Aliases for IRGC Gene

Aliases for IRGC Gene

  • Immunity Related GTPase Cinema 2 3 5
  • Immunity-Related GTPase Family, Cinema 1 2 3
  • Immunity-Related GTPase Cinema 1 3 4
  • Interferon-Inducible GTPase 5 3 4
  • CINEMA 2 3
  • IRGC1 3 4
  • Iigp5 2 3
  • Interferon-Gamma-Inducible GTPase IFGGE Protein 3
  • EC 3.6.5.- 4
  • R30953_1 3
  • EC 3.6.5 51
  • IFGGE 3
  • IIGP5 4
  • IRGC 5

External Ids for IRGC Gene

Previous HGNC Symbols for IRGC Gene

  • IRGC1

Previous GeneCards Identifiers for IRGC Gene

  • GC19P048915
  • GC19P044220
  • GC19P040652

Summaries for IRGC Gene

GeneCards Summary for IRGC Gene

IRGC (Immunity Related GTPase Cinema) is a Protein Coding gene. Diseases associated with IRGC include Multiple Personality Disorder and Animal Phobia. Gene Ontology (GO) annotations related to this gene include GTP binding and hydrolase activity, acting on acid anhydrides. An important paralog of this gene is IRGM.

Gene Wiki entry for IRGC Gene

Additional gene information for IRGC Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IRGC Gene

Genomics for IRGC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IRGC Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J043716 Promoter 0.6 EPDnew 600.7 +0.0 14 0.1 RFX1 EGR1 CTBP1 ESRRA GLIS2 IRGC RF00017-2994 SMG9
GH19J043773 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 +63.9 63900 12.3 ARHGAP35 CREB1 CTCF HNRNPL PRDM10 ZNF629 TFE3 ZNF512 RFX1 LEF1 KCNN4 ZNF45 ZNF180 ZNF225 ZNF284 ZNF224 ZNF227 ZNF223 ZNF283 ZNF234
GH19J043667 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 -45.9 -45871 6 CTCF PRDM10 ZNF629 REST IKZF1 KDM1A ZNF692 POLR2A JUND LARP7 MN297594 PLAUR ZNF45 ZNF180 ZNF225 ZNF224 ZNF155 ZNF284 ZNF234 ZNF223
GH19J043462 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.2 -251.3 -251267 4.4 CEBPG CREB1 PRDM10 ZNF629 ZNF512 IKZF1 ZNF692 TARDBP PRDM1 MTA2 LYPD3 ZNF225 ZNF223 ZNF226 ZNF45 ZNF235 ZNF227 ZNF283 ZNF284 ZNF221
GH19J043798 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 11.4 +82.9 82949 1.6 ARHGAP35 PRDM10 ZNF629 ZNF512 KDM1A ZNF692 JUND ZNF300 PRDM1 ZIC2 lnc-KCNN4-2 piR-52460 ZNF180 ZNF45 ZNF225 ZNF224 ZNF234 ZNF284 ZNF223 ZNF283
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IRGC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IRGC

Top Transcription factor binding sites by QIAGEN in the IRGC gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • c-Myc
  • c-Rel
  • Max
  • MZF-1
  • Pax-4a
  • Pax-5

Genomic Locations for IRGC Gene

Genomic Locations for IRGC Gene
3,954 bases
Plus strand
4,012 bases
Plus strand

Genomic View for IRGC Gene

Genes around IRGC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRGC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRGC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRGC Gene

Proteins for IRGC Gene

  • Protein details for IRGC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon-inducible GTPase 5
    Protein Accession:
    Secondary Accessions:
    • Q05BR8

    Protein attributes for IRGC Gene

    463 amino acids
    Molecular mass:
    50288 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IRGC Gene

Selected DME Specific Peptides for IRGC Gene


Post-translational modifications for IRGC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRGC Gene

Domains & Families for IRGC Gene

Gene Families for IRGC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IRGC Gene

Suggested Antigen Peptide Sequences for IRGC Gene

GenScript: Design optimal peptide antigens:
  • Immunity-related GTPase cinema 1 (IIGP5_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
genes like me logo Genes that share domains with IRGC: view

Function for IRGC Gene

Molecular function for IRGC Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;.

Enzyme Numbers (IUBMB) for IRGC Gene

Phenotypes From GWAS Catalog for IRGC Gene

Gene Ontology (GO) - Molecular Function for IRGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IBA 21873635
GO:0005525 GTP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with IRGC: view
genes like me logo Genes that share phenotypes with IRGC: view

Animal Model Products

CRISPR Products

miRNA for IRGC Gene

miRTarBase miRNAs that target IRGC

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRGC

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IRGC Gene

Localization for IRGC Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRGC gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for IRGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IRGC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for IRGC Gene

Pathways & Interactions for IRGC Gene

PathCards logo

SuperPathways for IRGC Gene

No Data Available

Gene Ontology (GO) - Biological Process for IRGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response IBA 21873635
GO:0035458 cellular response to interferon-beta IBA 21873635
genes like me logo Genes that share ontologies with IRGC: view

No data available for Pathways by source and SIGNOR curated interactions for IRGC Gene

Drugs & Compounds for IRGC Gene

(5) Drugs for IRGC Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Guanosine diphosphate Experimental Pharma Target 0
2-(N-morpholino)ethanesulfonic acid Experimental Pharma Target 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with IRGC: view

Transcripts for IRGC Gene

mRNA/cDNA for IRGC Gene

2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRGC

Alternative Splicing Database (ASD) splice patterns (SP) for IRGC Gene

No ASD Table

Relevant External Links for IRGC Gene

GeneLoc Exon Structure for

Expression for IRGC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IRGC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for IRGC Gene

This gene is overexpressed in Testis (x52.0).

Protein differential expression in normal tissues from HIPED for IRGC Gene

This gene is overexpressed in Testis (49.0) and Ovary (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IRGC Gene

Protein tissue co-expression partners for IRGC Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IRGC

SOURCE GeneReport for Unigene cluster for IRGC Gene:


Evidence on tissue expression from TISSUES for IRGC Gene

  • Nervous system(4.5)
  • Skin(2.5)
  • Blood(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with IRGC: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRGC Gene

Orthologs for IRGC Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRGC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IRGC 30 31
  • 99.71 (n)
(Canis familiaris)
Mammalia LOC476445 30
  • 88.55 (n)
  • 52 (a)
(Bos Taurus)
Mammalia IRGC 30 31
  • 86.44 (n)
(Rattus norvegicus)
Mammalia Irgc 30
  • 85.86 (n)
(Mus musculus)
Mammalia Irgc1 30 17 31
  • 85.54 (n)
(Ornithorhynchus anatinus)
Mammalia IRGC 31
  • 43 (a)
(Monodelphis domestica)
Mammalia IRGC 31
  • 42 (a)
(Anolis carolinensis)
Reptilia IRGC 31
  • 39 (a)
(Danio rerio)
Actinopterygii irgf1 31
  • 40 (a)
IRGC (2 of 7) 31
  • 40 (a)
irge4 31
  • 35 (a)
irgf2 31
  • 35 (a)
IRGC (1 of 7) 31
  • 34 (a)
IRGC (3 of 7) 31
  • 25 (a)
IRGC (6 of 7) 31
  • 21 (a)
Species where no ortholog for IRGC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IRGC Gene

Gene Tree for IRGC (if available)
Gene Tree for IRGC (if available)
Evolutionary constrained regions (ECRs) for IRGC: view image

Paralogs for IRGC Gene

Paralogs for IRGC Gene

(2) SIMAP similar genes for IRGC Gene using alignment to 2 proteins:

  • M0R0T1_HUMAN Pseudogenes for IRGC Gene

genes like me logo Genes that share paralogs with IRGC: view

Variants for IRGC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IRGC Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
712988 Benign: not provided 43,719,119(+) G/A SYNONYMOUS_VARIANT
rs11555891 - p.Asp135Asn

Additional dbSNP identifiers (rs#s) for IRGC Gene

Structural Variations from Database of Genomic Variants (DGV) for IRGC Gene

Variant ID Type Subtype PubMed ID
esv3644475 CNV loss 21293372
nsv2503 CNV insertion 18451855
nsv833839 CNV loss 17160897

Variation tolerance for IRGC Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.05; 68.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IRGC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRGC Gene

Disorders for IRGC Gene

MalaCards: The human disease database

(20) MalaCards diseases for IRGC Gene - From: DISEASES

Disorder Aliases PubMed IDs
multiple personality disorder
  • dissociative identity disorder
animal phobia
  • fear of animals
solar retinopathy
  • solar retinitis
dissociative disorder
  • dissociative disease
central nervous system origin vertigo
  • central vestibular vertigo
- elite association - COSMIC cancer census association via MalaCards
Search IRGC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IRGC

genes like me logo Genes that share disorders with IRGC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IRGC Gene

Publications for IRGC Gene

  1. Human IRGM gene "to be or not to be". (PMID: 20737271) Bekpen C … Eichler EE (Seminars in immunopathology 2010) 2 3
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for IRGC Gene

Sources for IRGC Gene