Aliases for IRX3 Gene
External Ids for IRX3 Gene
Previous GeneCards Identifiers for IRX3 Gene
IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).[supplied by OMIM, Aug 2009]
GeneCards Summary for IRX3 Gene
IRX3 (Iroquois Homeobox 3) is a Protein Coding gene. Diseases associated with IRX3 include Transient Refractive Change and Cycloplegia. Among its related pathways are FTO Obesity Variant Mechanism. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is IRX1.
UniProtKB/Swiss-Prot Summary for IRX3 Gene
Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism.