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Aliases for ISG20 Gene

Aliases for ISG20 Gene

  • Interferon Stimulated Exonuclease Gene 20 2 3 5
  • Promyelocytic Leukemia Nuclear Body-Associated Protein ISG20 3 4
  • Interferon Stimulated Exonuclease Gene 20kDa 2 3
  • Estrogen-Regulated Transcript 45 Protein 3 4
  • EC 3.1.13.1 4 56
  • HEM45 3 4
  • Interferon-Stimulated Gene 20 KDa Protein 3
  • CD25 3

External Ids for ISG20 Gene

Previous GeneCards Identifiers for ISG20 Gene

  • GC15P085474
  • GC15P082547
  • GC15P086766
  • GC15P086911
  • GC15P086983
  • GC15P089181
  • GC15P065293

Summaries for ISG20 Gene

GeneCards Summary for ISG20 Gene

ISG20 (Interferon Stimulated Exonuclease Gene 20) is a Protein Coding gene. Diseases associated with ISG20 include Hepatitis C and Viral Infectious Disease. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and 3-5-exoribonuclease activity. An important paralog of this gene is AEN.

UniProtKB/Swiss-Prot for ISG20 Gene

  • Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.

Gene Wiki entry for ISG20 Gene

Additional gene information for ISG20 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISG20 Gene

Genomics for ISG20 Gene

GeneHancer (GH) Regulatory Elements for ISG20 Gene

Promoters and enhancers for ISG20 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I088634 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 585.2 +3.0 2961 8.8 CLOCK MLX YBX1 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 ISG20 AEN ABHD2 PIR50540
GH15I088655 Enhancer 1.2 Ensembl ENCODE dbSUPER 27.6 +20.9 20933 3 PKNOX1 ZFP64 BMI1 IRF4 RAD21 ZNF143 ATF7 IKZF2 RUNX3 ZNF654 ISG20 AEN MIR7-2 ENSG00000173867 MRPL46 MRPS11 HAPLN3 PIR50540
GH15I088620 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.4 -9.2 -9167 11.7 HDGF PKNOX1 CLOCK SMAD1 MLX ARID4B SIN3A DMAP1 ZBTB7B IRF4 AEN POLG FANCI ISG20 PIR37400 GC15M088633 MIR3529
GH15I088647 Enhancer 1.2 Ensembl ENCODE dbSUPER 13.2 +14.1 14062 5.3 HDAC1 NFIB RAD21 EGR1 FOS BCLAF1 IKZF2 RUNX3 EGR2 SMARCA5 ISG20 PIR50540
GH15I088659 Enhancer 0.8 Ensembl ENCODE dbSUPER 16 +24.1 24144 1.2 JUND FOS ISG20 AEN ENSG00000173867 MRPS11 MRPL46 HAPLN3 ACAN PIR50540
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ISG20 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ISG20 gene promoter:

Genomic Locations for ISG20 Gene

Genomic Locations for ISG20 Gene
chr15:88,635,622-88,656,483
(GRCh38/hg38)
Size:
20,862 bases
Orientation:
Plus strand
chr15:89,179,384-89,199,714
(GRCh37/hg19)

Genomic View for ISG20 Gene

Genes around ISG20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ISG20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ISG20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISG20 Gene

Proteins for ISG20 Gene

  • Protein details for ISG20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AZ6-ISG20_HUMAN
    Recommended name:
    Interferon-stimulated gene 20 kDa protein
    Protein Accession:
    Q96AZ6
    Secondary Accessions:
    • O00441
    • O00586

    Protein attributes for ISG20 Gene

    Size:
    181 amino acids
    Molecular mass:
    20363 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Associates with PML and SP100 in the PML NB complex. Associates with survival motor neuron protein (SMN)-containing macromolecular nuclear complexes and U1 and U2 snRNAs and U3 snoRNA.

    Three dimensional structures from OCA and Proteopedia for ISG20 Gene

    Alternative splice isoforms for ISG20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ISG20 Gene

Selected DME Specific Peptides for ISG20 Gene

Q96AZ6:
  • HSSVEDA
  • VGHDLKHD

Post-translational modifications for ISG20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ISG20 Gene

Gene Families for ISG20 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ISG20 Gene

Graphical View of Domain Structure for InterPro Entry

Q96AZ6

UniProtKB/Swiss-Prot:

ISG20_HUMAN :
  • Belongs to the exonuclease superfamily.
Family:
  • Belongs to the exonuclease superfamily.
genes like me logo Genes that share domains with ISG20: view

Function for ISG20 Gene

Molecular function for ISG20 Gene

GENATLAS Biochemistry:
interferon stimulated PML nuclear body associated protein 20kDa,Xenopus XPMC2 homolog
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.0.;
UniProtKB/Swiss-Prot CatalyticActivity:
Exonucleolytic cleavage in the 3- to 5-direction to yield nucleoside 5-phosphates.
UniProtKB/Swiss-Prot Function:
Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.
UniProtKB/Swiss-Prot Induction:
Induced by interferons alpha and beta. Weaker induction was seen with interferon gamma. Increased expression was seen at the transcriptional level.

Enzyme Numbers (IUBMB) for ISG20 Gene

Phenotypes From GWAS Catalog for ISG20 Gene

Gene Ontology (GO) - Molecular Function for ISG20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3-5-exoribonuclease activity IDA 11401564
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IMP 21036379
genes like me logo Genes that share ontologies with ISG20: view
genes like me logo Genes that share phenotypes with ISG20: view

Animal Models for ISG20 Gene

MGI Knock Outs for ISG20:

miRNA for ISG20 Gene

miRTarBase miRNAs that target ISG20

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ISG20 Gene

Localization for ISG20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISG20 Gene

Nucleus. Nucleus, nucleolus. Cytoplasm. Nucleus, Cajal body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ISG20 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 2
plasma membrane 1
mitochondrion 1
endosome 1

Gene Ontology (GO) - Cellular Components for ISG20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21036379
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA,IEA 16514659
GO:0005737 cytoplasm IEA,IDA 16514659
GO:0015030 Cajal body IDA,IEA 16514659
genes like me logo Genes that share ontologies with ISG20: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ISG20 Gene

Pathways & Interactions for ISG20 Gene

genes like me logo Genes that share pathways with ISG20: view

Pathways by source for ISG20 Gene

Gene Ontology (GO) - Biological Process for ISG20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000738 DNA catabolic process, exonucleolytic IDA 11401564
GO:0002376 immune system process IEA --
GO:0006364 rRNA processing IEA --
GO:0006401 RNA catabolic process IDA 11401564
GO:0008283 cell proliferation TAS 9569007
genes like me logo Genes that share ontologies with ISG20: view

No data available for SIGNOR curated interactions for ISG20 Gene

Drugs & Compounds for ISG20 Gene

(7) Drugs for ISG20 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 37
Uridine monophosphate Experimental Pharma Target 0

(3) Additional Compounds for ISG20 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ISG20: view

Transcripts for ISG20 Gene

Unigene Clusters for ISG20 Gene

Interferon stimulated exonuclease gene 20kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ISG20 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: -
SP5:
SP6:

Relevant External Links for ISG20 Gene

GeneLoc Exon Structure for
ISG20
ECgene alternative splicing isoforms for
ISG20

Expression for ISG20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ISG20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ISG20 Gene

This gene is overexpressed in Whole Blood (x11.7) and Spleen (x5.8).

Protein differential expression in normal tissues from HIPED for ISG20 Gene

This gene is overexpressed in Tlymphocyte (15.6), Lymph node (15.5), and Blymphocyte (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ISG20 Gene



Protein tissue co-expression partners for ISG20 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ISG20 Gene:

ISG20

SOURCE GeneReport for Unigene cluster for ISG20 Gene:

Hs.459265

mRNA Expression by UniProt/SwissProt for ISG20 Gene:

Q96AZ6-ISG20_HUMAN
Tissue specificity: Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung. Up regulated by E2 in estrogen receptor-positive breast cancer lines.

Evidence on tissue expression from TISSUES for ISG20 Gene

  • Nervous system(4.3)
  • Spleen(2.9)
  • Lymph node(2.7)
  • Blood(2.5)
  • Liver(2.3)
  • Lung(2.2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with ISG20: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ISG20 Gene

Orthologs for ISG20 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ISG20 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Isg20 33 16 34
  • 83.06 (n)
rat
(Rattus norvegicus)
Mammalia Isg20 33
  • 82.78 (n)
dog
(Canis familiaris)
Mammalia ISG20 33 34
  • 82.46 (n)
cow
(Bos Taurus)
Mammalia ISG20 33 34
  • 82.25 (n)
chimpanzee
(Pan troglodytes)
Mammalia ISG20 33 34
  • 80.37 (n)
oppossum
(Monodelphis domestica)
Mammalia ISG20 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ISG20 34
  • 56 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REX4 34
  • 24 (a)
OneToMany
Species where no ortholog for ISG20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ISG20 Gene

ENSEMBL:
Gene Tree for ISG20 (if available)
TreeFam:
Gene Tree for ISG20 (if available)

Paralogs for ISG20 Gene

Paralogs for ISG20 Gene

(7) SIMAP similar genes for ISG20 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ISG20: view

Variants for ISG20 Gene

Sequence variations from dbSNP and Humsavar for ISG20 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000119046 -- 88,656,015(+) C/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000245559 -- 88,645,281(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000298002 -- 88,645,032(+) GAGGA/GA genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000420011 -- 88,639,263(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000465614 -- 88,635,377(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ISG20 Gene

Variant ID Type Subtype PubMed ID
nsv1115982 CNV insertion 24896259
nsv570384 CNV loss 21841781
nsv827428 CNV loss 20364138
nsv952023 CNV deletion 24416366

Variation tolerance for ISG20 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ISG20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ISG20

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISG20 Gene

Disorders for ISG20 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ISG20 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatitis c
  • chronic hepatitis c
viral infectious disease
  • viral disease
hepatitis c virus
  • hepatitis c virus, susceptibility to
aicardi-goutieres syndrome
  • cree encephalitis
- elite association - COSMIC cancer census association via MalaCards
Search ISG20 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ISG20

genes like me logo Genes that share disorders with ISG20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ISG20 Gene

Publications for ISG20 Gene

  1. Molecular cloning of a new interferon-induced PML nuclear body-associated protein. (PMID: 9235947) Gongora C … Mechti N (The Journal of biological chemistry 1997) 2 3 4 22 58
  2. The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes. (PMID: 16514659) Espert L … Mechti N (Journal of cellular biochemistry 2006) 3 4 22 58
  3. ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses. (PMID: 12594219) Espert L … Mechti N (The Journal of biological chemistry 2003) 3 4 22 58
  4. The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro. (PMID: 11401564) Nguyen LH … Wilson DM (Biochemistry 2001) 3 4 22 58
  5. Antiviral activities of ISG20 in positive-strand RNA virus infections. (PMID: 21036379) Zhou Z … Li K (Virology 2011) 3 4 58

Products for ISG20 Gene

Sources for ISG20 Gene

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