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Aliases for ISLR2 Gene

Aliases for ISLR2 Gene

  • Immunoglobulin Superfamily Containing Leucine Rich Repeat 2 2 3 5
  • Leucine-Rich Repeat Domain And Immunoglobulin Domain-Containing Axon Extension Protein 3 4
  • LINX 3 4
  • Immunoglobulin Superfamily Containing Leucine-Rich Repeat Protein 2 3
  • KIAA1465 4

External Ids for ISLR2 Gene

Previous GeneCards Identifiers for ISLR2 Gene

  • GC15P072209
  • GC15P074421
  • GC15P051215
  • GC15P074392

Summaries for ISLR2 Gene

GeneCards Summary for ISLR2 Gene

ISLR2 (Immunoglobulin Superfamily Containing Leucine Rich Repeat 2) is a Protein Coding gene. An important paralog of this gene is ISLR.

UniProtKB/Swiss-Prot for ISLR2 Gene

  • Required for axon extension during neural development.

Additional gene information for ISLR2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISLR2 Gene

Genomics for ISLR2 Gene

GeneHancer (GH) Regulatory Elements for ISLR2 Gene

Promoters and enhancers for ISLR2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I074100 Promoter/Enhancer 1.6 Ensembl ENCODE 550.8 +0.2 189 1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF213 E2F8 ZNF207 ZNF143 ISLR2 LOC732265 EDC3 ISLR CD276 GC15P074104 GC15P074105 PIR58467
GH15I074127 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.3 +28.5 28462 2.8 ARID4B SIN3A ZNF2 ZNF121 ZNF213 ARID2 ZNF143 ZNF548 SP3 REST LOC283731 ISLR2 PML GC15P074104 GC15P074105 PIR58467
GH15I074130 Promoter/Enhancer 1.3 EPDnew ENCODE 550.3 +30.3 30301 0.5 MXI1 KLF1 SUZ12 KLF17 ZIC2 ZNF2 ZNF335 POLR2A PATZ1 VEZF1 LOC283731 ISLR2 GC15P074141 PIR54119
GH15I074131 Promoter 1 EPDnew 550.3 +29.9 29919 0.1 MXI1 MAZ ZNF449 ZEB2 ZIC2 ZNF335 POLR2A GLIS1 VEZF1 ZNF341 LOC283731 ISLR2 GC15P074141 PIR54119
GH15I074199 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 +101.7 101732 5.3 SIN3A FEZF1 ZNF2 GLIS2 ZNF143 ZNF548 FOS DEK SP3 JUNB CCDC33 STRA6 PML ISLR2 ISLR ENSG00000261543
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ISLR2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ISLR2 gene promoter:

Genomic Locations for ISLR2 Gene

Genomic Locations for ISLR2 Gene
41,531 bases
Plus strand

Genomic View for ISLR2 Gene

Genes around ISLR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ISLR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ISLR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISLR2 Gene

Proteins for ISLR2 Gene

  • Protein details for ISLR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin superfamily containing leucine-rich repeat protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K352
    • Q9P263

    Protein attributes for ISLR2 Gene

    745 amino acids
    Molecular mass:
    78990 Da
    Quaternary structure:
    • Homomultimer. Interacts with NTRK1/TrkA (By similarity).
    • Sequence=BAA95989.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ISLR2 Gene

Post-translational modifications for ISLR2 Gene

  • Glycosylation at isoforms=52, isoforms=121, posLast=337337, posLast=364364, posLast=474474, and posLast=563563

No data available for DME Specific Peptides for ISLR2 Gene

Domains & Families for ISLR2 Gene

Gene Families for ISLR2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ISLR2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ISLR2: view

No data available for UniProtKB/Swiss-Prot for ISLR2 Gene

Function for ISLR2 Gene

Molecular function for ISLR2 Gene

UniProtKB/Swiss-Prot Function:
Required for axon extension during neural development.
genes like me logo Genes that share phenotypes with ISLR2: view

Animal Models for ISLR2 Gene

MGI Knock Outs for ISLR2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ISLR2 Gene

Localization for ISLR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISLR2 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ISLR2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ISLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ISLR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ISLR2 Gene

Pathways & Interactions for ISLR2 Gene

SuperPathways for ISLR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ISLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0045773 positive regulation of axon extension IBA,ISS --
genes like me logo Genes that share ontologies with ISLR2: view

No data available for Pathways by source and SIGNOR curated interactions for ISLR2 Gene

Drugs & Compounds for ISLR2 Gene

No Compound Related Data Available

Transcripts for ISLR2 Gene

Unigene Clusters for ISLR2 Gene

Immunoglobulin superfamily containing leucine-rich repeat 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ISLR2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: -

Relevant External Links for ISLR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ISLR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ISLR2 Gene

mRNA differential expression in normal tissues according to GTEx for ISLR2 Gene

This gene is overexpressed in Testis (x6.2), Brain - Nucleus accumbens (basal ganglia) (x5.2), Brain - Cortex (x5.1), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Putamen (basal ganglia) (x4.7), Brain - Caudate (basal ganglia) (x4.2), and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for ISLR2 Gene

This gene is overexpressed in Lavage (35.8), Fetal Brain (19.5), and Prostate (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ISLR2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ISLR2 Gene:


SOURCE GeneReport for Unigene cluster for ISLR2 Gene:


Evidence on tissue expression from TISSUES for ISLR2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ISLR2: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ISLR2 Gene

Orthologs for ISLR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ISLR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ISLR2 33 34
  • 98.75 (n)
(Canis familiaris)
Mammalia ISLR2 33 34
  • 86.88 (n)
(Bos Taurus)
Mammalia ISLR2 33 34
  • 86.58 (n)
(Mus musculus)
Mammalia Islr2 33 16 34
  • 84.54 (n)
(Rattus norvegicus)
Mammalia LOC100910729 33
  • 84.09 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 63 (a)
(Gallus gallus)
Aves ISLR2 33 34
  • 63.44 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia islr2 33
  • 54.11 (n)
(Danio rerio)
Actinopterygii islr2 33 34
  • 54.34 (n)
fruit fly
(Drosophila melanogaster)
Insecta kek4 34
  • 17 (a)
kek2 34
  • 14 (a)
kek3 34
  • 14 (a)
kek5 34
  • 14 (a)
kek1 34
  • 13 (a)
kek6 34
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 26 (a)
CSA.1672 34
  • 20 (a)
-- 34
  • 19 (a)
Species where no ortholog for ISLR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ISLR2 Gene

Gene Tree for ISLR2 (if available)
Gene Tree for ISLR2 (if available)

Paralogs for ISLR2 Gene

Paralogs for ISLR2 Gene

(9) SIMAP similar genes for ISLR2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ISLR2: view

Variants for ISLR2 Gene

Sequence variations from dbSNP and Humsavar for ISLR2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000021785 -- 74,140,679(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000027460 -- 74,135,936(+) G/C 3_prime_UTR_variant, intron_variant
rs1000028981 -- 74,136,896(+) C/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000219885 -- 74,140,916(+) T/A genic_downstream_transcript_variant, intron_variant
rs1000394964 -- 74,128,440(+) G/A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ISLR2 Gene

Variant ID Type Subtype PubMed ID
nsv951993 CNV deletion 24416366
nsv833053 CNV loss 17160897
nsv827385 CNV gain 20364138
nsv469619 CNV loss 16826518
nsv428308 CNV gain+loss 18775914
nsv1121512 CNV deletion 24896259
nsv1050884 CNV gain 25217958
nsv1047564 CNV gain 25217958
esv2760040 CNV gain+loss 17122850

Variation tolerance for ISLR2 Gene

Residual Variation Intolerance Score: 5.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ISLR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISLR2 Gene

Disorders for ISLR2 Gene

Additional Disease Information for ISLR2

No disorders were found for ISLR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ISLR2 Gene

Publications for ISLR2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ISLR2 Gene

Sources for ISLR2 Gene

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