Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]
ISG15 (ISG15 Ubiquitin Like Modifier) is a Protein Coding gene. Diseases associated with ISG15 include Immunodeficiency 38 With Basal Ganglia Calcification and Influenza. Among its related pathways are Interferon gamma signaling and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. Gene Ontology (GO) annotations related to this gene include protein tag. An important paralog of this gene is UBC.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005178 | integrin binding | IPI | 29100055 |
GO:0005515 | protein binding | IPI | 16189514 |
GO:0031386 | protein tag | IBA | 21873635 |
GO:0031625 | ubiquitin protein ligase binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA,IDA | 22859821 |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002376 | immune system process | IEA | -- |
GO:0007229 | integrin-mediated signaling pathway | IDA | 29100055 |
GO:0009617 | response to bacterium | IEA | -- |
GO:0016032 | viral process | IEA | -- |
GO:0016567 | NOT protein ubiquitination | IBA | 21873635 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC100609237 30 |
|
||
ISG15 31 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | ISG15 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Isg15 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ISG15 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Isg15 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | ISG15 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
639487 | Uncertain Significance: Immunodeficiency 38 with basal ganglia calcification | 1,014,047(+) | A/G | MISSENSE_VARIANT | |
648609 | Uncertain Significance: Immunodeficiency 38 with basal ganglia calcification | 1,014,359(+) | G/A | MISSENSE_VARIANT | |
651310 | Uncertain Significance: Immunodeficiency 38 with basal ganglia calcification | 1,014,452(+) | G/A | MISSENSE_VARIANT | |
652606 | Uncertain Significance: Immunodeficiency 38 with basal ganglia calcification | 1,014,138(+) | C/T | MISSENSE_VARIANT | |
655870 | Uncertain Significance: Immunodeficiency 38 with basal ganglia calcification | 1,014,222(+) | C/T | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv17n54 | CNV | loss | 21841781 |
dgv2n67 | CNV | gain | 20364138 |
dgv5n100 | CNV | gain | 25217958 |
esv2762302 | CNV | gain | 21179565 |
nsv1013524 | CNV | gain | 25217958 |
nsv10161 | CNV | gain+loss | 18304495 |
nsv1160644 | CNV | deletion | 26073780 |
nsv428334 | CNV | gain | 18775914 |
nsv482937 | CNV | loss | 15286789 |
nsv509146 | CNV | insertion | 20534489 |
nsv517709 | CNV | gain+loss | 19592680 |
nsv544895 | CNV | loss | 21841781 |
nsv945741 | CNV | duplication | 23825009 |
nsv950451 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
immunodeficiency 38 with basal ganglia calcification |
|
|
influenza |
|
|
basal ganglia calcification |
|
|
middle east respiratory syndrome |
|
|
systemic lupus erythematosus 3 |
|
|