COP

Disorder Aliases PubMed IDs
  • podoconiosis, susceptibility to
griscelli syndrome, type 1
  • gs1
- elite association - COSMIC cancer census association via MalaCards
Search ITFG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ITFG1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ITFG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITFG1 Gene

Publications for ITFG1 Gene

  1. TIP, a T-cell factor identified using high-throughput screening increases survival in a graft-versus-host disease model. (PMID: 12598909) Fiscella M … Migone TS (Nature biotechnology 2003) 2 3 4 23
  2. LINKIN, a new transmembrane protein necessary for cell adhesion. (PMID: 25437307) Kato M … Sternberg PW (eLife 2014) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ITFG1 Gene

Sources for ITFG1 Gene