ISG15 Gene (Protein Coding)

ISG15 Ubiquitin Like Modifier

GC01P001001
GIFtS:
47
The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiv... See more...

Aliases for ISG15 Gene

Aliases for ISG15 Gene

  • ISG15 Ubiquitin Like Modifier 2 3 5
  • Interferon, Alpha-Inducible Protein (Clone IFI-15K) 2 3
  • Ubiquitin Cross-Reactive Protein 3 4
  • Ubiquitin-Like Protein ISG15 3 4
  • HUCRP 3 4
  • G1P2 3 4
  • IP17 3 4
  • UCRP 3 4
  • Interferon-Induced 17-KDa/15-KDa Protein 3
  • Interferon-Stimulated Protein, 15 KDa 3
  • Interferon-Induced 15 KDa Protein 4
  • Interferon-Induced 17 KDa Protein 4
  • IFI15 3
  • IMD38 3

External Ids for ISG15 Gene

Previous HGNC Symbols for ISG15 Gene

  • G1P2

Previous GeneCards Identifiers for ISG15 Gene

  • GC01P000478
  • GC01P000938
  • GC01P000220

Summaries for ISG15 Gene

Entrez Gene Summary for ISG15 Gene

  • The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]

GeneCards Summary for ISG15 Gene

ISG15 (ISG15 Ubiquitin Like Modifier) is a Protein Coding gene. Diseases associated with ISG15 include Immunodeficiency 38 With Basal Ganglia Calcification and Influenza. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein tag. An important paralog of this gene is UBC.

UniProtKB/Swiss-Prot Summary for ISG15 Gene

  • Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include IFIT1, MX1/MxA, PPM1B, UBE2L6, UBA7, CHMP5, CHMP2A, CHMP4B and CHMP6. Can also isgylate: EIF2AK2/PKR which results in its activation, DDX58/RIG-I which inhibits its function in antiviral signaling response, EIF4E2 which enhances its cap structure-binding activity and translation-inhibition activity, UBE2N and UBE2E1 which negatively regulates their activity, IRF3 which inhibits its ubiquitination and degradation and FLNB which prevents its ability to interact with the upstream activators of the JNK cascade thereby inhibiting IFNA-induced JNK signaling. Exhibits antiviral activity towards both DNA and RNA viruses, including influenza A, HIV-1 and Ebola virus. Restricts HIV-1 and ebola virus via disruption of viral budding. Inhibits the ubiquitination of HIV-1 Gag and host TSG101 and disrupts their interaction, thereby preventing assembly and release of virions from infected cells. Inhibits Ebola virus budding mediated by the VP40 protein by disrupting ubiquitin ligase activity of NEDD4 and its ability to ubiquitinate VP40. ISGylates influenza A virus NS1 protein which causes a loss of function of the protein and the inhibition of virus replication. The secreted form of ISG15 can: induce natural killer cell proliferation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity. The secreted form acts through the integrin ITGAL/ITGB2 receptor to initiate activation of SRC family tyrosine kinases including LYN, HCK and FGR which leads to secretion of IFNG and IL10; the interaction is mediated by ITGAL (PubMed:29100055).

Gene Wiki entry for ISG15 Gene

Additional gene information for ISG15 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ISG15 Gene

Genomics for ISG15 Gene

GeneHancer (GH) Regulatory Elements for ISG15 Gene

Promoters and enhancers for ISG15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ISG15 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ISG15

Top Transcription factor binding sites by QIAGEN in the ISG15 gene promoter:
  • CREB
  • deltaCREB
  • MyoD
  • p53
  • STAT3

Genomic Locations for ISG15 Gene

Genomic Locations for ISG15 Gene
chr1:1,001,138-1,014,540
(GRCh38/hg38)
Size:
13,403 bases
Orientation:
Plus strand
chr1:948,803-949,920
(GRCh37/hg19)
Size:
1,118 bases
Orientation:
Plus strand

Genomic View for ISG15 Gene

Genes around ISG15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ISG15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ISG15 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ISG15 Gene

Proteins for ISG15 Gene

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  • Protein details for ISG15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05161-ISG15_HUMAN
    Recommended name:
    Ubiquitin-like protein ISG15
    Protein Accession:
    P05161
    Secondary Accessions:
    • Q5SVA4
    • Q7Z2G2
    • Q96GF0

    Protein attributes for ISG15 Gene

    Size:
    165 amino acids
    Molecular mass:
    17888 Da
    Quaternary structure:
    • Homodimer; disulfide-linked (PubMed:2440890). Interacts with, and is conjugated to its targets by UBE1L (E1 enzyme) and UBE2E2 (E2 enzyme) (PubMed:11157743, PubMed:15131269). Interacts with NEDD4 (PubMed:18305167).
    • (Microbial infection) Interacts with vaccinia virus protein E3.
    • (Microbial infection) Interaction with influenza B NS1 protein inhibits its conjugation.

    Three dimensional structures from OCA and Proteopedia for ISG15 Gene

neXtProt entry for ISG15 Gene

Protein Expression for ISG15 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ISG15 Gene

  • S-nitrosylation decreases its dimerization, thereby increasing the availability as well as the solubility of monomeric ISG15 for its conjugation to cellular proteins.
  • Induced as an inactive, precursor protein that is cleaved by specific proteases to expose the C-terminal diglycine (LRLRGG) motif. This motif is essential not only for its conjugation to substrates but also for its recognition by the relevant processing proteases.
  • Ubiquitination at Lys35 and Lys77
  • Modification sites at PhosphoSitePlus

Other Protein References for ISG15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ISG15 Gene

Domains & Families for ISG15 Gene

Gene Families for ISG15 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ISG15 Gene

Blocks:
  • Ubiquitin domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ISG15 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin cross-reactive protein (ISG15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05161

UniProtKB/Swiss-Prot:

ISG15_HUMAN :
  • Both the Ubiquitin-like 1 and Ubiquitin-like 2 domains are required for its efficient conjugation to cellular proteins. The two domains play different roles in the ISGylation pathway: Ubiquitin-like 2 domain is necessary for the first two steps allowing the linking of ISG15 to the E1 and E2 enzymes while Ubiquitin-like 1 domain is essential for the final, E3-mediated transfer of ISG15, from the E2 to the Lys of the target protein (PubMed:18356159).
Domain:
  • Both the Ubiquitin-like 1 and Ubiquitin-like 2 domains are required for its efficient conjugation to cellular proteins. The two domains play different roles in the ISGylation pathway: Ubiquitin-like 2 domain is necessary for the first two steps allowing the linking of ISG15 to the E1 and E2 enzymes while Ubiquitin-like 1 domain is essential for the final, E3-mediated transfer of ISG15, from the E2 to the Lys of the target protein (PubMed:18356159).
genes like me logo Genes that share domains with ISG15: view

Function for ISG15 Gene

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Molecular function for ISG15 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include IFIT1, MX1/MxA, PPM1B, UBE2L6, UBA7, CHMP5, CHMP2A, CHMP4B and CHMP6. Can also isgylate: EIF2AK2/PKR which results in its activation, DDX58/RIG-I which inhibits its function in antiviral signaling response, EIF4E2 which enhances its cap structure-binding activity and translation-inhibition activity, UBE2N and UBE2E1 which negatively regulates their activity, IRF3 which inhibits its ubiquitination and degradation and FLNB which prevents its ability to interact with the upstream activators of the JNK cascade thereby inhibiting IFNA-induced JNK signaling. Exhibits antiviral activity towards both DNA and RNA viruses, including influenza A, HIV-1 and Ebola virus. Restricts HIV-1 and ebola virus via disruption of viral budding. Inhibits the ubiquitination of HIV-1 Gag and host TSG101 and disrupts their interaction, thereby preventing assembly and release of virions from infected cells. Inhibits Ebola virus budding mediated by the VP40 protein by disrupting ubiquitin ligase activity of NEDD4 and its ability to ubiquitinate VP40. ISGylates influenza A virus NS1 protein which causes a loss of function of the protein and the inhibition of virus replication. The secreted form of ISG15 can: induce natural killer cell proliferation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity. The secreted form acts through the integrin ITGAL/ITGB2 receptor to initiate activation of SRC family tyrosine kinases including LYN, HCK and FGR which leads to secretion of IFNG and IL10; the interaction is mediated by ITGAL (PubMed:29100055).
UniProtKB/Swiss-Prot Induction:
Strongly induced upon exposure to type I interferons, viruses, LPS, and other stresses, including certain genotoxic stresses.

Phenotypes From GWAS Catalog for ISG15 Gene

Gene Ontology (GO) - Molecular Function for ISG15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IPI 29100055
GO:0005515 protein binding IPI,IEA 16189514
GO:0031386 protein tag IBA 21873635
GO:0031625 ubiquitin protein ligase binding IBA 21873635
genes like me logo Genes that share ontologies with ISG15: view
genes like me logo Genes that share phenotypes with ISG15: view

Human Phenotype Ontology for ISG15 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ISG15 Gene

MGI Knock Outs for ISG15:

Animal Model Products

CRISPR Products

miRNA for ISG15 Gene

miRTarBase miRNAs that target ISG15

Clone Products

  • Addgene plasmids for ISG15

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ISG15 Gene

Localization for ISG15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISG15 Gene

Cytoplasm. Secreted. Note=Exists in three distinct states: free within the cell, released into the extracellular space, or conjugated to target proteins.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ISG15 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ISG15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA,IEA 22859821
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ISG15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ISG15 Gene

Pathways & Interactions for ISG15 Gene

genes like me logo Genes that share pathways with ISG15: view

Pathways by source for ISG15 Gene

1 GeneGo (Thomson Reuters) pathway for ISG15 Gene
  • Immune response IFN alpha/beta signaling pathway

Gene Ontology (GO) - Biological Process for ISG15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007229 integrin-mediated signaling pathway IDA 29100055
GO:0009617 response to bacterium IEA --
GO:0016032 viral process IEA --
GO:0016567 NOT protein ubiquitination IBA 21873635
GO:0019941 modification-dependent protein catabolic process IBA 21873635
genes like me logo Genes that share ontologies with ISG15: view

No data available for SIGNOR curated interactions for ISG15 Gene

Drugs & Compounds for ISG15 Gene

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  1. Drug

(10) Drugs for ISG15 Gene - From: ClinicalTrials, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Irinotecan Approved, Investigational Pharma inhibitor, Biomarker Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1353
topoisomerase I inhibitors Pharma 1597
Topoisomerase Inhibitors Pharma 5875

(5) Additional Compounds for ISG15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ISG15: view

Transcripts for ISG15 Gene

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mRNA/cDNA for ISG15 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for ISG15

Alternative Splicing Database (ASD) splice patterns (SP) for ISG15 Gene

No ASD Table

Relevant External Links for ISG15 Gene

GeneLoc Exon Structure for
ISG15

Expression for ISG15 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ISG15 Gene

mRNA expression in normal human tissues for ISG15 Gene
mRNA expression by BioGPS for ISG15 GenemRNA expression by GTEx for ISG15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ISG15 Gene

This gene is overexpressed in Brain - Substantia nigra (x8.2).

Protein differential expression in normal tissues from HIPED for ISG15 Gene

This gene is overexpressed in Amniocyte (11.1), Breast (8.3), Oral epithelium (8.1), and Platelet (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ISG15 Gene



Protein tissue co-expression partners for ISG15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ISG15

SOURCE GeneReport for Unigene cluster for ISG15 Gene:

Hs.458485

mRNA Expression by UniProt/SwissProt for ISG15 Gene:

P05161-ISG15_HUMAN
Tissue specificity: Detected in lymphoid cells, striated and smooth muscle, several epithelia and neurons. Expressed in neutrophils, monocytes and lymphocytes. Enhanced expression seen in pancreatic adenocarcinoma, endometrial cancer, and bladder cancer, as compared to non-cancerous tissue. In bladder cancer, the increase in expression exhibits a striking positive correlation with more advanced stages of the disease.

Evidence on tissue expression from TISSUES for ISG15 Gene

  • Liver(4.5)
  • Intestine(4.4)
  • Spleen(2.8)
  • Blood(2.7)
  • Kidney(2.3)
  • Lung(2.3)
  • Lymph node(2.1)
  • Bone marrow(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ISG15 Gene

Germ Layers:
  • endoderm
  • mesoderm
Systems:
  • immune
  • lymphatic
  • respiratory
Regions:
Thorax:
  • lung
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with ISG15: view

Orthologs for ISG15 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ISG15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ISG15 31 31 30
  • 99.39 (n)
 OneToMany
dog
(Canis familiaris)
 Mammalia ISG15 31 30
  • 77.42 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Isg15 17 31 30
  • 76.5 (n)
cow
(Bos Taurus)
 Mammalia ISG15 31 30
  • 76.41 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Isg15 30
  • 73.25 (n)
oppossum
(Monodelphis domestica)
 Mammalia ISG15 31
  • 46 (a)
 OneToOne
Species where no ortholog for ISG15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ISG15 Gene

ENSEMBL:
Gene Tree for ISG15 (if available)
TreeFam:
Gene Tree for ISG15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ISG15: view image

Paralogs for ISG15 Gene

Paralogs for ISG15 Gene

(6) SIMAP similar genes for ISG15 Gene using alignment to 1 proteins:

  • ISG15_HUMAN
genes like me logo Genes that share paralogs with ISG15: view

Variants for ISG15 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ISG15 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
568195 Uncertain Significance: Immunodeficiency 38 with basal ganglia calcification 1,014,276(+) G/A MISSENSE_VARIANT
571208 Uncertain Significance: Immunodeficiency 38 with basal ganglia calcification 1,014,255(+) G/A MISSENSE_VARIANT
639487 Uncertain Significance: Immunodeficiency 38 with basal ganglia calcification 1,014,047(+) A/G MISSENSE_VARIANT
648609 Uncertain Significance: Immunodeficiency 38 with basal ganglia calcification 1,014,359(+) G/A MISSENSE_VARIANT
651310 Uncertain Significance: Immunodeficiency 38 with basal ganglia calcification 1,014,452(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ISG15 Gene

Structural Variations from Database of Genomic Variants (DGV) for ISG15 Gene

Variant ID Type Subtype PubMed ID
dgv17n54 CNV loss 21841781
dgv2n67 CNV gain 20364138
dgv5n100 CNV gain 25217958
esv2762302 CNV gain 21179565
nsv1013524 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160644 CNV deletion 26073780
nsv428334 CNV gain 18775914
nsv482937 CNV loss 15286789
nsv509146 CNV insertion 20534489
nsv517709 CNV gain+loss 19592680
nsv544895 CNV loss 21841781
nsv945741 CNV duplication 23825009
nsv950451 CNV deletion 24416366

Variation tolerance for ISG15 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.95; 79.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ISG15 Gene

Human Gene Mutation Database (HGMD)
ISG15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ISG15

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISG15 Gene

Disorders for ISG15 Gene

MalaCards: The human disease database

(16) MalaCards diseases for ISG15 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 38 with basal ganglia calcification
  • imd38
influenza
  • flu
basal ganglia calcification
  • fahr disease
systemic lupus erythematosus 3
  • systemic lupus erythematosus, susceptibility to, 3
avian influenza
  • avian flu
- elite association - COSMIC cancer census association via MalaCards
Search ISG15 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ISG15_HUMAN
  • Immunodeficiency 38, with basal ganglia calcification (IMD38) [MIM:616126]: A primary immunodeficiency predisposing individuals to severe clinical disease upon infection with weakly virulent mycobacteria, including Mycobacterium bovis Bacille Calmette-Guerin (BCG) vaccines. Patients are also susceptible to Salmonella and Mycobacterium tubercolosis infections. Affected individuals have intracranial calcification. {ECO:0000269 PubMed:22859821}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ISG15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ISG15: view

No data available for Genatlas for ISG15 Gene

Publications for ISG15 Gene

  1. ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells. (PMID: 20133869) Zhao C … Krug RM (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 23 54
  2. ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway. (PMID: 19270716) Jeon YJ … Chung CH (EMBO reports 2009) 3 4 23 54
  3. Interferon-induced ISG15 conjugation inhibits influenza A virus gene expression and replication in human cells. (PMID: 19357168) Hsiang TY … Krug RM (Journal of virology 2009) 3 4 23 54
  4. Nitrosylation of ISG15 prevents the disulfide bond-mediated dimerization of ISG15 and contributes to effective ISGylation. (PMID: 18606809) Okumura F … Zhang DE (The Journal of biological chemistry 2008) 3 4 23 54
  5. Different roles for two ubiquitin-like domains of ISG15 in protein modification. (PMID: 18356159) Chang YG … Hu HY (The Journal of biological chemistry 2008) 3 4 23 54

ExternalLinks

View latest publications for ISG15 gene in Mastermind

Products for ISG15 Gene

  • Addgene plasmids for ISG15

Sources for ISG15 Gene