Aliases for IRX3 Gene
External Ids for IRX3 Gene
Previous GeneCards Identifiers for IRX3 Gene
IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).[supplied by OMIM, Aug 2009]
GeneCards Summary for IRX3 Gene
IRX3 (Iroquois Homeobox 3) is a Protein Coding gene. Diseases associated with IRX3 include Cycloplegia and Aniseikonia. Among its related pathways are FTO Obesity Variant Mechanism. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is IRX1.
UniProtKB/Swiss-Prot Summary for IRX3 Gene
Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism.