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Aliases for ISY1 Gene
Aliases for ISY1 Gene
External Ids for ISY1 Gene
- HGNC: 29201
- NCBI Entrez Gene: 57461
- Ensembl: ENSG00000240682
- OMIM®: 612764
- UniProtKB/Swiss-Prot: Q9ULR0
Previous GeneCards Identifiers for ISY1 Gene
- GC03M130292
- GC03M128846
- GC03M126234
Summaries for ISY1 Gene
GeneCards Summary for ISY1 Gene
ISY1 (ISY1 Splicing Factor Homolog) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Transcription-Coupled Nucleotide Excision Repair (TC-NER). An important paralog of this gene is ISY1-RAB43.
UniProtKB/Swiss-Prot Summary for ISY1 Gene
-
Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (By similarity). By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes transition to the primed state (By similarity). Involved in pre-mRNA splicing as component of the spliceosome.
Additional gene information for ISY1 Gene
- HGNC (29201)
- NCBI Entrez Gene (57461)
- Ensembl (ENSG00000240682)
- OMIM® (612764)
- UniProtKB/Swiss-Prot (Q9ULR0)
- Open Targets Platform(ENSG00000240682)
- Search for ISY1 at DataMed
- Search for ISY1 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ISY1 Gene
Genomics for ISY1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ISY1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ISY1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ISY1
- Top Transcription factor binding sites by QIAGEN in the ISY1 gene promoter:
-
- AML1a
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- Elk-1
- POU6F1 (c2)
- STAT5A
Genomic Locations for ISY1 Gene
Latest Assembly
- chr3:129,127,415-129,161,063
- (GRCh38/hg38)
- Size:
- 33,649 bases
- Orientation:
- Minus strand
Previous Assembly
- chr3:128,846,258-128,879,906
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 33,649 bases
- Orientation:
- Minus strand
- chr3:128,846,258-128,880,136
- (GRCh37/hg19 by Ensembl)
- Size:
- 33,879 bases
- Orientation:
- Minus strand
Genomic View for ISY1 Gene
Genes around ISY1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q21.3 by HGNC
- 3q21.3 by Entrez Gene
- 3q21.3 by Ensembl
ISY1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ISY1 Gene
Proteins for ISY1 Gene
-
Protein details for ISY1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9ULR0-ISY1_HUMAN
- Recommended name:
- Pre-mRNA-splicing factor ISY1 homolog
- Protein Accession:
- Q9ULR0
- Q96IL2
- Q9BT05
Protein attributes for ISY1 Gene
- Size:
- 285 amino acids
- Molecular mass:
- 32992 Da
- Quaternary structure:
-
- Identified in the spliceosome C complex (PubMed:11991638, PubMed:29301961). Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE (PubMed:17981804). Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex (PubMed:25599396). The IB complex does not contain PRPF19 (PubMed:25599396). Interacts with CPSF3; this interaction is in an RNA independent manner (By similarity). Interacts with the microprocessor complex subunits DGCR8 and DROSHA; this interaction is in an RNA dependent manner (By similarity).
- SequenceCaution:
-
- Sequence=BAA86474.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 2]: Based on a readthrough transcript which may produce a ISY1-RAB43 fusion protein.
Three dimensional structures from OCA and Proteopedia for ISY1 Gene
Protein Expression for ISY1 Gene
Post-translational modifications for ISY1 Gene
Other Protein References for ISY1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for ISY1
- Invitrogen Antibodies for ISY1 (AFLGC-ISY1)
- antibodies-online: Show 5 available ISY1 Antibodies ranked by validation data
- Compare Top ISY1 Antibodies
-
Quality Products:
-
Boster Bio Antibodies for ISY1
-
Custom Antibody ServicesProSci Antibodies for ISY1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ISY1
Protein products for research
-
OriGene Purified Proteins for ISY1
- Search Origene for MassSpec and Protein Over-expression Lysates for ISY1
- Origene Custom Protein Services for ISY1
- antibodies-online: Show 8 available ISY1 Proteins ranked by validation data
- Compare Top ISY1 Proteins
-
Quality Products:
Assay products for research
- antibodies-online: Search results for available ISY1 related products ranked by validation data
No data available for DME Specific Peptides for ISY1 Gene
Domains & Families for ISY1 Gene
Gene Families for ISY1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ISY1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ISY1 Gene
- GenScript: Design optimal peptide antigens:
-
- Pre-mRNA-splicing factor ISY1 homolog (ISY1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9ULR0- Family:
-
- Belongs to the ISY1 family.
Function for ISY1 Gene
Molecular function for ISY1 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (By similarity). By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes transition to the primed state (By similarity). Involved in pre-mRNA splicing as component of the spliceosome.
