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Aliases for IRS2 Gene

Aliases for IRS2 Gene

  • Insulin Receptor Substrate 2 2 3 3 5
  • IRS-2 3 4

External Ids for IRS2 Gene

Previous GeneCards Identifiers for IRS2 Gene

  • GC13M108766
  • GC13M104793
  • GC13M109242
  • GC13M108132
  • GC13M108104
  • GC13M109204
  • GC13M110406
  • GC13M091005

Summaries for IRS2 Gene

Entrez Gene Summary for IRS2 Gene

  • This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]

GeneCards Summary for IRS2 Gene

IRS2 (Insulin Receptor Substrate 2) is a Protein Coding gene. Diseases associated with IRS2 include Diabetes Mellitus, Noninsulin-Dependent and Ascaris Lumbricoides Infection. Among its related pathways are ERK Signaling and Development EGFR signaling via small GTPases. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein domain specific binding. An important paralog of this gene is IRS1.

UniProtKB/Swiss-Prot for IRS2 Gene

  • May mediate the control of various cellular processes by insulin.

Gene Wiki entry for IRS2 Gene

Additional gene information for IRS2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRS2 Gene

Genomics for IRS2 Gene

GeneHancer (GH) Regulatory Elements for IRS2 Gene

Promoters and enhancers for IRS2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J109776 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 662 +4.2 4152 11.6 PKNOX1 SIN3A FEZF1 YY1 ZNF766 E2F8 FOS KLF13 SP3 REST IRS2 RN7SKP10 MYO16-AS2 RPL21P107 ENSG00000275741 GC13M109755
GH13J109653 Enhancer 1.1 FANTOM5 Ensembl ENCODE 18.2 +131.9 131867 3.4 SUZ12 ZSCAN4 CEBPB MAX CEBPG MNT SP1 NFATC1 RCOR1 MYC IRS2 PIR55972 LOC101927627 LOC105370359
GH13J109704 Enhancer 1.4 FANTOM5 Ensembl ENCODE 13.5 +80.6 80570 3.8 FOXA2 PKNOX1 ATF1 ARNT BRCA1 YY1 POLR2B ZNF766 CBX5 ATF7 LINC00676 IRS2 PIR55972 LOC105370359 LOC101927627
GH13J109153 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11 +628.5 628463 9.3 HDGF SMAD1 RB1 SIN3A STAT5A BMI1 BATF KLF5 IRF4 RAD21 IRS2 ABHD13 MYO16-AS1 MYO16 LOC105370356
GH13J110023 Enhancer 0.9 Ensembl ENCODE dbSUPER 19.4 -237.5 -237542 1.2 PKNOX1 POLR2A EBF1 MEF2B IRS2 ENSG00000276269 LOC101927646 ENSG00000274331
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IRS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IRS2 gene promoter:
  • AP-1
  • NRSF form 2
  • NRSF form 1
  • C/EBPalpha
  • ATF-2
  • c-Jun
  • E2F

Genomic Locations for IRS2 Gene

Genomic Locations for IRS2 Gene
33,871 bases
Minus strand
32,732 bases
Minus strand

Genomic View for IRS2 Gene

Genes around IRS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRS2 Gene

Proteins for IRS2 Gene

  • Protein details for IRS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin receptor substrate 2
    Protein Accession:
    Secondary Accessions:
    • Q96RR2
    • Q9BZG0
    • Q9Y6I5

    Protein attributes for IRS2 Gene

    1338 amino acids
    Molecular mass:
    137334 Da
    Quaternary structure:
    • Interacts with PHIP.

    Three dimensional structures from OCA and Proteopedia for IRS2 Gene

neXtProt entry for IRS2 Gene

Post-translational modifications for IRS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IRS2 Gene

Domains & Families for IRS2 Gene

Gene Families for IRS2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IRS2: view

No data available for UniProtKB/Swiss-Prot for IRS2 Gene

Function for IRS2 Gene

Molecular function for IRS2 Gene

UniProtKB/Swiss-Prot Function:
May mediate the control of various cellular processes by insulin.
GENATLAS Biochemistry:
insulin receptor substrate 2,pleiotropes mediator of insulin coordinating Igf-1 receptor-mediated beta cell development and peripheral insertion signaling,interacting with several proteins containing SH2 domains,such as PIKRs,GRB2,unlikely to be involved in NIDDM

Phenotypes From GWAS Catalog for IRS2 Gene

Gene Ontology (GO) - Molecular Function for IRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 obsolete signal transducer activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005158 insulin receptor binding IEA,IBA --
GO:0005515 protein binding IPI 8662806
GO:0016303 1-phosphatidylinositol-3-kinase activity TAS --
genes like me logo Genes that share ontologies with IRS2: view
genes like me logo Genes that share phenotypes with IRS2: view

Animal Models for IRS2 Gene

MGI Knock Outs for IRS2:

Animal Model Products

Clone Products

  • Addgene plasmids for IRS2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IRS2 Gene

Localization for IRS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRS2 Gene

Cytoplasm, cytosol.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRS2 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 4
endoplasmic reticulum 2
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Aggresome (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IBA --
GO:0005886 plasma membrane IEA,TAS --
GO:0032991 protein-containing complex IEA --
genes like me logo Genes that share ontologies with IRS2: view

Pathways & Interactions for IRS2 Gene

SuperPathway Contained pathways
1 RET signaling
2 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
3 Regulation of lipid metabolism Insulin signaling-generic cascades
4 PI3K/AKT activation
5 Type I Interferon Signaling Pathways
genes like me logo Genes that share pathways with IRS2: view

SIGNOR curated interactions for IRS2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0002053 positive regulation of mesenchymal cell proliferation IEA --
GO:0002903 negative regulation of B cell apoptotic process ISS,IEA --
GO:0006006 glucose metabolic process TAS 9495343
GO:0007165 signal transduction TAS 7675087
genes like me logo Genes that share ontologies with IRS2: view

Drugs & Compounds for IRS2 Gene

(25) Drugs for IRS2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(14) Additional Compounds for IRS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IRS2: view

Transcripts for IRS2 Gene

mRNA/cDNA for IRS2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(216) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IRS2 Gene

Insulin receptor substrate 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for IRS2

Alternative Splicing Database (ASD) splice patterns (SP) for IRS2 Gene

No ASD Table

Relevant External Links for IRS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IRS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IRS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IRS2 Gene

This gene is overexpressed in Brain (27.8) and Cerebrospinal fluid (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IRS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of IRS2 Gene:


SOURCE GeneReport for Unigene cluster for IRS2 Gene:


Evidence on tissue expression from TISSUES for IRS2 Gene

  • Liver(4.7)
  • Blood(4.5)
  • Nervous system(3.5)
  • Muscle(3.1)
  • Pancreas(3)
  • Heart(2.3)
  • Intestine(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with IRS2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRS2 Gene

Orthologs for IRS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IRS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IRS2 34 33
  • 97.69 (n)
(Canis familiaris)
Mammalia IRS2 34 33
  • 87.38 (n)
(Bos Taurus)
Mammalia IRS2 34 33
  • 84.79 (n)
(Rattus norvegicus)
Mammalia Irs2 33
  • 81.48 (n)
(Mus musculus)
Mammalia Irs2 16 34 33
  • 80.8 (n)
(Monodelphis domestica)
Mammalia IRS2 34
  • 73 (a)
(Gallus gallus)
Aves IRS2 34 33
  • 74.39 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498409 33
  • 57.07 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.694 33
(Danio rerio)
Actinopterygii irs2 33
  • 61.73 (n)
IRS2 34
  • 53 (a)
zgc56306 33
fruit fly
(Drosophila melanogaster)
Insecta chico 34
  • 19 (a)
(Oryza sativa)
Liliopsida Os.5303 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
Species where no ortholog for IRS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRS2 Gene

