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This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms ha... See more...
Aliases for IST1 Gene
Aliases for IST1 Gene
External Ids for IST1 Gene
- HGNC: 28977
- Entrez Gene: 9798
- Ensembl: ENSG00000182149
- OMIM: 616434
- UniProtKB: P53990
Previous HGNC Symbols for IST1 Gene
- KIAA0174
Previous GeneCards Identifiers for IST1 Gene
- GC16P071930
- GC16P071881
Summaries for IST1 Gene
-
This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
GeneCards Summary for IST1 Gene
IST1 (IST1 Factor Associated With ESCRT-III) is a Protein Coding gene. Diseases associated with IST1 include Gastric Squamous Cell Carcinoma and Spastic Paraplegia 20, Autosomal Recessive. Among its related pathways are Innate Immune System and Endocytosis. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and MIT domain binding.
UniProtKB/Swiss-Prot Summary for IST1 Gene
-
ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).
Additional gene information for IST1 Gene
- HGNC(28977)
- Entrez Gene(9798)
- Ensembl(ENSG00000182149)
- OMIM(616434)
- UniProtKB(P53990)
- Open Targets Platform(ENSG00000182149)
- Monarch Initiative
- Search for IST1 at DataMed
- Search for IST1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IST1 Gene
Genomics for IST1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IST1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IST1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IST1
Genomic Locations for IST1 Gene
Genomic Locations for IST1 Gene
- chr16:71,845,996-71,931,199
- (GRCh38/hg38)
- Size:
- 85,204 bases
- Orientation:
- Plus strand
- chr16:71,879,899-71,962,913
- (GRCh37/hg19)
- Size:
- 83,015 bases
- Orientation:
- Plus strand
Genomic View for IST1 Gene
Genes around IST1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q22.2 by HGNC
- 16q22.2 by Entrez Gene
- 16q22.2 by Ensembl
IST1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IST1 Gene
Proteins for IST1 Gene
-
Protein details for IST1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P53990-IST1_HUMAN
- Recommended name:
- IST1 homolog
- Protein Accession:
- P53990
- A8KAH5
- J3QLU7
- Q3SYM4
- Q9BQ81
- Q9BWN2
Protein attributes for IST1 Gene
- Size:
- 364 amino acids
- Molecular mass:
- 39751 Da
- Quaternary structure:
-
- Interacts with CHMP1A, CHMP1B, VPS4A and VTA1. Interacts with SPAST, STAMBP, and USP8. May interact with VPS37B. May associate with the ESCRT-I complex. Interacts with MITD1, in competition with VSP4 (PubMed:23015756). Interacts with SPART (via MIT domain); leading to the recruitment of SPART to midbodies (PubMed:20719964). Interacts with SPAST (PubMed:23897888, PubMed:26040712).
- SequenceCaution:
-
- Sequence=BAA11491.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for IST1 Gene
Protein Expression for IST1 Gene
Post-translational modifications for IST1 Gene
Other Protein References for IST1 Gene
- ENSEMBL proteins:
-
- ENSP00000456200
- ENSP00000455409
- ENSP00000457844
- ENSP00000455860
- ENSP00000455590
- ENSP00000368076
- ENSP00000457646
- ENSP00000398505
- ENSP00000330408
- ENSP00000463711
- ENSP00000455805
- ENSP00000454541
- ENSP00000368075
- ENSP00000455757
- ENSP00000410081
- ENSP00000414942
- ENSP00000463833
- ENSP00000475853
- ENSP00000438399
- ENSP00000486751
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ IST1 Antibody
- Novus Biologicals Antibodies for IST1
-
Abcam antibodies for IST1
- Invitrogen Antibodies for IST1 (AFLGC-IST1)
-
Biorbyt antibodies for IST1
-
Boster Bio Antibodies for IST1
Protein Products
-
OriGene Purified Proteins for IST1
- Search Origene for MassSpec and Protein Over-expression Lysates for IST1
- Origene Custom Protein Services for IST1
- Novus Biologicals proteins for IST1
-
Abcam proteins for IST1
No data available for DME Specific Peptides for IST1 Gene
Domains & Families for IST1 Gene
Gene Families for IST1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for IST1 Gene
Suggested Antigen Peptide Sequences for IST1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ77725 (A8KAH5_HUMAN)
- Putative MAPK-activating protein PM28 (IST1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P53990- Family:
-
- Belongs to the IST1 family.
Function for IST1 Gene
Molecular function for IST1 Gene
- UniProtKB/Swiss-Prot Function:
- ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).
Phenotypes From GWAS Catalog for IST1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0019904 | protein domain specific binding | IPI | 20719964 |
| GO:0044877 | protein-containing complex binding | IDA | 19129479 |
| GO:0045296 | cadherin binding | HDA | 25468996 |
| GO:0090541 | MIT domain binding | IPI | 19129479 |
Phenotypes for IST1 Gene
- GenomeRNAi human phenotypes for IST1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
- Decreased viability after sindbis virus (SIN) dsTE12Q infection
- Decreased vaccinia virus (VACV) infection
- Increased IL-8 secretion
- Increased NF-kappaB reporter expression
- Decreased viability after Maraba virus infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IST1 - Select products 50% OFF >
- * IST1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IST1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IST1
-
Santa Cruz Biotechnology (SCBT) CRISPR for IST1
miRNA for IST1 Gene
- miRTarBase miRNAs that target IST1
-
- mmu-miR-15a-5p (MIRT011784)
- mmu-miR-9-5p (MIRT015362)
- hsa-miR-1-3p (MIRT023986)
- hsa-miR-192-3p (MIRT442053)
- hsa-miR-4712-3p (MIRT442054)
- hsa-miR-1278 (MIRT442055)
- hsa-miR-1183 (MIRT442056)
- hsa-miR-122-5p (MIRT736108)
- hsa-miR-1236-5p (MIRT736290)
- hsa-miR-218-5p (MIRT739045)
- hsa-miR-3659 (MIRT741952)
- hsa-miR-4419a (MIRT744183)
- hsa-miR-4510 (MIRT745622)
- hsa-miR-4663 (MIRT746714)
- hsa-miR-4765 (MIRT748595)
- hsa-miR-6077 (MIRT751705)
- hsa-miR-6081 (MIRT751760)
- hsa-miR-6127 (MIRT752097)
- hsa-miR-6129 (MIRT752169)
- hsa-miR-6130 (MIRT752258)
- hsa-miR-6133 (MIRT752362)
- hsa-miR-6165 (MIRT752508)
- hsa-miR-6873-5p (MIRT758068)
- hsa-miR-7160-5p (MIRT759320)
- hsa-miR-8077 (MIRT760140)
- hsa-miR-873-5p (MIRT760310)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IST1
- Browse OriGene Inhibitory RNA Products For IST1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IST1
Clone Products
- Applied Biological Materials (abm): Clones for IST1 - Select products 50% OFF >
- * IST1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203871
- MG205554
- MR203871
- MR203871L3
- MR203871L4
- MR205554
- MR205554L3
- MR205554L4
- RC201347
- RC201347L1
- RC201347L2
- RC201347L3
- RC201347L4
- RC233469
- RC233470
- RC233805
- RC233891
- RC233926
- RG201347
- RG233469
- RG233470
- RG233805
- RG233891
- RG233926
- RR201868
- RR201868L3
- RR201868L4
- MR203871L3V
- MR203871L4V
- MR205554L3V
- MR205554L4V
- RC201347L1V
- RC201347L2V
- RC201347L3V
- RC201347L4V
- RR201868L3V
- RR201868L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IST1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IST1
Cell Line Products
-
Horizon Cell Lines for IST1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IST1 Gene
Localization for IST1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IST1 Gene
- Cytoplasmic vesicle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Nucleus envelope. Note=Localizes to centrosome and midbody of dividing cells (PubMed:19129480, PubMed:19129479, PubMed:20719964). Colocalized with SPART to the ends of Flemming bodies during cytokinesis (PubMed:20719964). Localizes to the nuclear envelope during late anaphase (PubMed:26040712). {ECO:0000269 PubMed:19129479, ECO:0000269 PubMed:19129480, ECO:0000269 PubMed:20719964, ECO:0000269 PubMed:26040712}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| cytosol | 5 |
| extracellular | 4 |
| nucleus | 4 |
| lysosome | 4 |
| endosome | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | colocalizes_with chromatin | IDA | 28242692 |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005635 | nuclear envelope | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for IST1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Endocytosis | ||
Pathways by source for IST1 Gene
3 Reactome pathways for IST1 Gene
1 KEGG pathway for IST1 Gene
Interacting Proteins for IST1 Gene
Selected Interacting proteins:
P53990-IST1_HUMAN
ENSP00000438399
for IST1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for IST1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007049 | cell cycle | IEA | -- |
| GO:0008104 | protein localization | IBA,IMP | 20719964 |
| GO:0009838 | abscission | IMP | 19525971 |
| GO:0015031 | protein transport | IEA | -- |
| GO:0019076 | viral release from host cell | IDA | 19129479 |
No data available for SIGNOR curated interactions for IST1 Gene
Transcripts for IST1 Gene
mRNA/cDNA for IST1 Gene
- 6 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 27 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000329908 2356 nts (view in UCSC)
- ENST00000378798 2255 nts (view in UCSC)
- ENST00000378799 4561 nts (view in UCSC)
- ENST00000424485 521 nts (view in UCSC)
- ENST00000439924 1841 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IST1 - Select products 50% OFF >
- * IST1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IST1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IST1
-
Santa Cruz Biotechnology (SCBT) CRISPR for IST1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IST1
- Browse OriGene Inhibitory RNA Products For IST1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IST1
Clone Products
- Applied Biological Materials (abm): Clones for IST1 - Select products 50% OFF >
- * IST1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203871
- MG205554
- MR203871
- MR203871L3
- MR203871L4
- MR205554
- MR205554L3
- MR205554L4
- RC201347
- RC201347L1
- RC201347L2
- RC201347L3
- RC201347L4
- RC233469
- RC233470
- RC233805
- RC233891
- RC233926
- RG201347
- RG233469
- RG233470
- RG233805
- RG233891
- RG233926
- RR201868
- RR201868L3
- RR201868L4
- MR203871L3V
- MR203871L4V
- MR205554L3V
- MR205554L4V
- RC201347L1V
- RC201347L2V
- RC201347L3V
- RC201347L4V
- RR201868L3V
- RR201868L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IST1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IST1
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: |
| ExUns: | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | · | 17c | · | 17d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||