Phenotypes From GWAS Catalog for ISY1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IPI | 22365833 |
Phenotypes for ISY1 Gene
- GenomeRNAi human phenotypes for ISY1:
-
- Increased gamma-H2AX phosphorylation
- Mitotic spindle defects
- Increased vaccinia virus (VACV) infection
- Decreased viability
- FOXO1 nuclear localization
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased homologous recombination repair frequency
- Decreased viability in colon lineage
- Increased the percentage of infected cells
- HIV Rev nuclear localization
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ISY1 - Starting at $85 >
- * ISY1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ISY1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ISY1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ISY1
miRNA for ISY1 Gene
- miRTarBase miRNAs that target ISY1
-
- hsa-miR-421 (MIRT039403)
- hsa-miR-6855-5p (MIRT515611)
- hsa-miR-3170 (MIRT515612)
- hsa-miR-6807-5p (MIRT515613)
- hsa-miR-7151-3p (MIRT515614)
- hsa-miR-5095 (MIRT515615)
- hsa-miR-193b-5p (MIRT515616)
- hsa-miR-5589-5p (MIRT515617)
- hsa-miR-6720-3p (MIRT515618)
- hsa-miR-4731-5p (MIRT515619)
- hsa-miR-668-5p (MIRT515620)
- hsa-miR-4252 (MIRT515621)
- hsa-miR-7155-5p (MIRT515622)
- hsa-miR-1273g-3p (MIRT515623)
- hsa-miR-4438 (MIRT515624)
- hsa-miR-519c-3p (MIRT721703)
- hsa-miR-129-5p (MIRT721704)
- hsa-miR-6513-5p (MIRT721705)
- hsa-miR-887-5p (MIRT721706)
- hsa-miR-3913-5p (MIRT721707)
- hsa-miR-3122 (MIRT721708)
- hsa-miR-450a-1-3p (MIRT721709)
- hsa-miR-4298 (MIRT721710)
- hsa-miR-1302 (MIRT721711)
- hsa-miR-4797-5p (MIRT721712)
- hsa-miR-106a-5p (MIRT761122)
- hsa-miR-106b-5p (MIRT761130)
- hsa-miR-1266-5p (MIRT761747)
- hsa-miR-150-5p (MIRT762866)
- hsa-miR-17-5p (MIRT762952)
- hsa-miR-186-3p (MIRT763193)
- hsa-miR-20a-5p (MIRT763759)
- hsa-miR-20b-5p (MIRT763771)
- hsa-miR-211-3p (MIRT763794)
- hsa-miR-302a-3p (MIRT764442)
- hsa-miR-302b-3p (MIRT764463)
- hsa-miR-302c-3p (MIRT764479)
- hsa-miR-302d-3p (MIRT764495)
- hsa-miR-302e (MIRT764511)
- hsa-miR-3187-3p (MIRT765287)
- hsa-miR-3194-5p (MIRT765484)
- hsa-miR-372-3p (MIRT767240)
- hsa-miR-373-3p (MIRT767283)
- hsa-miR-4270 (MIRT768246)
- hsa-miR-4435 (MIRT769102)
- hsa-miR-4441 (MIRT769149)
- hsa-miR-4518 (MIRT769939)
- hsa-miR-4687-5p (MIRT771065)
- hsa-miR-4690-3p (MIRT771078)
- hsa-miR-4701-5p (MIRT771341)
- hsa-miR-512-3p (MIRT773354)
- hsa-miR-519d-3p (MIRT773719)
- hsa-miR-520a-3p (MIRT773754)
- hsa-miR-520b (MIRT773774)
- hsa-miR-520c-3p (MIRT773787)
- hsa-miR-520d-3p (MIRT773803)
- hsa-miR-520e (MIRT773819)
- hsa-miR-520g-3p (MIRT773842)
- hsa-miR-520h (MIRT773869)
- hsa-miR-526b-3p (MIRT773915)
- hsa-miR-548s (MIRT774505)
- hsa-miR-5685 (MIRT774964)
- hsa-miR-588 (MIRT775344)
- hsa-miR-671-5p (MIRT777698)
- hsa-miR-6754-5p (MIRT778378)
- hsa-miR-93-5p (MIRT782759)
- hsa-miR-9500 (MIRT782983)
- hsa-miR-1304-3p (MIRT783678)
- hsa-miR-3940-5p (MIRT785471)
- hsa-miR-4507 (MIRT786034)
- hsa-miR-4536-3p (MIRT786229)
- hsa-miR-4639-3p (MIRT786257)
- hsa-miR-5007-5p (MIRT786950)
- hsa-miR-6793-5p (MIRT788760)
- hsa-miR-6794-3p (MIRT788769)
- hsa-miR-6821-5p (MIRT788957)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ISY1
- Browse OriGene Inhibitory RNA Products For ISY1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ISY1
Clone products for research
- Applied Biological Materials (abm): Clones for ISY1 - Starting at $45 >
- * ISY1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ISY1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ISY1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ISY1 Gene
Localization for ISY1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ISY1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| golgi apparatus | 1 |
- Nuclear speckles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000974 | Prp19 complex | IBA | 21873635 |
| GO:0005634 | nucleus | IEA,IDA | 29301961 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005681 | spliceosomal complex | IEA | -- |
| GO:0071006 | U2-type catalytic step 1 spliceosome | IDA | 29301961 |
Pathways & Interactions for ISY1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
| 2 | mRNA Splicing - Major Pathway |
.79
|
.47
|
| 3 | DNA Double-Strand Break Repair |
.53
|
|
| 4 | Gene Expression |
.48
|
|
Pathways by source for ISY1 Gene
10 Reactome pathways for ISY1 Gene
1 KEGG pathway for ISY1 Gene
Interacting Proteins for ISY1 Gene
Selected Interacting proteins:
Q9ULR0-ISY1_HUMAN
ENSP00000273541
for ISY1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ISY1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000350 | generation of catalytic spliceosome for second transesterification step | IEA,IBA | 21873635 |
| GO:0000389 | mRNA 3'-splice site recognition | IBA | 21873635 |
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006283 | transcription-coupled nucleotide-excision repair | TAS | -- |
| GO:0006397 | mRNA processing | IEA | -- |
No data available for SIGNOR curated interactions for ISY1 Gene
Transcripts for ISY1 Gene
mRNA/cDNA for ISY1 Gene
- 2 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000273541 1704 nts (view in UCSC)
- ENST00000393292 988 nts (view in UCSC)
- ENST00000393295 3612 nts (view in UCSC)
- ENST00000471306 552 nts (view in UCSC)
- ENST00000471497 1211 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ISY1 - Starting at $85 >
