Aliases for IST1 Gene
Aliases for IST1 Gene
External Ids for IST1 Gene
- HGNC: 28977
- Entrez Gene: 9798
- Ensembl: ENSG00000182149
- OMIM: 616434
- UniProtKB: P53990
Previous HGNC Symbols for IST1 Gene
- KIAA0174
Previous GeneCards Identifiers for IST1 Gene
- GC16P071930
- GC16P071881
Summaries for IST1 Gene
-
This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
GeneCards Summary for IST1 Gene
IST1 (IST1, ESCRT-III Associated Factor) is a Protein Coding gene. Diseases associated with IST1 include Lung Squamous Cell Carcinoma. Among its related pathways are Innate Immune System and Endocytosis. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and MIT domain binding.
UniProtKB/Swiss-Prot for IST1 Gene
-
ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).
Additional gene information for IST1 Gene
- Monarch Initiative
- Search for IST1 at DataMed
- Search for IST1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IST1 Gene
Genomics for IST1 Gene
GeneHancer (GH) Regulatory Elements for IST1 Gene
Promoters and enhancers for IST1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH16I071893 | Promoter/Enhancer | 2.4 | EPDnew FANTOM5 Ensembl ENCODE | 572.6 | +49.7 | 49652 | 3.8 | MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC | IST1 PIR43283 PIR45337 ZNF821 PHLPP2 HYDIN ENSG00000247324 ZNF19 MARVELD3 DHX38 | |
| GH16I071844 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 561 | +0.1 | 112 | 2.5 | HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 | IST1 ATXN1L MARVELD3 GC16P071851 | |
| GH16I071915 | Promoter | 0.6 | EPDnew | 550.2 | +69.6 | 69605 | 0.1 | JUN | PIR48135 IST1 PIR45337 | |
| GH16I071908 | Promoter | 0.6 | EPDnew | 550.2 | +62.3 | 62267 | 0.1 | ZBTB33 | IST1 PIR48135 PIR45337 | |
| GH16I071287 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 16.4 | -556.9 | -556873 | 2.5 | HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 | CMTR2 LOC102723786 SF3B3 ZNF19 IST1 FUK HYDIN ZNF23 AP1G1 DHX38 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around IST1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for IST1 Gene
Genomic Locations for IST1 Gene
- chr16:71,845,996-71,931,199
- (GRCh38/hg38)
- Size:
- 85,204 bases
- Orientation:
- Plus strand
- chr16:71,879,899-71,962,913
- (GRCh37/hg19)
Genomic View for IST1 Gene
Genes around IST1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q22.2 by Ensembl
- 16q22.2 by Entrez Gene
- 16q22.2 by HGNC
IST1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IST1 Gene
Proteins for IST1 Gene
-
Protein details for IST1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P53990-IST1_HUMAN
- Recommended name:
- IST1 homolog
- Protein Accession:
- P53990
- A8KAH5
- J3QLU7
- Q3SYM4
- Q9BQ81
- Q9BWN2
Protein attributes for IST1 Gene
- Size:
- 364 amino acids
- Molecular mass:
- 39751 Da
- Quaternary structure:
-
- Interacts with CHMP1A, CHMP1B, VPS4A and VTA1. Interacts with SPAST, STAMBP, and USP8. May interact with VPS37B. May associate with the ESCRT-I complex. Interacts with MITD1, in competition with VSP4 (PubMed:23015756). Interacts with SPART (via MIT domain); leading to the recruitment of SPART to midbodies (PubMed:20719964). Interacts with SPAST (PubMed:23897888, PubMed:26040712).
- SequenceCaution:
-
- Sequence=BAA11491.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for IST1 Gene
Protein Expression for IST1 Gene
Post-translational modifications for IST1 Gene
Other Protein References for IST1 Gene
- ENSEMBL proteins:
-
- ENSP00000368075
- ENSP00000368076
- ENSP00000398505
- ENSP00000410081
- ENSP00000414942
- ENSP00000438399
- ENSP00000454541
- ENSP00000455409
- ENSP00000455590
- ENSP00000455757
- ENSP00000455805
- ENSP00000455860
- ENSP00000457646
- ENSP00000457844
- ENSP00000463711
- ENSP00000463833
- ENSP00000475853
- ENSP00000486751
- ENSP00000330408
- ENSP00000456200
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for IST1
-
Abcam antibodies for IST1
- Invitrogen Antibodies for IST1
- GeneTex IST1 antibody for IST1
Protein Products
-
OriGene Purified Proteins for IST1
- Search Origene for MassSpec and Protein Over-expression Lysates for IST1
- Origene Custom Protein Services for IST1
- Novus Biologicals proteins for IST1
- Search GeneTex for Proteins for IST1
-
Abcam proteins for IST1
Assay Products
- antibodies-online: Search results for available IST1 related products ranked by validation data
No data available for DME Specific Peptides for IST1 Gene
Domains & Families for IST1 Gene
Gene Families for IST1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for IST1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for IST1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P53990- Family:
-
- Belongs to the IST1 family.
Function for IST1 Gene
Molecular function for IST1 Gene
- UniProtKB/Swiss-Prot Function:
- ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).
Phenotypes From GWAS Catalog for IST1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0019904 | protein domain specific binding | IPI | 20719964 |
| GO:0032403 | protein complex binding | IDA | 19129479 |
| GO:0045296 | cadherin binding | IDA | 25468996 |
| GO:0090541 | MIT domain binding | IPI | 19129479 |
Phenotypes for IST1 Gene
- GenomeRNAi human phenotypes for IST1:
-
- Increased vaccinia virus (VACV) infection
- Decreased NF-kappaB reporter expression
- Decreased viability after Maraba virus infection
- Decreased IL-8 secretion
- Wnt reporter downregulated
- Decreased viability after sindbis virus (SIN) dsTE12Q infection
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IST1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for IST1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IST1 gene
- Search ViGene Biosciences for IST1
CRISPR Products
-
OriGene CRISPR knockouts for IST1
- genomics-online: gRNA clones - Search results for 129 available IST1 gene related products
- Overview of 129 available IST1 gene related products
- Applied Biological Materials CRISPR for IST1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IST1
- GenScript: Design CRISPR guide RNA sequences for IST1
miRNA for IST1 Gene
- miRTarBase miRNAs that target IST1
-
- hsa-mir-1-3p (MIRT023986)
- hsa-mir-192-3p (MIRT442053)
- hsa-mir-4712-3p (MIRT442054)
- hsa-mir-1278 (MIRT442055)
- hsa-mir-1183 (MIRT442056)
- hsa-mir-122-5p (MIRT736108)
- hsa-mir-1236-5p (MIRT736290)
- hsa-mir-218-5p (MIRT739045)
- hsa-mir-3659 (MIRT741952)
- hsa-mir-4419a (MIRT744183)
- hsa-mir-4510 (MIRT745622)
- hsa-mir-4663 (MIRT746714)
- hsa-mir-4765 (MIRT748595)
- hsa-mir-6077 (MIRT751705)
- hsa-mir-6081 (MIRT751760)
- hsa-mir-6127 (MIRT752097)
- hsa-mir-6129 (MIRT752169)
- hsa-mir-6130 (MIRT752258)
- hsa-mir-6133 (MIRT752362)
- hsa-mir-6165 (MIRT752508)
- hsa-mir-6873-5p (MIRT758068)
- hsa-mir-7160-5p (MIRT759320)
- hsa-mir-8077 (MIRT760140)
- hsa-mir-873-5p (MIRT760310)
miRNA Products
- Search ViGene Biosciences for IST1
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for IST1
- Browse OriGene Inhibitory RNA Products For IST1
- genomics-online: shRNA clones - Search results for 129 available IST1 gene related products
- Overview of 129 available IST1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for IST1 gene
Clone Products
- Sino Biological Human cDNA Clone for IST1
- VectorBuilder custom plasmid, inducible vectors for IST1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IST1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for IST1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for IST1
-
ViGene Biosciences adenoviral particle packaged cDNA for IST1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for IST1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IST1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IST1 Gene
Localization for IST1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IST1 Gene
- Cytoplasmic vesicle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Nucleus envelope. Note=Localizes to centrosome and midbody of dividing cells (PubMed:19129480, PubMed:19129479, PubMed:20719964). Colocalized with SPART to the ends of Flemming bodies during cytokinesis (PubMed:20719964). Localizes to the nuclear envelope during late anaphase (PubMed:26040712). {ECO:0000269 PubMed:19129479, ECO:0000269 PubMed:19129480, ECO:0000269 PubMed:20719964, ECO:0000269 PubMed:26040712}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytoskeleton | 5 |
| cytosol | 5 |
| nucleus | 4 |
| lysosome | 4 |
| endosome | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | colocalizes_with chromatin | IDA | 28242692 |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005635 | nuclear envelope | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for IST1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Endocytosis | ||
Pathways by source for IST1 Gene
3 Reactome pathways for IST1 Gene
1 KEGG pathway for IST1 Gene
Interacting Proteins for IST1 Gene
Selected Interacting proteins:
ENSP00000330408
P53990-IST1_HUMAN
for IST1 Gene via
STRING
UniProtKB
IID
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000910 | cytokinesis | IMP | 19525971 |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0008104 | protein localization | IMP | 20719964 |
| GO:0009838 | abscission | IMP | 19525971 |
| GO:0015031 | protein transport | IEA | -- |
No data available for SIGNOR curated interactions for IST1 Gene
Transcripts for IST1 Gene
mRNA/cDNA for IST1 Gene
- (6) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (743) Selected AceView cDNA sequences:
- (27) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for IST1 Gene
- Increased sodium tolerance 1 homolog (yeast):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for IST1
- genomics-online: gRNA clones - Search results for 129 available IST1 gene related products
- Overview of 129 available IST1 gene related products
- Applied Biological Materials CRISPR for IST1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IST1
- GenScript: Design CRISPR guide RNA sequences for IST1
miRNA Products
- Search ViGene Biosciences for IST1
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for IST1
- Browse OriGene Inhibitory RNA Products For IST1
- genomics-online: shRNA clones - Search results for 129 available IST1 gene related products
- Overview of 129 available IST1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for IST1 gene
Clone Products
- Sino Biological Human cDNA Clone for IST1
- VectorBuilder custom plasmid, inducible vectors for IST1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IST1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for IST1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: |
| ExUns: | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | · | 17c | · | 17d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||
| SP5: | |||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||
| SP10: | - | - | |||||||||||||||||||||
| SP11: | |||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||
| SP17: | - | ||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||
| SP21: | |||||||||||||||||||||||
| SP22: | - | - | - | ||||||||||||||||||||
| SP23: |
Expression for IST1 Gene
This gene is overexpressed in Breast (16.8) and Urine (9.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IST1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of IST1 Gene:
IST1SOURCE GeneReport for Unigene cluster for IST1 Gene:
Hs.232194Evidence on tissue expression from TISSUES for IST1 Gene
- Nervous system(4.9)
- Lung(4.7)
- Liver(4.6)
- Eye(4.5)
- Bone marrow(4.4)
- Kidney(4.1)
- Intestine(4)
- Spleen(3.7)
- Blood(3.5)
- Skin(3.3)
Primer Products
-
OriGene qPCR primer pairs for IST1
-
OriGene qPCR primer pairs and template standards for IST1
- genomics-online: primer clones - Search results for 129 available IST1 gene related products
- Overview of 129 available IST1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IST1 Gene
Orthologs for IST1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IST1 33 |
|
||
| dog (Canis familiaris) |
Mammalia | IST1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | IST1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ist1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ist1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | IST1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | IST1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | IST1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | IST1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ist1 33 |
|
||
| Str.10305 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.25431 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ist1 33 34 |
|
||
| Dr.1122 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2448 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG10103 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005882 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | istr-1 34 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IST1 34 36 |
|
OneToOne |
- Species where no ortholog for IST1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for IST1 Gene
Pseudogenes.org Pseudogenes for IST1 Gene
No data available for Paralogs for IST1 Gene
Variants for IST1 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000025639 | -- | 71,899,094(+) | A/T | intron_variant | |
| rs1000108891 | -- | 71,923,567(+) | C/G | intron_variant | |
| rs1000192989 | -- | 71,916,899(+) | C/T | intron_variant | |
| rs1000214207 | -- | 71,903,001(+) | C/A | intron_variant | |
| rs1000224223 | -- | 71,917,212(+) | T/C | intron_variant |
Residual Variation Intolerance Score:
38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.66;
31.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IST1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- IST1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IST1 Gene
Disorders for IST1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lung squamous cell carcinoma |
|
|
Search IST1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IST1
No data available for UniProtKB/Swiss-Prot and Genatlas for IST1 Gene
Publications for IST1 Gene
- Essential role of hIST1 in cytokinesis. (PMID: 19129480) Agromayor M … Martin-Serrano J (Molecular biology of the cell 2009) 2 3 4 58
- Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4 58
- Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing. (PMID: 26040712) Vietri M … Stenmark H (Nature 2015) 3 4 58
- An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome. (PMID: 23897888) Allison R … Reid E (The Journal of cell biology 2013) 3 4 58
- MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis. (PMID: 23015756) Lee S … Blackstone C (Molecular biology of the cell 2012) 3 4 58
Products for IST1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for IST1
- Search Origene for MassSpec and Protein Over-expression Lysates for IST1
- Origene Custom Protein Services for IST1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IST1
- Browse OriGene Inhibitory RNA Products For IST1
- OriGene qPCR primer pairs and template standards for IST1
- OriGene qPCR primer pairs for IST1
- OriGene CRISPR knockouts for IST1
- OriGene ORF clones in human for IST1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IST1
- GenScript: Next-day shipping of latest version cDNA ORF clones for IST1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for IST1
- GenScript Custom Assay Services for IST1
- GenScript Custom overexpressing Cell Line Services for IST1
- GenScript: Design CRISPR guide RNA sequences for IST1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for IST1
- Sino Biological Human cDNA Clone for IST1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for IST1
- Novus Biologicals proteins for IST1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for IST1
- Abcam proteins for IST1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for IST1
- VectorBuilder custom plasmid, inducible vectors for IST1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IST1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 31 available IST1 Antibodies ranked by validation data
- Compare Top IST1 Antibodies
- antibodies-online: Search results for available IST1 related products ranked by validation data
- antibodies-online: Search results for 4 available IST1 Proteins ranked by validation data
- Compare Top IST1 Proteins
- GeneTex IST1 antibody for IST1
- Search GeneTex for Proteins for IST1
- ViGene Biosciences adenoviral particle packaged cDNA for IST1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for IST1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for IST1 gene
- Search ViGene Biosciences for IST1
- Horizon Cell Lines for IST1
- genomics-online: cdna clones - Search results for 129 available IST1 gene related products
- Overview of 129 available IST1 gene related products
- orf clones - Search results for 129 available IST1 gene related products
- Overview of 129 available IST1 gene related products
- genomics-online: gRNA clones - Search results for 129 available IST1 gene related products
- Overview of 129 available IST1 gene related products
- genomics-online: primer clones - Search results for 129 available IST1 gene related products
- Overview of 129 available IST1 gene related products
- genomics-online: shRNA clones - Search results for 129 available IST1 gene related products
- Overview of 129 available IST1 gene related products
Sources for IST1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems