This gene encodes a 3'-5' exoribonuclease that may be involved in the processing of the 12S pre-rRNA. Pseudogenes have been identified on chromosomes 6 and 11. [provided by RefSeq, Dec 2014] See more...

Aliases for ISG20L2 Gene

Aliases for ISG20L2 Gene

  • Interferon Stimulated Exonuclease Gene 20 Like 2 2 3 5
  • Interferon-Stimulated 20 KDa Exonuclease-Like 2 3 4
  • Interferon Stimulated Exonuclease Gene 20kDa-Like 2 2
  • Interferon Stimulated Exonuclease Gene 20kDa Like 2 3
  • EC 3.1.-.- 4
  • FLJ12671 2
  • ISG20L2 5
  • HSD38 3

External Ids for ISG20L2 Gene

Previous GeneCards Identifiers for ISG20L2 Gene

  • GC01M153506
  • GC01M154959
  • GC01M156691
  • GC01M128049

Summaries for ISG20L2 Gene

Entrez Gene Summary for ISG20L2 Gene

  • This gene encodes a 3'-5' exoribonuclease that may be involved in the processing of the 12S pre-rRNA. Pseudogenes have been identified on chromosomes 6 and 11. [provided by RefSeq, Dec 2014]

GeneCards Summary for ISG20L2 Gene

ISG20L2 (Interferon Stimulated Exonuclease Gene 20 Like 2) is a Protein Coding gene. Diseases associated with ISG20L2 include Inflammatory Bowel Disease 3 and Bladder Carcinoma In Situ. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and exonuclease activity. An important paralog of this gene is AEN.

UniProtKB/Swiss-Prot Summary for ISG20L2 Gene

  • 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group.

Additional gene information for ISG20L2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ISG20L2 Gene

Genomics for ISG20L2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ISG20L2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ISG20L2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ISG20L2

Top Transcription factor binding sites by QIAGEN in the ISG20L2 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Ik-2
  • PPAR-gamma2
  • STAT1
  • STAT1alpha

Genomic Locations for ISG20L2 Gene

Genomic Locations for ISG20L2 Gene
chr1:156,721,891-156,728,766
(GRCh38/hg38)
Size:
6,876 bases
Orientation:
Minus strand
chr1:156,691,683-156,698,591
(GRCh37/hg19)
Size:
6,909 bases
Orientation:
Minus strand

Genomic View for ISG20L2 Gene

Genes around ISG20L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ISG20L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ISG20L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISG20L2 Gene

Proteins for ISG20L2 Gene

  • Protein details for ISG20L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9L3-I20L2_HUMAN
    Recommended name:
    Interferon-stimulated 20 kDa exonuclease-like 2
    Protein Accession:
    Q9H9L3
    Secondary Accessions:
    • D3DVC6
    • Q64KA2

    Protein attributes for ISG20L2 Gene

    Size:
    353 amino acids
    Molecular mass:
    39154 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ISG20L2 Gene

Post-translational modifications for ISG20L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ISG20L2 Gene

No data available for DME Specific Peptides for ISG20L2 Gene

Domains & Families for ISG20L2 Gene

Gene Families for ISG20L2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ISG20L2 Gene

Suggested Antigen Peptide Sequences for ISG20L2 Gene

GenScript: Design optimal peptide antigens:
  • Interferon-stimulated 20 kDa exonuclease-like 2 (I20L2_HUMAN)
genes like me logo Genes that share domains with ISG20L2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ISG20L2 Gene

Function for ISG20L2 Gene

Molecular function for ISG20L2 Gene

UniProtKB/Swiss-Prot Function:
3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group.

Enzyme Numbers (IUBMB) for ISG20L2 Gene

Phenotypes From GWAS Catalog for ISG20L2 Gene

Gene Ontology (GO) - Molecular Function for ISG20L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3'-5'-exoribonuclease activity EXP 18065403
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IBA 21873635
genes like me logo Genes that share ontologies with ISG20L2: view
genes like me logo Genes that share phenotypes with ISG20L2: view

Animal Model Products

CRISPR Products

miRNA for ISG20L2 Gene

miRTarBase miRNAs that target ISG20L2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ISG20L2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ISG20L2 Gene

Localization for ISG20L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISG20L2 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ISG20L2 gene
Compartment Confidence
nucleus 5
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ISG20L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with ISG20L2: view

Pathways & Interactions for ISG20L2 Gene

genes like me logo Genes that share pathways with ISG20L2: view

Gene Ontology (GO) - Biological Process for ISG20L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0042254 ribosome biogenesis IEA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA --
genes like me logo Genes that share ontologies with ISG20L2: view

No data available for SIGNOR curated interactions for ISG20L2 Gene

Drugs & Compounds for ISG20L2 Gene

No Compound Related Data Available

Transcripts for ISG20L2 Gene

mRNA/cDNA for ISG20L2 Gene

5 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ISG20L2

Alternative Splicing Database (ASD) splice patterns (SP) for ISG20L2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6
SP1: - -
SP2: -
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for ISG20L2 Gene

GeneLoc Exon Structure for
ISG20L2

Expression for ISG20L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ISG20L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for ISG20L2 Gene

This gene is overexpressed in Testis (x5.2).

Protein differential expression in normal tissues from HIPED for ISG20L2 Gene

This gene is overexpressed in Lung (22.4), Peripheral blood mononuclear cells (16.2), CD8 Tcells (8.8), Pancreas (8.0), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ISG20L2 Gene



Protein tissue co-expression partners for ISG20L2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ISG20L2

SOURCE GeneReport for Unigene cluster for ISG20L2 Gene:

Hs.301904

Evidence on tissue expression from TISSUES for ISG20L2 Gene

  • Heart(5)
  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ISG20L2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ISG20L2 Gene

Orthologs for ISG20L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ISG20L2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ISG20L2 30 31
  • 98.01 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ISG20L2 30 31
  • 88.7 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ISG20L2 30 31
  • 87.26 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Isg20l2 30
  • 79.26 (n)
Mouse
(Mus musculus)
Mammalia Isg20l2 30 17 31
  • 78.5 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ISG20L2 31
  • 71 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ISG20L2 31
  • 56 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ISG20L2 31
  • 45 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia isg20l2 30
  • 55.93 (n)
Zebrafish
(Danio rerio)
Actinopterygii isg20l2 31
  • 42 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REX4 31
  • 33 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 33 (a)
OneToMany
Species where no ortholog for ISG20L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ISG20L2 Gene

ENSEMBL:
Gene Tree for ISG20L2 (if available)
TreeFam:
Gene Tree for ISG20L2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ISG20L2: view image

Paralogs for ISG20L2 Gene

Paralogs for ISG20L2 Gene

(4) SIMAP similar genes for ISG20L2 Gene using alignment to 1 proteins:

  • I20L2_HUMAN

Pseudogenes.org Pseudogenes for ISG20L2 Gene

genes like me logo Genes that share paralogs with ISG20L2: view

Variants for ISG20L2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ISG20L2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs3795737 - p.Asn130Ser

Additional dbSNP identifiers (rs#s) for ISG20L2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ISG20L2 Gene

Variant ID Type Subtype PubMed ID
nsv831648 CNV loss 17160897

Variation tolerance for ISG20L2 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ISG20L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ISG20L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISG20L2 Gene

Disorders for ISG20L2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ISG20L2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
inflammatory bowel disease 3
  • ibd3
bladder carcinoma in situ
  • bladder ca in situ
noonan syndrome 2
  • ns2
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ISG20L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ISG20L2 Gene

Publications for ISG20L2 Gene

  1. ISG20L2, a novel vertebrate nucleolar exoribonuclease involved in ribosome biogenesis. (PMID: 18065403) Couté Y … Diaz JJ (Molecular & cellular proteomics : MCP 2008) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4

Products for ISG20L2 Gene

Sources for ISG20L2 Gene