- * ISY1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ISY1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ISY1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ISY1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ISY1
- Browse OriGene Inhibitory RNA Products For ISY1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ISY1
Clone products for research
- Applied Biological Materials (abm): Clones for ISY1 - Starting at $45 >
- * ISY1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ISY1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ISY1
Relevant External Links for ISY1 Gene
- GeneLoc Exon Structure for
- ISY1
Expression for ISY1 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (15.8) and Testis (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ISY1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ISY1
SOURCE GeneReport for Unigene cluster for ISY1 Gene:
Hs.512661Evidence on tissue expression from TISSUES for ISY1 Gene
- Nervous system(4.6)
- Lung(4.3)
- Skin(3.1)
Primer products for research
-
OriGene qPCR primer pairs for ISY1
-
OriGene qPCR primer pairs and template standards for ISY1
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ISY1 Gene
Orthologs for ISY1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ISY1 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | ISY1 31 |
|
OneToMany | |
| Mouse (Mus musculus) |
Mammalia | Isy1 31 |
|
OneToMany | |
| Cow (Bos Taurus) |
Mammalia | ISY1 31 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.19464 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | MGC76019 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rab43 31 |
|
OneToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG9667 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | F53B7.3 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ISY1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2201 30 |
|
- Species where no ortholog for ISY1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ISY1 Gene
- ENSEMBL:
- Gene Tree for ISY1 (if available)
- TreeFam:
- Gene Tree for ISY1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ISY1: view image
Paralogs for ISY1 Gene
Paralogs for ISY1 Gene
(1) SIMAP similar genes for ISY1 Gene using alignment to 4 proteins:
- ISY1_HUMAN
- A8MVI5_HUMAN
- D6RC18_HUMAN
- H0YA89_HUMAN
Variants for ISY1 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
25.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.06;
1.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ISY1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ISY1
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ISY1 Gene
Disorders for ISY1 Gene
Additional Disease Information for ISY1
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for ISY1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ISY1 Gene
Publications for ISY1 Gene
- Structure of a human catalytic step I spliceosome. (PMID: 29301961) Zhan X … Shi Y (Science (New York, N.Y.) 2018) 3 4
- The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes. (PMID: 25599396) De I … Pena V (Nature structural & molecular biology 2015) 3 4
- The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing. (PMID: 16103217) Villa T … Guthrie C (Genes & development 2005) 2 3
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica MS … Moore MJ (RNA (New York, N.Y.) 2002) 3 4
ExternalLinks
Products for ISY1 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ISY1
- Search Origene for MassSpec and Protein Over-expression Lysates for ISY1
- Origene Custom Protein Services for ISY1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ISY1
- Browse OriGene Inhibitory RNA Products For ISY1
- OriGene qPCR primer pairs for ISY1
- OriGene qPCR primer pairs and template standards for ISY1
- OriGene CRISPR knockouts for ISY1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ISY1
- Sino Biological Human cDNA Clone for ISY1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ISY1
- Novus Biologicals proteins and lysates for ISY1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for ISY1 (AFLGC-ISY1)
- VectorBuilder Custom and pre-made DNA vectors for ISY1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ISY1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ISY1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ISY1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ISY1
- antibodies-online: Show 5 available ISY1 Antibodies ranked by validation data
- Compare Top ISY1 Antibodies
- Quality Products:
- antibodies-online: Search results for available ISY1 related products ranked by validation data
- antibodies-online: Show 8 available ISY1 Proteins ranked by validation data
- Compare Top ISY1 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for ISY1
- Search Santa Cruz Biotechnology (SCBT) for ISY1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ISY1
- Custom Antibody ServicesProSci Antibodies for ISY1
- Search for ISY1 Proteins at ProSci
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ISY1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ISY1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ISY1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ISY1
- Boster Bio Antibodies for ISY1
- Browse Boster Bio ELISA Kits
Sources for ISY1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB