Aliases for ISCA1 Gene
External Ids for ISCA1 Gene
Previous HGNC Symbols for ISCA1 Gene
Previous GeneCards Identifiers for ISCA1 Gene
ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a role in electron-transfer reactions (Cozar-Castellano et al., 2004 [PubMed 15262227]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ISCA1 Gene
ISCA1 (Iron-Sulfur Cluster Assembly 1) is a Protein Coding gene. Diseases associated with ISCA1 include Multiple Mitochondrial Dysfunctions Syndrome 5 and Multiple Mitochondrial Dysfunctions Syndrome. Gene Ontology (GO) annotations related to this gene include structural molecule activity and iron-sulfur cluster binding. An important paralog of this gene is ISCA2.
UniProtKB/Swiss-Prot Summary for ISCA1 Gene
Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.