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Aliases for ITFG1 Gene

Aliases for ITFG1 Gene

  • Integrin Alpha FG-GAP Repeat Containing 1 2 3 5
  • LINKIN 2 3 4
  • Integrin-Alpha FG-GAP Repeat-Containing Protein 1 3 4
  • LNKN-1 3 4
  • TIP 3 4
  • T Cell Immunomodulatory Protein 2
  • T-Cell Immunomodulatory Protein 3
  • 2310047C21Rik 3
  • Protein TIP 4
  • CDA08 3

External Ids for ITFG1 Gene

Previous GeneCards Identifiers for ITFG1 Gene

  • GC16M045747
  • GC16M033078

Summaries for ITFG1 Gene

GeneCards Summary for ITFG1 Gene

ITFG1 (Integrin Alpha FG-GAP Repeat Containing 1) is a Protein Coding gene. Diseases associated with ITFG1 include Alcohol-Induced Mental Disorder and Alcoholic Psychosis.

UniProtKB/Swiss-Prot for ITFG1 Gene

  • Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity).

Additional gene information for ITFG1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITFG1 Gene

Genomics for ITFG1 Gene

GeneHancer (GH) Regulatory Elements for ITFG1 Gene

Promoters and enhancers for ITFG1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I047459 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +2.4 2443 5 PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 E2F8 ZNF207 ZNF143 ITFG1 PHKB ENSG00000261131 SIAH1 SHCBP1 GPT2 LONP2
GH16I047464 Enhancer 0.9 Ensembl dbSUPER 550.8 -0.3 -252 0.4 NFRKB MAX EBF1 ZNF644 ZBTB40 BRD9 POLR2A RCOR1 CHD2 L3MBTL2 ITFG1 PHKB PIR32661
GH16I047523 Enhancer 1 Ensembl ENCODE 10.5 -59.6 -59570 1.2 ELF3 FOXA2 ARID4B BATF IRF4 RAD21 RARA SLC30A9 ATF7 ETV6 ITFG1 PHKB SHCBP1 ENSG00000262038 RNA5SP425
GH16I047565 Enhancer 0.8 Ensembl ENCODE 10.7 -101.5 -101451 1.2 JUN ZNF592 GABPA FOSL1 JUND POLR2A GABPB1 ETV6 RUNX3 EIF4BP5 ITFG1 PHKB LOC100420642
GH16I047617 Enhancer 0.6 ENCODE 10.7 -153.8 -153756 0.2 HDAC1 SOX13 MAFG CBFA2T3 TCF12 ZNF316 HDAC2 CBFA2T2 KDM1A EMSY ITFG1 PHKB PIR31968 NDUFA5P11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ITFG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ITFG1 gene promoter:

Genomic Locations for ITFG1 Gene

Genomic Locations for ITFG1 Gene
309,763 bases
Minus strand

Genomic View for ITFG1 Gene

Genes around ITFG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITFG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITFG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITFG1 Gene

Proteins for ITFG1 Gene

  • Protein details for ITFG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell immunomodulatory protein
    Protein Accession:
    Secondary Accessions:
    • Q96SR4
    • Q9BRE2
    • Q9H2V9

    Protein attributes for ITFG1 Gene

    612 amino acids
    Molecular mass:
    68108 Da
    Quaternary structure:
    • Interacts with RUVBL1, RUVBL2 and alpha-tubulin.
    • Sequence=AAG41782.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for ITFG1 Gene

Post-translational modifications for ITFG1 Gene

  • Glycosylation at isoforms=36, isoforms=95, isoforms=139, posLast=146146, isoforms=151, isoforms=176, posLast=188188, posLast=226226, posLast=243243, isoforms=353, isoforms=371, and isoforms=482

Other Protein References for ITFG1 Gene

No data available for DME Specific Peptides for ITFG1 Gene

Domains & Families for ITFG1 Gene

Gene Families for ITFG1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ITFG1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TIP family.
  • Belongs to the TIP family.
genes like me logo Genes that share domains with ITFG1: view

Function for ITFG1 Gene

Molecular function for ITFG1 Gene

UniProtKB/Swiss-Prot Function:
Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity).
genes like me logo Genes that share phenotypes with ITFG1: view

Animal Model Products

miRNA for ITFG1 Gene

miRTarBase miRNAs that target ITFG1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ITFG1 Gene

Localization for ITFG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITFG1 Gene

Secreted. Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITFG1 gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 3
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Aggresome (2)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ITFG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA,HDA 23533145
genes like me logo Genes that share ontologies with ITFG1: view

Pathways & Interactions for ITFG1 Gene

SuperPathways for ITFG1 Gene

No Data Available

Interacting Proteins for ITFG1 Gene

Gene Ontology (GO) - Biological Process for ITFG1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ITFG1 Gene

Drugs & Compounds for ITFG1 Gene

(1) Drugs for ITFG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ITFG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ITFG1: view

Transcripts for ITFG1 Gene

Unigene Clusters for ITFG1 Gene

Integrin alpha FG-GAP repeat containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITFG1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP2: -

Relevant External Links for ITFG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ITFG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ITFG1 Gene

Protein differential expression in normal tissues from HIPED for ITFG1 Gene

This gene is overexpressed in Islet of Langerhans (13.3), Fetal Brain (8.8), Brain (7.1), Salivary gland (6.9), and Heart (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ITFG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ITFG1 Gene:


SOURCE GeneReport for Unigene cluster for ITFG1 Gene:


mRNA Expression by UniProt/SwissProt for ITFG1 Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for ITFG1 Gene

  • Nervous system(4.7)
  • Muscle(4.4)
  • Liver(4.3)
  • Skin(4.3)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with ITFG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITFG1 Gene

Orthologs for ITFG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITFG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ITFG1 33 34
  • 99.62 (n)
(Canis familiaris)
Mammalia ITFG1 33 34
  • 92.58 (n)
(Bos Taurus)
Mammalia ITFG1 33 34
  • 90.83 (n)
(Mus musculus)
Mammalia Itfg1 33 16 34
  • 86.81 (n)
(Rattus norvegicus)
Mammalia Itfg1 33
  • 85.82 (n)
(Monodelphis domestica)
Mammalia ITFG1 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia ITFG1 34
  • 76 (a)
(Gallus gallus)
Aves ITFG1 33 34
  • 76.49 (n)
(Anolis carolinensis)
Reptilia ITFG1 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia itfg1 33
  • 66.1 (n)
Str.10543 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.32852 33
(Danio rerio)
Actinopterygii ITFG1 34
  • 67 (a)
itfg1 33
  • 62.99 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4814 33
fruit fly
(Drosophila melanogaster)
Insecta CG7739 33 34
  • 49.08 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011964 33
  • 47.37 (n)
(Caenorhabditis elegans)
Secernentea tag-256 33 34
  • 46.86 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
-- 34
  • 36 (a)
Species where no ortholog for ITFG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITFG1 Gene

Gene Tree for ITFG1 (if available)
Gene Tree for ITFG1 (if available)

Paralogs for ITFG1 Gene

No data available for Paralogs for ITFG1 Gene

Variants for ITFG1 Gene

Sequence variations from dbSNP and Humsavar for ITFG1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs763900696 likely-benign, not specified 47,461,306(-) A/G upstream_transcript_variant
rs1000014357 -- 47,315,865(-) A/T intron_variant
rs1000025616 -- 47,341,959(-) G/T intron_variant
rs1000035660 -- 47,158,119(-) G/A intron_variant
rs1000050951 -- 47,183,444(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ITFG1 Gene

Variant ID Type Subtype PubMed ID
nsv833217 CNV gain 17160897
nsv572537 CNV loss 21841781
nsv528423 CNV loss 19592680
nsv525170 CNV gain 19592680
nsv520355 CNV gain 19592680
nsv510418 OTHER sequence alteration 20534489
nsv474668 CNV novel sequence insertion 20440878
nsv472719 CNV novel sequence insertion 20440878
nsv1796 CNV insertion 18451855
nsv1138449 CNV deletion 24896259
nsv1066115 CNV gain 25217958
esv3638558 CNV loss 21293372
esv3638557 CNV gain 21293372
esv3638556 CNV loss 21293372
esv3638555 CNV loss 21293372
esv3638554 CNV loss 21293372
esv3638553 CNV gain 21293372
esv3638551 CNV loss 21293372
esv34317 CNV gain 17911159
esv3359649 CNV insertion 20981092
esv2758644 CNV gain 17122850
esv2671280 CNV deletion 23128226
dgv518e214 CNV loss 21293372

Variation tolerance for ITFG1 Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ITFG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITFG1 Gene

Disorders for ITFG1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ITFG1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
alcohol-induced mental disorder
  • psychoses, alcoholic
alcoholic psychosis
  • alcoholic psychoses
- elite association - COSMIC cancer census association via MalaCards
Search ITFG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ITFG1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ITFG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITFG1 Gene

Publications for ITFG1 Gene

  1. TIP, a T-cell factor identified using high-throughput screening increases survival in a graft-versus-host disease model. (PMID: 12598909) Fiscella M … Migone TS (Nature biotechnology 2003) 2 3 4 22 58
  2. LINKIN, a new transmembrane protein necessary for cell adhesion. (PMID: 25437307) Kato M … Sternberg PW (eLife 2014) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ITFG1 Gene

Sources for ITFG1 Gene

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