Free for academic non-profit institutions. Other users need a Commercial license
Aliases for ISLR2 Gene
Aliases for ISLR2 Gene
External Ids for ISLR2 Gene
- HGNC: 29286
- Entrez Gene: 57611
- Ensembl: ENSG00000167178
- OMIM: 614179
- UniProtKB: Q6UXK2
Previous GeneCards Identifiers for ISLR2 Gene
- GC15P072209
- GC15P074421
- GC15P051215
- GC15P074392
Summaries for ISLR2 Gene
GeneCards Summary for ISLR2 Gene
ISLR2 (Immunoglobulin Superfamily Containing Leucine Rich Repeat 2) is a Protein Coding gene. Diseases associated with ISLR2 include Hernia, Hiatus and Chicken Egg Allergy. An important paralog of this gene is ISLR.
UniProtKB/Swiss-Prot Summary for ISLR2 Gene
-
Required for axon extension during neural development.
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ISLR2 Gene
Genomics for ISLR2 Gene
GeneHancer (GH) Regulatory Elements for ISLR2 Gene
Promoters and enhancers for ISLR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ISLR2 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ISLR2
- Top Transcription factor binding sites by QIAGEN in the ISLR2 gene promoter:
-
- AP-4
- FOXI1
- HFH-3
Genomic Locations for ISLR2 Gene
Genomic Locations for ISLR2 Gene
- chr15:74,100,311-74,141,841
- (GRCh38/hg38)
- Size:
- 41,531 bases
- Orientation:
- Plus strand
- chr15:74,392,652-74,430,881
- (GRCh37/hg19)
- Size:
- 38,230 bases
- Orientation:
- Plus strand
Genomic View for ISLR2 Gene
Genes around ISLR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q24.1 by HGNC
- 15q24.1 by Entrez Gene
- 15q24.1 by Ensembl
ISLR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ISLR2 Gene
Proteins for ISLR2 Gene
-
Protein details for ISLR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UXK2-ISLR2_HUMAN
- Recommended name:
- Immunoglobulin superfamily containing leucine-rich repeat protein 2
- Protein Accession:
- Q6UXK2
- A8K352
- Q9P263
Protein attributes for ISLR2 Gene
- Size:
- 745 amino acids
- Molecular mass:
- 78990 Da
- Quaternary structure:
-
- Homomultimer. Interacts with NTRK1/TrkA (By similarity).
- SequenceCaution:
-
- Sequence=BAA95989.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ISLR2 Gene
Post-translational modifications for ISLR2 Gene
Other Protein References for ISLR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-ISLR2 polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for ISLR2
- Novus Biologicals Antibodies for ISLR2
-
Abcam antibodies for ISLR2
- Invitrogen Antibodies for ISLR2 (AFLGC-ISLR2)
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ISLR2
- Origene Custom Protein Services for ISLR2
- Novus Biologicals proteins for ISLR2
No data available for DME Specific Peptides for ISLR2 Gene
Domains & Families for ISLR2 Gene
Gene Families for ISLR2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ISLR2 Gene
- Blocks:
-
- Immunoglobulin I-set
- Cysteine-rich flanking region, C-terminal
- Cysteine-rich flanking region, N-terminal
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ISLR2 Gene
- GenScript: Design optimal peptide antigens:
-
- Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein (ISLR2_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ISLR2 Gene
Function for ISLR2 Gene
Molecular function for ISLR2 Gene
- UniProtKB/Swiss-Prot Function:
- Required for axon extension during neural development.
Phenotypes From GWAS Catalog for ISLR2 Gene
Phenotypes for ISLR2 Gene
- MGI mutant phenotypes for ISLR2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ISLR2:
Animal Models for ISLR2 Gene
- MGI Knock Outs for ISLR2:
-
- Islr2 Islr2<tm1.1Ddg>
Animal Model Products
-
Taconic Biosciences Mouse Models for ISLR2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ISLR2 - Select products 50% OFF >
- * ISLR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ISLR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ISLR2
- genomics-online: gRNA clones - Search for available ISLR2 gRNA products
- Overview of 180 available ISLR2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ISLR2
miRNA for ISLR2 Gene
- miRTarBase miRNAs that target ISLR2
-
- hsa-mir-615-3p (MIRT039768)
- hsa-mir-6798-3p (MIRT528987)
- hsa-mir-3162-3p (MIRT528988)
- hsa-mir-4640-3p (MIRT528989)
- hsa-mir-603 (MIRT528990)
- hsa-mir-8485 (MIRT528991)
- hsa-mir-3613-3p (MIRT528992)
- hsa-mir-3163 (MIRT528993)
- hsa-mir-5692a (MIRT528994)
- hsa-mir-4282 (MIRT528995)
- hsa-mir-425-3p (MIRT571092)
- hsa-mir-6802-5p (MIRT571093)
- hsa-mir-7847-3p (MIRT571094)
- hsa-mir-6716-5p (MIRT571095)
- hsa-mir-6880-5p (MIRT571096)
- hsa-mir-6851-5p (MIRT571097)
- hsa-mir-3689d (MIRT571098)
- hsa-mir-6865-5p (MIRT571099)
- hsa-mir-6815-5p (MIRT571101)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ISLR2
- Browse OriGene Inhibitory RNA Products For ISLR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ISLR2
- genomics-online: shRNA clones - Search for available ISLR2 shRNA products
- Overview of 180 available ISLR2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ISLR2 - Select products 50% OFF >
- * ISLR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210423
- MG223162
- MG223169
- MG223578
- MG223995
- MG223998
- MG224397
- MG224405
- MR210423
- MR210423L3
- MR210423L4
- MR223162
- MR223162L3
- MR223162L4
- MR223169
- MR223169L3
- MR223169L4
- MR223578
- MR223578L3
- MR223578L4
- MR223995
- MR223995L3
- MR223995L4
- MR223998
- MR223998L3
- MR223998L4
- MR224397
- MR224397L3
- MR224397L4
- MR224405
- MR224405L3
- MR224405L4
- RC217963
- RC217963L3
- RC217963L4
- RC226130
- RC226130L3
- RC226130L4
- RC226131
- RC226131L3
- RC226131L4
- RC226132
- RC226132L3
- RC226132L4
- RG217963
- RG226130
- RG226131
- RG226132
- MR210423L3V
- MR210423L4V
- MR223162L3V
- MR223162L4V
- MR223169L3V
- MR223169L4V
- MR223578L3V
- MR223578L4V
- MR223995L3V
- MR223995L4V
- MR223998L3V
- MR223998L4V
- MR224397L3V
- MR224397L4V
- MR224405L3V
- MR224405L4V
- RC217963L3V
- RC217963L4V
- RC226130L3V
- RC226130L4V
- RC226131L3V
- RC226131L4V
- RC226132L3V
- RC226132L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ISLR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ISLR2
- genomics-online: cdna clones - Search for available ISLR2 CDNA products
- Overview of 180 available ISLR2 gene related products
- orf clones - Search for available ISLR2 ORF products
- Overview of 180 available ISLR2 gene related products
Cell Line Products
-
Horizon Cell Lines for ISLR2
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ISLR2 Gene
Localization for ISLR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ISLR2 Gene
- Cell membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endosome | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
| peroxisome | 0 |
| endoplasmic reticulum | 0 |
| lysosome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0009986 | cell surface | ISS,IBA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ISLR2 Gene
Pathways & Interactions for ISLR2 Gene
Interacting Proteins for ISLR2 Gene
GPS-Prot Interaction Network for ISLR2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0045773 | positive regulation of axon extension | ISS,IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ISLR2 Gene
Transcripts for ISLR2 Gene
mRNA/cDNA for ISLR2 Gene
- 4 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000361742 4817 bps (ENST00000361742.7)
- ENST00000419208 2306 bps (ENST00000419208.2)
- ENST00000435464 4259 bps (ENST00000435464.5)
- ENST00000453268 4202 bps (ENST00000453268.3)
- ENST00000561740 630 bps (ENST00000561740.5)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ISLR2 - Select products 50% OFF >
- * ISLR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ISLR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ISLR2
- genomics-online: gRNA clones - Search for available ISLR2 gRNA products
- Overview of 180 available ISLR2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ISLR2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ISLR2
- Browse OriGene Inhibitory RNA Products For ISLR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ISLR2
- genomics-online: shRNA clones - Search for available ISLR2 shRNA products
- Overview of 180 available ISLR2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ISLR2 - Select products 50% OFF >
- * ISLR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210423
- MG223162
- MG223169
- MG223578
- MG223995
- MG223998
- MG224397
- MG224405
- MR210423
- MR210423L3
- MR210423L4
- MR223162
- MR223162L3
- MR223162L4
- MR223169
- MR223169L3
- MR223169L4
- MR223578
- MR223578L3
- MR223578L4
- MR223995
- MR223995L3
- MR223995L4
- MR223998
- MR223998L3
- MR223998L4
- MR224397
- MR224397L3
- MR224397L4
- MR224405
- MR224405L3
- MR224405L4
- RC217963
- RC217963L3
- RC217963L4
- RC226130
- RC226130L3
- RC226130L4
- RC226131
- RC226131L3
- RC226131L4
- RC226132
- RC226132L3
- RC226132L4
- RG217963
- RG226130
- RG226131
- RG226132
- MR210423L3V
- MR210423L4V
- MR223162L3V
- MR223162L4V
- MR223169L3V
- MR223169L4V
- MR223578L3V
- MR223578L4V
- MR223995L3V
- MR223995L4V
- MR223998L3V
- MR223998L4V
- MR224397L3V
- MR224397L4V
- MR224405L3V
- MR224405L4V
- RC217963L3V
- RC217963L4V
- RC226130L3V
- RC226130L4V
- RC226131L3V
- RC226131L4V
- RC226132L3V
- RC226132L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ISLR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ISLR2
- genomics-online: cdna clones - Search for available ISLR2 CDNA products
- Overview of 180 available ISLR2 gene related products
- orf clones - Search for available ISLR2 ORF products
- Overview of 180 available ISLR2 gene related products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for ISLR2 Gene
- GeneLoc Exon Structure for
- ISLR2
Expression for ISLR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
- Neurons
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for ISLR2 Gene
This gene is overexpressed in Testis (x6.2), Brain - Nucleus accumbens (basal ganglia) (x5.2), Brain - Cortex (x5.1), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Putamen (basal ganglia) (x4.7), Brain - Caudate (basal ganglia) (x4.2), and Brain - Frontal Cortex (BA9) (x4.1).
This gene is overexpressed in Lavage (35.8), Fetal Brain (19.5), and Prostate (12.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ISLR2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ISLR2
SOURCE GeneReport for Unigene cluster for ISLR2 Gene:
Hs.254775Evidence on tissue expression from TISSUES for ISLR2 Gene
- Nervous system(4.6)
Primer Products
-
OriGene qPCR primer pairs for ISLR2
Gene Expression Assay Products
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ISLR2 Gene
Orthologs for ISLR2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ISLR2 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ISLR2 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ISLR2 31 30 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Islr2 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100910729 30 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | ISLR2 31 30 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | islr2 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | islr2 31 30 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | kek4 31 |
|
ManyToMany | |
| kek3 31 |
|
ManyToMany | |||
| kek5 31 |
|
ManyToMany | |||
| kek2 31 |
|
ManyToMany | |||
| kek1 31 |
|
ManyToMany | |||
| kek6 31 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| CSA.1672 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany |
- Species where no ortholog for ISLR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ISLR2 Gene
- ENSEMBL:
- Gene Tree for ISLR2 (if available)
- TreeFam:
- Gene Tree for ISLR2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ISLR2: view image
Paralogs for ISLR2 Gene
Variants for ISLR2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ISLR2 Gene
| SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1567164285 | Uncertain Significance: not provided | 74,134,413(+) | CT/C | FRAMESHIFT_VARIANT | |
| rs3889598 | - | p.Ser137Phe |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2760040 | CNV | gain+loss | 17122850 |
| nsv1047564 | CNV | gain | 25217958 |
| nsv1050884 | CNV | gain | 25217958 |
| nsv1121512 | CNV | deletion | 24896259 |
| nsv428308 | CNV | gain+loss | 18775914 |
| nsv469619 | CNV | loss | 16826518 |
| nsv827385 | CNV | gain | 20364138 |
| nsv833053 | CNV | loss | 17160897 |
| nsv951993 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
5.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.59;
56.26% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ISLR2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ISLR2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISLR2 Gene
Disorders for ISLR2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hernia, hiatus |
|
|
| chicken egg allergy |
|
|
| malignant otitis externa |
|
|
| rumination disorder |
|
|
Search ISLR2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ISLR2
No data available for UniProtKB/Swiss-Prot and Genatlas for ISLR2 Gene
Publications for ISLR2 Gene
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 54
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 54
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
- A novel ISLR2-linked autosomal recessive syndrome of congenital hydrocephalus, arthrogryposis and abdominal distension. (PMID: 30483960) Alazami AM … Alkuraya FS (Human genetics 2019) 3 54
- Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 54
ExternalLinks
Products for ISLR2 Gene
- View all 4 R&D Systems ISLR2 (ISLR-2) Products
- View all R&D Systems ISLR2 (ISLR-2) Proteins and Enzymes
- View all 2 R&D Systems ISLR2 (ISLR-2) Primary Antibodies
- View all R&D Systems ISLR2 (ISLR-2) cDNA Clones
- Learn more about R&D Systems custom ISLR2 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for ISLR2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ISLR2
- Origene Custom Protein Services for ISLR2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ISLR2
- Browse OriGene Inhibitory RNA Products For ISLR2
- OriGene qPCR primer pairs for ISLR2
- OriGene CRISPR knockouts for ISLR2
- MG210423
- MG223162
- MG223169
- MG223578
- MG223995
- MG223998
- MG224397
- MG224405
- MR210423
- MR210423L3
- MR210423L4
- MR223162
- MR223162L3
- MR223162L4
- MR223169
- MR223169L3
- MR223169L4
- MR223578
- MR223578L3
- MR223578L4
- MR223995
- MR223995L3
- MR223995L4
- MR223998
- MR223998L3
- MR223998L4
- MR224397
- MR224397L3
- MR224397L4
- MR224405
- MR224405L3
- MR224405L4
- RC217963
- RC217963L3
- RC217963L4
- RC226130
- RC226130L3
- RC226130L4
- RC226131
- RC226131L3
- RC226131L4
- RC226132
- RC226132L3
- RC226132L4
- RG217963
- RG226130
- RG226131
- RG226132
- MR210423L3V
- MR210423L4V
- MR223162L3V
- MR223162L4V
- MR223169L3V
- MR223169L4V
- MR223578L3V
- MR223578L4V
- MR223995L3V
- MR223995L4V
- MR223998L3V
- MR223998L4V
- MR224397L3V
- MR224397L4V
- MR224405L3V
- MR224405L4V
- RC217963L3V
- RC217963L4V
- RC226130L3V
- RC226130L4V
- RC226131L3V
- RC226131L4V
- RC226132L3V
- RC226132L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ISLR2
- Sino Biological Human cDNA Clone for ISLR2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ISLR2
- Novus Biologicals proteins for ISLR2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ISLR2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for ISLR2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ISLR2 (AFLGC-ISLR2)
- VectorBuilder Custom and pre-made DNA vectors for ISLR2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ISLR2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ISLR2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ISLR2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ISLR2
- antibodies-online: Show 7 available ISLR2 Antibodies ranked by validation data
- Compare Top ISLR2 Antibodies
- antibodies-online: Search results for available ISLR2 related products ranked by validation data
- antibodies-online: Show 6 available ISLR2 Proteins ranked by validation data
- Compare Top ISLR2 Proteins
- Horizon Cell Lines for ISLR2
- genomics-online: cdna clones - Search for available ISLR2 CDNA products
- Overview of 180 available ISLR2 gene related products
- orf clones - Search for available ISLR2 ORF products
- Overview of 180 available ISLR2 gene related products
- genomics-online: gRNA clones - Search for available ISLR2 gRNA products
- Overview of 180 available ISLR2 gene related products
- genomics-online: primer clones - Search for available ISLR2 Primer products
- Overview of 180 available ISLR2 gene related products
- genomics-online: shRNA clones - Search for available ISLR2 shRNA products
- Overview of 180 available ISLR2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ISLR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ISLR2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ISLR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ISLR2
Sources for ISLR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody