External Ids for IRS1 Gene
Previous GeneCards Identifiers for IRS1 Gene
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
GeneCards Summary for IRS1 Gene
IRS1 (Insulin Receptor Substrate 1) is a Protein Coding gene. Diseases associated with IRS1 include Diabetes Mellitus, Noninsulin-Dependent and Rare Diabetes Mellitus Type 2. Among its related pathways are PI3K/AKT activation and Development IGF-1 receptor signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein kinase C binding. An important paralog of this gene is IRS2.
UniProtKB/Swiss-Prot Summary for IRS1 Gene
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).