Gene Tree for IRS2 (if available)
Gene Tree for IRS2 (if available)
Evolutionary constrained regions (ECRs) for IRS2: view image

Paralogs for IRS2 Gene

Paralogs for IRS2 Gene

(2) SIMAP similar genes for IRS2 Gene using alignment to 6 proteins:

  • L0R5B5_HUMAN
  • Q96RG4_HUMAN
  • Q96RG5_HUMAN
  • Q9UP29_HUMAN
genes like me logo Genes that share paralogs with IRS2: view

Variants for IRS2 Gene

Sequence variations from dbSNP and Humsavar for IRS2 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs137852740 risk-factor, DIABETES, TYPE II, SUSCEPTIBILITY TO 109,784,115(-) G/A/C coding_sequence_variant, missense_variant, synonymous_variant
rs1805097 risk-factor, DIABETES, TYPE II, SUSCEPTIBILITY TO 109,782,884(-) C/T coding_sequence_variant, missense_variant
rs1000090189 -- 109,773,878(-) G/C intron_variant
rs1000280917 -- 109,759,379(-) T/C intron_variant
rs1000417619 -- 109,787,793(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IRS2 Gene

Variant ID Type Subtype PubMed ID
dgv3385n54 CNV loss 21841781
dgv3386n54 CNV gain+loss 21841781
dgv3387n54 CNV gain 21841781
dgv3388n54 CNV gain 21841781
dgv3389n54 CNV gain+loss 21841781
dgv348n67 CNV gain 20364138
dgv349n67 CNV gain 20364138
esv2157648 CNV deletion 18987734
esv22887 CNV loss 19812545
esv2500078 CNV deletion 19546169
esv2658062 CNV deletion 23128226
esv2660355 CNV deletion 23128226
esv2747995 CNV deletion 23290073
esv2747997 CNV deletion 23290073
esv29023 CNV gain+loss 19812545
esv3403446 CNV duplication 20981092
esv3582827 CNV gain 25503493
nsv1044855 CNV gain 25217958
nsv1071125 CNV deletion 25765185
nsv1126353 CNV deletion 24896259
nsv1131065 CNV deletion 24896259
nsv1136175 CNV deletion 24896259
nsv512337 CNV loss 21212237
nsv526943 CNV loss 19592680
nsv563072 CNV loss 21841781
nsv563076 CNV loss 21841781
nsv563088 CNV loss 21841781
nsv563094 CNV loss 21841781
nsv818995 CNV gain 17921354
nsv821265 CNV deletion 20802225
nsv826791 CNV loss 20364138
nsv826796 CNV gain 20364138
nsv9108 CNV gain+loss 18304495
nsv951919 CNV deletion 24416366

Variation tolerance for IRS2 Gene

Gene Damage Index Score: 6.02; 75.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IRS2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRS2 Gene

Disorders for IRS2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for IRS2 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search IRS2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IRS2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IRS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IRS2 Gene

Publications for IRS2 Gene

  1. Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation. (PMID: 12687350) Lautier C … Grigorescu F (Human genetics 2003) 3 4 22 44 58
  2. Insulin receptor substrate-2 gene polymorphism: is it associated with endometrial cancer? (PMID: 20184486) Cayan F … Dilek S (Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2010) 3 22 44 58
  3. The IRS2 Gly1057Asp variant is associated with human longevity. (PMID: 19887537) Barbieri M … Paolisso G (The journals of gerontology. Series A, Biological sciences and medical sciences 2010) 3 22 44 58
  4. The G1057D polymorphism of IRS-2 gene is not associated with type 2 diabetes and obese patients among ethnic groups in Tunisian population. (PMID: 19332049) Ouederni TB … Benammar-Elgaaied A (Clinical biochemistry 2009) 3 22 44 58
  5. Association of the FTO gene with obesity and the metabolic syndrome is independent of the IRS-2 gene in the female population of Southern France. (PMID: 19818665) Attaoua R … Grigorescu F (Diabetes & metabolism 2009) 3 22 44 58

Products for IRS2 Gene

Sources for IRS2 Gene

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