Aliases for IST1 Gene
External Ids for IST1 Gene
Previous HGNC Symbols for IST1 Gene
Previous GeneCards Identifiers for IST1 Gene
This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
GeneCards Summary for IST1 Gene
IST1 (IST1 Factor Associated With ESCRT-III) is a Protein Coding gene. Diseases associated with IST1 include Gastric Squamous Cell Carcinoma and Spastic Paraplegia 20, Autosomal Recessive. Among its related pathways are Innate Immune System and Endocytosis. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and MIT domain binding.
UniProtKB/Swiss-Prot Summary for IST1 Gene
ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).