Aliases for ISG20 Gene
External Ids for ISG20 Gene
Previous GeneCards Identifiers for ISG20 Gene
GeneCards Summary for ISG20 Gene
ISG20 (Interferon Stimulated Exonuclease Gene 20) is a Protein Coding gene. Diseases associated with ISG20 include Hepatitis C and Systemic Lupus Erythematosus 5. Among its related pathways are Innate Immune System and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and 3-5-exoribonuclease activity. An important paralog of this gene is AEN.
UniProtKB/Swiss-Prot for ISG20 Gene
Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.