| SP5: | |||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||
| SP10: | - | - | |||||||||||||||||||||
| SP11: | |||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||
| SP17: | - | ||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||
| SP21: | |||||||||||||||||||||||
| SP22: | - | - | - | ||||||||||||||||||||
| SP23: |
Relevant External Links for IST1 Gene
- GeneLoc Exon Structure for
- IST1
Expression for IST1 Gene
This gene is overexpressed in Breast (16.8) and Urine (9.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IST1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IST1
SOURCE GeneReport for Unigene cluster for IST1 Gene:
Hs.232194Evidence on tissue expression from TISSUES for IST1 Gene
- Nervous system(5)
- Lung(4.8)
- Liver(4.7)
- Eye(4.5)
- Bone marrow(4.4)
- Kidney(4.3)
- Intestine(4.1)
- Blood(3.8)
- Skin(3.7)
- Spleen(3.7)
- Stomach(2.4)
- Lymph node(2.3)
- Muscle(2.2)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for IST1
-
OriGene qPCR primer pairs and template standards for IST1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IST1 Gene
Orthologs for IST1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IST1 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | IST1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IST1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ist1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ist1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | IST1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IST1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | IST1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | IST1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ist1 30 |
|
||
| Str.10305 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.25431 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ist1 30 31 |
|
OneToOne | |
| Dr.1122 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2448 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG10103 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005882 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | istr-1 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IST1 31 33 |
|
OneToOne |
- Species where no ortholog for IST1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for IST1 Gene
- ENSEMBL:
- Gene Tree for IST1 (if available)
- TreeFam:
- Gene Tree for IST1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IST1: view image
Paralogs for IST1 Gene
Pseudogenes.org Pseudogenes for IST1 Gene
No data available for Paralogs for IST1 Gene
Variants for IST1 Gene
Residual Variation Intolerance Score:
38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.66;
31.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IST1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- IST1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IST1 Gene
Disorders for IST1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gastric squamous cell carcinoma |
|
|
| spastic paraplegia 20, autosomal recessive |
|
|
| pulp degeneration |
|
|
| masa syndrome |
|
|
| lung cancer |
|
|
Search IST1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IST1
No data available for UniProtKB/Swiss-Prot and Genatlas for IST1 Gene
Publications for IST1 Gene
- Essential role of hIST1 in cytokinesis. (PMID: 19129480) Agromayor M … Martin-Serrano J (Molecular biology of the cell 2009) 2 3 4
- Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4
- Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing. (PMID: 26040712) Vietri M … Stenmark H (Nature 2015) 3 4
- An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome. (PMID: 23897888) Allison R … Reid E (The Journal of cell biology 2013) 3 4
- MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis. (PMID: 23015756) Lee S … Blackstone C (Molecular biology of the cell 2012) 3 4
ExternalLinks
Products for IST1 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for IST1
- Search Origene for MassSpec and Protein Over-expression Lysates for IST1
- Origene Custom Protein Services for IST1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IST1
- Browse OriGene Inhibitory RNA Products For IST1
- OriGene qPCR primer pairs for IST1
- OriGene qPCR primer pairs and template standards for IST1
- OriGene CRISPR knockouts for IST1
- MG203871
- MG205554
- MR203871
- MR203871L3
- MR203871L4
- MR205554
- MR205554L3
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- RC201347
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- RC201347L4V
- RR201868L3V
- RR201868L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IST1
- Sino Biological Human cDNA Clone for IST1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for IST1
- Novus Biologicals proteins for IST1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for IST1
- Abcam proteins for IST1
- Find your target
- Browse Primary Antibodies
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
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- Invitrogen Antibodies for IST1 (AFLGC-IST1)
- VectorBuilder Custom and pre-made DNA vectors for IST1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for IST1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for IST1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for IST1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for IST1
- antibodies-online: Show 7 available IST1 Antibodies ranked by validation data
- Compare Top IST1 Antibodies
- antibodies-online: Search results for available IST1 related products ranked by validation data
- antibodies-online: Show 4 available IST1 Proteins ranked by validation data
- Compare Top IST1 Proteins
- Horizon Cell Lines for IST1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IST1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IST1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for IST1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IST1
- Boster Bio Antibodies for IST1
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for IST1
Sources for IST1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB