IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been iden... See more...

Aliases for IRF7 Gene

Aliases for IRF7 Gene

  • Interferon Regulatory Factor 7 2 3 4 5
  • IRF-7 3 4
  • Interferon Regulatory Factor 7G Isoform 3
  • Interferon Regulatory Factor-7H 3
  • IRF-7H 3
  • IMD39 3
  • IRF7A 3
  • IRF7B 3
  • IRF7C 3
  • IRF7H 3

External Ids for IRF7 Gene

Previous GeneCards Identifiers for IRF7 Gene

  • GC11P001127
  • GC11P001065
  • GC11P000583
  • GC11M000602
  • GC11M000427

Summaries for IRF7 Gene

Entrez Gene Summary for IRF7 Gene

  • IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]

GeneCards Summary for IRF7 Gene

IRF7 (Interferon Regulatory Factor 7) is a Protein Coding gene. Diseases associated with IRF7 include Immunodeficiency 39 and Vaccinia. Among its related pathways are Toll-like Receptor Signaling Pathway and Cytosolic sensors of pathogen-associated DNA. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is IRF5.

UniProtKB/Swiss-Prot Summary for IRF7 Gene

  • Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.

Gene Wiki entry for IRF7 Gene

Additional gene information for IRF7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IRF7 Gene

Genomics for IRF7 Gene

GeneHancer (GH) Regulatory Elements for IRF7 Gene

Promoters and enhancers for IRF7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IRF7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IRF7

Top Transcription factor binding sites by QIAGEN in the IRF7 gene promoter:
  • C/EBPalpha
  • p300
  • STAT3

Genomic Locations for IRF7 Gene

Genomic Locations for IRF7 Gene
chr11:612,553-615,999
(GRCh38/hg38)
Size:
3,447 bases
Orientation:
Minus strand
chr11:612,553-615,999
(GRCh37/hg19)
Size:
3,447 bases
Orientation:
Minus strand

Genomic View for IRF7 Gene

Genes around IRF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRF7 Gene

Proteins for IRF7 Gene

  • Protein details for IRF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92985-IRF7_HUMAN
    Recommended name:
    Interferon regulatory factor 7
    Protein Accession:
    Q92985
    Secondary Accessions:
    • B9EGL3
    • O00331
    • O00332
    • O00333
    • O75924
    • Q9UE79

    Protein attributes for IRF7 Gene

    Size:
    503 amino acids
    Molecular mass:
    54278 Da
    Quaternary structure:
    • Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF3. Interacts with TICAM1 and TICAM2. Interacts with MYD88 AND TRAF6.
    • (Microbial infection) Interacts with Epstein-Barr virus LF2 and LMP1.
    • (Microbial infection) Interacts with rotavirus A NSP1; this interaction leads to the proteasome-dependent degradation of IRF7.
    • (Microbial infection) Interacts with human herpes virus 8/HHV-8 proteins ORF45 and vIRF-1.
    • (Microbial infection) Interacts with human T-cell leukemia virus 1/HTLV-1 protein HBZ.
    • (Microbial infection) Interacts with Seneca Valley virus protease 3C; this interaction is involved in the suppression of IRF7 expression and phosphorylation by the virus.
    Miscellaneous:
    • [Isoform C]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Three dimensional structures from OCA and Proteopedia for IRF7 Gene

    Alternative splice isoforms for IRF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IRF7 Gene

Post-translational modifications for IRF7 Gene

  • Acetylation inhibits its DNA-binding ability and activity.
  • In response to a viral infection, phosphorylated on Ser-477 and Ser-479 by TBK1 and IKBKE1. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3. In TLR7- and TLR9-mediated signaling pathway, phosphorylated by IRAK1.
  • TRAF6-mediated ubiquitination is required for IRF7 activation.
  • Sumoylated by TRIM28, which inhibits its transactivation activity.
  • (Microbial infection) Cleaved and inactivated by the protease 3C of enterovirus 71 allowing the virus to disrupt the host type I interferon production.
  • Ubiquitination at Lys120 and Lys341
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for IRF7

No data available for DME Specific Peptides for IRF7 Gene

Domains & Families for IRF7 Gene

Gene Families for IRF7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for IRF7 Gene

Suggested Antigen Peptide Sequences for IRF7 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61529, highly similar to Interferon regulatory factor 7 (B4E1B1_HUMAN)
  • Interferon regulatory factor 7 (IRF7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92985

UniProtKB/Swiss-Prot:

IRF7_HUMAN :
  • Belongs to the IRF family.
Family:
  • Belongs to the IRF family.
genes like me logo Genes that share domains with IRF7: view

Function for IRF7 Gene

Molecular function for IRF7 Gene

UniProtKB/Swiss-Prot Function:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.
UniProtKB/Swiss-Prot EnzymeRegulation:
In the absence of viral infection, maintained as a monomer in an autoinhibited state and phosphorylation disrupts this autoinhibition leading to the liberation of the DNA-binding and dimerization activities and its nuclear localization where it can activate type I IFN and ISG genes.
UniProtKB/Swiss-Prot Induction:
By type I interferon (IFN) and viruses.
GENATLAS Biochemistry:
interferon regulatory factor 7,with three alternatively spliced isoforms,predominantly expressed in spleen,thymus and peripheral blood leukocytes regulator (? activator,? repressor) of IFNA,IFN-stimulated genes and Epstein-Barr virus

Phenotypes From GWAS Catalog for IRF7 Gene

Gene Ontology (GO) - Molecular Function for IRF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 17404045
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IEA,NAS 19274049
GO:0000987 proximal promoter sequence-specific DNA binding IEA --
GO:0001158 enhancer sequence-specific DNA binding IEA --
GO:0003677 DNA binding IMP 12374802
genes like me logo Genes that share ontologies with IRF7: view
genes like me logo Genes that share phenotypes with IRF7: view

Human Phenotype Ontology for IRF7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IRF7 Gene

MGI Knock Outs for IRF7:
  • Irf7 Irf7<tm1(KOMP)Wtsi>
  • Irf7 Irf7<tm1Ttg>

Animal Model Products

CRISPR Products

miRNA for IRF7 Gene

miRTarBase miRNAs that target IRF7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IRF7 Gene

Localization for IRF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRF7 Gene

Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRF7 gene
Compartment Confidence
nucleus 5
endosome 5
cytosol 5
extracellular 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IRF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IDA 22065573
GO:0005654 nucleoplasm TAS,IDA --
GO:0005737 cytoplasm TAS,IDA 19176627
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with IRF7: view

Pathways & Interactions for IRF7 Gene

genes like me logo Genes that share pathways with IRF7: view

SIGNOR curated interactions for IRF7 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IRF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 9315633
GO:0002376 immune system process IBA 21873635
GO:0002819 regulation of adaptive immune response IDA 17404045
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS 9315633
genes like me logo Genes that share ontologies with IRF7: view

Drugs & Compounds for IRF7 Gene

(2) Drugs for IRF7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for IRF7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IRF7: view

Transcripts for IRF7 Gene

mRNA/cDNA for IRF7 Gene

4 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRF7 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c · 12d
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5: - - -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for IRF7 Gene

GeneLoc Exon Structure for
IRF7

Expression for IRF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IRF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IRF7 Gene

This gene is overexpressed in Whole Blood (x9.5).

Protein differential expression in normal tissues from HIPED for IRF7 Gene

This gene is overexpressed in Plasma (31.8) and Heart (31.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IRF7 Gene



Protein tissue co-expression partners for IRF7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IRF7

SOURCE GeneReport for Unigene cluster for IRF7 Gene:

Hs.166120

mRNA Expression by UniProt/SwissProt for IRF7 Gene:

Q92985-IRF7_HUMAN
Tissue specificity: Expressed predominantly in spleen, thymus and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for IRF7 Gene

  • Spleen(4.7)
  • Heart(4.3)
  • Gall bladder(3.9)
  • Intestine(3.7)
  • Kidney(3.7)
  • Lung(3.7)
  • Blood(3.6)
  • Pancreas(3.2)
  • Adrenal gland(3.1)
  • Liver(3)
  • Lymph node(3)
  • Nervous system(3)
  • Eye(2.5)
  • Bone marrow(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IRF7 Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
  • lymphatic
Regions:
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with IRF7: view

Orthologs for IRF7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRF7 31 30
  • 98.46 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IRF7 31
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IRF7 31 30
  • 77.78 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Irf7 17 31 30
  • 72.86 (n)
rat
(Rattus norvegicus)
Mammalia Irf7 30
  • 72.55 (n)
chicken
(Gallus gallus)
Aves IRF7 30
  • 55.24 (n)
IRF-3 31
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IRF7 31
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496395 30
  • 49.07 (n)
zebrafish
(Danio rerio)
Actinopterygii irf7 31 30
  • 44.21 (n)
OneToOne
Species where no ortholog for IRF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRF7 Gene

ENSEMBL:
Gene Tree for IRF7 (if available)
TreeFam:
Gene Tree for IRF7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IRF7: view image

Paralogs for IRF7 Gene

Paralogs for IRF7 Gene

(3) SIMAP similar genes for IRF7 Gene using alignment to 7 proteins:

  • IRF7_HUMAN
  • B4E1B1_HUMAN
  • E9PIA7_HUMAN
  • E9PQ11_HUMAN
  • E9PR03_HUMAN
  • E9PSE3_HUMAN
  • M9RSF4_HUMAN
genes like me logo Genes that share paralogs with IRF7: view

Variants for IRF7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IRF7 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
639623 Uncertain Significance: Immunodeficiency 39 614,212(-) C/T MISSENSE_VARIANT
640013 Uncertain Significance: Immunodeficiency 39 612,767(-) C/T MISSENSE_VARIANT
641202 Uncertain Significance: Immunodeficiency 39 615,255(-) C/T MISSENSE_VARIANT
643503 Uncertain Significance: Immunodeficiency 39 612,764(-) T/A MISSENSE_VARIANT
645048 Uncertain Significance: Immunodeficiency 39 613,589(-) C/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for IRF7 Gene

Structural Variations from Database of Genomic Variants (DGV) for IRF7 Gene

Variant ID Type Subtype PubMed ID
dgv1522n54 CNV loss 21841781
dgv1523n54 CNV gain 21841781
dgv1524n54 CNV loss 21841781
dgv182e199 CNV deletion 23128226
esv2759794 CNV loss 17122850
esv2762889 CNV loss 21179565
nsv1039558 CNV gain 25217958
nsv1053964 CNV gain 25217958
nsv1159791 CNV deletion 26073780
nsv467634 CNV loss 19166990
nsv467635 CNV loss 19166990
nsv469923 CNV loss 18288195
nsv527327 CNV loss 19592680
nsv528415 CNV loss 19592680
nsv552854 CNV loss 21841781
nsv552856 CNV gain 21841781
nsv552861 CNV loss 21841781
nsv552862 CNV loss 21841781
nsv552865 CNV loss 21841781
nsv951270 CNV deletion 24416366

Variation tolerance for IRF7 Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IRF7 Gene

Human Gene Mutation Database (HGMD)
IRF7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IRF7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRF7 Gene

Disorders for IRF7 Gene

MalaCards: The human disease database

(23) MalaCards diseases for IRF7 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 39
  • imd39
vaccinia
influenza
  • flu
yellow fever
  • jungle yellow fever
hepatitis c
  • chronic hepatitis c
- elite association - COSMIC cancer census association via MalaCards
Search IRF7 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IRF7_HUMAN
  • Immunodeficiency 39 (IMD39) [MIM:616345]: A primary immunodeficiency causing severe, life-threatening acute respiratory distress upon infection with H1N1 influenza A. {ECO:0000269 PubMed:25814066}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for IRF7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IRF7: view

No data available for Genatlas for IRF7 Gene

Publications for IRF7 Gene

  1. Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients. (PMID: 20112359) Salloum R … Niewold TB (Arthritis and rheumatism 2010) 3 23 41 54
  2. Association of interferon regulatory factor-7 gene polymorphism with liver cirrhosis in chronic hepatitis C patients. (PMID: 18397234) Sermasathanasawadi R … Omata M (Liver international : official journal of the International Association for the Study of the Liver 2008) 3 23 41 54
  3. IRF-7: new role in the regulation of genes involved in adaptive immunity. (PMID: 17404045) Sgarbanti M … Battistini A (Annals of the New York Academy of Sciences 2007) 3 4 23 54
  4. Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. (PMID: 14739303) Han KJ … Shu HB (The Journal of biological chemistry 2004) 3 4 23 54
  5. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. (PMID: 15361868) Kawai T … Akira S (Nature immunology 2004) 3 4 23 54

Products for IRF7 Gene

Sources for IRF7 Gene